AU2009282419B2 - Pharmaceutical composition and administrations thereof - Google Patents

Pharmaceutical composition and administrations thereof Download PDF

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Publication number
AU2009282419B2
AU2009282419B2 AU2009282419A AU2009282419A AU2009282419B2 AU 2009282419 B2 AU2009282419 B2 AU 2009282419B2 AU 2009282419 A AU2009282419 A AU 2009282419A AU 2009282419 A AU2009282419 A AU 2009282419A AU 2009282419 B2 AU2009282419 B2 AU 2009282419B2
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AU
Australia
Prior art keywords
solid dispersion
pharmaceutical composition
weight
composition
amorphous compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
AU2009282419A
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English (en)
Other versions
AU2009282419A2 (en
AU2009282419A1 (en
Inventor
Martyn Botfield
Kirk Dinehart
Peter D. J. Grootenhuis
Alfredo Grossi
Patricia Hurter
Kirk Overhoff
William Rowe
Marinus Jacobus Verwijs
Christopher Young
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41206223&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2009282419(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of AU2009282419A1 publication Critical patent/AU2009282419A1/en
Publication of AU2009282419A2 publication Critical patent/AU2009282419A2/en
Application granted granted Critical
Publication of AU2009282419B2 publication Critical patent/AU2009282419B2/en
Priority to AU2016216569A priority Critical patent/AU2016216569B2/en
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Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pregnancy & Childbirth (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
AU2009282419A 2008-08-13 2009-08-13 Pharmaceutical composition and administrations thereof Active AU2009282419B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2016216569A AU2016216569B2 (en) 2008-08-13 2016-08-16 Pharmaceutical composition and administrations thereof

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US8870408P 2008-08-13 2008-08-13
US61/088,704 2008-08-13
US8880108P 2008-08-14 2008-08-14
US61/088,801 2008-08-14
US9009608P 2008-08-19 2008-08-19
US61/090,096 2008-08-19
US14616309P 2009-01-21 2009-01-21
US61/146,163 2009-01-21
US18152709P 2009-05-27 2009-05-27
US61/181,527 2009-05-27
US18334509P 2009-06-02 2009-06-02
US61/183,345 2009-06-02
PCT/US2009/004629 WO2010019239A2 (en) 2008-08-13 2009-08-13 Pharmaceutical composition and administrations thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2016216569A Division AU2016216569B2 (en) 2008-08-13 2016-08-16 Pharmaceutical composition and administrations thereof

Publications (3)

Publication Number Publication Date
AU2009282419A1 AU2009282419A1 (en) 2010-02-18
AU2009282419A2 AU2009282419A2 (en) 2011-03-31
AU2009282419B2 true AU2009282419B2 (en) 2016-05-19

Family

ID=41206223

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2009282419A Active AU2009282419B2 (en) 2008-08-13 2009-08-13 Pharmaceutical composition and administrations thereof
AU2016216569A Active AU2016216569B2 (en) 2008-08-13 2016-08-16 Pharmaceutical composition and administrations thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2016216569A Active AU2016216569B2 (en) 2008-08-13 2016-08-16 Pharmaceutical composition and administrations thereof

Country Status (27)

Country Link
US (1) US20120220625A1 (enExample)
EP (3) EP3345625B1 (enExample)
JP (2) JP5575768B2 (enExample)
KR (5) KR20110042356A (enExample)
CN (1) CN102231990B (enExample)
AU (2) AU2009282419B2 (enExample)
BR (1) BRPI0916877A2 (enExample)
CA (1) CA2733908C (enExample)
CY (2) CY1119945T1 (enExample)
DK (2) DK2328618T3 (enExample)
EA (1) EA021706B1 (enExample)
ES (2) ES2660143T3 (enExample)
HR (2) HRP20180328T1 (enExample)
HU (2) HUE035931T2 (enExample)
IL (3) IL211203A (enExample)
LT (2) LT2328618T (enExample)
ME (1) ME03019B (enExample)
MX (3) MX366161B (enExample)
NO (1) NO2328618T3 (enExample)
NZ (1) NZ591535A (enExample)
PL (2) PL3345625T3 (enExample)
PT (2) PT3345625T (enExample)
RS (2) RS56894B1 (enExample)
SI (2) SI2328618T1 (enExample)
SM (2) SMT201800074T1 (enExample)
WO (1) WO2010019239A2 (enExample)
ZA (1) ZA201101097B (enExample)

Families Citing this family (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2006111093A (ru) 2003-09-06 2007-10-27 Вертекс Фармасьютикалз Инкорпорейтед (Us) Модуляторы атр-связывающих кассетных транспортеров
US7977322B2 (en) 2004-08-20 2011-07-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
PL2489659T3 (pl) 2004-06-24 2018-06-29 Vertex Pharma Modulatory transporterów posiadających kasetę wiążącą atp
KR20080053297A (ko) 2005-08-11 2008-06-12 버텍스 파마슈티칼스 인코포레이티드 낭포성 섬유종 트랜스막 전도도 조정자의 조절자
DK2774925T3 (en) 2005-11-08 2017-02-27 Vertex Pharma Heterocyclic modulators of ATP binding cassette transporters
NZ569327A (en) 2005-12-28 2011-09-30 Vertex Pharma 1-(benzo [d] [1,3] dioxol-5-yl) -n- (phenyl) cyclopropane- carboxamide derivatives and related compounds as modulators of ATP-binding cassette transporters for the treatment of cystic fibrosis
PT1993360T (pt) 2005-12-28 2017-05-25 Vertex Pharma Formas sólidas de n-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-di-hidro-4-oxoquinolina-3-carboxamida
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
ES2882684T3 (es) 2006-04-07 2021-12-02 Vertex Pharma Preparación de moduladores de transportadores del casete de unión a ATP
USRE50453E1 (en) 2006-04-07 2025-06-10 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
NZ581259A (en) 2007-05-09 2012-07-27 Vertex Pharma Modulators of cystic fibrosis transmembrane conductance regulator
ES2578735T3 (es) 2007-08-24 2016-07-29 Vertex Pharmaceuticals Incorporated Isotiazolopiridinonas útiles para el tratamiento de (entre otros) fibrosis quística
EP2578571B1 (en) 2007-11-16 2015-09-16 Vertex Pharmaceuticals Incorporated Isoquinoline modulators of ATP-binding cassette transporters
AU2008335440B2 (en) 2007-12-07 2013-11-07 Vertex Pharmaceuticals Incorporated Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
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