RU2516027C2 - Комбинация противораковых агентов - Google Patents
Комбинация противораковых агентов Download PDFInfo
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- RU2516027C2 RU2516027C2 RU2010139840/14A RU2010139840A RU2516027C2 RU 2516027 C2 RU2516027 C2 RU 2516027C2 RU 2010139840/14 A RU2010139840/14 A RU 2010139840/14A RU 2010139840 A RU2010139840 A RU 2010139840A RU 2516027 C2 RU2516027 C2 RU 2516027C2
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- Russia
- Prior art keywords
- lucanton
- pemetrexed
- administered
- therapeutically effective
- cancer
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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| RU2010139840A RU2010139840A (ru) | 2012-04-10 |
| RU2516027C2 true RU2516027C2 (ru) | 2014-05-20 |
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| JP6182313B2 (ja) * | 2010-03-08 | 2017-08-16 | スペクトラム ファーマシューティカルズ インコーポレイテッド | 癌治療のためのチオキサントンをベースとしたオートファジー阻害剤療法 |
| EP2425830A1 (en) | 2010-09-03 | 2012-03-07 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Synergistic drug combination for the treatment of cancer |
| CA3240916A1 (en) * | 2021-12-14 | 2023-06-22 | Daniel Pierce RADIN | Compositions and methods for treating cancers of the central nervous system (cns), including glioblastoma and chemoresistant cns tumors, and related compositions and methods for inhibiting and eliminating cns cancer stem cell |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6391911B1 (en) * | 1999-02-26 | 2002-05-21 | Robert E. Bases | Coadministration of lucanthone and radiation for treatment of cancer |
| US6562363B1 (en) * | 1997-09-26 | 2003-05-13 | Noven Pharmaceuticals, Inc. | Bioadhesive compositions and methods for topical administration of active agents |
| WO2007071970A2 (en) * | 2005-12-22 | 2007-06-28 | Astrazeneca Ab | Combination of azd2171 and pemetrexed |
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| DK1971338T3 (da) * | 2005-12-22 | 2011-05-23 | Astrazeneca Ab | Kombination af ZD6474 og pemetrexed |
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- 2009-02-20 RU RU2010139840/14A patent/RU2516027C2/ru not_active IP Right Cessation
- 2009-02-20 KR KR1020107021665A patent/KR20100126453A/ko not_active Abandoned
- 2009-02-20 CA CA2717100A patent/CA2717100A1/en not_active Abandoned
- 2009-02-20 EP EP09714301A patent/EP2257285A1/en not_active Withdrawn
- 2009-02-20 CN CN2009801154644A patent/CN102014895A/zh active Pending
- 2009-02-20 MX MX2010009502A patent/MX2010009502A/es active IP Right Grant
- 2009-02-20 WO PCT/US2009/034629 patent/WO2009108573A1/en not_active Ceased
- 2009-02-20 AU AU2009219464A patent/AU2009219464B2/en not_active Ceased
- 2009-02-20 JP JP2010548807A patent/JP5590560B2/ja not_active Expired - Fee Related
- 2009-02-20 BR BRPI0908398-7A patent/BRPI0908398A2/pt not_active Application Discontinuation
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2010
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- 2010-08-29 IL IL207859A patent/IL207859A/en not_active IP Right Cessation
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6562363B1 (en) * | 1997-09-26 | 2003-05-13 | Noven Pharmaceuticals, Inc. | Bioadhesive compositions and methods for topical administration of active agents |
| RU2234337C2 (ru) * | 1997-09-26 | 2004-08-20 | Ноувен Фамэсьютикэлз, Инк. | Биоадгезивная композиция (варианты), способ ее получения (варианты), устройство для доставки через слизистую оболочку активного агента, способ пролонгированного местного введения одного или более активных агентов субъекту (варианты) и способ сокращения времени, требуемого для приклеивания композиции к слизистой ткани |
| US6391911B1 (en) * | 1999-02-26 | 2002-05-21 | Robert E. Bases | Coadministration of lucanthone and radiation for treatment of cancer |
| WO2007071970A2 (en) * | 2005-12-22 | 2007-06-28 | Astrazeneca Ab | Combination of azd2171 and pemetrexed |
Non-Patent Citations (2)
| Title |
|---|
| HANAUSKE A.R. et al., Pemetrexed disodium: a novel antifolate clinically active against multiple solid tumors, Oncologist, 2001, 6(4):363-73, Abstract, найдено из PubMed: http://www.ncbi.nlm.nih.gov/pubmed/11524555. MEIHUA LUO et al., Inhibition of the human apurinic/apyrimidinic endonuclease (Ape 1) repair activity and sensitization of breast cancer cells to DNA alkylating agents with lucanthone, anticancer research 24: 2127-2134 (2004), найдено из интернет: http://ar.iiarjournals.org/content/24/4/2127.full.pdf+html. FOSSELLA F.V., Pemetrexed for treatment of advanced non small cell lung cancer, Semin Oncol. 2004 Feb,31(1 Suppl 1):100-5, Abstract, найдено из PubMed: http://www.ncbi.nlm.nih.gov/pubmed/14981587 * |
| ГУТУРОВ С.Л., Современные позиции гемцитабина и пеметрекседа в лечении немелкоклеточного рака легкого, 2006, найдено из интернет: http://netoncology.ru/press/articles/673/674/. * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009219464B2 (en) | 2015-04-09 |
| JP2011513315A (ja) | 2011-04-28 |
| ZA201006123B (en) | 2011-05-25 |
| KR20100126453A (ko) | 2010-12-01 |
| WO2009108573A1 (en) | 2009-09-03 |
| JP5590560B2 (ja) | 2014-09-17 |
| MX2010009502A (es) | 2010-11-10 |
| IL207859A0 (en) | 2010-12-30 |
| IL207859A (en) | 2015-09-24 |
| AU2009219464A1 (en) | 2009-09-03 |
| CA2717100A1 (en) | 2009-09-03 |
| EP2257285A1 (en) | 2010-12-08 |
| US20090221615A1 (en) | 2009-09-03 |
| RU2010139840A (ru) | 2012-04-10 |
| CN102014895A (zh) | 2011-04-13 |
| BRPI0908398A2 (pt) | 2015-08-11 |
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