AU2010248831A1 - Organisms for the production of cyclohexanone - Google Patents
Organisms for the production of cyclohexanone Download PDFInfo
- Publication number
- AU2010248831A1 AU2010248831A1 AU2010248831A AU2010248831A AU2010248831A1 AU 2010248831 A1 AU2010248831 A1 AU 2010248831A1 AU 2010248831 A AU2010248831 A AU 2010248831A AU 2010248831 A AU2010248831 A AU 2010248831A AU 2010248831 A1 AU2010248831 A1 AU 2010248831A1
- Authority
- AU
- Australia
- Prior art keywords
- coa
- syn
- microbial organism
- cyclohexanone
- naturally occurring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 title claims abstract description 748
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- 108090000790 Enzymes Proteins 0.000 claims abstract description 357
- 230000037361 pathway Effects 0.000 claims abstract description 355
- 230000000813 microbial effect Effects 0.000 claims abstract description 315
- 150000007523 nucleic acids Chemical class 0.000 claims abstract description 211
- 108020004707 nucleic acids Proteins 0.000 claims abstract description 204
- 102000039446 nucleic acids Human genes 0.000 claims abstract description 204
- 108090000604 Hydrolases Proteins 0.000 claims abstract description 117
- 102000004157 Hydrolases Human genes 0.000 claims abstract description 116
- 102000004357 Transferases Human genes 0.000 claims abstract description 79
- 108090000992 Transferases Proteins 0.000 claims abstract description 79
- 102000003960 Ligases Human genes 0.000 claims abstract description 72
- 108090000364 Ligases Proteins 0.000 claims abstract description 72
- 108090000472 Phosphoenolpyruvate carboxykinase (ATP) Proteins 0.000 claims abstract description 71
- 108090000489 Carboxy-Lyases Proteins 0.000 claims abstract description 69
- 150000007970 thio esters Chemical class 0.000 claims abstract description 56
- POROIMOHDIEBBO-UHFFFAOYSA-N 2-oxocyclohexanecarboxylic acid Chemical compound OC(=O)C1CCCCC1=O POROIMOHDIEBBO-UHFFFAOYSA-N 0.000 claims abstract description 50
- 102000004316 Oxidoreductases Human genes 0.000 claims abstract description 48
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- FWFSEYBSWVRWGL-UHFFFAOYSA-N cyclohex-2-enone Chemical compound O=C1CCCC=C1 FWFSEYBSWVRWGL-UHFFFAOYSA-N 0.000 claims abstract description 37
- 108030004902 Cyclohexanone dehydrogenases Proteins 0.000 claims abstract description 32
- QNVIXZIHJGSYSU-UHFFFAOYSA-N 6-oxocyclohexene-1-carboxylic acid Chemical compound OC(=O)C1=CCCCC1=O QNVIXZIHJGSYSU-UHFFFAOYSA-N 0.000 claims abstract description 25
- MGTZCLMLSSAXLD-UHFFFAOYSA-N 5-oxohexanoic acid Chemical compound CC(=O)CCCC(O)=O MGTZCLMLSSAXLD-UHFFFAOYSA-N 0.000 claims abstract description 22
- PNPPVRALIYXJBW-UHFFFAOYSA-N 6-oxohexanoic acid Chemical compound OC(=O)CCCCC=O PNPPVRALIYXJBW-UHFFFAOYSA-N 0.000 claims abstract description 20
- IYNRULSFFKEOLT-UHFFFAOYSA-N 3-oxopimelic acid Chemical compound OC(=O)CCCC(=O)CC(O)=O IYNRULSFFKEOLT-UHFFFAOYSA-N 0.000 claims abstract description 15
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- LYCRXMTYUZDUGA-UYRKPTJQSA-N pimeloyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCCCC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 LYCRXMTYUZDUGA-UYRKPTJQSA-N 0.000 claims description 111
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- KJXFOFKTZDJLMQ-UYRKPTJQSA-N 3-oxopimeloyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)CCCC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 KJXFOFKTZDJLMQ-UYRKPTJQSA-N 0.000 claims description 48
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Classifications
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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| US20100184173A1 (en) * | 2008-11-14 | 2010-07-22 | Genomatica, Inc. | Microorganisms for the production of methyl ethyl ketone and 2-butanol |
| JP2012511928A (ja) | 2008-12-16 | 2012-05-31 | ゲノマチカ, インク. | 合成ガス及び他の炭素源の有用な製品への変換のための微生物及び方法 |
| BRPI1012877A2 (pt) * | 2009-05-15 | 2016-04-05 | Genomatica Inc | organismo para produção de ciclohexanona |
| JP2012529889A (ja) * | 2009-06-10 | 2012-11-29 | ゲノマチカ, インク. | Mek及び2−ブタノールの炭素効率のよい生合成のための微生物及び方法 |
| RU2012128843A (ru) | 2009-12-10 | 2014-01-20 | Дженоматика, Инк. | Способы и организмы для превращения синтез-газа или других газообразных источников углерода и метанола в 1,3-бутандиол |
| BR112012018620A2 (pt) * | 2010-01-29 | 2015-09-15 | Genomatica Inc | organismo microbiano de ocorrência não-natural, método para produzir (2-hidroxi-3-metil-4-oxobutoxi) fosfonato, método para produção de p-toluato, método para produzir tereftalato |
| SG183294A1 (en) | 2010-02-12 | 2012-09-27 | Gevo Inc | Yeast microorganisms with reduced by-product accumulation for improved production of fuels, chemicals, and amino acids |
| US8445244B2 (en) * | 2010-02-23 | 2013-05-21 | Genomatica, Inc. | Methods for increasing product yields |
| EP2720997A1 (en) | 2011-06-17 | 2014-04-23 | Invista Technologies S.à.r.l. | Use of hydrolases to increase monomer content in waste stream |
| WO2013003432A1 (en) * | 2011-06-29 | 2013-01-03 | Genomatica, Inc. | Microorganisms for producing succinate and methods related thereto |
| JP2014525741A (ja) * | 2011-06-30 | 2014-10-02 | インビスタ テクノロジーズ エス.アー.エール.エル. | ナイロン−7、ナイロン−7,7、およびポリエステルを生産するための生物変換方法 |
| EP2753689B1 (en) * | 2011-09-07 | 2018-02-14 | William Marsh Rice University | Functionalized carboxylic acids and alcohols by reverse fatty acid oxidation |
| US8940509B2 (en) | 2011-11-02 | 2015-01-27 | Genomatica, Inc. | Microorganisms and methods for the production of caprolactone |
| US9102960B2 (en) | 2011-12-16 | 2015-08-11 | Invista North America S.á.r.l. | Methods of producing 6-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage |
| US9102958B2 (en) | 2011-12-16 | 2015-08-11 | Invista North America S.á.r.l. | Methods of producing 6-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage |
| JP6231011B2 (ja) * | 2011-12-20 | 2017-11-15 | サイエンティスト・オブ・フォーチュン・ソシエテ・アノニム | 3−ヒドロキシアルク−4−エノエートおよび/または3−ホスホノキシアルク−4−エノエートの酵素変換による1,3−ジエンの産生 |
| BR112015013413A2 (pt) | 2012-12-14 | 2017-11-14 | Invista Tech Sarl | método para biosintetizar um produto e hospedeiro recombinante |
| CN105008543A (zh) | 2012-12-31 | 2015-10-28 | 英威达技术有限责任公司 | 通过芳香族化合物生产7-碳化学物的方法 |
| US9580733B2 (en) | 2012-12-31 | 2017-02-28 | Invista North America S.A.R.L. | Methods of producing 6-carbon chemicals via methyl-ester shielded carbon chain elongation |
| CN105189770A (zh) | 2012-12-31 | 2015-12-23 | 英威达技术有限责任公司 | 通过与环己烷羧酸合成相关的碳链延伸生产7碳化学物的方法 |
| WO2014105790A2 (en) | 2012-12-31 | 2014-07-03 | Invista North America S.A.R.L. | Methods of producing 7-carbon chemicals via c1 carbon chain elongation associated with coenzyme b synthesis |
| US10196657B2 (en) | 2012-12-31 | 2019-02-05 | Invista North America S.A.R.L. | Methods of producing 7-carbon chemicals via methyl-ester shielded carbon chain elongation |
| CN105026570A (zh) | 2012-12-31 | 2015-11-04 | 英威达技术有限责任公司 | 通过氧化裂解从长链脂肪酸生产7-碳化学物的方法 |
| WO2014105797A2 (en) | 2012-12-31 | 2014-07-03 | Invista North America S.A.R.L. | Methods of producing 7-carbon chemicals via pyruvate and succinate semialdehyde aldol condensation |
| EP2971021A4 (en) | 2013-03-15 | 2016-12-21 | Genomatica Inc | MICROORGANISMS AND METHOD FOR THE PRODUCTION OF BUTADIENE AND RELATED COMPOUNDS BY FORMATASSIMILATION |
| EP3077501B1 (en) | 2013-12-03 | 2021-07-28 | Genomatica, Inc. | Microorganisms and methods for improving product yields on methanol using acetyl-coa synthesis |
| CN113481217A (zh) | 2013-12-13 | 2021-10-08 | 巴斯夫欧洲公司 | 用于精细化学品的改进生产的重组微生物 |
| CA3192376A1 (en) | 2013-12-27 | 2015-07-02 | Genomatica, Inc. | Methods and organisms with increased carbon flux efficiencies |
| EP3143152A1 (en) | 2014-05-15 | 2017-03-22 | Invista Technologies S.à r.l. | Methods of producing 6-carbon chemicals using 2,6-diaminopimelate as precursor to 2-aminopimelate |
| CN106795531A (zh) | 2014-06-16 | 2017-05-31 | 英威达技术有限责任公司 | 用于生物合成化合物的方法、试剂和细胞 |
| EP3155108A1 (en) | 2014-06-16 | 2017-04-19 | Invista Technologies S.à.r.l. | Methods, reagents and cells for biosynthesizing compounds |
| WO2015195707A1 (en) | 2014-06-16 | 2015-12-23 | Invista Technologies S.A.R.L. | Methods, reagents and cells for biosynthesizing compounds |
| EP3155111A1 (en) | 2014-06-16 | 2017-04-19 | Invista Technologies S.à r.l. | Process for producing glutarate and glutaric acid methyl ester |
| BR112017005665A2 (pt) | 2014-09-18 | 2017-12-12 | Genomatica Inc | organismos microbianos não naturais com eficiência energética melhorada |
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| CN110688745A (zh) * | 2019-09-16 | 2020-01-14 | 北京工业大学 | 基于多目标优化的绿色云数据中心利润最大化方法 |
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2010
- 2010-05-14 BR BRPI1012877A patent/BRPI1012877A2/pt not_active IP Right Cessation
- 2010-05-14 AU AU2010248831A patent/AU2010248831A1/en not_active Abandoned
- 2010-05-14 WO PCT/US2010/035015 patent/WO2010132845A1/en not_active Ceased
- 2010-05-14 JP JP2012511059A patent/JP2012526561A/ja active Pending
- 2010-05-14 US US12/780,802 patent/US8663957B2/en active Active
- 2010-05-14 EP EP10775646.2A patent/EP2429587A4/en not_active Withdrawn
- 2010-05-14 KR KR20117029936A patent/KR20120036851A/ko not_active Withdrawn
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| EP2429587A4 (en) | 2014-10-08 |
| BRPI1012877A2 (pt) | 2016-04-05 |
| US9139853B2 (en) | 2015-09-22 |
| EP2429587A1 (en) | 2012-03-21 |
| US20140356919A1 (en) | 2014-12-04 |
| KR20120036851A (ko) | 2012-04-18 |
| WO2010132845A1 (en) | 2010-11-18 |
| JP2012526561A (ja) | 2012-11-01 |
| US20110014668A1 (en) | 2011-01-20 |
| US8663957B2 (en) | 2014-03-04 |
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