AU2010272243A1 - Detoxified Escherichia coli immunogens - Google Patents

Detoxified Escherichia coli immunogens Download PDF

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Publication number
AU2010272243A1
AU2010272243A1 AU2010272243A AU2010272243A AU2010272243A1 AU 2010272243 A1 AU2010272243 A1 AU 2010272243A1 AU 2010272243 A AU2010272243 A AU 2010272243A AU 2010272243 A AU2010272243 A AU 2010272243A AU 2010272243 A1 AU2010272243 A1 AU 2010272243A1
Authority
AU
Australia
Prior art keywords
antigen
orf3526
protein
amino acids
terminal amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2010272243A
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English (en)
Inventor
Maria Rita Fontana
Danilo Gomes Moriel
Laura Serino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of AU2010272243A1 publication Critical patent/AU2010272243A1/en
Priority to AU2013203188A priority Critical patent/AU2013203188A1/en
Abandoned legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/025Enterobacteriales, e.g. Enterobacter
    • A61K39/0258Escherichia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245Escherichia (G)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24Metalloendopeptidases (3.4.24)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2010272243A 2009-07-16 2010-07-16 Detoxified Escherichia coli immunogens Abandoned AU2010272243A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2013203188A AU2013203188A1 (en) 2009-07-16 2013-04-09 Detoxified Escherichia coli immunogens

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US22621909P 2009-07-16 2009-07-16
US61/226,219 2009-07-16
US29065409P 2009-12-29 2009-12-29
US61/290,654 2009-12-29
PCT/IB2010/002043 WO2011007257A1 (en) 2009-07-16 2010-07-16 Detoxified escherichia coli immunogens

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2013203188A Division AU2013203188A1 (en) 2009-07-16 2013-04-09 Detoxified Escherichia coli immunogens

Publications (1)

Publication Number Publication Date
AU2010272243A1 true AU2010272243A1 (en) 2012-03-08

Family

ID=43126814

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010272243A Abandoned AU2010272243A1 (en) 2009-07-16 2010-07-16 Detoxified Escherichia coli immunogens

Country Status (17)

Country Link
US (2) US8871214B2 (https=)
EP (2) EP2464658B1 (https=)
JP (1) JP2012532626A (https=)
CN (1) CN102770443A (https=)
AU (1) AU2010272243A1 (https=)
CA (1) CA2768343A1 (https=)
DK (1) DK2464658T3 (https=)
ES (2) ES2670799T3 (https=)
HR (1) HRP20141270T1 (https=)
IL (1) IL217539A0 (https=)
MX (1) MX2012000734A (https=)
PL (1) PL2464658T3 (https=)
PT (1) PT2464658E (https=)
SG (1) SG178035A1 (https=)
SI (1) SI2464658T1 (https=)
WO (1) WO2011007257A1 (https=)
ZA (1) ZA201200833B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2755994A2 (en) 2011-09-14 2014-07-23 Novartis AG Escherichia coli vaccine combination
WO2014102694A1 (en) * 2012-12-24 2014-07-03 Novartis Ag Novel mucinase for use in therapy or prophylaxis
EP3153519A1 (en) * 2015-10-06 2017-04-12 Syddansk Universitet Glycosylated yghj polypeptides from enterotoxigenic escherichia coli (etec)
IL268626B2 (en) * 2017-02-13 2024-04-01 Alexandre Eduardo Nowill Immunogenic composition for modulating the immune system and methods to treat bacterial infections in a subject
US11260119B2 (en) 2018-08-24 2022-03-01 Pfizer Inc. Escherichia coli compositions and methods thereof
US12138302B2 (en) 2020-10-27 2024-11-12 Pfizer Inc. Escherichia coli compositions and methods thereof
US12357681B2 (en) 2020-12-23 2025-07-15 Pfizer Inc. E. coli FimH mutants and uses thereof
JP2025538284A (ja) 2022-10-19 2025-11-27 グライプロバック アプス 尿路病原性E.コリ(E.coli)からのグリコシル化YGHJポリペプチド
WO2025219177A1 (en) 2024-04-18 2025-10-23 Glyprovac Aps Optimized plasmids for expression of yghj polypeptides

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US10058600B2 (en) 2018-08-28
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EP2464658A1 (en) 2012-06-20
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CA2768343A1 (en) 2011-01-20
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DK2464658T3 (en) 2014-12-15
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SI2464658T1 (sl) 2015-02-27
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