AU2010212560B2 - Derivatives of azaindoles as inhibitors of protein kinases Abl and Src - Google Patents

Derivatives of azaindoles as inhibitors of protein kinases Abl and Src Download PDF

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Publication number
AU2010212560B2
AU2010212560B2 AU2010212560A AU2010212560A AU2010212560B2 AU 2010212560 B2 AU2010212560 B2 AU 2010212560B2 AU 2010212560 A AU2010212560 A AU 2010212560A AU 2010212560 A AU2010212560 A AU 2010212560A AU 2010212560 B2 AU2010212560 B2 AU 2010212560B2
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AU
Australia
Prior art keywords
group
methyl
pyrrolo
optionally mono
polysubstituted
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Ceased
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AU2010212560A
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AU2010212560A1 (en
Inventor
Cedric Bories
Gwenael Cheve
Louis Delon
Abdelaziz Yasri
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Oribase Pharma
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Oribase Pharma
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2010212560A 2009-02-12 2010-02-12 Derivatives of azaindoles as inhibitors of protein kinases Abl and Src Ceased AU2010212560B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US20227909P 2009-02-12 2009-02-12
FR0900631 2009-02-12
US61/202,279 2009-02-12
FR0900631A FR2941948B1 (fr) 2009-02-12 2009-02-12 Derives d'azaindoles en tant qu'inhibiteur des proteines kinases abl et src
PCT/IB2010/000593 WO2010092489A1 (en) 2009-02-12 2010-02-12 Derivatives of azaindoles as inhibitors of protein kinases abl and src

Publications (2)

Publication Number Publication Date
AU2010212560A1 AU2010212560A1 (en) 2011-08-11
AU2010212560B2 true AU2010212560B2 (en) 2016-01-21

Family

ID=40886859

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010212560A Ceased AU2010212560B2 (en) 2009-02-12 2010-02-12 Derivatives of azaindoles as inhibitors of protein kinases Abl and Src

Country Status (15)

Country Link
US (1) US8580815B2 (enrdf_load_stackoverflow)
EP (1) EP2396325B1 (enrdf_load_stackoverflow)
JP (1) JP5583698B2 (enrdf_load_stackoverflow)
AU (1) AU2010212560B2 (enrdf_load_stackoverflow)
CA (1) CA2751478A1 (enrdf_load_stackoverflow)
DK (1) DK2396325T3 (enrdf_load_stackoverflow)
ES (1) ES2540962T3 (enrdf_load_stackoverflow)
FR (1) FR2941948B1 (enrdf_load_stackoverflow)
HR (1) HRP20150697T8 (enrdf_load_stackoverflow)
HU (1) HUE024989T2 (enrdf_load_stackoverflow)
PL (1) PL2396325T3 (enrdf_load_stackoverflow)
PT (1) PT2396325E (enrdf_load_stackoverflow)
SI (1) SI2396325T1 (enrdf_load_stackoverflow)
SM (1) SMT201500175B (enrdf_load_stackoverflow)
WO (1) WO2010092489A1 (enrdf_load_stackoverflow)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2935248T (lt) * 2012-12-21 2018-04-10 Plexxikon Inc. Kinazės moduliavimo junginiai ir būdai bei indikacijos
FR3000492B1 (fr) * 2012-12-28 2015-09-11 Oribase Pharma Nouveaux derives azaindole en tant qu'inhibiteurs multikinases
FR3000494B1 (fr) * 2012-12-28 2015-08-21 Oribase Pharma Nouveaux derives d'azaindoles en tant qu'inhibiteurs de proteines kinases
FR3000493A1 (fr) 2012-12-28 2014-07-04 Oribase Pharma Nouveaux inhibiteurs de proteines kinases
US10722484B2 (en) 2016-03-09 2020-07-28 K-Gen, Inc. Methods of cancer treatment
WO2018172852A1 (en) * 2017-03-21 2018-09-27 Arbutus Biopharma Corporation Substituted dihydroindene-4-carboxamides and analogs thereof, and methods using same
CN111943947B (zh) * 2020-07-24 2021-04-30 重庆文理学院 1H-吡咯[2,3-b]吡啶衍生物及其合成方法与应用
MX2023003995A (es) 2020-10-05 2023-06-12 Enliven Inc Compuestos de 5-y 6-azaindol para la inhibicion de tirosina cinasas bcr-abl.
US20240043420A1 (en) * 2020-10-05 2024-02-08 Enliven Therapeutics, Inc. 7-azaindole compounds for inhibition of bcr-abl tyrosine kinases

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009111278A2 (en) * 2008-02-29 2009-09-11 Array Biopharma Inc. Raf inhibitor compounds and methods of use thereof
WO2010062171A2 (en) * 2008-11-03 2010-06-03 Syntarga B.V. Novel cc-1065 analogs and their conjugates

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0330042D0 (en) 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions them
GB0330043D0 (en) * 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them
US20060058339A1 (en) * 2004-06-17 2006-03-16 Ibrahim Prabha N Compounds modulating c-kit activity and uses therefor
US7709645B2 (en) 2004-07-27 2010-05-04 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
US7361764B2 (en) 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
EP1781654A1 (en) 2004-07-27 2007-05-09 SGX Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
EP1863792B1 (en) * 2005-03-28 2009-01-21 Brystol-Myers Squibb Company Atp competitive kinase inhibitors
MX2009002010A (es) * 2006-09-06 2009-03-05 Hoffmann La Roche Derivados de heteroarilo como inhibidores de la proteina cinasa.
CN101600714B (zh) * 2006-11-10 2013-08-21 百时美施贵宝公司 吡咯并吡啶激酶抑制剂
WO2008144253A1 (en) * 2007-05-14 2008-11-27 Irm Llc Protein kinase inhibitors and methods for using thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009111278A2 (en) * 2008-02-29 2009-09-11 Array Biopharma Inc. Raf inhibitor compounds and methods of use thereof
US8338452B2 (en) * 2008-02-29 2012-12-25 Array Biopharma Inc. Raf inhibitor compounds and methods of use thereof
WO2010062171A2 (en) * 2008-11-03 2010-06-03 Syntarga B.V. Novel cc-1065 analogs and their conjugates

Also Published As

Publication number Publication date
US20110312959A1 (en) 2011-12-22
PL2396325T3 (pl) 2015-10-30
EP2396325A1 (en) 2011-12-21
WO2010092489A1 (en) 2010-08-19
ES2540962T3 (es) 2015-07-15
JP5583698B2 (ja) 2014-09-03
DK2396325T3 (en) 2015-06-29
HUE024989T2 (en) 2016-01-28
FR2941948B1 (fr) 2013-04-05
AU2010212560A1 (en) 2011-08-11
CA2751478A1 (en) 2010-08-19
SI2396325T1 (sl) 2015-08-31
FR2941948A1 (fr) 2010-08-13
SMT201500175B (it) 2015-09-07
PT2396325E (pt) 2015-08-21
HRP20150697T1 (hr) 2015-08-14
JP2012517465A (ja) 2012-08-02
EP2396325B1 (en) 2015-04-01
US8580815B2 (en) 2013-11-12
HRP20150697T8 (xx) 2015-11-06

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