AU2009283199B2 - Antibodies to CCR2 - Google Patents
Antibodies to CCR2 Download PDFInfo
- Publication number
- AU2009283199B2 AU2009283199B2 AU2009283199A AU2009283199A AU2009283199B2 AU 2009283199 B2 AU2009283199 B2 AU 2009283199B2 AU 2009283199 A AU2009283199 A AU 2009283199A AU 2009283199 A AU2009283199 A AU 2009283199A AU 2009283199 B2 AU2009283199 B2 AU 2009283199B2
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- AU
- Australia
- Prior art keywords
- ccr2
- antibody
- seq
- antibodies
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011019679A1 (en) * | 2009-08-11 | 2011-02-17 | Allergan, Inc. | Ccr2 inhibitors for treating conditions of the eye |
| CA2793657A1 (en) * | 2010-03-18 | 2011-09-22 | Colorado State University Research Foundation | Myeloid derived suppressor cell inhibiting agents |
| EP2663330B1 (en) | 2011-01-10 | 2019-03-06 | NovImmune S.A. | Anti-tlr4 antibodies and methods of use thereof |
| CN102603649B (zh) * | 2011-01-20 | 2016-05-25 | 赣南师范学院 | 一种以地巴唑为先导分子的荧光探针化合物及其制备方法 |
| US20120288442A1 (en) * | 2011-05-11 | 2012-11-15 | Atomic Energy Council-Institute Of Nuclear Energy Research | Nuclear Imaging Method Using Molecular Target Detection Agent for Liver Fibrosis |
| US9726666B2 (en) | 2011-06-13 | 2017-08-08 | Tla Targeted Immunotherapies Ab | Diagnosing and treating inflammatory diseases |
| WO2012172336A2 (en) | 2011-06-13 | 2012-12-20 | Ith Immune Therapy Holdings | Treating inflammatory skin diseases |
| ES2801901T3 (es) | 2011-06-13 | 2021-01-14 | Tla Targeted Immunotherapies Ab | Tratamiento de afecciones asociadas al síndrome metabólico |
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| DK2718311T3 (en) | 2011-06-13 | 2018-04-16 | Tla Targeted Immunotherapies Ab | TREATMENT OF MULTIPLE SCLEROSIS |
| DK3228631T3 (da) | 2011-06-13 | 2020-09-28 | Tla Targeted Immunotherapies Ab | Behandling af respiratoriske tilstande |
| ES2688081T3 (es) | 2011-06-13 | 2018-10-30 | Tla Targeted Immunotherapies Ab | Tratamiento de dolencias asociadas a septicemia |
| WO2013089647A1 (en) * | 2011-12-16 | 2013-06-20 | Agency For Science, Technology And Research | Binding molecules against dengue virus and uses thereof |
| US9315579B2 (en) | 2012-06-22 | 2016-04-19 | Sorrento Therapeutics, Inc. | Antigen binding proteins that bind CCR2 |
| US8975290B2 (en) | 2013-03-01 | 2015-03-10 | Colorado State University Research Foundation | Methods and compositions for enhancing an immune response, blocking monocyte migration, amplifying vaccine immunity and inhibiting tumor growth and metastasis |
| CU24446B1 (es) * | 2013-03-13 | 2019-10-04 | Prothena Biosciences Ltd | Un anticuerpo monoclonal humanizado que se une a tau |
| NL2011406C2 (en) | 2013-09-06 | 2015-03-10 | Bionovion Holding B V | Method for obtaining april-binding peptides, process for producing the peptides, april-binding peptides obtainable with said method/process and use of the april-binding peptides. |
| WO2016081801A1 (en) * | 2014-11-21 | 2016-05-26 | Millennium Pharmaceuticals, Inc. | Use of an anti-ccr2 antagonist in the treatment of an infectious disease |
| NL2014108B1 (en) | 2015-01-09 | 2016-09-30 | Aduro Biotech Holdings Europe B V | Altered april binding antibodies. |
| EP3262418B1 (en) * | 2015-02-26 | 2019-05-01 | Innovative Concepts in Drug Development | Diagnostic markers of cognitive impairments, kits and uses thereof |
| BR112018072394A2 (pt) | 2016-05-02 | 2019-02-19 | Prothena Biosciences Limited | anticorpos que reconhecem a tau |
| US10889638B2 (en) | 2016-05-02 | 2021-01-12 | Prothena Biosciences Limited | Antibodies recognizing tau |
| ES2933491T3 (es) | 2016-05-02 | 2023-02-09 | Prothena Biosciences Ltd | Inmunoterapia tau |
| SG11201810602YA (en) | 2016-06-03 | 2018-12-28 | Chemocentryx Inc | Method of treating liver fibrosis |
| AU2017363299B2 (en) | 2016-11-23 | 2022-12-22 | Chemocentryx, Inc. | Method of treating focal segmental glomerulosclerosis |
| US20180193003A1 (en) | 2016-12-07 | 2018-07-12 | Progenity Inc. | Gastrointestinal tract detection methods, devices and systems |
| WO2018112264A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
| JP2020517256A (ja) | 2017-04-19 | 2020-06-18 | エルスター セラピューティクス， インコーポレイテッド | 多重特異性分子およびその使用 |
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| SG11202002975YA (en) | 2017-10-11 | 2020-04-29 | Chemocentryx Inc | Treatment of focal segmental glomerulosclerosis with ccr2 antagonists |
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| JP7317016B2 (ja) | 2017-12-19 | 2023-07-28 | スロゼン オペレーティング， インコーポレイテッド | 抗ｌｒｐ５／６抗体及び使用方法 |
| AU2018393073B2 (en) | 2017-12-19 | 2025-09-18 | Surrozen Operating, Inc. | Wnt surrogate molecules and uses thereof |
| MA53102B1 (fr) | 2018-07-03 | 2025-11-28 | Fennec Pharmaceuticals, Inc. | Formulations de thiosulfate de sodium anhydre |
| US20210317461A1 (en) | 2018-08-09 | 2021-10-14 | Verseau Therapeutics, Inc. | Oligonucleotide compositions for targeting ccr2 and csf1r and uses thereof |
| AU2019346645A1 (en) | 2018-09-27 | 2021-04-29 | Marengo Therapeutics, Inc. | CSF1R/CCR2 multispecific antibodies |
| JP7482866B2 (ja) | 2018-11-19 | 2024-05-14 | ビオラ・セラピューティクス・インコーポレイテッド | 生物学的治療薬による疾患処置方法およびデバイス |
| EP3891181A4 (en) * | 2018-12-04 | 2022-08-17 | Novartis AG | BINDING MOLECULES AGAINST CD3 AND USES THEREOF |
| SG11202106525TA (en) | 2018-12-24 | 2021-07-29 | Sanofi Sa | Multispecific binding proteins with mutant fab domains |
| US20220146534A1 (en) * | 2019-01-16 | 2022-05-12 | Yeda Research And Development, Co., Ltd. | Biomarkers for CNS Disease Modification |
| PE20212324A1 (es) | 2019-03-03 | 2021-12-14 | Prothena Biosciences Ltd | Anticuerpos que reconocen tau |
| CA3135694A1 (en) * | 2019-04-17 | 2020-10-22 | Hiroshima University | Therapeutic agent for urological cancer which is characterized by being administered with il-6 inhibitor and ccr2 inhibitor in combination |
| WO2020232127A1 (en) | 2019-05-13 | 2020-11-19 | The Research Foundation For The State University Of New York | Compositions and methods to block and bind ccr2 to modulate cellular function |
| JP2022538222A (ja) * | 2019-06-26 | 2022-09-01 | アムニクス ファーマシューティカルズ， インコーポレイテッド | Ｅｇｆｒ抗原結合断片およびそれを含む組成物 |
| CN121197633A (zh) | 2019-12-13 | 2025-12-26 | 比特比德科有限责任公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
| WO2022006470A1 (en) | 2020-07-01 | 2022-01-06 | Vanderbilt University | Methods of treatment for a kidney disease |
| US12319958B2 (en) * | 2020-07-21 | 2025-06-03 | Rutgers, The State University Of New Jersey | Method and kit for CCR2 expression profiling and disease stratification |
| MX2023005381A (es) | 2020-11-09 | 2023-05-23 | Takeda Pharmaceuticals Co | Conjugados de anticuerpo y farmaco. |
| AU2022378899A1 (en) | 2021-10-27 | 2024-03-07 | Granite Bio Ag | Antibodies targeting ccr2 |
| CN114990073A (zh) * | 2022-05-27 | 2022-09-02 | 河南农业大学 | 一种抗猪ccl2蛋白的单克隆抗体及其制备方法和应用 |
| WO2024245988A1 (en) | 2023-05-29 | 2024-12-05 | Granite Bio Ag | Antibodies targeting ccr2 |
| CN116510020A (zh) * | 2023-06-01 | 2023-08-01 | 中国人民解放军军事科学院军事医学研究院 | 降低ccr2含量或活性的物质在治疗或预防发热伴血小板减少综合征中的应用 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| ATE139258T1 (de) | 1990-01-12 | 1996-06-15 | Cell Genesys Inc | Erzeugung xenogener antikörper |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| AU664976B2 (en) | 1990-08-29 | 1995-12-14 | Gene Pharming Europe Bv | Homologous recombination in mammalian cells |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5789650A (en) | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| AU8507191A (en) | 1990-08-29 | 1992-03-30 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| AU2515992A (en) | 1991-08-20 | 1993-03-16 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
| DE69233125T2 (de) | 1991-12-02 | 2004-04-22 | Millennium Pharmaceuticals, Inc., South San Francisco | Inhibitorische immunglobulin-polypeptide gegen den pdgf beta-rezeptor |
| ATE381614T1 (de) | 1992-07-24 | 2008-01-15 | Amgen Fremont Inc | Bildung von xenogenen antikörpern |
| US5643763A (en) | 1994-11-04 | 1997-07-01 | Genpharm International, Inc. | Method for making recombinant yeast artificial chromosomes by minimizing diploid doubling during mating |
| US6130364A (en) | 1995-03-29 | 2000-10-10 | Abgenix, Inc. | Production of antibodies using Cre-mediated site-specific recombination |
| US6091001A (en) | 1995-03-29 | 2000-07-18 | Abgenix, Inc. | Production of antibodies using Cre-mediated site-specific recombination |
| EP0826034A4 (en) | 1995-04-21 | 2002-06-19 | Cell Genesys Inc | PRODUCTION OF LARGE GENOMIC DNA DELETIONS |
| AU5632296A (en) | 1995-04-27 | 1996-11-18 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| WO1996034096A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| SE9600820D0 (sv) | 1996-03-01 | 1996-03-01 | Pharmacia Ab | Antibodies and their use |
| US5714352A (en) | 1996-03-20 | 1998-02-03 | Xenotech Incorporated | Directed switch-mediated DNA recombination |
| US5994619A (en) | 1996-04-01 | 1999-11-30 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Production of chimeric bovine or porcine animals using cultured inner cell mass cells |
| US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
| EP2305027B1 (en) | 1996-12-03 | 2014-07-02 | Amgen Fremont Inc. | Transgenic mammals having human Ig loci including plural VH and Vkappa regions and antibodies produced therefrom |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| AU2978899A (en) | 1998-03-03 | 1999-09-20 | Abgenix, Inc. | Cd147 binding molecules as therapeutics |
| US20020029391A1 (en) | 1998-04-15 | 2002-03-07 | Claude Geoffrey Davis | Epitope-driven human antibody production and gene expression profiling |
| US6312689B1 (en) | 1998-07-23 | 2001-11-06 | Millennium Pharmaceuticals, Inc. | Anti-CCR2 antibodies and methods of use therefor |
| US6727349B1 (en) * | 1998-07-23 | 2004-04-27 | Millennium Pharmaceuticals, Inc. | Recombinant anti-CCR2 antibodies and methods of use therefor |
| WO2000009560A2 (en) | 1998-08-17 | 2000-02-24 | Abgenix, Inc. | Generation of modified molecules with increased serum half-lives |
| KR100617337B1 (ko) | 1998-12-23 | 2006-08-31 | 화이자 인크. | Ｃｔｌａ－４에 대한 인간 단일클론 항체 |
| CA2399080C (en) | 2000-02-03 | 2013-05-21 | Millennium Pharmaceuticals, Inc. | Humanized anti-ccr2 antibodies and methods of use therefor |
| GB0016138D0 (en) | 2000-06-30 | 2000-08-23 | Novartis Ag | Organic compounds |
| US20030165988A1 (en) * | 2002-02-08 | 2003-09-04 | Shaobing Hua | High throughput generation of human monoclonal antibody against peptide fragments derived from membrane proteins |
| ATE517855T1 (de) | 2001-11-30 | 2011-08-15 | Biogen Idec Inc | Antikörper gegen chemotaktische monozytenproteine |
| WO2003066830A2 (en) * | 2002-02-08 | 2003-08-14 | Genetastix Corporation | Human monoclonal antibodies against membrane proteins |
| RU2339647C2 (ru) | 2002-08-19 | 2008-11-27 | Астразенека Аб | Антитела против моноцитарного хемоаттрактантного белка-1 (мср-1) и их применение |
| WO2004024921A1 (ja) | 2002-09-12 | 2004-03-25 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | ヒト抗ヒトｍｃｐ−１抗体及び該抗体フラグメント |
| JP2007521248A (ja) | 2003-12-10 | 2007-08-02 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | ヒト化抗ｃｃｒ２抗体および該抗体を使用する方法 |
| SG188175A1 (en) | 2004-06-03 | 2013-03-28 | Novimmune Sa | Anti-cd3 antibodies and methods of use thereof |
| EP1784425A4 (en) | 2004-06-30 | 2009-02-18 | Centocor Inc | ANTI-MCP-1 ANTIBODIES, COMPOSITIONS, METHODS AND USES |
| CN101005855A (zh) * | 2004-07-30 | 2007-07-25 | 辉瑞产品公司 | 治疗由ccr2介导的疾病或紊乱的方法 |
| US20100074886A1 (en) | 2006-10-05 | 2010-03-25 | Anuk Das | Ccr2 antagonists for treatment of fibrosis |
-
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- 2011-02-09 ZA ZA2011/01047A patent/ZA201101047B/en unknown
- 2011-02-17 IL IL211284A patent/IL211284A/en active IP Right Grant
- 2011-03-11 CO CO11030038A patent/CO6351802A2/es active IP Right Grant
-
2014
- 2014-04-03 US US14/244,167 patent/US9238691B2/en active Active
Non-Patent Citations (1)
| Title |
|---|
| Ki Hoon Han et al., J. Biol. Chem. 1999, vol. 274, pgs. 32055-32062 * |
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