AU2009229433B2 - The polymorphs of 4-anilinoquinazoline derivatives, the preparation methods and uses thereof - Google Patents
The polymorphs of 4-anilinoquinazoline derivatives, the preparation methods and uses thereof Download PDFInfo
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- AU2009229433B2 AU2009229433B2 AU2009229433A AU2009229433A AU2009229433B2 AU 2009229433 B2 AU2009229433 B2 AU 2009229433B2 AU 2009229433 A AU2009229433 A AU 2009229433A AU 2009229433 A AU2009229433 A AU 2009229433A AU 2009229433 B2 AU2009229433 B2 AU 2009229433B2
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- Prior art keywords
- phenylamino
- tetrahydrofuran
- chloro
- benzyloxy
- fluoro
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Classifications
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- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2013231084A AU2013231084B2 (en) | 2008-03-25 | 2013-09-19 | The polymorphs of 4-anilinoquinazoline derivatives, the preparation methods and uses thereof |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| CN200810043189A CN101544609A (zh) | 2008-03-25 | 2008-03-25 | 4-苯胺喹唑啉衍生物的结晶形式 |
| CN200810043189.7 | 2008-03-25 | ||
| PCT/CN2009/000317 WO2009117899A1 (zh) | 2008-03-25 | 2009-03-25 | 4-苯胺喹唑啉衍生物多晶型物及其制法和应用 |
Related Child Applications (1)
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| AU2013231084A Division AU2013231084B2 (en) | 2008-03-25 | 2013-09-19 | The polymorphs of 4-anilinoquinazoline derivatives, the preparation methods and uses thereof |
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| AU2009229433A1 AU2009229433A1 (en) | 2009-10-01 |
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| EP (1) | EP2269994B1 (enExample) |
| JP (1) | JP5460689B2 (enExample) |
| KR (1) | KR101579148B1 (enExample) |
| CN (4) | CN101544609A (enExample) |
| AU (1) | AU2009229433B2 (enExample) |
| CA (1) | CA2719523C (enExample) |
| WO (1) | WO2009117899A1 (enExample) |
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| CN101584696A (zh) * | 2008-05-21 | 2009-11-25 | 上海艾力斯医药科技有限公司 | 包含喹唑啉衍生物的组合物及制备方法、用途 |
| CN104558042B (zh) * | 2015-01-30 | 2017-03-29 | 江苏康缘药业股份有限公司 | 含磷取代的喹唑啉衍生物的新晶型及其制备方法和应用 |
| CN104558043B (zh) * | 2015-01-30 | 2017-01-11 | 江苏康缘药业股份有限公司 | 含磷取代的喹唑啉衍生物的新晶型及其制备方法和应用 |
| CN104558041B (zh) * | 2015-01-30 | 2017-01-11 | 江苏康缘药业股份有限公司 | 含磷取代的喹唑啉衍生物的新晶型及其制备方法和应用 |
| CN104610364B (zh) * | 2015-01-30 | 2017-03-29 | 江苏康缘药业股份有限公司 | 含磷取代的喹唑啉衍生物的新晶型及其制备方法和应用 |
| CN104558040B (zh) * | 2015-01-30 | 2017-04-05 | 江苏康缘药业股份有限公司 | 含磷取代的喹唑啉衍生物的晶型及其制备方法和应用 |
| JP2019521175A (ja) * | 2016-07-22 | 2019-07-25 | メッドシャイン ディスカバリー インコーポレイテッド | ニトロイミダゾール系化合物の結晶形、塩形およびその製造方法 |
| KR102602820B1 (ko) * | 2017-01-30 | 2023-11-15 | 시오노기세이야쿠가부시키가이샤 | 퀴나졸린 유도체를 함유하는 고형 제제 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007082434A1 (en) * | 2006-01-20 | 2007-07-26 | Shanghai Allist Pharmaceutical., Inc. | Quinazoline derivatives,preparation methods and uses thereof |
| WO2008098485A1 (en) * | 2007-02-14 | 2008-08-21 | Shanghai Allist Pharmaceuticals, Inc. | The salts of 4-aniline quinazoline derivative |
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|---|---|---|---|---|
| DE69536015D1 (de) | 1995-03-30 | 2009-12-10 | Pfizer Prod Inc | Chinazolinone Derivate |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| ZA986732B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
| AR020114A1 (es) | 1998-07-30 | 2002-04-10 | America Home Products Corp | Proceso para la preparacion de derivados de quinazolina sustituida y compuestos para su exclusivo uso en dicho proceso |
| WO2000031048A1 (en) | 1998-11-19 | 2000-06-02 | Warner-Lambert Company | N-[4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide, an irreversible inhibitor of tyrosine kinases |
| KR100735639B1 (ko) | 2004-12-29 | 2007-07-04 | 한미약품 주식회사 | 암세포 성장 억제 효과를 갖는 퀴나졸린 유도체 및 이의제조방법 |
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2008
- 2008-03-25 CN CN200810043189A patent/CN101544609A/zh active Pending
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2009
- 2009-03-25 CA CA2719523A patent/CA2719523C/en active Active
- 2009-03-25 WO PCT/CN2009/000317 patent/WO2009117899A1/zh not_active Ceased
- 2009-03-25 JP JP2011501089A patent/JP5460689B2/ja active Active
- 2009-03-25 KR KR1020107023879A patent/KR101579148B1/ko active Active
- 2009-03-25 CN CN201310291127.9A patent/CN103382183B/zh active Active
- 2009-03-25 US US12/934,478 patent/US8338438B2/en active Active
- 2009-03-25 AU AU2009229433A patent/AU2009229433B2/en active Active
- 2009-03-25 CN CN201310290989.XA patent/CN103420925B/zh active Active
- 2009-03-25 CN CN200980110404.3A patent/CN102007104B/zh active Active
- 2009-03-25 EP EP09724386.9A patent/EP2269994B1/en active Active
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- 2012-11-19 US US13/680,330 patent/US8937079B2/en active Active
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007082434A1 (en) * | 2006-01-20 | 2007-07-26 | Shanghai Allist Pharmaceutical., Inc. | Quinazoline derivatives,preparation methods and uses thereof |
| WO2008098485A1 (en) * | 2007-02-14 | 2008-08-21 | Shanghai Allist Pharmaceuticals, Inc. | The salts of 4-aniline quinazoline derivative |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2269994B1 (en) | 2014-08-06 |
| CN103420925A (zh) | 2013-12-04 |
| KR101579148B1 (ko) | 2015-12-21 |
| CN103382183B (zh) | 2014-11-12 |
| CA2719523C (en) | 2016-07-19 |
| AU2009229433A1 (en) | 2009-10-01 |
| US20120004249A1 (en) | 2012-01-05 |
| CN103382183A (zh) | 2013-11-06 |
| US8338438B2 (en) | 2012-12-25 |
| CA2719523A1 (en) | 2010-09-24 |
| US8937079B2 (en) | 2015-01-20 |
| JP2011515421A (ja) | 2011-05-19 |
| US20150133476A1 (en) | 2015-05-14 |
| JP5460689B2 (ja) | 2014-04-02 |
| EP2269994A4 (en) | 2011-03-23 |
| KR20110040746A (ko) | 2011-04-20 |
| CN102007104B (zh) | 2014-02-19 |
| WO2009117899A1 (zh) | 2009-10-01 |
| EP2269994A1 (en) | 2011-01-05 |
| US20130137711A1 (en) | 2013-05-30 |
| CN102007104A (zh) | 2011-04-06 |
| US9102629B2 (en) | 2015-08-11 |
| CN103420925B (zh) | 2014-11-12 |
| CN101544609A (zh) | 2009-09-30 |
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Owner name: SHANGHAI ALLIST PHARMACEUTICALS CO., LTD. Free format text: FORMER NAME(S): SHANGHAI ALLIST PHARMACEUTICALS, INC. |