AU2010242910B2 - Pyrido [4,3-b] indoles and methods of use - Google Patents

Info

Publication number

AU2010242910B2

AU2010242910B2 AU2010242910A AU2010242910A AU2010242910B2 AU 2010242910 B2 AU2010242910 B2 AU 2010242910B2 AU 2010242910 A AU2010242910 A AU 2010242910A AU 2010242910 A AU2010242910 A AU 2010242910A AU 2010242910 B2 AU2010242910 B2 AU 2010242910B2

Authority

AU

Australia

Prior art keywords

compound

unsubstituted

salt

substituted

solvate

Prior art date

2009-04-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

Links

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• 238000000034 method Methods 0.000 title claims abstract description 80
• RDMFHRSPDKWERA-UHFFFAOYSA-N 5H-Pyrido[4,3-b]indole Chemical class C1=NC=C2C3=CC=CC=C3NC2=C1 RDMFHRSPDKWERA-UHFFFAOYSA-N 0.000 title abstract description 3
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• 125000000217 alkyl group Chemical group 0.000 claims description 135
• 125000005843 halogen group Chemical group 0.000 claims description 77
• -1 aminocarbonylamino, aminocarbonyloxy, aminosulfonyl Chemical group 0.000 claims description 72
• 239000012453 solvate Substances 0.000 claims description 65
• 125000001072 heteroaryl group Chemical group 0.000 claims description 64
• 125000003118 aryl group Chemical group 0.000 claims description 56
• 208000024891 symptom Diseases 0.000 claims description 51
• 125000003545 alkoxy group Chemical group 0.000 claims description 50
• 125000000623 heterocyclic group Chemical group 0.000 claims description 47
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 39
• 125000003342 alkenyl group Chemical group 0.000 claims description 21
• 125000000304 alkynyl group Chemical group 0.000 claims description 19
• 125000001309 chloro group Chemical group Cl* 0.000 claims description 17
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• 125000004104 aryloxy group Chemical group 0.000 claims description 15
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• 229910052757 nitrogen Inorganic materials 0.000 claims description 14
• 125000004076 pyridyl group Chemical group 0.000 claims description 14
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• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 13
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 11
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 11
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• 239000003937 drug carrier Substances 0.000 claims description 7
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• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 3
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• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 3
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 2
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