AU2009320139B2 - Synthetic mimetics of host defense and uses thereof - Google Patents
Synthetic mimetics of host defense and uses thereof Download PDFInfo
- Publication number
- AU2009320139B2 AU2009320139B2 AU2009320139A AU2009320139A AU2009320139B2 AU 2009320139 B2 AU2009320139 B2 AU 2009320139B2 AU 2009320139 A AU2009320139 A AU 2009320139A AU 2009320139 A AU2009320139 A AU 2009320139A AU 2009320139 B2 AU2009320139 B2 AU 2009320139B2
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- Prior art keywords
- compound
- formula
- tert
- pyrimidine
- formulation
- Prior art date
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- 230000007123 defense Effects 0.000 title description 4
- 150000001875 compounds Chemical class 0.000 claims abstract description 169
- 238000000034 method Methods 0.000 claims abstract description 48
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 99
- 239000001257 hydrogen Substances 0.000 claims description 98
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 67
- 239000008213 purified water Substances 0.000 claims description 55
- 150000002431 hydrogen Chemical class 0.000 claims description 50
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 47
- 238000009472 formulation Methods 0.000 claims description 45
- -1 {[(tert butoxycarbonyl)amino] [(tert-butoxycarbonyl)imino]methyl} amino Chemical group 0.000 claims description 40
- XIEOKRXVAACBHI-UHFFFAOYSA-N pyrimidine-4,6-dicarboxylic acid Chemical compound OC(=O)C1=CC(C(O)=O)=NC=N1 XIEOKRXVAACBHI-UHFFFAOYSA-N 0.000 claims description 38
- 150000003839 salts Chemical class 0.000 claims description 34
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 32
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- 208000015181 infectious disease Diseases 0.000 claims description 28
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- 230000000813 microbial effect Effects 0.000 claims description 22
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 19
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 claims description 18
- 229910052723 transition metal Inorganic materials 0.000 claims description 18
- 150000003624 transition metals Chemical class 0.000 claims description 18
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- 229920000858 Cyclodextrin Polymers 0.000 claims description 16
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 16
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- 229950001272 viomycin Drugs 0.000 description 1
- GXFAIFRPOKBQRV-GHXCTMGLSA-N viomycin Chemical compound N1C(=O)\C(=C\NC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)C[C@@H](N)CCCN)CNC(=O)[C@@H]1[C@@H]1NC(=N)N[C@@H](O)C1 GXFAIFRPOKBQRV-GHXCTMGLSA-N 0.000 description 1
- 229960003842 virginiamycin Drugs 0.000 description 1
- 235000019373 virginiamycin Nutrition 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10859508P | 2008-10-27 | 2008-10-27 | |
| US61/108,595 | 2008-10-27 | ||
| US12/605,584 US8278309B2 (en) | 2008-10-27 | 2009-10-26 | Synthetic mimetics of host defense and uses thereof |
| US12/605,584 | 2009-10-26 | ||
| PCT/US2009/062147 WO2010062573A1 (en) | 2008-10-27 | 2009-10-27 | Synthetic mimetics of host defense and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2009320139A1 AU2009320139A1 (en) | 2010-06-03 |
| AU2009320139B2 true AU2009320139B2 (en) | 2013-07-25 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2009320139A Ceased AU2009320139B2 (en) | 2008-10-27 | 2009-10-27 | Synthetic mimetics of host defense and uses thereof |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8278309B2 (OSRAM) |
| EP (1) | EP2358380A4 (OSRAM) |
| JP (1) | JP2012506908A (OSRAM) |
| KR (1) | KR20110074995A (OSRAM) |
| CN (1) | CN102256614B (OSRAM) |
| AU (1) | AU2009320139B2 (OSRAM) |
| BR (1) | BRPI0920251A2 (OSRAM) |
| CA (1) | CA2741764A1 (OSRAM) |
| IL (1) | IL212275A0 (OSRAM) |
| MX (1) | MX2011004360A (OSRAM) |
| RU (1) | RU2540077C2 (OSRAM) |
| TW (1) | TWI478915B (OSRAM) |
| UA (1) | UA104875C2 (OSRAM) |
| WO (1) | WO2010062573A1 (OSRAM) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090092574A1 (en) * | 2006-12-29 | 2009-04-09 | Scott Richard W | Ophthalmic And Otic Compositions Of Facially Amphiphilic Polymers And Oligomers And Uses Thereof |
| US8278309B2 (en) * | 2008-10-27 | 2012-10-02 | Polymedix, Inc. | Synthetic mimetics of host defense and uses thereof |
| EP2709619B1 (en) * | 2011-05-16 | 2017-10-11 | Cellceutix Corporation | Compounds for use in treatment of mucositis |
| US9758607B2 (en) | 2013-10-10 | 2017-09-12 | Research Foundation Of The City University Of New York | Polymer with antibacterial activity |
| JP6047203B2 (ja) * | 2015-02-20 | 2016-12-21 | セルセウティックス コーポレイション | 消化管の炎症性疾患の予防および／または治療のための宿主防御タンパク質（ｈｄｐ）模倣薬 |
| CN107574581B (zh) * | 2017-08-03 | 2019-09-10 | 天津大学 | 一种抗菌性聚(ε-己内酯)/模拟抗菌肽电纺纤维膜及其制备方法 |
| US20230218644A1 (en) | 2020-04-16 | 2023-07-13 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
| US11771694B2 (en) | 2020-06-05 | 2023-10-03 | Innovation Pharmaceuticals Inc. | Arylamide compounds for treatment and prevention of viral infections |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008083256A2 (en) * | 2006-12-29 | 2008-07-10 | Polymedix, Inc. | Ophthalmic and otic compositions of facially amphiphilic polymers and oligomers and uses thereof |
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| US3496179A (en) | 1967-10-11 | 1970-02-17 | Pfizer & Co C | 2-amino-3,4-dihydroquinazolines |
| EP0629347B1 (en) | 1992-01-23 | 1997-07-02 | Morinaga Milk Industry Co., Ltd. | Antibacterial agent and treatment of article therewith |
| AU758563B2 (en) | 1998-08-20 | 2003-03-27 | University Of North Carolina At Chapel Hill, The | Dicationic dibenzofuran and dibenzothiophene compounds and methods of use thereof |
| US6482799B1 (en) | 1999-05-25 | 2002-11-19 | The Regents Of The University Of California | Self-preserving multipurpose ophthalmic solutions incorporating a polypeptide antimicrobial |
| JP2001261674A (ja) | 2000-03-22 | 2001-09-26 | Mitsui Chemicals Inc | ベンゾチオフェン誘導体およびそれを有効成分として含有する核内レセプター作動薬 |
| FR2813080B1 (fr) | 2000-08-17 | 2002-11-29 | Stago Diagnostica | Peptides anti-heparine |
| PT1331902E (pt) | 2000-11-08 | 2008-12-02 | Fxs Ventures Llc | Soluções oftálmicas e para lentes de contacto melhoradas contendo formas de vitamina b |
| CN102295744B (zh) | 2001-03-08 | 2014-07-02 | 宾夕法尼亚州大学理事会 | 作为抗感染药的表面两亲聚合物 |
| BR0214357A (pt) * | 2001-11-21 | 2004-09-14 | Sugen Inc | Formulações farmacêuticas compreendendo derivados de indolinona |
| JP2005529158A (ja) | 2002-05-28 | 2005-09-29 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア | 両親媒性ポリマーのコンピュータ分析および設計のための方法、システムおよびコンピュータプログラム製品 |
| JP2005529604A (ja) | 2002-06-13 | 2005-10-06 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア | 粗粒度モデルを用いる生体膜をシミュレートするための方法、システム、およびコンピュータプログラム製品 |
| CA2519023C (en) | 2003-03-17 | 2014-05-20 | The Trustees Of The University Of Pennsylvania | Facially amphiphilic polymers and oligomers and uses thereof |
| AU2003249114A1 (en) | 2003-03-20 | 2004-10-11 | Shiseido International France | Cosmetic composition |
| US20050065091A1 (en) | 2003-09-18 | 2005-03-24 | Gholam Peyman | Stabilized ocular solutions |
| EP1711455A4 (en) | 2004-01-23 | 2007-11-07 | Univ Pennsylvania | FAZIAL AMPHIPHILE POLYARYL AND POLYARYL ALKINYL POLYMERS AND OLIGOMERS AND ITS APPLICATIONS |
| BRPI0510119A (pt) * | 2004-04-23 | 2007-09-25 | Cydex Inc | formulação para dpi contendo sulfoaquil éter de ciclodextrina |
| EP2380872B1 (en) | 2004-06-15 | 2014-04-23 | Cellceutix Corporation | Polycationic compounds and uses thereof |
| EP1771183B1 (en) | 2004-07-23 | 2014-09-03 | The Trustees of The University of Pennsylvania | Antimicrobial copolymers and uses thereof |
| DK2377557T3 (en) * | 2004-11-24 | 2017-02-06 | Meda Pharmaceuticals Inc | Compositions comprising azelastine and methods for its use |
| CA2591744A1 (en) | 2004-12-21 | 2006-06-29 | Pfizer Products Inc. | Stable non-dihydrate azithromycin oral suspensions |
| KR20080004475A (ko) | 2005-02-25 | 2008-01-09 | 유니버시티 오브 매사추세츠 | 표면적으로 양친매성인 중합체 및 올리고머, 그 조성물 및암치료방법으로서의 그 용도 |
| RU2325151C2 (ru) * | 2006-06-29 | 2008-05-27 | ООО "Научно-производственный центр "Амфион" | Способ получения системы доставки водонерастворимых и плохорастворимых биологически активных веществ и лекарственная форма на ее основе |
| JP2008137978A (ja) | 2006-12-05 | 2008-06-19 | Canon Inc | カルバゾール誘導体及びこれを用いた有機発光素子 |
| WO2009061697A1 (en) | 2007-11-09 | 2009-05-14 | The Board Of Trustees Of The University Of Illinois | Anticoagulant antagonist and hemophilia procoagulant |
| MX2011000971A (es) | 2008-07-28 | 2011-06-24 | Polymedix Inc | Compuestos antipaludicos. |
| US8278309B2 (en) * | 2008-10-27 | 2012-10-02 | Polymedix, Inc. | Synthetic mimetics of host defense and uses thereof |
-
2009
- 2009-10-26 US US12/605,584 patent/US8278309B2/en not_active Expired - Fee Related
- 2009-10-26 TW TW098136112A patent/TWI478915B/zh active
- 2009-10-27 CN CN200980151723.9A patent/CN102256614B/zh not_active Expired - Fee Related
- 2009-10-27 JP JP2011534666A patent/JP2012506908A/ja active Pending
- 2009-10-27 AU AU2009320139A patent/AU2009320139B2/en not_active Ceased
- 2009-10-27 KR KR1020117009356A patent/KR20110074995A/ko not_active Ceased
- 2009-10-27 BR BRPI0920251A patent/BRPI0920251A2/pt not_active IP Right Cessation
- 2009-10-27 UA UAA201106679A patent/UA104875C2/uk unknown
- 2009-10-27 EP EP09829578A patent/EP2358380A4/en not_active Withdrawn
- 2009-10-27 RU RU2011121354/04A patent/RU2540077C2/ru not_active IP Right Cessation
- 2009-10-27 CA CA2741764A patent/CA2741764A1/en not_active Abandoned
- 2009-10-27 MX MX2011004360A patent/MX2011004360A/es active IP Right Grant
- 2009-10-27 WO PCT/US2009/062147 patent/WO2010062573A1/en not_active Ceased
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2011
- 2011-04-12 IL IL212275A patent/IL212275A0/en unknown
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2012
- 2012-08-01 US US13/563,928 patent/US8975262B2/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008083256A2 (en) * | 2006-12-29 | 2008-07-10 | Polymedix, Inc. | Ophthalmic and otic compositions of facially amphiphilic polymers and oligomers and uses thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2540077C2 (ru) | 2015-01-27 |
| US20100105703A1 (en) | 2010-04-29 |
| EP2358380A4 (en) | 2012-05-02 |
| WO2010062573A1 (en) | 2010-06-03 |
| US8278309B2 (en) | 2012-10-02 |
| CN102256614B (zh) | 2014-01-08 |
| EP2358380A1 (en) | 2011-08-24 |
| UA104875C2 (uk) | 2014-03-25 |
| IL212275A0 (en) | 2011-06-30 |
| MX2011004360A (es) | 2011-08-12 |
| TWI478915B (zh) | 2015-04-01 |
| BRPI0920251A2 (pt) | 2016-01-05 |
| CN102256614A (zh) | 2011-11-23 |
| RU2011121354A (ru) | 2012-12-10 |
| KR20110074995A (ko) | 2011-07-05 |
| JP2012506908A (ja) | 2012-03-22 |
| US8975262B2 (en) | 2015-03-10 |
| AU2009320139A1 (en) | 2010-06-03 |
| CA2741764A1 (en) | 2010-06-03 |
| US20130090345A1 (en) | 2013-04-11 |
| TW201020249A (en) | 2010-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC1 | Assignment before grant (sect. 113) |
Owner name: CELLCEUTIX CORPORATION Free format text: FORMER APPLICANT(S): POLYMEDIX, INC. |
|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |