AU2009270718B2 - Compositions and methods for treating osteoarthritis - Google Patents

Info

Publication number

AU2009270718B2

AU2009270718B2 AU2009270718A AU2009270718A AU2009270718B2 AU 2009270718 B2 AU2009270718 B2 AU 2009270718B2 AU 2009270718 A AU2009270718 A AU 2009270718A AU 2009270718 A AU2009270718 A AU 2009270718A AU 2009270718 B2 AU2009270718 B2 AU 2009270718B2

Authority

AU

Australia

Prior art keywords

mrna

pct

column

protein

predicted

Prior art date

2008-07-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000203 mixture Substances 0.000 title claims abstract description 160
• 238000000034 method Methods 0.000 title claims abstract description 142
• 201000008482 osteoarthritis Diseases 0.000 title claims description 90
• 230000002159 abnormal effect Effects 0.000 claims abstract description 103
• 238000011282 treatment Methods 0.000 claims abstract description 27
• 108090000623 proteins and genes Proteins 0.000 claims description 361
• 230000014509 gene expression Effects 0.000 claims description 187
• JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims description 133
• JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims description 133
• 235000020673 eicosapentaenoic acid Nutrition 0.000 claims description 133
• 229960005135 eicosapentaenoic acid Drugs 0.000 claims description 133
• MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims description 130
• OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims description 58
• 229960004232 linoleic acid Drugs 0.000 claims description 58
• 206010003246 arthritis Diseases 0.000 claims description 31
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 23
• -1 RELA Proteins 0.000 claims description 20
• 206010039073 rheumatoid arthritis Diseases 0.000 claims description 20
• 208000018937 joint inflammation Diseases 0.000 claims description 17
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 16
• MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims description 16
• PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims description 14
• RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims description 14
• 229960004203 carnitine Drugs 0.000 claims description 13
• 235000020660 omega-3 fatty acid Nutrition 0.000 claims description 13
• 239000003963 antioxidant agent Substances 0.000 claims description 12
• 235000006708 antioxidants Nutrition 0.000 claims description 12
• 239000003814 drug Substances 0.000 claims description 12
• 229940012843 omega-3 fatty acid Drugs 0.000 claims description 12
• 235000019154 vitamin C Nutrition 0.000 claims description 12
• 239000011718 vitamin C Substances 0.000 claims description 12
• ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 11
• 229930003268 Vitamin C Natural products 0.000 claims description 11
• 150000002337 glycosamines Chemical class 0.000 claims description 11
• 239000011734 sodium Substances 0.000 claims description 11
• MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims description 10
• OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 claims description 10
• 230000003078 antioxidant effect Effects 0.000 claims description 10
• 229960002442 glucosamine Drugs 0.000 claims description 10
• 229910052708 sodium Inorganic materials 0.000 claims description 10
• 229930003799 tocopherol Natural products 0.000 claims description 10
• 239000011732 tocopherol Substances 0.000 claims description 10
• 125000002640 tocopherol group Chemical class 0.000 claims description 10
• 235000019149 tocopherols Nutrition 0.000 claims description 10
• SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims description 9
• VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 9
• 229920001287 Chondroitin sulfate Polymers 0.000 claims description 9
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 9
• OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 claims description 9
• MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 claims description 9
• 239000011575 calcium Substances 0.000 claims description 9
• 229940059329 chondroitin sulfate Drugs 0.000 claims description 9
• 229950006780 n-acetylglucosamine Drugs 0.000 claims description 9
• GJJVAFUKOBZPCB-ZGRPYONQSA-N (r)-3,4-dihydro-2-methyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2h-1-benzopyran-6-ol Chemical class OC1=CC=C2OC(CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1 GJJVAFUKOBZPCB-ZGRPYONQSA-N 0.000 claims description 8
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 8
• HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 8
• OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims description 8
• 235000013734 beta-carotene Nutrition 0.000 claims description 8
• 239000011648 beta-carotene Substances 0.000 claims description 8
• TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims description 8
• 229960002747 betacarotene Drugs 0.000 claims description 8
• 235000001465 calcium Nutrition 0.000 claims description 8
• 229910052791 calcium Inorganic materials 0.000 claims description 8
• 229910052742 iron Inorganic materials 0.000 claims description 8
• 229930003802 tocotrienol Natural products 0.000 claims description 8
• 239000011731 tocotrienol Substances 0.000 claims description 8
• 229940068778 tocotrienols Drugs 0.000 claims description 8
• 235000019148 tocotrienols Nutrition 0.000 claims description 8
• 239000011701 zinc Substances 0.000 claims description 8
• 229910052725 zinc Inorganic materials 0.000 claims description 8
• OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims description 8
• RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 7
• PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 7
• 108010024636 Glutathione Proteins 0.000 claims description 7
• 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 claims description 7
• FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 7
• YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 claims description 7
• ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 claims description 7
• OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 7
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 7
• BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 7
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 7
• 102100039360 Toll-like receptor 4 Human genes 0.000 claims description 7
• 229910017052 cobalt Inorganic materials 0.000 claims description 7
• 239000010941 cobalt Substances 0.000 claims description 7
• GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 7
• 229910052802 copper Inorganic materials 0.000 claims description 7
• 239000010949 copper Substances 0.000 claims description 7
• CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims description 7
• 229910052731 fluorine Inorganic materials 0.000 claims description 7
• 239000011737 fluorine Substances 0.000 claims description 7
• 229960003180 glutathione Drugs 0.000 claims description 7
• 235000003969 glutathione Nutrition 0.000 claims description 7
• PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 7
• AGBQKNBQESQNJD-UHFFFAOYSA-M lipoate Chemical compound [O-]C(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-M 0.000 claims description 7
• 235000019136 lipoic acid Nutrition 0.000 claims description 7
• 239000011777 magnesium Substances 0.000 claims description 7
• 229910052749 magnesium Inorganic materials 0.000 claims description 7
• WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims description 7
• 229960003987 melatonin Drugs 0.000 claims description 7
• DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 claims description 7
• 235000010755 mineral Nutrition 0.000 claims description 7
• 239000011707 mineral Substances 0.000 claims description 7
• 229910052750 molybdenum Inorganic materials 0.000 claims description 7
• 239000011733 molybdenum Substances 0.000 claims description 7
• 229910052759 nickel Inorganic materials 0.000 claims description 7
• 229910052698 phosphorus Inorganic materials 0.000 claims description 7
• 239000011574 phosphorus Substances 0.000 claims description 7
• 229910052700 potassium Inorganic materials 0.000 claims description 7
• 239000011591 potassium Substances 0.000 claims description 7
• 229910052711 selenium Inorganic materials 0.000 claims description 7
• 239000011669 selenium Substances 0.000 claims description 7
• 229910052717 sulfur Inorganic materials 0.000 claims description 7
• 239000011593 sulfur Substances 0.000 claims description 7
• 229960002663 thioctic acid Drugs 0.000 claims description 7
• 229910052720 vanadium Inorganic materials 0.000 claims description 7
• MSWZFWKMSRAUBD-GASJEMHNSA-N 2-amino-2-deoxy-D-galactopyranose Chemical group N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O MSWZFWKMSRAUBD-GASJEMHNSA-N 0.000 claims description 6
• 102100026802 72 kDa type IV collagenase Human genes 0.000 claims description 6
• 101710151806 72 kDa type IV collagenase Proteins 0.000 claims description 6
• 229920000045 Dermatan sulfate Polymers 0.000 claims description 6
• 229920002971 Heparan sulfate Polymers 0.000 claims description 6
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 6
• 229920000288 Keratan sulfate Polymers 0.000 claims description 6
• 102100026262 Metalloproteinase inhibitor 2 Human genes 0.000 claims description 6
• RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 claims description 6
• 108010031372 Tissue Inhibitor of Metalloproteinase-2 Proteins 0.000 claims description 6
• 229960001009 acetylcarnitine Drugs 0.000 claims description 6
• SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims description 6
• AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 claims description 6
• 229940051593 dermatan sulfate Drugs 0.000 claims description 6
• 229920000669 heparin Polymers 0.000 claims description 6
• 229960002897 heparin Drugs 0.000 claims description 6
• 229920002674 hyaluronan Polymers 0.000 claims description 6
• 229940099552 hyaluronan Drugs 0.000 claims description 6
• KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 claims description 6
• KXCLCNHUUKTANI-RBIYJLQWSA-N keratan Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@H](COS(O)(=O)=O)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H]([C@@H](COS(O)(=O)=O)O[C@@H](O)[C@@H]3O)O)[C@H](NC(C)=O)[C@H]2O)COS(O)(=O)=O)O[C@H](COS(O)(=O)=O)[C@@H]1O KXCLCNHUUKTANI-RBIYJLQWSA-N 0.000 claims description 6
• 108010068338 p38 Mitogen-Activated Protein Kinases Proteins 0.000 claims description 6
• 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 claims description 6
• 238000002360 preparation method Methods 0.000 claims description 6
• SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims description 6
• 102000003908 Cathepsin D Human genes 0.000 claims description 5
• 108090000258 Cathepsin D Proteins 0.000 claims description 5
• 108090000610 Cathepsin F Proteins 0.000 claims description 5
• 102000004176 Cathepsin F Human genes 0.000 claims description 5
• 102100035654 Cathepsin S Human genes 0.000 claims description 5
• 108090000613 Cathepsin S Proteins 0.000 claims description 5
• 102000004554 Interleukin-17 Receptors Human genes 0.000 claims description 5
• 108010017525 Interleukin-17 Receptors Proteins 0.000 claims description 5
• 235000020776 essential amino acid Nutrition 0.000 claims description 5
• 239000003797 essential amino acid Substances 0.000 claims description 5
• 102000000412 Annexin Human genes 0.000 claims description 4
• 108050008874 Annexin Proteins 0.000 claims description 4
• 101100339431 Arabidopsis thaliana HMGB2 gene Proteins 0.000 claims description 4
• 108700010013 HMGB1 Proteins 0.000 claims description 4
• 101150021904 HMGB1 gene Proteins 0.000 claims description 4
• 102100037907 High mobility group protein B1 Human genes 0.000 claims description 4
• 102000004556 Interleukin-15 Receptors Human genes 0.000 claims description 4
• 108010017535 Interleukin-15 Receptors Proteins 0.000 claims description 4
• 102100039364 Metalloproteinase inhibitor 1 Human genes 0.000 claims description 4
• 108700012920 TNF Proteins 0.000 claims description 4
• 108010031374 Tissue Inhibitor of Metalloproteinase-1 Proteins 0.000 claims description 4
• 102000002274 Matrix Metalloproteinases Human genes 0.000 claims description 3
• 108010000684 Matrix Metalloproteinases Proteins 0.000 claims description 3
• PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical compound C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 claims 2
• 230000000052 comparative effect Effects 0.000 claims 1
• LEONUFNNVUYDNQ-UHFFFAOYSA-N vanadium atom Chemical compound [V] LEONUFNNVUYDNQ-UHFFFAOYSA-N 0.000 claims 1
• 108020004999 messenger RNA Proteins 0.000 description 310
• 241001465754 Metazoa Species 0.000 description 246
• 241000282472 Canis lupus familiaris Species 0.000 description 214
• 239000000523 sample Substances 0.000 description 187
• 241000282414 Homo sapiens Species 0.000 description 140
• 102000004169 proteins and genes Human genes 0.000 description 115
• 235000018102 proteins Nutrition 0.000 description 113
• 102000040430 polynucleotide Human genes 0.000 description 89
• 108091033319 polynucleotide Proteins 0.000 description 89
• 239000002157 polynucleotide Substances 0.000 description 89
• 235000021355 Stearic acid Nutrition 0.000 description 79
• QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 79
• OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 79
• 239000008117 stearic acid Substances 0.000 description 79
• 239000000090 biomarker Substances 0.000 description 75
• 230000002917 arthritic effect Effects 0.000 description 73
• 108090000765 processed proteins & peptides Proteins 0.000 description 68
• 229920002477 rna polymer Polymers 0.000 description 66
• 102000004196 processed proteins & peptides Human genes 0.000 description 60
• 108010067163 Perilipin-2 Proteins 0.000 description 59
• 102000017794 Perilipin-2 Human genes 0.000 description 59
• 229920001184 polypeptide Polymers 0.000 description 58
• 241000282326 Felis catus Species 0.000 description 54
• 102100021084 Forkhead box protein C1 Human genes 0.000 description 53
• 101000818310 Homo sapiens Forkhead box protein C1 Proteins 0.000 description 53
• 239000002299 complementary DNA Substances 0.000 description 53
• 241000282465 Canis Species 0.000 description 51
• 208000012659 Joint disease Diseases 0.000 description 47
• 210000001519 tissue Anatomy 0.000 description 46
• 235000013305 food Nutrition 0.000 description 45
• OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 45
• JBYXPOFIGCOSSB-GOJKSUSPSA-N 9-cis,11-trans-octadecadienoic acid Chemical compound CCCCCC\C=C\C=C/CCCCCCCC(O)=O JBYXPOFIGCOSSB-GOJKSUSPSA-N 0.000 description 43
• 210000004027 cell Anatomy 0.000 description 43
• 229940108924 conjugated linoleic acid Drugs 0.000 description 42
• 210000000349 chromosome Anatomy 0.000 description 38
• 239000000047 product Substances 0.000 description 38
• 230000036961 partial effect Effects 0.000 description 37
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 36
• 239000000126 substance Substances 0.000 description 34
• 238000012360 testing method Methods 0.000 description 32
• 241000283690 Bos taurus Species 0.000 description 25
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 25
• 230000000694 effects Effects 0.000 description 25
• 238000009396 hybridization Methods 0.000 description 25
• 108091028043 Nucleic acid sequence Proteins 0.000 description 24
• 238000004458 analytical method Methods 0.000 description 24
• 210000004369 blood Anatomy 0.000 description 24
• 239000008280 blood Substances 0.000 description 24
• 210000000845 cartilage Anatomy 0.000 description 24
• 235000016709 nutrition Nutrition 0.000 description 24
• 108020004414 DNA Proteins 0.000 description 23
• GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 22
• 241000282324 Felis Species 0.000 description 21
• 239000000306 component Substances 0.000 description 21
• 201000010099 disease Diseases 0.000 description 21
• 239000012634 fragment Substances 0.000 description 20
• 125000003729 nucleotide group Chemical group 0.000 description 20
• 239000002773 nucleotide Substances 0.000 description 19
• 102000001708 Protein Isoforms Human genes 0.000 description 18
• 235000001014 amino acid Nutrition 0.000 description 18
• 150000001413 amino acids Chemical class 0.000 description 18
• 108010029485 Protein Isoforms Proteins 0.000 description 17
• 229940024606 amino acid Drugs 0.000 description 17
• 230000008859 change Effects 0.000 description 16
• 230000000295 complement effect Effects 0.000 description 16
• 235000005911 diet Nutrition 0.000 description 16
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
• 229920002683 Glycosaminoglycan Polymers 0.000 description 15
• 108091034117 Oligonucleotide Proteins 0.000 description 15
• 208000024191 minimally invasive lung adenocarcinoma Diseases 0.000 description 15
• 239000003153 chemical reaction reagent Substances 0.000 description 13
• 230000009274 differential gene expression Effects 0.000 description 13
• 230000001105 regulatory effect Effects 0.000 description 13
• 238000012546 transfer Methods 0.000 description 13
• PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 description 12
• 241000699660 Mus musculus Species 0.000 description 12
• 108010083644 Ribonucleases Proteins 0.000 description 12
• 102000006382 Ribonucleases Human genes 0.000 description 12
• 238000003556 assay Methods 0.000 description 12
• 210000001124 body fluid Anatomy 0.000 description 12
• 230000037213 diet Effects 0.000 description 12
• 239000004615 ingredient Substances 0.000 description 12
• 238000004519 manufacturing process Methods 0.000 description 12
• 239000002207 metabolite Substances 0.000 description 12
• HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 description 12
• 235000019165 vitamin E Nutrition 0.000 description 12
• 239000011709 vitamin E Substances 0.000 description 12
• 229930003427 Vitamin E Natural products 0.000 description 11
• 238000003745 diagnosis Methods 0.000 description 11
• WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 11
• 230000004054 inflammatory process Effects 0.000 description 11
• 239000000463 material Substances 0.000 description 11
• 239000012528 membrane Substances 0.000 description 11
• 239000002243 precursor Substances 0.000 description 11
• 239000000243 solution Substances 0.000 description 11
• 229940046009 vitamin E Drugs 0.000 description 11
• 206010061218 Inflammation Diseases 0.000 description 10
• 108091000080 Phosphotransferase Proteins 0.000 description 10
• 239000000872 buffer Substances 0.000 description 10
• 235000012041 food component Nutrition 0.000 description 10
• 239000008188 pellet Substances 0.000 description 10
• 102000020233 phosphotransferase Human genes 0.000 description 10
• 238000004393 prognosis Methods 0.000 description 10
• 239000000758 substrate Substances 0.000 description 10
• 229910001868 water Inorganic materials 0.000 description 10
• 102100025674 Angiopoietin-related protein 4 Human genes 0.000 description 9
• 239000003795 chemical substances by application Substances 0.000 description 9
• 229940079593 drug Drugs 0.000 description 9
• 239000007788 liquid Substances 0.000 description 9
• 239000002417 nutraceutical Substances 0.000 description 9
• 235000021436 nutraceutical agent Nutrition 0.000 description 9
• 238000012216 screening Methods 0.000 description 9
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
• 102000016911 Deoxyribonucleases Human genes 0.000 description 8
• 108010053770 Deoxyribonucleases Proteins 0.000 description 8
• 238000003491 array Methods 0.000 description 8
• 239000013068 control sample Substances 0.000 description 8
• 238000001514 detection method Methods 0.000 description 8
• 238000011161 development Methods 0.000 description 8
• 230000018109 developmental process Effects 0.000 description 8
• 210000001503 joint Anatomy 0.000 description 8
• 238000002493 microarray Methods 0.000 description 8
• 102000039446 nucleic acids Human genes 0.000 description 8
• 108020004707 nucleic acids Proteins 0.000 description 8
• 150000007523 nucleic acids Chemical class 0.000 description 8
• 229920000642 polymer Polymers 0.000 description 8
• 230000009870 specific binding Effects 0.000 description 8
• 239000013589 supplement Substances 0.000 description 8
• 238000012706 support-vector machine Methods 0.000 description 8
• 108010035532 Collagen Proteins 0.000 description 7
• 102000008186 Collagen Human genes 0.000 description 7
• 238000000018 DNA microarray Methods 0.000 description 7
• 101710088194 Dehydrogenase Proteins 0.000 description 7
• 108010008532 Deoxyribonuclease I Proteins 0.000 description 7
• 241000287828 Gallus gallus Species 0.000 description 7
• 241000282577 Pan troglodytes Species 0.000 description 7
• LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 7
• 238000002123 RNA extraction Methods 0.000 description 7
• 230000008355 cartilage degradation Effects 0.000 description 7
• 229920001436 collagen Polymers 0.000 description 7
• 238000010195 expression analysis Methods 0.000 description 7
• 230000006870 function Effects 0.000 description 7
• 210000004698 lymphocyte Anatomy 0.000 description 7
• 235000015097 nutrients Nutrition 0.000 description 7
• 239000006228 supernatant Substances 0.000 description 7
• 229940088594 vitamin Drugs 0.000 description 7
• 229930003231 vitamin Natural products 0.000 description 7
• 235000013343 vitamin Nutrition 0.000 description 7
• 239000011782 vitamin Substances 0.000 description 7
• YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 6
• 102100039318 HAUS augmin-like complex subunit 6 Human genes 0.000 description 6
• 101001035815 Homo sapiens HAUS augmin-like complex subunit 6 Proteins 0.000 description 6
• 101001096050 Homo sapiens Perilipin-2 Proteins 0.000 description 6
• KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
• AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 6
• 108091036066 Three prime untranslated region Proteins 0.000 description 6
• 230000027455 binding Effects 0.000 description 6
• 230000015556 catabolic process Effects 0.000 description 6
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
• 230000001419 dependent effect Effects 0.000 description 6
• 235000014113 dietary fatty acids Nutrition 0.000 description 6
• 235000015872 dietary supplement Nutrition 0.000 description 6
• 239000000194 fatty acid Substances 0.000 description 6
• 229930195729 fatty acid Natural products 0.000 description 6
• 150000004665 fatty acids Chemical class 0.000 description 6
• OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 6
• 238000000338 in vitro Methods 0.000 description 6
• 238000003752 polymerase chain reaction Methods 0.000 description 6
• 102000005962 receptors Human genes 0.000 description 6
• 108020003175 receptors Proteins 0.000 description 6
• 229940091258 selenium supplement Drugs 0.000 description 6
• 239000007787 solid Substances 0.000 description 6
• 208000024891 symptom Diseases 0.000 description 6
• GPPXJZIENCGNKB-UHFFFAOYSA-N vanadium Chemical compound [V]#[V] GPPXJZIENCGNKB-UHFFFAOYSA-N 0.000 description 6
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 5
• 102000040650 (ribonucleotides)n+m Human genes 0.000 description 5
• 102100027995 Collagenase 3 Human genes 0.000 description 5
• 108050005238 Collagenase 3 Proteins 0.000 description 5
• 102100030012 Deoxyribonuclease-1 Human genes 0.000 description 5
• 102100024412 GTPase IMAP family member 4 Human genes 0.000 description 5
• 206010021143 Hypoxia Diseases 0.000 description 5
• 208000023178 Musculoskeletal disease Diseases 0.000 description 5
• PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 5
• 108020004711 Nucleic Acid Probes Proteins 0.000 description 5
• 238000011529 RT qPCR Methods 0.000 description 5
• 102100035174 SEC14-like protein 2 Human genes 0.000 description 5
• 108020004459 Small interfering RNA Proteins 0.000 description 5
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
• 239000012472 biological sample Substances 0.000 description 5
• 210000001612 chondrocyte Anatomy 0.000 description 5
• 229940000406 drug candidate Drugs 0.000 description 5
• 238000011223 gene expression profiling Methods 0.000 description 5
• 230000002068 genetic effect Effects 0.000 description 5
• 230000036541 health Effects 0.000 description 5
• 239000003550 marker Substances 0.000 description 5
• 230000037353 metabolic pathway Effects 0.000 description 5
• 238000012544 monitoring process Methods 0.000 description 5
• 239000002853 nucleic acid probe Substances 0.000 description 5
• 239000006014 omega-3 oil Substances 0.000 description 5
• 239000013641 positive control Substances 0.000 description 5
• 235000021195 test diet Nutrition 0.000 description 5
• 238000013518 transcription Methods 0.000 description 5
• 230000035897 transcription Effects 0.000 description 5
• 230000003827 upregulation Effects 0.000 description 5
• XMGQYMWWDOXHJM-JTQLQIEISA-N (+)-α-limonene Chemical compound CC(=C)[C@@H]1CCC(C)=CC1 XMGQYMWWDOXHJM-JTQLQIEISA-N 0.000 description 4
• GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 4
• 102100036601 Aggrecan core protein Human genes 0.000 description 4
• 108010067219 Aggrecans Proteins 0.000 description 4
• HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
• 102000004127 Cytokines Human genes 0.000 description 4
• 108090000695 Cytokines Proteins 0.000 description 4
• ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 4
• 108010017123 Kruppel-Like Transcription Factors Proteins 0.000 description 4
• 102000004434 Kruppel-Like Transcription Factors Human genes 0.000 description 4
• UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 4
• 208000002193 Pain Diseases 0.000 description 4
• 239000004743 Polypropylene Substances 0.000 description 4
• 102000016611 Proteoglycans Human genes 0.000 description 4
• 108010067787 Proteoglycans Proteins 0.000 description 4
• REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 4
• 238000011530 RNeasy Mini Kit Methods 0.000 description 4
• 101710188106 SEC14-like protein 2 Proteins 0.000 description 4
• 102100023085 Serine/threonine-protein kinase mTOR Human genes 0.000 description 4
• 241000282898 Sus scrofa Species 0.000 description 4
• 108010055215 Syndecan-4 Proteins 0.000 description 4
• QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 4
• 239000002253 acid Substances 0.000 description 4
• 230000015572 biosynthetic process Effects 0.000 description 4
• 238000005119 centrifugation Methods 0.000 description 4
• 238000007796 conventional method Methods 0.000 description 4
• 238000006731 degradation reaction Methods 0.000 description 4
• 230000000378 dietary effect Effects 0.000 description 4
• 208000035475 disorder Diseases 0.000 description 4
• 238000005516 engineering process Methods 0.000 description 4
• 239000000499 gel Substances 0.000 description 4
• 150000004676 glycans Chemical class 0.000 description 4
• 230000012010 growth Effects 0.000 description 4
• 230000004968 inflammatory condition Effects 0.000 description 4
• 230000003993 interaction Effects 0.000 description 4
• 230000035990 intercellular signaling Effects 0.000 description 4
• 238000005259 measurement Methods 0.000 description 4
• 230000002438 mitochondrial effect Effects 0.000 description 4
• 230000004048 modification Effects 0.000 description 4
• 238000012986 modification Methods 0.000 description 4
• 229960003512 nicotinic acid Drugs 0.000 description 4
• 235000001968 nicotinic acid Nutrition 0.000 description 4
• 239000011664 nicotinic acid Substances 0.000 description 4
• 229910052757 nitrogen Inorganic materials 0.000 description 4
• 238000010606 normalization Methods 0.000 description 4
• 229920001155 polypropylene Polymers 0.000 description 4
• 229920001282 polysaccharide Polymers 0.000 description 4
• 239000005017 polysaccharide Substances 0.000 description 4
• 230000002265 prevention Effects 0.000 description 4
• LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 4
• 230000004044 response Effects 0.000 description 4
• 238000007619 statistical method Methods 0.000 description 4
• 238000006467 substitution reaction Methods 0.000 description 4
• 235000000346 sugar Nutrition 0.000 description 4
• 238000003786 synthesis reaction Methods 0.000 description 4
• XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 4
• 230000014616 translation Effects 0.000 description 4
• CBOJBBMQJBVCMW-BTVCFUMJSA-N (2r,3r,4s,5r)-2-amino-3,4,5,6-tetrahydroxyhexanal;hydrochloride Chemical compound Cl.O=C[C@H](N)[C@@H](O)[C@H](O)[C@H](O)CO CBOJBBMQJBVCMW-BTVCFUMJSA-N 0.000 description 3
• FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 3
• 101710113902 26S proteasome non-ATPase regulatory subunit 10 Proteins 0.000 description 3
• 102100036734 26S proteasome non-ATPase regulatory subunit 10 Human genes 0.000 description 3
• 102100034613 Annexin A2 Human genes 0.000 description 3
• 108090000668 Annexin A2 Proteins 0.000 description 3
• 102100035025 Ataxin-10 Human genes 0.000 description 3
• 108010077544 Chromatin Proteins 0.000 description 3
• 102100023774 Cold-inducible RNA-binding protein Human genes 0.000 description 3
• 101710164904 Cold-inducible RNA-binding protein Proteins 0.000 description 3
• 108020003264 Cotransporters Proteins 0.000 description 3
• 102000034534 Cotransporters Human genes 0.000 description 3
• 108091029523 CpG island Proteins 0.000 description 3
• 102100025525 Cullin-5 Human genes 0.000 description 3
• 101710094483 Cullin-5 Proteins 0.000 description 3
• AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 3
• 101000693076 Homo sapiens Angiopoietin-related protein 4 Proteins 0.000 description 3
• 101001028703 Homo sapiens Probable JmjC domain-containing histone demethylation protein 2C Proteins 0.000 description 3
• AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 3
• 102100025211 Mitogen-activated protein kinase kinase kinase 14 Human genes 0.000 description 3
• 241000699666 Mus <mouse, genus> Species 0.000 description 3
• OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 3
• 206010028980 Neoplasm Diseases 0.000 description 3
• 102000012547 Olfactory receptors Human genes 0.000 description 3
• 108050002069 Olfactory receptors Proteins 0.000 description 3
• 102100032619 Phosphatidylinositol 4-kinase beta Human genes 0.000 description 3
• 241000700157 Rattus norvegicus Species 0.000 description 3
• 102000000011 Syndecan-4 Human genes 0.000 description 3
• 102100030268 Thioredoxin domain-containing protein 6 Human genes 0.000 description 3
• 101710154459 Thioredoxin domain-containing protein 6 Proteins 0.000 description 3
• 102100040247 Tumor necrosis factor Human genes 0.000 description 3
• 102100039257 Type II inositol 1,4,5-trisphosphate 5-phosphatase Human genes 0.000 description 3
• FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 3
• 229930003316 Vitamin D Natural products 0.000 description 3
• FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 3
• 230000003321 amplification Effects 0.000 description 3
• 235000019728 animal nutrition Nutrition 0.000 description 3
• 230000000975 bioactive effect Effects 0.000 description 3
• 230000031018 biological processes and functions Effects 0.000 description 3
• 229960002685 biotin Drugs 0.000 description 3
• 235000020958 biotin Nutrition 0.000 description 3
• 239000011616 biotin Substances 0.000 description 3
• 210000000988 bone and bone Anatomy 0.000 description 3
• 235000021466 carotenoid Nutrition 0.000 description 3
• 150000001747 carotenoids Chemical class 0.000 description 3
• 238000006243 chemical reaction Methods 0.000 description 3
• 235000013330 chicken meat Nutrition 0.000 description 3
• 210000003483 chromatin Anatomy 0.000 description 3
• 230000007423 decrease Effects 0.000 description 3
• 230000007613 environmental effect Effects 0.000 description 3
• DNJIEGIFACGWOD-UHFFFAOYSA-N ethyl mercaptane Natural products CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 description 3
• 230000007717 exclusion Effects 0.000 description 3
• 210000002950 fibroblast Anatomy 0.000 description 3
• 229960000304 folic acid Drugs 0.000 description 3
• 235000019152 folic acid Nutrition 0.000 description 3
• 239000011724 folic acid Substances 0.000 description 3
• BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 3
• VZCCETWTMQHEPK-QNEBEIHSSA-N gamma-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O VZCCETWTMQHEPK-QNEBEIHSSA-N 0.000 description 3
• 229960001911 glucosamine hydrochloride Drugs 0.000 description 3
• 239000003102 growth factor Substances 0.000 description 3
• 238000000265 homogenisation Methods 0.000 description 3
• 238000007834 ligase chain reaction Methods 0.000 description 3
• 235000020778 linoleic acid Nutrition 0.000 description 3
• 230000033001 locomotion Effects 0.000 description 3
• 239000011159 matrix material Substances 0.000 description 3
• 229940057917 medium chain triglycerides Drugs 0.000 description 3
• 229930182817 methionine Natural products 0.000 description 3
• 235000006109 methionine Nutrition 0.000 description 3
• 238000003199 nucleic acid amplification method Methods 0.000 description 3
• 238000003499 nucleic acid array Methods 0.000 description 3
• SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 3
• 230000008569 process Effects 0.000 description 3
• 238000012545 processing Methods 0.000 description 3
• 239000012474 protein marker Substances 0.000 description 3
• 238000011002 quantification Methods 0.000 description 3
• 230000009467 reduction Effects 0.000 description 3
• 235000019192 riboflavin Nutrition 0.000 description 3
• 239000002151 riboflavin Substances 0.000 description 3
• 229960002477 riboflavin Drugs 0.000 description 3
• 239000001509 sodium citrate Substances 0.000 description 3
• NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 3
• 238000012956 testing procedure Methods 0.000 description 3
• 238000013519 translation Methods 0.000 description 3
• 150000003626 triacylglycerols Chemical class 0.000 description 3
• 235000019155 vitamin A Nutrition 0.000 description 3
• 239000011719 vitamin A Substances 0.000 description 3
• 235000019166 vitamin D Nutrition 0.000 description 3
• 239000011710 vitamin D Substances 0.000 description 3
• 150000003710 vitamin D derivatives Chemical class 0.000 description 3
• 229940045997 vitamin a Drugs 0.000 description 3
• 229940046008 vitamin d Drugs 0.000 description 3
• DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 3
• PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 2
• IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
• 102100027452 ATP-dependent DNA helicase Q4 Human genes 0.000 description 2
• 101710132586 ATP-dependent DNA helicase Q4 Proteins 0.000 description 2
• 102100034561 Alpha-N-acetylglucosaminidase Human genes 0.000 description 2
• 241000219195 Arabidopsis thaliana Species 0.000 description 2
• 102100022278 Arachidonate 5-lipoxygenase-activating protein Human genes 0.000 description 2
• 241000271566 Aves Species 0.000 description 2
• 108091028026 C-DNA Proteins 0.000 description 2
• 108010065376 COUP Transcription Factor I Proteins 0.000 description 2
• VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
• 102000002666 Carnitine O-palmitoyltransferase Human genes 0.000 description 2
• 108010018424 Carnitine O-palmitoyltransferase Proteins 0.000 description 2
• 102000014914 Carrier Proteins Human genes 0.000 description 2
• GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 2
• 229920001661 Chitosan Polymers 0.000 description 2
• ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 2
• 206010056370 Congestive cardiomyopathy Diseases 0.000 description 2
• 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 description 2
• 102000003849 Cytochrome P450 Human genes 0.000 description 2
• 102000053602 DNA Human genes 0.000 description 2
• 241000252212 Danio rerio Species 0.000 description 2
• 201000010046 Dilated cardiomyopathy Diseases 0.000 description 2
• 102100036437 Ectonucleoside triphosphate diphosphohydrolase 6 Human genes 0.000 description 2
• 101710116079 Ectonucleoside triphosphate diphosphohydrolase 6 Proteins 0.000 description 2
• 102000004190 Enzymes Human genes 0.000 description 2
• 108090000790 Enzymes Proteins 0.000 description 2
• 241000283073 Equus caballus Species 0.000 description 2
• 102100022642 Fructose-2,6-bisphosphatase Human genes 0.000 description 2
• 101710190481 GTPase IMAP family member 4 Proteins 0.000 description 2
• 102000034575 Glutamate transporters Human genes 0.000 description 2
• 108091006151 Glutamate transporters Proteins 0.000 description 2
• 241000237902 Hirudo medicinalis Species 0.000 description 2
• 108700027094 Hirudo medicinalis gliarin Proteins 0.000 description 2
• 241000282412 Homo Species 0.000 description 2
• 101000873095 Homo sapiens Ataxin-10 Proteins 0.000 description 2
• 101000833375 Homo sapiens GTPase IMAP family member 4 Proteins 0.000 description 2
• 101000575041 Homo sapiens Male-enhanced antigen 1 Proteins 0.000 description 2
• 101000990528 Homo sapiens Methyltransferase-like protein 17, mitochondrial Proteins 0.000 description 2
• 101001052493 Homo sapiens Mitogen-activated protein kinase 1 Proteins 0.000 description 2
• 101000730433 Homo sapiens Phosphatidylinositol 4-kinase beta Proteins 0.000 description 2
• 101000831567 Homo sapiens Toll-like receptor 2 Proteins 0.000 description 2
• 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 description 2
• 102100037195 Inactive sodium-dependent neutral amino acid transporter B(0)AT3 Human genes 0.000 description 2
• 101710151178 Inositol polyphosphate-5-phosphatase A Proteins 0.000 description 2
• 102100039343 Intraflagellar transport protein 27 homolog Human genes 0.000 description 2
• 101710119233 Intraflagellar transport protein 27 homolog Proteins 0.000 description 2
• 108091092195 Intron Proteins 0.000 description 2
• IPMYMEWFZKHGAX-UHFFFAOYSA-N Isotheaflavin Natural products OC1CC2=C(O)C=C(O)C=C2OC1C(C1=C2)=CC(O)=C(O)C1=C(O)C(=O)C=C2C1C(O)CC2=C(O)C=C(O)C=C2O1 IPMYMEWFZKHGAX-UHFFFAOYSA-N 0.000 description 2
• FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 2
• JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 description 2
• IFTRFNLCKUZSNG-ZZAFTVETSA-N Lycoxanthin Natural products OC/C(=C\CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(\C)/C)\C)/C)\C)/C)\C)/C)/C IFTRFNLCKUZSNG-ZZAFTVETSA-N 0.000 description 2
• 102100025532 Male-enhanced antigen 1 Human genes 0.000 description 2
• 241000124008 Mammalia Species 0.000 description 2
• 102100024299 Maternal embryonic leucine zipper kinase Human genes 0.000 description 2
• 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 description 2
• 108010016113 Matrix Metalloproteinase 1 Proteins 0.000 description 2
• MJVAVZPDRWSRRC-UHFFFAOYSA-N Menadione Chemical compound C1=CC=C2C(=O)C(C)=CC(=O)C2=C1 MJVAVZPDRWSRRC-UHFFFAOYSA-N 0.000 description 2
• 102100030508 Methyltransferase-like protein 17, mitochondrial Human genes 0.000 description 2
• 102000006404 Mitochondrial Proteins Human genes 0.000 description 2
• 108010058682 Mitochondrial Proteins Proteins 0.000 description 2
• 102100024193 Mitogen-activated protein kinase 1 Human genes 0.000 description 2
• 101710084102 Mitogen-activated protein kinase kinase kinase 14 Proteins 0.000 description 2
• 241000772415 Neovison vison Species 0.000 description 2
• DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
• 240000007594 Oryza sativa Species 0.000 description 2
• 235000007164 Oryza sativa Nutrition 0.000 description 2
• 208000008558 Osteophyte Diseases 0.000 description 2
• 102000035195 Peptidases Human genes 0.000 description 2
• 108091005804 Peptidases Proteins 0.000 description 2
• 108010068204 Peptide Elongation Factors Proteins 0.000 description 2
• 102000002508 Peptide Elongation Factors Human genes 0.000 description 2
• 102100026918 Phospholipase A2 Human genes 0.000 description 2
• 101710096328 Phospholipase A2 Proteins 0.000 description 2
• 102000010995 Pleckstrin homology domains Human genes 0.000 description 2
• 108050001185 Pleckstrin homology domains Proteins 0.000 description 2
• WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
• 102100037169 Probable JmjC domain-containing histone demethylation protein 2C Human genes 0.000 description 2
• 102000002727 Protein Tyrosine Phosphatase Human genes 0.000 description 2
• ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 2
• 101000720130 Rattus norvegicus Acyl-coenzyme A synthetase ACSM3, mitochondrial Proteins 0.000 description 2
• QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 description 2
• HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 2
• MEFKEPWMEQBLKI-AIRLBKTGSA-N S-adenosyl-L-methioninate Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H](N)C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-N 0.000 description 2
• 102000037054 SLC-Transporter Human genes 0.000 description 2
• 108091006207 SLC-Transporter Proteins 0.000 description 2
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 2
• 101710168082 Sodium-dependent neutral amino acid transporter B(0)AT3 Proteins 0.000 description 2
• 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 description 2
• UXRMWRBWCAGDQB-UHFFFAOYSA-N Theaflavin Natural products C1=CC(C2C(CC3=C(O)C=C(O)C=C3O2)O)=C(O)C(=O)C2=C1C(C1OC3=CC(O)=CC(O)=C3CC1O)=CC(O)=C2O UXRMWRBWCAGDQB-UHFFFAOYSA-N 0.000 description 2
• 239000004473 Threonine Substances 0.000 description 2
• 102100024333 Toll-like receptor 2 Human genes 0.000 description 2
• LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 description 2
• 102000040945 Transcription factor Human genes 0.000 description 2
• 108091023040 Transcription factor Proteins 0.000 description 2
• 102000004357 Transferases Human genes 0.000 description 2
• 108090000992 Transferases Proteins 0.000 description 2
• 108010092464 Urate Oxidase Proteins 0.000 description 2
• 229930003448 Vitamin K Natural products 0.000 description 2
• XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
• JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 2
• 238000002835 absorbance Methods 0.000 description 2
• 150000007513 acids Chemical class 0.000 description 2
• 239000012190 activator Substances 0.000 description 2
• 229960001570 ademetionine Drugs 0.000 description 2
• DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 2
• 230000004075 alteration Effects 0.000 description 2
• 239000000427 antigen Substances 0.000 description 2
• 108091007433 antigens Proteins 0.000 description 2
• 102000036639 antigens Human genes 0.000 description 2
• 239000008346 aqueous phase Substances 0.000 description 2
• YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 2
• 108091008324 binding proteins Proteins 0.000 description 2
• 230000033228 biological regulation Effects 0.000 description 2
• 230000037396 body weight Effects 0.000 description 2
• 150000001746 carotenes Chemical class 0.000 description 2
• 235000005473 carotenes Nutrition 0.000 description 2
• 235000005487 catechin Nutrition 0.000 description 2
• ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 2
• 239000013592 cell lysate Substances 0.000 description 2
• 210000000170 cell membrane Anatomy 0.000 description 2
• 229950001002 cianidanol Drugs 0.000 description 2
• 238000003776 cleavage reaction Methods 0.000 description 2
• FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 description 2
• 235000017471 coenzyme Q10 Nutrition 0.000 description 2
• ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 2
• 150000001875 compounds Chemical class 0.000 description 2
• 238000005520 cutting process Methods 0.000 description 2
• 230000003247 decreasing effect Effects 0.000 description 2
• 239000008367 deionised water Substances 0.000 description 2
• 229910021641 deionized water Inorganic materials 0.000 description 2
• 238000012217 deletion Methods 0.000 description 2
• 230000037430 deletion Effects 0.000 description 2
• 238000002405 diagnostic procedure Methods 0.000 description 2
• 150000002016 disaccharides Chemical group 0.000 description 2
• 238000009826 distribution Methods 0.000 description 2
• 238000010828 elution Methods 0.000 description 2
• 229940088598 enzyme Drugs 0.000 description 2
• 238000011156 evaluation Methods 0.000 description 2
• 238000002474 experimental method Methods 0.000 description 2
• 235000019197 fats Nutrition 0.000 description 2
• 238000009472 formulation Methods 0.000 description 2
• 230000008014 freezing Effects 0.000 description 2
• 238000007710 freezing Methods 0.000 description 2
• 238000011331 genomic analysis Methods 0.000 description 2
• 238000010438 heat treatment Methods 0.000 description 2
• 210000003035 hyaline cartilage Anatomy 0.000 description 2
• 229910052739 hydrogen Inorganic materials 0.000 description 2
• 239000001257 hydrogen Substances 0.000 description 2
• 230000006872 improvement Effects 0.000 description 2
• 238000001727 in vivo Methods 0.000 description 2
• 229910052500 inorganic mineral Inorganic materials 0.000 description 2
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
• 238000002955 isolation Methods 0.000 description 2
• MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 2
• 239000000787 lecithin Substances 0.000 description 2
• 229940067606 lecithin Drugs 0.000 description 2
• 235000010445 lecithin Nutrition 0.000 description 2
• AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical compound OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 description 2
• 238000011068 loading method Methods 0.000 description 2
• 235000012661 lycopene Nutrition 0.000 description 2
• 229960004999 lycopene Drugs 0.000 description 2
• 239000001751 lycopene Substances 0.000 description 2
• OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 description 2
• 235000008699 lycoxanthin Nutrition 0.000 description 2
• IFTRFNLCKUZSNG-UHFFFAOYSA-N lycoxanthin Chemical compound CC(C)=CCCC(C)=CC=CC(C)=CC=CC(C)=CC=CC=C(C)C=CC=C(C)C=CC=C(C)CCC=C(C)CO IFTRFNLCKUZSNG-UHFFFAOYSA-N 0.000 description 2
• 210000004962 mammalian cell Anatomy 0.000 description 2
• 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 2
• 239000000101 novel biomarker Substances 0.000 description 2
• 230000035764 nutrition Effects 0.000 description 2
• 210000003463 organelle Anatomy 0.000 description 2
• 229940055726 pantothenic acid Drugs 0.000 description 2
• 235000019161 pantothenic acid Nutrition 0.000 description 2
• 239000011713 pantothenic acid Substances 0.000 description 2
• 230000037361 pathway Effects 0.000 description 2
• 230000004481 post-translational protein modification Effects 0.000 description 2
• VYXXMAGSIYIYGD-NWAYQTQBSA-N propan-2-yl 2-[[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-(pyrimidine-4-carbonylamino)phosphoryl]amino]-2-methylpropanoate Chemical compound CC(C)OC(=O)C(C)(C)NP(=O)(CO[C@H](C)Cn1cnc2c(N)ncnc12)NC(=O)c1ccncn1 VYXXMAGSIYIYGD-NWAYQTQBSA-N 0.000 description 2
• 238000003498 protein array Methods 0.000 description 2
• 108020000494 protein-tyrosine phosphatase Proteins 0.000 description 2
• 235000008160 pyridoxine Nutrition 0.000 description 2
• 239000011677 pyridoxine Substances 0.000 description 2
• 238000003908 quality control method Methods 0.000 description 2
• 235000005875 quercetin Nutrition 0.000 description 2
• 229960001285 quercetin Drugs 0.000 description 2
• NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 description 2
• 235000021283 resveratrol Nutrition 0.000 description 2
• 229940016667 resveratrol Drugs 0.000 description 2
• 230000000717 retained effect Effects 0.000 description 2
• 238000003757 reverse transcription PCR Methods 0.000 description 2
• 230000002441 reversible effect Effects 0.000 description 2
• 102000004291 ribosomal protein L6 Human genes 0.000 description 2
• 108090000892 ribosomal protein L6 Proteins 0.000 description 2
• 230000007017 scission Effects 0.000 description 2
• 238000003196 serial analysis of gene expression Methods 0.000 description 2
• 230000011664 signaling Effects 0.000 description 2
• 239000011780 sodium chloride Substances 0.000 description 2
• 235000002639 sodium chloride Nutrition 0.000 description 2
• 239000001488 sodium phosphate Substances 0.000 description 2
• 229910000162 sodium phosphate Inorganic materials 0.000 description 2
• 239000002904 solvent Substances 0.000 description 2
• 241000894007 species Species 0.000 description 2
• 238000011895 specific detection Methods 0.000 description 2
• 238000003860 storage Methods 0.000 description 2
• 210000005065 subchondral bone plate Anatomy 0.000 description 2
• 150000008163 sugars Chemical class 0.000 description 2
• 230000002194 synthesizing effect Effects 0.000 description 2
• 229960003080 taurine Drugs 0.000 description 2
• 235000014620 theaflavin Nutrition 0.000 description 2
• 229940026509 theaflavin Drugs 0.000 description 2
• IPMYMEWFZKHGAX-ZKSIBHASSA-N theaflavin Chemical compound C1=C2C([C@H]3OC4=CC(O)=CC(O)=C4C[C@H]3O)=CC(O)=C(O)C2=C(O)C(=O)C=C1[C@@H]1[C@H](O)CC2=C(O)C=C(O)C=C2O1 IPMYMEWFZKHGAX-ZKSIBHASSA-N 0.000 description 2
• 238000002560 therapeutic procedure Methods 0.000 description 2
• 229960002898 threonine Drugs 0.000 description 2
• ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 2
• 230000005029 transcription elongation Effects 0.000 description 2
• RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
• 229940035936 ubiquinone Drugs 0.000 description 2
• 229940005267 urate oxidase Drugs 0.000 description 2
• NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 2
• QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 2
• 235000019168 vitamin K Nutrition 0.000 description 2
• 239000011712 vitamin K Substances 0.000 description 2
• 150000003721 vitamin K derivatives Chemical class 0.000 description 2
• 229940011671 vitamin b6 Drugs 0.000 description 2
• 229940046010 vitamin k Drugs 0.000 description 2
• 238000003260 vortexing Methods 0.000 description 2
• 238000001262 western blot Methods 0.000 description 2
• MJYQFWSXKFLTAY-OVEQLNGDSA-N (2r,3r)-2,3-bis[(4-hydroxy-3-methoxyphenyl)methyl]butane-1,4-diol;(2r,3r,4s,5s,6r)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O.C1=C(O)C(OC)=CC(C[C@@H](CO)[C@H](CO)CC=2C=C(OC)C(O)=CC=2)=C1 MJYQFWSXKFLTAY-OVEQLNGDSA-N 0.000 description 1
• VSWSDTLXDWESGZ-AWEZNQCLSA-N (2s)-3-[4-(4-hydroxyphenoxy)phenyl]-2-(iodoamino)propanoic acid Chemical compound C1=CC(C[C@@H](C(=O)O)NI)=CC=C1OC1=CC=C(O)C=C1 VSWSDTLXDWESGZ-AWEZNQCLSA-N 0.000 description 1
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
• 102000001556 1-Phosphatidylinositol 4-Kinase Human genes 0.000 description 1
• 108010029190 1-Phosphatidylinositol 4-Kinase Proteins 0.000 description 1
• PZNPLUBHRSSFHT-RRHRGVEJSA-N 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCC PZNPLUBHRSSFHT-RRHRGVEJSA-N 0.000 description 1
• 101150000874 11 gene Proteins 0.000 description 1
• 239000001763 2-hydroxyethyl(trimethyl)azanium Substances 0.000 description 1
• 102100022681 40S ribosomal protein S27 Human genes 0.000 description 1
• 102100023990 60S ribosomal protein L17 Human genes 0.000 description 1
• 101710187806 60S ribosomal protein L17 Proteins 0.000 description 1
• 102100023247 60S ribosomal protein L23a Human genes 0.000 description 1
• 101710154747 60S ribosomal protein L23a Proteins 0.000 description 1
• 102100035322 60S ribosomal protein L24 Human genes 0.000 description 1
• 241000251468 Actinopterygii Species 0.000 description 1
• 108010085238 Actins Proteins 0.000 description 1
• 102000007469 Actins Human genes 0.000 description 1
• 102000005369 Aldehyde Dehydrogenase Human genes 0.000 description 1
• 108020002663 Aldehyde Dehydrogenase Proteins 0.000 description 1
• 108700028369 Alleles Proteins 0.000 description 1
• 101710106740 Alpha-N-acetylglucosaminidase Proteins 0.000 description 1
• 102100039375 Ankyrin repeat domain-containing protein 2 Human genes 0.000 description 1
• 102000004145 Annexin A1 Human genes 0.000 description 1
• 108090000663 Annexin A1 Proteins 0.000 description 1
• 101710187011 Arachidonate 5-lipoxygenase-activating protein Proteins 0.000 description 1
• 239000004475 Arginine Substances 0.000 description 1
• 208000006820 Arthralgia Diseases 0.000 description 1
• 241000316927 Aspergillus nidulans FGSC A4 Species 0.000 description 1
• 108010043914 Ataxin-10 Proteins 0.000 description 1
• 241000972773 Aulopiformes Species 0.000 description 1
• 102100020689 Autophagy-related protein 13 Human genes 0.000 description 1
• 241000894006 Bacteria Species 0.000 description 1
• 108010001572 Basic-Leucine Zipper Transcription Factors Proteins 0.000 description 1
• 102000000806 Basic-Leucine Zipper Transcription Factors Human genes 0.000 description 1
• 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
• 238000009010 Bradford assay Methods 0.000 description 1
• 102100028228 COUP transcription factor 1 Human genes 0.000 description 1
• 108010042955 Calcineurin Proteins 0.000 description 1
• 102000004631 Calcineurin Human genes 0.000 description 1
• 239000004215 Carbon black (E152) Substances 0.000 description 1
• 108091005462 Cation channels Proteins 0.000 description 1
• 108091006146 Channels Proteins 0.000 description 1
• 235000019743 Choline chloride Nutrition 0.000 description 1
• 102100038449 Claudin-6 Human genes 0.000 description 1
• 108090000229 Claudin-6 Proteins 0.000 description 1
• 102000005221 Cleavage Stimulation Factor Human genes 0.000 description 1
• 108010081236 Cleavage Stimulation Factor Proteins 0.000 description 1
• 108091026890 Coding region Proteins 0.000 description 1
• 102100031144 Coilin Human genes 0.000 description 1
• 102000012422 Collagen Type I Human genes 0.000 description 1
• 108010022452 Collagen Type I Proteins 0.000 description 1
• 102000000503 Collagen Type II Human genes 0.000 description 1
• 108010041390 Collagen Type II Proteins 0.000 description 1
• 102100029136 Collagen alpha-1(II) chain Human genes 0.000 description 1
• 102100031611 Collagen alpha-1(III) chain Human genes 0.000 description 1
• 102100022145 Collagen alpha-1(IV) chain Human genes 0.000 description 1
• 102100029384 Copine-8 Human genes 0.000 description 1
• 101710125091 Copine-8 Proteins 0.000 description 1
• 108091007045 Cullin Ring E3 Ligases Proteins 0.000 description 1
• 102000036364 Cullin Ring E3 Ligases Human genes 0.000 description 1
• 102000016736 Cyclin Human genes 0.000 description 1
• 108050006400 Cyclin Proteins 0.000 description 1
• 102000001493 Cyclophilins Human genes 0.000 description 1
• 108010068682 Cyclophilins Proteins 0.000 description 1
• 102000015833 Cystatin Human genes 0.000 description 1
• 102100031649 Cytochrome c oxidase subunit 6B1 Human genes 0.000 description 1
• 102100037147 Cytoplasmic dynein 2 heavy chain 1 Human genes 0.000 description 1
• 102100039315 Cytoplasmic polyadenylation element-binding protein 4 Human genes 0.000 description 1
• 101710143199 Cytoplasmic polyadenylation element-binding protein 4 Proteins 0.000 description 1
• 101150097493 D gene Proteins 0.000 description 1
• 239000004470 DL Methionine Substances 0.000 description 1
• 102000052510 DNA-Binding Proteins Human genes 0.000 description 1
• 108700020911 DNA-Binding Proteins Proteins 0.000 description 1
• 241000798860 Debaryomyces hansenii CBS767 Species 0.000 description 1
• 102100030220 Diacylglycerol kinase zeta Human genes 0.000 description 1
• 101710192015 Diacylglycerol kinase zeta Proteins 0.000 description 1
• 206010061818 Disease progression Diseases 0.000 description 1
• 102100031245 Disks large-associated protein 2 Human genes 0.000 description 1
• 108050003184 Disks large-associated protein 2 Proteins 0.000 description 1
• 241000255581 Drosophila <fruit fly, genus> Species 0.000 description 1
• 241000255601 Drosophila melanogaster Species 0.000 description 1
• 102100025699 Dual specificity protein phosphatase CDC14B Human genes 0.000 description 1
• 102100023228 Dynein axonemal intermediate chain 4 Human genes 0.000 description 1
• 238000002965 ELISA Methods 0.000 description 1
• 238000012286 ELISA Assay Methods 0.000 description 1
• 102100031856 ERBB receptor feedback inhibitor 1 Human genes 0.000 description 1
• 101710156695 ERBB receptor feedback inhibitor 1 Proteins 0.000 description 1
• 102000008013 Electron Transport Complex I Human genes 0.000 description 1
• 108010089760 Electron Transport Complex I Proteins 0.000 description 1
• 108010067770 Endopeptidase K Proteins 0.000 description 1
• 102100023882 Endoribonuclease ZC3H12A Human genes 0.000 description 1
• 108010086672 Endosomal Sorting Complexes Required for Transport Proteins 0.000 description 1
• 102000006770 Endosomal Sorting Complexes Required for Transport Human genes 0.000 description 1
• 241000206602 Eukaryota Species 0.000 description 1
• 108700024394 Exon Proteins 0.000 description 1
• 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
• 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
• 108010066805 F-Box Proteins Proteins 0.000 description 1
• 102000018700 F-Box Proteins Human genes 0.000 description 1
• 102100028408 FERM and PDZ domain-containing protein 1 Human genes 0.000 description 1
• 108010054218 Factor VIII Proteins 0.000 description 1
• 102000001690 Factor VIII Human genes 0.000 description 1
• 108010071289 Factor XIII Proteins 0.000 description 1
• 108010049003 Fibrinogen Proteins 0.000 description 1
• 102000008946 Fibrinogen Human genes 0.000 description 1
• 102100028073 Fibroblast growth factor 5 Human genes 0.000 description 1
• 229920001917 Ficoll Polymers 0.000 description 1
• 101710086299 Fructose-2,6-bisphosphatase Proteins 0.000 description 1
• 108091006027 G proteins Proteins 0.000 description 1
• 102100022688 GATOR complex protein DEPDC5 Human genes 0.000 description 1
• 101710128580 GATOR complex protein DEPDC5 Proteins 0.000 description 1
• 102000013446 GTP Phosphohydrolases Human genes 0.000 description 1
• 102000030782 GTP binding Human genes 0.000 description 1
• 108091000058 GTP-Binding Proteins 0.000 description 1
• 108091006109 GTPases Proteins 0.000 description 1
• 101710177291 Gag polyprotein Proteins 0.000 description 1
• IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
• 208000018522 Gastrointestinal disease Diseases 0.000 description 1
• 101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 description 1
• 102100039847 Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 Human genes 0.000 description 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
• 101710171268 Glutaredoxin-3 Proteins 0.000 description 1
• 108010063907 Glutathione Reductase Proteins 0.000 description 1
• 102000006587 Glutathione peroxidase Human genes 0.000 description 1
• 108700016172 Glutathione peroxidases Proteins 0.000 description 1
• 102100036442 Glutathione reductase, mitochondrial Human genes 0.000 description 1
• 102100034294 Glutathione synthetase Human genes 0.000 description 1
• 244000068988 Glycine max Species 0.000 description 1
• 235000010469 Glycine max Nutrition 0.000 description 1
• 108060003393 Granulin Proteins 0.000 description 1
• 208000031886 HIV Infections Diseases 0.000 description 1
• 241000243974 Haemonchus contortus Species 0.000 description 1
• 102300044370 Hemojuvelin isoform a Human genes 0.000 description 1
• 108010020382 Hepatocyte Nuclear Factor 1-alpha Proteins 0.000 description 1
• 102100022057 Hepatocyte nuclear factor 1-alpha Human genes 0.000 description 1
• 201000005379 Hermansky-Pudlak syndrome 1 Diseases 0.000 description 1
• 102100028902 Hermansky-Pudlak syndrome 1 protein Human genes 0.000 description 1
• 102000009331 Homeodomain Proteins Human genes 0.000 description 1
• 108010048671 Homeodomain Proteins Proteins 0.000 description 1
• 101000678466 Homo sapiens 40S ribosomal protein S27 Proteins 0.000 description 1
• 101100379085 Homo sapiens ANKRD2 gene Proteins 0.000 description 1
• 101000961307 Homo sapiens Ankyrin repeat domain-containing protein 2 Proteins 0.000 description 1
• 101000785138 Homo sapiens Autophagy-related protein 13 Proteins 0.000 description 1
• 101000916406 Homo sapiens Calsyntenin-2 Proteins 0.000 description 1
• 101000771163 Homo sapiens Collagen alpha-1(II) chain Proteins 0.000 description 1
• 101000993285 Homo sapiens Collagen alpha-1(III) chain Proteins 0.000 description 1
• 101000901150 Homo sapiens Collagen alpha-1(IV) chain Proteins 0.000 description 1
• 101000884345 Homo sapiens Cyclin-dependent kinase 12 Proteins 0.000 description 1
• 101000922367 Homo sapiens Cytochrome c oxidase subunit 6B1 Proteins 0.000 description 1
• 101000881344 Homo sapiens Cytoplasmic dynein 2 heavy chain 1 Proteins 0.000 description 1
• 101000932600 Homo sapiens Dual specificity protein phosphatase CDC14A Proteins 0.000 description 1
• 101000932592 Homo sapiens Dual specificity protein phosphatase CDC14B Proteins 0.000 description 1
• 101000907302 Homo sapiens Dynein axonemal intermediate chain 4 Proteins 0.000 description 1
• 101000976212 Homo sapiens Endoribonuclease ZC3H12A Proteins 0.000 description 1
• 101001060980 Homo sapiens FERM and PDZ domain-containing protein 1 Proteins 0.000 description 1
• 101001060267 Homo sapiens Fibroblast growth factor 5 Proteins 0.000 description 1
• 101000823442 Homo sapiens Fructose-2,6-bisphosphatase Proteins 0.000 description 1
• 101100014647 Homo sapiens GIMAP4 gene Proteins 0.000 description 1
• 101000887519 Homo sapiens Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 Proteins 0.000 description 1
• 101001069973 Homo sapiens Glutathione synthetase Proteins 0.000 description 1
• 101100507419 Homo sapiens HPSE2 gene Proteins 0.000 description 1
• 101000838926 Homo sapiens Hermansky-Pudlak syndrome 1 protein Proteins 0.000 description 1
• 101000986379 Homo sapiens High mobility group protein HMGI-C Proteins 0.000 description 1
• 101000839066 Homo sapiens Hypoxia-inducible lipid droplet-associated protein Proteins 0.000 description 1
• 101001047811 Homo sapiens Inactive heparanase-2 Proteins 0.000 description 1
• 101001002695 Homo sapiens Integrin-linked protein kinase Proteins 0.000 description 1
• 101001055222 Homo sapiens Interleukin-8 Proteins 0.000 description 1
• 101001050321 Homo sapiens Junctional adhesion molecule C Proteins 0.000 description 1
• 101001006895 Homo sapiens Krueppel-like factor 11 Proteins 0.000 description 1
• 101001004313 Homo sapiens LHFPL tetraspan subfamily member 2 protein Proteins 0.000 description 1
• 101000619105 Homo sapiens Leucine-rich repeat-containing protein 45 Proteins 0.000 description 1
• 101000980026 Homo sapiens Maternal embryonic leucine zipper kinase Proteins 0.000 description 1
• 101000581533 Homo sapiens Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial Proteins 0.000 description 1
• 101001005550 Homo sapiens Mitogen-activated protein kinase kinase kinase 14 Proteins 0.000 description 1
• 101000995157 Homo sapiens Netrin-3 Proteins 0.000 description 1
• 101001024120 Homo sapiens Nipped-B-like protein Proteins 0.000 description 1
• 101000578287 Homo sapiens Non-POU domain-containing octamer-binding protein Proteins 0.000 description 1
• 101001121964 Homo sapiens OCIA domain-containing protein 1 Proteins 0.000 description 1
• 101000613798 Homo sapiens OTU domain-containing protein 7B Proteins 0.000 description 1
• 101000598905 Homo sapiens Olfactory receptor 6C6 Proteins 0.000 description 1
• 101100189478 Homo sapiens PBX3 gene Proteins 0.000 description 1
• 101000922137 Homo sapiens Peripheral plasma membrane protein CASK Proteins 0.000 description 1
• 101000906619 Homo sapiens Polyribonucleotide 5'-hydroxyl-kinase Clp1 Proteins 0.000 description 1
• 101001003584 Homo sapiens Prelamin-A/C Proteins 0.000 description 1
• 101001116222 Homo sapiens Proenkephalin-B Proteins 0.000 description 1
• 101000654452 Homo sapiens Protein transport protein Sec16B Proteins 0.000 description 1
• 101000580370 Homo sapiens RAD52 motif-containing protein 1 Proteins 0.000 description 1
• 101000687317 Homo sapiens RNA-binding motif protein, X chromosome Proteins 0.000 description 1
• 101000580720 Homo sapiens RNA-binding protein 25 Proteins 0.000 description 1
• 101000665509 Homo sapiens Ral GTPase-activating protein subunit alpha-1 Proteins 0.000 description 1
• 101000620593 Homo sapiens Ras-related protein Rab-37 Proteins 0.000 description 1
• 101001077409 Homo sapiens Ras-related protein Rab-5B Proteins 0.000 description 1
• 101000756808 Homo sapiens Repulsive guidance molecule A Proteins 0.000 description 1
• 101000742854 Homo sapiens Roquin-1 Proteins 0.000 description 1
• 101001093919 Homo sapiens SEC14-like protein 2 Proteins 0.000 description 1
• 101000598315 Homo sapiens Serine protease inhibitor Kazal-type 14 Proteins 0.000 description 1
• 101001059454 Homo sapiens Serine/threonine-protein kinase MARK2 Proteins 0.000 description 1
• 101000654500 Homo sapiens Signal-induced proliferation-associated 1-like protein 2 Proteins 0.000 description 1
• 101000642345 Homo sapiens Sperm-associated antigen 16 protein Proteins 0.000 description 1
• 101000631826 Homo sapiens Stearoyl-CoA desaturase Proteins 0.000 description 1
• 101100369049 Homo sapiens TECPR2 gene Proteins 0.000 description 1
• 101001098095 Homo sapiens Transcriptional repressor p66-alpha Proteins 0.000 description 1
• 101000637950 Homo sapiens Transmembrane protein 127 Proteins 0.000 description 1
• 101000962366 Homo sapiens Type II inositol 1,4,5-trisphosphate 5-phosphatase Proteins 0.000 description 1
• 101000671811 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 37 Proteins 0.000 description 1
• 101000662296 Homo sapiens Ubiquitin-like protein 4A Proteins 0.000 description 1
• 101001046934 Homo sapiens Uncharacterized protein KIAA2013 Proteins 0.000 description 1
• 101000771982 Homo sapiens Vacuolar protein sorting-associated protein 45 Proteins 0.000 description 1
• 241000713340 Human immunodeficiency virus 2 Species 0.000 description 1
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
• 102100028891 Hypoxia-inducible lipid droplet-associated protein Human genes 0.000 description 1
• 108060003951 Immunoglobulin Proteins 0.000 description 1
• 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
• 102100037978 InaD-like protein Human genes 0.000 description 1
• 101710088275 InaD-like protein Proteins 0.000 description 1
• 102100024022 Inactive heparanase-2 Human genes 0.000 description 1
• 102100039253 Inositol polyphosphate-5-phosphatase A Human genes 0.000 description 1
• 102100023915 Insulin Human genes 0.000 description 1
• 108090001061 Insulin Proteins 0.000 description 1
• 102100020944 Integrin-linked protein kinase Human genes 0.000 description 1
• 102000004344 Interferon regulatory factor 2 Human genes 0.000 description 1
• 108090000908 Interferon regulatory factor 2 Proteins 0.000 description 1
• 102000003812 Interleukin-15 Human genes 0.000 description 1
• 108090000172 Interleukin-15 Proteins 0.000 description 1
• 102000011845 Iodide peroxidase Human genes 0.000 description 1
• 108010036012 Iodide peroxidase Proteins 0.000 description 1
• 240000007218 Ipomoea hederacea Species 0.000 description 1
• 108010044467 Isoenzymes Proteins 0.000 description 1
• 102000004195 Isomerases Human genes 0.000 description 1
• 108090000769 Isomerases Proteins 0.000 description 1
• 206010023230 Joint stiffness Diseases 0.000 description 1
• 102100023429 Junctional adhesion molecule C Human genes 0.000 description 1
• ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
• HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
• KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
• 102100025687 LHFPL tetraspan subfamily member 2 protein Human genes 0.000 description 1
• 102000004856 Lectins Human genes 0.000 description 1
• 108090001090 Lectins Proteins 0.000 description 1
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
• 102100022562 Leucine-rich repeat-containing protein 45 Human genes 0.000 description 1
• 241001480167 Lotus japonicus Species 0.000 description 1
• 238000003231 Lowry assay Methods 0.000 description 1
• 238000009013 Lowry's assay Methods 0.000 description 1
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
• 239000004472 Lysine Substances 0.000 description 1
• 102100040405 Lysophosphatidic acid receptor 4 Human genes 0.000 description 1
• 101710149746 Lysophosphatidic acid receptor 4 Proteins 0.000 description 1
• 108010029223 MAP kinase kinase kinase 7 Proteins 0.000 description 1
• 101150083522 MECP2 gene Proteins 0.000 description 1
• 108700018351 Major Histocompatibility Complex Proteins 0.000 description 1
• 101710125418 Major capsid protein Proteins 0.000 description 1
• 101710154611 Maternal embryonic leucine zipper kinase Proteins 0.000 description 1
• 102000055008 Matrilin Proteins Human genes 0.000 description 1
• 108010072582 Matrilin Proteins Proteins 0.000 description 1
• ABSPRNADVQNDOU-UHFFFAOYSA-N Menaquinone 1 Natural products C1=CC=C2C(=O)C(CC=C(C)C)=C(C)C(=O)C2=C1 ABSPRNADVQNDOU-UHFFFAOYSA-N 0.000 description 1
• 102000016193 Metabotropic glutamate receptors Human genes 0.000 description 1
• 108010010914 Metabotropic glutamate receptors Proteins 0.000 description 1
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 1
• 102100039124 Methyl-CpG-binding protein 2 Human genes 0.000 description 1
• 102100027320 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial Human genes 0.000 description 1
• 108091092878 Microsatellite Proteins 0.000 description 1
• 108091022875 Microtubule Proteins 0.000 description 1
• 102000029749 Microtubule Human genes 0.000 description 1
• 102300054427 Microtubule-associated protein 2 isoform 2 Human genes 0.000 description 1
• 108020005196 Mitochondrial DNA Proteins 0.000 description 1
• 108090000744 Mitogen-Activated Protein Kinase Kinases Proteins 0.000 description 1
• 102000004232 Mitogen-Activated Protein Kinase Kinases Human genes 0.000 description 1
• 102100026888 Mitogen-activated protein kinase kinase kinase 7 Human genes 0.000 description 1
• 101150097381 Mtor gene Proteins 0.000 description 1
• 241001529936 Murinae Species 0.000 description 1
• 101000889455 Mus musculus Ankyrin repeat domain-containing protein 49 Proteins 0.000 description 1
• 101000978728 Mus musculus Nephrin Proteins 0.000 description 1
• 101100366086 Mus musculus Snf8 gene Proteins 0.000 description 1
• 101000667352 Mus musculus von Willebrand factor A domain-containing protein 1 Proteins 0.000 description 1
• 102100036639 Myosin-11 Human genes 0.000 description 1
• 101710115164 Myosin-11 Proteins 0.000 description 1
• 102000006746 NADH Dehydrogenase Human genes 0.000 description 1
• 108010086428 NADH Dehydrogenase Proteins 0.000 description 1
• 108700019961 Neoplasm Genes Proteins 0.000 description 1
• 102000048850 Neoplasm Genes Human genes 0.000 description 1
• 102100034393 Netrin-3 Human genes 0.000 description 1
• 102100031801 Nexilin Human genes 0.000 description 1
• 101710168877 Nexilin Proteins 0.000 description 1
• 241000207746 Nicotiana benthamiana Species 0.000 description 1
• 102100035377 Nipped-B-like protein Human genes 0.000 description 1
• 102100028102 Non-POU domain-containing octamer-binding protein Human genes 0.000 description 1
• 238000000636 Northern blotting Methods 0.000 description 1
• 102100022165 Nuclear factor 1 B-type Human genes 0.000 description 1
• 101710170464 Nuclear factor 1 B-type Proteins 0.000 description 1
• 102000007399 Nuclear hormone receptor Human genes 0.000 description 1
• 108020005497 Nuclear hormone receptor Proteins 0.000 description 1
• 102100027183 OCIA domain-containing protein 1 Human genes 0.000 description 1
• 102100040562 OTU domain-containing protein 7B Human genes 0.000 description 1
• 208000008589 Obesity Diseases 0.000 description 1
• 102100037749 Olfactory receptor 6C6 Human genes 0.000 description 1
• 108020005187 Oligonucleotide Probes Proteins 0.000 description 1
• 108700020796 Oncogene Proteins 0.000 description 1
• 206010033128 Ovarian cancer Diseases 0.000 description 1
• 206010061535 Ovarian neoplasm Diseases 0.000 description 1
• 102000004316 Oxidoreductases Human genes 0.000 description 1
• 108090000854 Oxidoreductases Proteins 0.000 description 1
• 101150078967 PAPPA gene Proteins 0.000 description 1
• 101150025786 PCLO gene Proteins 0.000 description 1
• 102000005327 Palmitoyl protein thioesterase Human genes 0.000 description 1
• 108020002591 Palmitoyl protein thioesterase Proteins 0.000 description 1
• 108030001694 Pappalysin-1 Proteins 0.000 description 1
• 241000286209 Phasianidae Species 0.000 description 1
• 108010092528 Phosphate Transport Proteins Proteins 0.000 description 1
• 102000016462 Phosphate Transport Proteins Human genes 0.000 description 1
• 101710188589 Phosphatidylinositol 4-kinase beta Proteins 0.000 description 1
• 102000011755 Phosphoglycerate Kinase Human genes 0.000 description 1
• 101150054668 Piwil4 gene Proteins 0.000 description 1
• 241001053217 Plasmodium yoelii yoelii 17XNL Species 0.000 description 1
• 101710159752 Poly(3-hydroxyalkanoate) polymerase subunit PhaE Proteins 0.000 description 1
• 229920000388 Polyphosphate Polymers 0.000 description 1
• 102100023504 Polyribonucleotide 5'-hydroxyl-kinase Clp1 Human genes 0.000 description 1
• 241000282405 Pongo abelii Species 0.000 description 1
• 102000005819 Pregnancy-Associated Plasma Protein-A Human genes 0.000 description 1
• 241000288906 Primates Species 0.000 description 1
• 101710130262 Probable Vpr-like protein Proteins 0.000 description 1
• 206010036790 Productive cough Diseases 0.000 description 1
• 102100024622 Proenkephalin-B Human genes 0.000 description 1
• 239000004365 Protease Substances 0.000 description 1
• 229940124158 Protease/peptidase inhibitor Drugs 0.000 description 1
• 102100031481 Protein transport protein Sec16B Human genes 0.000 description 1
• 102100027352 Pumilio homolog 2 Human genes 0.000 description 1
• 101710087309 Pumilio homolog 2 Proteins 0.000 description 1
• 244000184734 Pyrus japonica Species 0.000 description 1
• 102100027420 RAD52 motif-containing protein 1 Human genes 0.000 description 1
• 102000009572 RNA Polymerase II Human genes 0.000 description 1
• 108010009460 RNA Polymerase II Proteins 0.000 description 1
• 238000010802 RNA extraction kit Methods 0.000 description 1
• 239000013614 RNA sample Substances 0.000 description 1
• 230000004570 RNA-binding Effects 0.000 description 1
• 102100024939 RNA-binding motif protein, X chromosome Human genes 0.000 description 1
• 102100024910 Rabenosyn-5 Human genes 0.000 description 1
• 101710083931 Rabenosyn-5 Proteins 0.000 description 1
• 102100038202 Ral GTPase-activating protein subunit alpha-1 Human genes 0.000 description 1
• 102100025132 Ras-related protein Rab-5B Human genes 0.000 description 1
• 101000975761 Rattus norvegicus Acid ceramidase Proteins 0.000 description 1
• 102000019196 RecQ Helicases Human genes 0.000 description 1
• 108010012737 RecQ Helicases Proteins 0.000 description 1
• 102000016983 Releasing hormones receptors Human genes 0.000 description 1
• 108070000025 Releasing hormones receptors Proteins 0.000 description 1
• 208000006289 Rett Syndrome Diseases 0.000 description 1
• 108010000605 Ribosomal Proteins Proteins 0.000 description 1
• 102000002278 Ribosomal Proteins Human genes 0.000 description 1
• 102100038043 Roquin-1 Human genes 0.000 description 1
• 108091006792 SLC20A2 Proteins 0.000 description 1
• 208000034189 Sclerosis Diseases 0.000 description 1
• 102100030053 Secreted frizzled-related protein 3 Human genes 0.000 description 1
• 102100036967 Serine protease inhibitor Kazal-type 14 Human genes 0.000 description 1
• 102100023230 Serine/threonine-protein kinase MAK Human genes 0.000 description 1
• 101710169366 Serine/threonine-protein kinase MAK Proteins 0.000 description 1
• 102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 description 1
• 101710142052 Serine/threonine-protein kinase mTOR Proteins 0.000 description 1
• 102100031451 Signal-induced proliferation-associated 1-like protein 2 Human genes 0.000 description 1
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
• 108020004682 Single-Stranded DNA Proteins 0.000 description 1
• 102100032419 Sodium-dependent phosphate transporter 2 Human genes 0.000 description 1
• 235000019764 Soybean Meal Nutrition 0.000 description 1
• 102100036373 Sperm-associated antigen 16 protein Human genes 0.000 description 1
• 108010090804 Streptavidin Proteins 0.000 description 1
• 102100037220 Syndecan-4 Human genes 0.000 description 1
• 102100021228 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Human genes 0.000 description 1
• 101710178958 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Proteins 0.000 description 1
• 102100030904 Target of rapamycin complex 2 subunit MAPKAP1 Human genes 0.000 description 1
• 101710084952 Target of rapamycin complex 2 subunit MAPKAP1 Proteins 0.000 description 1
• 102100028651 Tenascin-N Human genes 0.000 description 1
• 101710087911 Tenascin-N Proteins 0.000 description 1
• 108010077678 Tetraspanin 30 Proteins 0.000 description 1
• 102000010428 Tetraspanin 30 Human genes 0.000 description 1
• 101001099217 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) Triosephosphate isomerase Proteins 0.000 description 1
• AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
• 101000861046 Thunnus obesus Cytochrome c oxidase subunit 6B Proteins 0.000 description 1
• 108010046075 Thymosin Proteins 0.000 description 1
• 102000007501 Thymosin Human genes 0.000 description 1
• 108090000340 Transaminases Proteins 0.000 description 1
• 102100028502 Transcription factor EB Human genes 0.000 description 1
• 101710162524 Transcription factor EB Proteins 0.000 description 1
• 102100037558 Transcriptional repressor p66-alpha Human genes 0.000 description 1
• 108090001012 Transforming Growth Factor beta Proteins 0.000 description 1
• 102000004887 Transforming Growth Factor beta Human genes 0.000 description 1
• 102100032072 Transmembrane protein 127 Human genes 0.000 description 1
• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
• 101710156238 Type II inositol 1,4,5-trisphosphate 5-phosphatase Proteins 0.000 description 1
• 102100040111 Ubiquitin carboxyl-terminal hydrolase 37 Human genes 0.000 description 1
• 102000018390 Ubiquitin-Specific Proteases Human genes 0.000 description 1
• 108010066496 Ubiquitin-Specific Proteases Proteins 0.000 description 1
• 102100037842 Ubiquitin-like protein 4A Human genes 0.000 description 1
• 102100022852 Uncharacterized protein KIAA2013 Human genes 0.000 description 1
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
• GXBMIBRIOWHPDT-UHFFFAOYSA-N Vasopressin Natural products N1C(=O)C(CC=2C=C(O)C=CC=2)NC(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CC1=CC=CC=C1 GXBMIBRIOWHPDT-UHFFFAOYSA-N 0.000 description 1
• 108010004977 Vasopressins Proteins 0.000 description 1
• 102000002852 Vasopressins Human genes 0.000 description 1
• 102100031495 Vesicle-trafficking protein SEC22a Human genes 0.000 description 1
• 108091012768 Vesicle-trafficking protein Sec22a Proteins 0.000 description 1
• 102100035071 Vimentin Human genes 0.000 description 1
• 108010065472 Vimentin Proteins 0.000 description 1
• 229930003779 Vitamin B12 Natural products 0.000 description 1
• PFRQBZFETXBLTP-UHFFFAOYSA-N Vitamin K2 Natural products C1=CC=C2C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C(=O)C2=C1 PFRQBZFETXBLTP-UHFFFAOYSA-N 0.000 description 1
• 108010020277 WD repeat containing planar cell polarity effector Proteins 0.000 description 1
• 241000269368 Xenopus laevis Species 0.000 description 1
• 241000798866 Yarrowia lipolytica CLIB122 Species 0.000 description 1
• 240000008042 Zea mays Species 0.000 description 1
• 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
• 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
• 101710185494 Zinc finger protein Proteins 0.000 description 1
• 102100028393 Zinc finger protein 25 Human genes 0.000 description 1
• 101710160528 Zinc finger protein 25 Proteins 0.000 description 1
• 102100029023 Zinc finger protein 329 Human genes 0.000 description 1
• 101710146920 Zinc finger protein 329 Proteins 0.000 description 1
• 102100023597 Zinc finger protein 816 Human genes 0.000 description 1
• 102100034825 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial Human genes 0.000 description 1
• 101710143997 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial Proteins 0.000 description 1
• 230000002378 acidificating effect Effects 0.000 description 1
• 230000004913 activation Effects 0.000 description 1
• 102000035181 adaptor proteins Human genes 0.000 description 1
• 108091005764 adaptor proteins Proteins 0.000 description 1
• 108010003059 aggrecanase Proteins 0.000 description 1
• 239000000556 agonist Substances 0.000 description 1
• IAJILQKETJEXLJ-QTBDOELSSA-N aldehydo-D-glucuronic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-QTBDOELSSA-N 0.000 description 1
• 229940060587 alpha e Drugs 0.000 description 1
• 108010009380 alpha-N-acetyl-D-glucosaminidase Proteins 0.000 description 1
• 235000020661 alpha-linolenic acid Nutrition 0.000 description 1
• 125000003277 amino group Chemical group 0.000 description 1
• 238000000137 annealing Methods 0.000 description 1
• 239000005557 antagonist Substances 0.000 description 1
• 238000013459 approach Methods 0.000 description 1
• 235000021342 arachidonic acid Nutrition 0.000 description 1
• 229940114079 arachidonic acid Drugs 0.000 description 1
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
• 210000001188 articular cartilage Anatomy 0.000 description 1
• 238000003149 assay kit Methods 0.000 description 1
• 230000009286 beneficial effect Effects 0.000 description 1
• 230000008901 benefit Effects 0.000 description 1
• 150000001556 benzimidazoles Chemical class 0.000 description 1
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
• 229940093797 bioflavonoids Drugs 0.000 description 1
• 239000013060 biological fluid Substances 0.000 description 1
• 230000008236 biological pathway Effects 0.000 description 1
• OHJMTUPIZMNBFR-UHFFFAOYSA-N biuret Chemical compound NC(=O)NC(N)=O OHJMTUPIZMNBFR-UHFFFAOYSA-N 0.000 description 1
• 239000010839 body fluid Substances 0.000 description 1
• 229940098773 bovine serum albumin Drugs 0.000 description 1
• 239000006227 byproduct Substances 0.000 description 1
• 238000010804 cDNA synthesis Methods 0.000 description 1
• FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 description 1
• 229910000019 calcium carbonate Inorganic materials 0.000 description 1
• 235000010216 calcium carbonate Nutrition 0.000 description 1
• 229960002079 calcium pantothenate Drugs 0.000 description 1
• 108010086826 calponin Proteins 0.000 description 1
• 102000006783 calponin Human genes 0.000 description 1
• 201000011510 cancer Diseases 0.000 description 1
• 239000002775 capsule Substances 0.000 description 1
• 150000001720 carbohydrates Chemical class 0.000 description 1
• 235000014633 carbohydrates Nutrition 0.000 description 1
• 108010059877 carboxy-terminal domain phosphatase Proteins 0.000 description 1
• 230000022159 cartilage development Effects 0.000 description 1
• 230000034303 cell budding Effects 0.000 description 1
• 239000006143 cell culture medium Substances 0.000 description 1
• 230000032823 cell division Effects 0.000 description 1
• 108091092328 cellular RNA Proteins 0.000 description 1
• 230000019522 cellular metabolic process Effects 0.000 description 1
• 230000005754 cellular signaling Effects 0.000 description 1
• 239000001913 cellulose Substances 0.000 description 1
• WOWHHFRSBJGXCM-UHFFFAOYSA-M cetyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)C WOWHHFRSBJGXCM-UHFFFAOYSA-M 0.000 description 1
• 238000012512 characterization method Methods 0.000 description 1
• 150000005829 chemical entities Chemical class 0.000 description 1
• 229960001231 choline Drugs 0.000 description 1
• OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
• SGMZJAMFUVOLNK-UHFFFAOYSA-M choline chloride Chemical compound [Cl-].C[N+](C)(C)CCO SGMZJAMFUVOLNK-UHFFFAOYSA-M 0.000 description 1
• 229960003178 choline chloride Drugs 0.000 description 1
• 229960004106 citric acid Drugs 0.000 description 1
• 108060001643 clathrin heavy chain Proteins 0.000 description 1
• 102000014907 clathrin heavy chain Human genes 0.000 description 1
• 238000004140 cleaning Methods 0.000 description 1
• 238000010367 cloning Methods 0.000 description 1
• 230000037319 collagen production Effects 0.000 description 1
• 238000012875 competitive assay Methods 0.000 description 1
• 235000021310 complex sugar Nutrition 0.000 description 1
• 238000003271 compound fluorescence assay Methods 0.000 description 1
• 239000012141 concentrate Substances 0.000 description 1
• 235000020940 control diet Nutrition 0.000 description 1
• 229910000365 copper sulfate Inorganic materials 0.000 description 1
• ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
• 235000005822 corn Nutrition 0.000 description 1
• 238000012258 culturing Methods 0.000 description 1
• 238000011461 current therapy Methods 0.000 description 1
• 108050004038 cystatin Proteins 0.000 description 1
• 230000009089 cytolysis Effects 0.000 description 1
• 230000006378 damage Effects 0.000 description 1
• 238000007405 data analysis Methods 0.000 description 1
• 230000007547 defect Effects 0.000 description 1
• 230000005786 degenerative changes Effects 0.000 description 1
• 230000003412 degenerative effect Effects 0.000 description 1
• 238000001212 derivatisation Methods 0.000 description 1
• 229960000633 dextran sulfate Drugs 0.000 description 1
• 238000012631 diagnostic technique Methods 0.000 description 1
• 235000007882 dietary composition Nutrition 0.000 description 1
• 235000013325 dietary fiber Nutrition 0.000 description 1
• 235000021196 dietary intervention Nutrition 0.000 description 1
• 230000004069 differentiation Effects 0.000 description 1
• 230000006806 disease prevention Effects 0.000 description 1
• 230000005750 disease progression Effects 0.000 description 1
• 208000037765 diseases and disorders Diseases 0.000 description 1
• BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 description 1
• 239000002552 dosage form Substances 0.000 description 1
• 230000003828 downregulation Effects 0.000 description 1
• 230000009977 dual effect Effects 0.000 description 1
• 239000012636 effector Substances 0.000 description 1
• 230000002255 enzymatic effect Effects 0.000 description 1
• 230000003628 erosive effect Effects 0.000 description 1
• 235000020774 essential nutrients Nutrition 0.000 description 1
• 210000002744 extracellular matrix Anatomy 0.000 description 1
• 210000001723 extracellular space Anatomy 0.000 description 1
• 238000013213 extrapolation Methods 0.000 description 1
• 230000002349 favourable effect Effects 0.000 description 1
• 239000011790 ferrous sulphate Substances 0.000 description 1
• 235000003891 ferrous sulphate Nutrition 0.000 description 1
• 208000018634 fetal akinesia deformation sequence Diseases 0.000 description 1
• 208000012165 fetal akinesia deformation sequence syndrome Diseases 0.000 description 1
• 239000000835 fiber Substances 0.000 description 1
• 229940012952 fibrinogen Drugs 0.000 description 1
• 102000034240 fibrous proteins Human genes 0.000 description 1
• 108091005899 fibrous proteins Proteins 0.000 description 1
• 235000019688 fish Nutrition 0.000 description 1
• 235000021323 fish oil Nutrition 0.000 description 1
• 229930003935 flavonoid Natural products 0.000 description 1
• 108010015706 flavonoid 3'-hydroxylase Proteins 0.000 description 1
• 235000017173 flavonoids Nutrition 0.000 description 1
• 150000002215 flavonoids Chemical class 0.000 description 1
• 239000000796 flavoring agent Substances 0.000 description 1
• 235000019634 flavors Nutrition 0.000 description 1
• 235000004426 flaxseed Nutrition 0.000 description 1
• 239000012530 fluid Substances 0.000 description 1
• 238000002421 fluorescence-activated droplet sorting Methods 0.000 description 1
• 239000005428 food component Substances 0.000 description 1
• 230000004927 fusion Effects 0.000 description 1
• 238000003500 gene array Methods 0.000 description 1
• 102000034356 gene-regulatory proteins Human genes 0.000 description 1
• 108091006104 gene-regulatory proteins Proteins 0.000 description 1
• 102000054766 genetic haplotypes Human genes 0.000 description 1
• 239000008103 glucose Substances 0.000 description 1
• 235000001727 glucose Nutrition 0.000 description 1
• 230000004153 glucose metabolism Effects 0.000 description 1
• 229940097043 glucuronic acid Drugs 0.000 description 1
• 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 1
• 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 1
• 210000005003 heart tissue Anatomy 0.000 description 1
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
• 230000003284 homeostatic effect Effects 0.000 description 1
• 229940088597 hormone Drugs 0.000 description 1
• 239000005556 hormone Substances 0.000 description 1
• 229930195733 hydrocarbon Natural products 0.000 description 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
• 230000036039 immunity Effects 0.000 description 1
• 102000018358 immunoglobulin Human genes 0.000 description 1
• 238000001114 immunoprecipitation Methods 0.000 description 1
• 230000001976 improved effect Effects 0.000 description 1
• 238000011065 in-situ storage Methods 0.000 description 1
• 230000028709 inflammatory response Effects 0.000 description 1
• 230000000977 initiatory effect Effects 0.000 description 1
• 208000014674 injury Diseases 0.000 description 1
• 229940125396 insulin Drugs 0.000 description 1
• 238000009830 intercalation Methods 0.000 description 1
• 230000002687 intercalation Effects 0.000 description 1
• 102000010681 interleukin-8 receptors Human genes 0.000 description 1
• 230000003834 intracellular effect Effects 0.000 description 1
• 238000011835 investigation Methods 0.000 description 1
• BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 1
• 229910000359 iron(II) sulfate Inorganic materials 0.000 description 1
• AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
• 229960000310 isoleucine Drugs 0.000 description 1
• 230000008407 joint function Effects 0.000 description 1
• 230000000366 juvenile effect Effects 0.000 description 1
• 210000003734 kidney Anatomy 0.000 description 1
• 229940043355 kinase inhibitor Drugs 0.000 description 1
• 210000003127 knee Anatomy 0.000 description 1
• 238000002372 labelling Methods 0.000 description 1
• 239000002523 lectin Substances 0.000 description 1
• 230000000670 limiting effect Effects 0.000 description 1
• 229960004488 linolenic acid Drugs 0.000 description 1
• 230000037356 lipid metabolism Effects 0.000 description 1
• 150000002632 lipids Chemical class 0.000 description 1
• FCCDDURTIIUXBY-UHFFFAOYSA-N lipoamide Chemical compound NC(=O)CCCCC1CCSS1 FCCDDURTIIUXBY-UHFFFAOYSA-N 0.000 description 1
• 210000004185 liver Anatomy 0.000 description 1
• 230000007774 longterm Effects 0.000 description 1
• 101150117702 lpl3 gene Proteins 0.000 description 1
• 230000001050 lubricating effect Effects 0.000 description 1
• 210000003563 lymphoid tissue Anatomy 0.000 description 1
• 239000006166 lysate Substances 0.000 description 1
• 235000018977 lysine Nutrition 0.000 description 1
• 229920002521 macromolecule Polymers 0.000 description 1
• 235000021073 macronutrients Nutrition 0.000 description 1
• 210000002540 macrophage Anatomy 0.000 description 1
• 238000012423 maintenance Methods 0.000 description 1
• PPNAOCWZXJOHFK-UHFFFAOYSA-N manganese(2+);oxygen(2-) Chemical compound [O-2].[Mn+2] PPNAOCWZXJOHFK-UHFFFAOYSA-N 0.000 description 1
• VASIZKWUTCETSD-UHFFFAOYSA-N manganese(II) oxide Inorganic materials [Mn]=O VASIZKWUTCETSD-UHFFFAOYSA-N 0.000 description 1
• 101150010039 mapkap1 gene Proteins 0.000 description 1
• 238000004949 mass spectrometry Methods 0.000 description 1
• 235000012054 meals Nutrition 0.000 description 1
• 238000002483 medication Methods 0.000 description 1
• 201000001441 melanoma Diseases 0.000 description 1
• 101150054634 melk gene Proteins 0.000 description 1
• 102000006240 membrane receptors Human genes 0.000 description 1
• 108020004084 membrane receptors Proteins 0.000 description 1
• DKHGMERMDICWDU-GHDNBGIDSA-N menaquinone-4 Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)=C(C)C(=O)C2=C1 DKHGMERMDICWDU-GHDNBGIDSA-N 0.000 description 1
• 230000002503 metabolic effect Effects 0.000 description 1
• 230000004060 metabolic process Effects 0.000 description 1
• 235000020938 metabolic status Nutrition 0.000 description 1
• FFEARJCKVFRZRR-UHFFFAOYSA-N methionine Chemical compound CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 description 1
• 229960004452 methionine Drugs 0.000 description 1
• 238000010208 microarray analysis Methods 0.000 description 1
• 238000012775 microarray technology Methods 0.000 description 1
• 239000011785 micronutrient Substances 0.000 description 1
• 235000013369 micronutrients Nutrition 0.000 description 1
• 210000004688 microtubule Anatomy 0.000 description 1
• 101150067126 mig-6 gene Proteins 0.000 description 1
• 230000001483 mobilizing effect Effects 0.000 description 1
• 229930003658 monoterpene Natural products 0.000 description 1
• 150000002773 monoterpene derivatives Chemical class 0.000 description 1
• 235000002577 monoterpenes Nutrition 0.000 description 1
• 230000000877 morphologic effect Effects 0.000 description 1
• 230000004899 motility Effects 0.000 description 1
• 230000037023 motor activity Effects 0.000 description 1
• 210000003205 muscle Anatomy 0.000 description 1
• 229930014626 natural product Natural products 0.000 description 1
• 239000013642 negative control Substances 0.000 description 1
• 210000005036 nerve Anatomy 0.000 description 1
• 230000001537 neural effect Effects 0.000 description 1
• 235000005152 nicotinamide Nutrition 0.000 description 1
• 229960003966 nicotinamide Drugs 0.000 description 1
• 239000011570 nicotinamide Substances 0.000 description 1
• FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
• 108020004017 nuclear receptors Proteins 0.000 description 1
• 238000011330 nucleic acid test Methods 0.000 description 1
• 108010060866 nucleoside triphosphate diphosphohydrolase 6 Proteins 0.000 description 1
• 235000003170 nutritional factors Nutrition 0.000 description 1
• 235000003715 nutritional status Nutrition 0.000 description 1
• 235000008935 nutritious Nutrition 0.000 description 1
• 235000020824 obesity Nutrition 0.000 description 1
• 239000003921 oil Substances 0.000 description 1
• 235000019198 oils Nutrition 0.000 description 1
• 239000002751 oligonucleotide probe Substances 0.000 description 1
• 229940033080 omega-6 fatty acid Drugs 0.000 description 1
• 235000020665 omega-6 fatty acid Nutrition 0.000 description 1
• 150000002891 organic anions Chemical class 0.000 description 1
• 230000011164 ossification Effects 0.000 description 1
• 230000003349 osteoarthritic effect Effects 0.000 description 1
• 108010051876 p80-coilin Proteins 0.000 description 1
• 235000019629 palatability Nutrition 0.000 description 1
• 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• 230000008506 pathogenesis Effects 0.000 description 1
• 230000007170 pathology Effects 0.000 description 1
• 239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
• 230000002093 peripheral effect Effects 0.000 description 1
• 239000012071 phase Substances 0.000 description 1
• 235000009048 phenolic acids Nutrition 0.000 description 1
• 150000007965 phenolic acids Chemical class 0.000 description 1
• COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
• 150000003905 phosphatidylinositols Chemical class 0.000 description 1
• 108010019737 phosphoinositide 5-phosphatase Proteins 0.000 description 1
• 239000003757 phosphotransferase inhibitor Substances 0.000 description 1
• 235000019175 phylloquinone Nutrition 0.000 description 1
• 239000011772 phylloquinone Substances 0.000 description 1
• MBWXNTAXLNYFJB-NKFFZRIASA-N phylloquinone Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C)C(=O)C2=C1 MBWXNTAXLNYFJB-NKFFZRIASA-N 0.000 description 1
• 230000004962 physiological condition Effects 0.000 description 1
• 230000035479 physiological effects, processes and functions Effects 0.000 description 1
• 229960001898 phytomenadione Drugs 0.000 description 1
• 102000054765 polymorphisms of proteins Human genes 0.000 description 1
• 239000001205 polyphosphate Substances 0.000 description 1
• 235000011176 polyphosphates Nutrition 0.000 description 1
• 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
• 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
• 235000015277 pork Nutrition 0.000 description 1
• 239000001103 potassium chloride Substances 0.000 description 1
• 235000011164 potassium chloride Nutrition 0.000 description 1
• 229920003124 powdered cellulose Polymers 0.000 description 1
• 235000019814 powdered cellulose Nutrition 0.000 description 1
• 239000002244 precipitate Substances 0.000 description 1
• 108010074732 preproenkephalin Proteins 0.000 description 1
• 230000003518 presynaptic effect Effects 0.000 description 1
• 230000037452 priming Effects 0.000 description 1
• 238000007639 printing Methods 0.000 description 1
• 108010013873 proacrosin Proteins 0.000 description 1
• 230000035755 proliferation Effects 0.000 description 1
• 230000001737 promoting effect Effects 0.000 description 1
• 230000000069 prophylactic effect Effects 0.000 description 1
• 230000004224 protection Effects 0.000 description 1
• 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
• 238000000746 purification Methods 0.000 description 1
• 150000003212 purines Chemical class 0.000 description 1
• ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
• 229960004172 pyridoxine hydrochloride Drugs 0.000 description 1
• 235000019171 pyridoxine hydrochloride Nutrition 0.000 description 1
• 239000011764 pyridoxine hydrochloride Substances 0.000 description 1
• 150000003230 pyrimidines Chemical class 0.000 description 1
• 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
• 238000010791 quenching Methods 0.000 description 1
• 230000000171 quenching effect Effects 0.000 description 1
• 150000004053 quinones Chemical class 0.000 description 1
• 150000003254 radicals Chemical class 0.000 description 1
• 238000003127 radioimmunoassay Methods 0.000 description 1
• 238000003753 real-time PCR Methods 0.000 description 1
• 230000002829 reductive effect Effects 0.000 description 1
• 239000013074 reference sample Substances 0.000 description 1
• 230000014493 regulation of gene expression Effects 0.000 description 1
• 230000008439 repair process Effects 0.000 description 1
• 230000003252 repetitive effect Effects 0.000 description 1
• 108091008146 restriction endonucleases Proteins 0.000 description 1
• 108010025463 ribosomal protein L24 Proteins 0.000 description 1
• 235000009566 rice Nutrition 0.000 description 1
• 235000020748 rosemary extract Nutrition 0.000 description 1
• 229940092258 rosemary extract Drugs 0.000 description 1
• 239000001233 rosmarinus officinalis l. extract Substances 0.000 description 1
• 238000010079 rubber tapping Methods 0.000 description 1
• 235000019515 salmon Nutrition 0.000 description 1
• 238000002416 scanning tunnelling spectroscopy Methods 0.000 description 1
• 230000035945 sensitivity Effects 0.000 description 1
• 238000000926 separation method Methods 0.000 description 1
• 238000012163 sequencing technique Methods 0.000 description 1
• 210000002966 serum Anatomy 0.000 description 1
• 235000021391 short chain fatty acids Nutrition 0.000 description 1
• 150000004666 short chain fatty acids Chemical class 0.000 description 1
• 239000000741 silica gel Substances 0.000 description 1
• 229910002027 silica gel Inorganic materials 0.000 description 1
• 235000021309 simple sugar Nutrition 0.000 description 1
• 229960002930 sirolimus Drugs 0.000 description 1
• 210000002027 skeletal muscle Anatomy 0.000 description 1
• 150000003384 small molecules Chemical class 0.000 description 1
• 210000002460 smooth muscle Anatomy 0.000 description 1
• IFGCUJZIWBUILZ-UHFFFAOYSA-N sodium 2-[[2-[[hydroxy-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid Chemical compound [Na+].C=1NC2=CC=CC=C2C=1CC(C(O)=O)NC(=O)C(CC(C)C)NP(O)(=O)OC1OC(C)C(O)C(O)C1O IFGCUJZIWBUILZ-UHFFFAOYSA-N 0.000 description 1
• FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
• 239000012064 sodium phosphate buffer Substances 0.000 description 1
• 229940048086 sodium pyrophosphate Drugs 0.000 description 1
• 239000011781 sodium selenite Substances 0.000 description 1
• 229960001471 sodium selenite Drugs 0.000 description 1
• 235000015921 sodium selenite Nutrition 0.000 description 1
• 239000004455 soybean meal Substances 0.000 description 1
• 239000008347 soybean phospholipid Substances 0.000 description 1
• 238000007811 spectroscopic assay Methods 0.000 description 1
• 238000004611 spectroscopical analysis Methods 0.000 description 1
• 208000024794 sputum Diseases 0.000 description 1
• 210000003802 sputum Anatomy 0.000 description 1
• 101150037721 ssu72 gene Proteins 0.000 description 1
• 239000008174 sterile solution Substances 0.000 description 1
• 239000011550 stock solution Substances 0.000 description 1
• WPLOVIFNBMNBPD-ATHMIXSHSA-N subtilin Chemical compound CC1SCC(NC2=O)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NC(=C)C(=O)NC(CCCCN)C(O)=O)CSC(C)C2NC(=O)C(CC(C)C)NC(=O)C1NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1NC(=O)C(=C/C)/NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CNC(=O)C3CCCN3C(=O)C(NC(=O)C3NC(=O)C(CC(C)C)NC(=O)C(=C)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)CC=4C5=CC=CC=C5NC=4)CSC3)C(C)SC2)C(C)C)C(C)SC1)CC1=CC=CC=C1 WPLOVIFNBMNBPD-ATHMIXSHSA-N 0.000 description 1
• 230000008093 supporting effect Effects 0.000 description 1
• 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 1
• 210000001258 synovial membrane Anatomy 0.000 description 1
• 229920001059 synthetic polymer Polymers 0.000 description 1
• 208000011317 telomere syndrome Diseases 0.000 description 1
• 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
• 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
• ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 1
• 229940124597 therapeutic agent Drugs 0.000 description 1
• 230000001225 therapeutic effect Effects 0.000 description 1
• UIERGBJEBXXIGO-UHFFFAOYSA-N thiamine mononitrate Chemical compound [O-][N+]([O-])=O.CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N UIERGBJEBXXIGO-UHFFFAOYSA-N 0.000 description 1
• 229960004860 thiamine mononitrate Drugs 0.000 description 1
• 235000019191 thiamine mononitrate Nutrition 0.000 description 1
• 239000011748 thiamine mononitrate Substances 0.000 description 1
• LCJVIYPJPCBWKS-NXPQJCNCSA-N thymosin Chemical compound SC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O LCJVIYPJPCBWKS-NXPQJCNCSA-N 0.000 description 1
• 210000001541 thymus gland Anatomy 0.000 description 1
• 210000001685 thyroid gland Anatomy 0.000 description 1
• 210000003371 toe Anatomy 0.000 description 1
• 230000002103 transcriptional effect Effects 0.000 description 1
• 230000001131 transforming effect Effects 0.000 description 1
• 230000008733 trauma Effects 0.000 description 1
• 229960004799 tryptophan Drugs 0.000 description 1
• 238000000539 two dimensional gel electrophoresis Methods 0.000 description 1
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
• 210000002700 urine Anatomy 0.000 description 1
• 239000004474 valine Substances 0.000 description 1
• 229960003726 vasopressin Drugs 0.000 description 1
• 108700026220 vif Genes Proteins 0.000 description 1
• 210000005048 vimentin Anatomy 0.000 description 1
• 230000000007 visual effect Effects 0.000 description 1
• 235000019156 vitamin B Nutrition 0.000 description 1
• 239000011720 vitamin B Substances 0.000 description 1
• 235000019163 vitamin B12 Nutrition 0.000 description 1
• 239000011715 vitamin B12 Substances 0.000 description 1
• MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
• 235000005282 vitamin D3 Nutrition 0.000 description 1
• 239000011647 vitamin D3 Substances 0.000 description 1
• 235000019143 vitamin K2 Nutrition 0.000 description 1
• 239000011728 vitamin K2 Substances 0.000 description 1
• 235000012711 vitamin K3 Nutrition 0.000 description 1
• 239000011652 vitamin K3 Substances 0.000 description 1
• 229940021056 vitamin d3 Drugs 0.000 description 1
• 150000003722 vitamin derivatives Chemical class 0.000 description 1
• 229940041603 vitamin k 3 Drugs 0.000 description 1
• 238000005406 washing Methods 0.000 description 1
• 235000020985 whole grains Nutrition 0.000 description 1
• 239000012224 working solution Substances 0.000 description 1
• 239000011787 zinc oxide Substances 0.000 description 1
• GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1