AU2009219464B2 - Combination anti-cancer agents - Google Patents
Combination anti-cancer agents Download PDFInfo
- Publication number
- AU2009219464B2 AU2009219464B2 AU2009219464A AU2009219464A AU2009219464B2 AU 2009219464 B2 AU2009219464 B2 AU 2009219464B2 AU 2009219464 A AU2009219464 A AU 2009219464A AU 2009219464 A AU2009219464 A AU 2009219464A AU 2009219464 B2 AU2009219464 B2 AU 2009219464B2
- Authority
- AU
- Australia
- Prior art keywords
- lucanthone
- metabolite
- administered
- therapeutically effective
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
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- 238000002513 implantation Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 125000003453 indazolyl group Chemical class N1N=C(C2=C1C=CC=C2)* 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
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- 239000007951 isotonicity adjuster Substances 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
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- 231100000518 lethal Toxicity 0.000 description 1
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- 235000010355 mannitol Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 description 1
- 229960001428 mercaptopurine Drugs 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
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- 244000005700 microbiome Species 0.000 description 1
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- 239000007922 nasal spray Substances 0.000 description 1
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- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 1
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- 238000011580 nude mouse model Methods 0.000 description 1
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- 239000012188 paraffin wax Substances 0.000 description 1
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- 150000003077 polyols Chemical class 0.000 description 1
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- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
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- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 239000002534 radiation-sensitizing agent Substances 0.000 description 1
- 230000000637 radiosensitizating effect Effects 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
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- 150000004760 silicates Chemical class 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
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- 239000002904 solvent Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3283108P | 2008-02-29 | 2008-02-29 | |
| US61/032,831 | 2008-02-29 | ||
| PCT/US2009/034629 WO2009108573A1 (en) | 2008-02-29 | 2009-02-20 | Combination anti-cancer agents |
Publications (2)
| Publication Number | Publication Date |
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| AU2009219464A1 AU2009219464A1 (en) | 2009-09-03 |
| AU2009219464B2 true AU2009219464B2 (en) | 2015-04-09 |
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| AU2009219464A Ceased AU2009219464B2 (en) | 2008-02-29 | 2009-02-20 | Combination anti-cancer agents |
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|---|---|
| US (1) | US20090221615A1 (enExample) |
| EP (1) | EP2257285A1 (enExample) |
| JP (1) | JP5590560B2 (enExample) |
| KR (1) | KR20100126453A (enExample) |
| CN (1) | CN102014895A (enExample) |
| AU (1) | AU2009219464B2 (enExample) |
| BR (1) | BRPI0908398A2 (enExample) |
| CA (1) | CA2717100A1 (enExample) |
| IL (1) | IL207859A (enExample) |
| MX (1) | MX2010009502A (enExample) |
| RU (1) | RU2516027C2 (enExample) |
| WO (1) | WO2009108573A1 (enExample) |
| ZA (1) | ZA201006123B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6182313B2 (ja) * | 2010-03-08 | 2017-08-16 | スペクトラム ファーマシューティカルズ インコーポレイテッド | 癌治療のためのチオキサントンをベースとしたオートファジー阻害剤療法 |
| EP2425830A1 (en) | 2010-09-03 | 2012-03-07 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Synergistic drug combination for the treatment of cancer |
| CA3240916A1 (en) * | 2021-12-14 | 2023-06-22 | Daniel Pierce RADIN | Compositions and methods for treating cancers of the central nervous system (cns), including glioblastoma and chemoresistant cns tumors, and related compositions and methods for inhibiting and eliminating cns cancer stem cell |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000050031A1 (en) * | 1999-02-26 | 2000-08-31 | Robert Bases | Co-administration of lucanthone and radiation for treatment of cancer |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999015210A2 (en) * | 1997-09-26 | 1999-04-01 | Noven Pharmaceuticals, Inc. | Bioadhesive compositions and methods for topical administration of active agents |
| DK1971338T3 (da) * | 2005-12-22 | 2011-05-23 | Astrazeneca Ab | Kombination af ZD6474 og pemetrexed |
| KR20080077678A (ko) * | 2005-12-22 | 2008-08-25 | 아스트라제네카 아베 | Ａｚｄ2171 및 페메트렉시드의 조합물 |
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2009
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- 2009-02-20 RU RU2010139840/14A patent/RU2516027C2/ru not_active IP Right Cessation
- 2009-02-20 KR KR1020107021665A patent/KR20100126453A/ko not_active Abandoned
- 2009-02-20 CA CA2717100A patent/CA2717100A1/en not_active Abandoned
- 2009-02-20 EP EP09714301A patent/EP2257285A1/en not_active Withdrawn
- 2009-02-20 CN CN2009801154644A patent/CN102014895A/zh active Pending
- 2009-02-20 MX MX2010009502A patent/MX2010009502A/es active IP Right Grant
- 2009-02-20 WO PCT/US2009/034629 patent/WO2009108573A1/en not_active Ceased
- 2009-02-20 AU AU2009219464A patent/AU2009219464B2/en not_active Ceased
- 2009-02-20 JP JP2010548807A patent/JP5590560B2/ja not_active Expired - Fee Related
- 2009-02-20 BR BRPI0908398-7A patent/BRPI0908398A2/pt not_active Application Discontinuation
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2010
- 2010-08-27 ZA ZA2010/06123A patent/ZA201006123B/en unknown
- 2010-08-29 IL IL207859A patent/IL207859A/en not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000050031A1 (en) * | 1999-02-26 | 2000-08-31 | Robert Bases | Co-administration of lucanthone and radiation for treatment of cancer |
Non-Patent Citations (2)
| Title |
|---|
| FOSSELLA F. V., et al, "Pemetrexed for treatment of advanced non-small cell lung cancer", Seminars in Oncology, 2004, vol 31, pages 100-105 * |
| ROSELL R., et al, "Pemetrexed combination therapy in the treatment of non-small cell lung cancer", Seminars in Oncology, 2002, vol 29, no 2, suppl 5, pages 23-29 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011513315A (ja) | 2011-04-28 |
| ZA201006123B (en) | 2011-05-25 |
| KR20100126453A (ko) | 2010-12-01 |
| WO2009108573A1 (en) | 2009-09-03 |
| RU2516027C2 (ru) | 2014-05-20 |
| JP5590560B2 (ja) | 2014-09-17 |
| MX2010009502A (es) | 2010-11-10 |
| IL207859A0 (en) | 2010-12-30 |
| IL207859A (en) | 2015-09-24 |
| AU2009219464A1 (en) | 2009-09-03 |
| CA2717100A1 (en) | 2009-09-03 |
| EP2257285A1 (en) | 2010-12-08 |
| US20090221615A1 (en) | 2009-09-03 |
| RU2010139840A (ru) | 2012-04-10 |
| CN102014895A (zh) | 2011-04-13 |
| BRPI0908398A2 (pt) | 2015-08-11 |
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| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |