AU2010228068A1 - Tissue kallikrein for the treatment of pancreatic beta-cell dysfunction - Google Patents

Tissue kallikrein for the treatment of pancreatic beta-cell dysfunction Download PDF

Info

Publication number
AU2010228068A1
AU2010228068A1 AU2010228068A AU2010228068A AU2010228068A1 AU 2010228068 A1 AU2010228068 A1 AU 2010228068A1 AU 2010228068 A AU2010228068 A AU 2010228068A AU 2010228068 A AU2010228068 A AU 2010228068A AU 2010228068 A1 AU2010228068 A1 AU 2010228068A1
Authority
AU
Australia
Prior art keywords
seq
purified
isolated
klki
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2010228068A
Other languages
English (en)
Inventor
Kevin Richardson
Mark Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Diamedica Therapeutics Inc
Original Assignee
Diamedica Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diamedica Inc filed Critical Diamedica Inc
Publication of AU2010228068A1 publication Critical patent/AU2010228068A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4853—Kallikrein (3.4.21.34 or 3.4.21.35)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2010228068A 2009-03-25 2010-03-25 Tissue kallikrein for the treatment of pancreatic beta-cell dysfunction Abandoned AU2010228068A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16317309P 2009-03-25 2009-03-25
US61/163,173 2009-03-25
PCT/CA2010/000413 WO2010108262A1 (en) 2009-03-25 2010-03-25 TISSUE KALLIKREIN FOR THE TREATMENT OF PANCREATIC β-CELL DYSFUNCTION

Publications (1)

Publication Number Publication Date
AU2010228068A1 true AU2010228068A1 (en) 2011-10-20

Family

ID=42780097

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010228068A Abandoned AU2010228068A1 (en) 2009-03-25 2010-03-25 Tissue kallikrein for the treatment of pancreatic beta-cell dysfunction

Country Status (8)

Country Link
US (1) US20120070425A1 (https=)
EP (1) EP2411042A4 (https=)
JP (1) JP2012521366A (https=)
CN (1) CN102438648A (https=)
AU (1) AU2010228068A1 (https=)
CA (1) CA2756801A1 (https=)
NZ (1) NZ595364A (https=)
WO (1) WO2010108262A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2182978A4 (en) 2007-07-20 2012-03-21 Sanomune Inc TISSUE KALLIKREIN FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AMYLOID PROTEIN
US20140205578A1 (en) * 2011-06-17 2014-07-24 The John Hopkins University Methods for increasing insulin sensitivity and treating diabetes
US20130315891A1 (en) 2012-05-25 2013-11-28 Matthew Charles Formulations of human tissue kallikrein-1 for parenteral delivery and related methods
US20130323222A1 (en) 2012-06-04 2013-12-05 Matthew Charles Human tissue kallikrein 1 glycosylation isoforms
CN104073482A (zh) * 2013-12-30 2014-10-01 江苏众红生物工程创药研究院有限公司 聚乙二醇化的组织激肽释放酶及其制备方法和应用
AU2018230478B2 (en) 2017-03-09 2025-01-23 Diamedica Inc. Dosage forms of tissue kallikrein 1
CN112481268B (zh) * 2021-01-25 2024-01-30 河南大学 一种棉花启动子PGhPGF及其重组载体和应用
CN116135973A (zh) * 2021-11-16 2023-05-19 江苏众红生物工程创药研究院有限公司 低糖基化修饰的激肽原酶及其聚乙二醇修饰物和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5534615A (en) 1994-04-25 1996-07-09 Genentech, Inc. Cardiac hypertrophy factor and uses therefor
EP1079792A2 (en) * 1998-05-22 2001-03-07 EntreMed, Inc. Compositions and methods for inhibiting endothelial cell proliferation and regulating angiogenesis using serine proteases
CN1228447C (zh) * 2001-02-20 2005-11-23 深圳市人民医院 一种含有人胰腺组织激肽释放酶成熟蛋白基因的重组表达载体
CN100338212C (zh) * 2003-01-29 2007-09-19 中国科学院大连化学物理研究所 人组织激肽释放酶的微囊化细胞及其微囊化方法和应用
CA2575791A1 (en) * 2004-08-03 2006-02-16 Dyax Corp. Hk1-binding proteins
CN101094869A (zh) * 2004-08-03 2007-12-26 戴埃克斯有限公司 Hk1结合蛋白
CA2659012A1 (en) * 2006-07-26 2008-01-31 Diamedica Inc. Methods of diagnosis and treatment for metabolic disorders
WO2008016883A2 (en) * 2006-07-31 2008-02-07 Activesite Pharmaceuticals, Inc. Inhibitors of plasma kallikrein
CN101134953B (zh) * 2007-07-02 2011-02-09 广东天普生化医药股份有限公司 重组人胰激肽原酶
CN101255438B (zh) * 2008-04-11 2012-01-25 深圳大学 表达人组织激肽释放酶的转基因莱茵衣藻的构建方法

Also Published As

Publication number Publication date
EP2411042A1 (en) 2012-02-01
WO2010108262A1 (en) 2010-09-30
US20120070425A1 (en) 2012-03-22
CN102438648A (zh) 2012-05-02
CA2756801A1 (en) 2010-09-30
NZ595364A (en) 2013-09-27
EP2411042A4 (en) 2012-12-12
JP2012521366A (ja) 2012-09-13

Similar Documents

Publication Publication Date Title
AU2010228068A1 (en) Tissue kallikrein for the treatment of pancreatic beta-cell dysfunction
Nakajima et al. Pancrelipase: an evidence-based review of its use for treating pancreatic exocrine insufficiency
CA2641070C (en) Enzyme replacement therapy for treating lysosomal storage diseases
CN101914150B (zh) 一种多肽及其在制药中的应用
Suzuki et al. Recent developments in therapeutic peptides for the glucagon-like peptide 1 and 2 receptors
CN102389413B (zh) 用于治疗糖尿病的组合物及其应用
EA013821B1 (ru) Проостровковые пептиды человека, их производные и аналоги и способы их применения
JP2014534265A (ja) インスリンアミノ酸配列を含む治療薬
TWI714862B (zh) 一種調控glp-1/glp-1r的方法和藥物
KR101535791B1 (ko) 개량형 이듀로네이트-2-설파타제 및 이의 용도
BR112015000183B1 (pt) Composição terapêutica
KR20150122136A (ko) 골격 성장 지연 질환의 예방 또는 치료에 사용하기 위한 용해성 섬유아세포 성장 인자 수용체 3(fgr3) 폴리펩티드
Boj-Carceller Proton pump inhibitors: impact on glucose metabolism
CN114075296A (zh) 一种多功能变体蛋白及其融合蛋白
CN108463236A (zh) 一种预防或治疗放射性和化学性损伤的方法
US6274549B1 (en) Treatment of type 1 diabetes
Shaikh et al. Advanced approaches in insulin delivery
CN102458454A (zh) 用于治疗亨廷顿病的组织激肽释放酶
JP2019520341A (ja) 代謝疾患を治療する組成物と方法
CA2590804C (en) Use of bombesin/gastrin-releasing peptide antagonist for the treatment of sepsis, acute lung injury, septic shock or rheumatoid arthritis
GB2476789A (en) Use of thymosin for treatment of type 2 diabetes
CN104470532A (zh) SorCS1在治疗肥胖症及超重中的应用
US9340593B2 (en) Method of treating diabetes by a CTRP12 polypeptide
Whitcomb Molecular and genetic mechanisms of acute and chronic pancreatitis
TW202440649A (zh) 一種包含glp-1 融合蛋白的藥物製劑及其用途

Legal Events

Date Code Title Description
MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application