AU2008358909B2 - Treatment of antibiotic-resistant bacteria infection - Google Patents
Treatment of antibiotic-resistant bacteria infection Download PDFInfo
- Publication number
- AU2008358909B2 AU2008358909B2 AU2008358909A AU2008358909A AU2008358909B2 AU 2008358909 B2 AU2008358909 B2 AU 2008358909B2 AU 2008358909 A AU2008358909 A AU 2008358909A AU 2008358909 A AU2008358909 A AU 2008358909A AU 2008358909 B2 AU2008358909 B2 AU 2008358909B2
- Authority
- AU
- Australia
- Prior art keywords
- compound
- mrsa
- resistant
- bacteria
- vancomycin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- BJOIZNZVOZKDIG-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC(OC)=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 BJOIZNZVOZKDIG-MDEJGZGSSA-N 0.000 description 1
- 229960003147 reserpine Drugs 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 150000003385 sodium Chemical class 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 229960001608 teicoplanin Drugs 0.000 description 1
- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- QEMXHQIAXOOASZ-UHFFFAOYSA-N tetramethylammonium Chemical compound C[N+](C)(C)C QEMXHQIAXOOASZ-UHFFFAOYSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- ILWRPSCZWQJDMK-UHFFFAOYSA-N triethylazanium;chloride Chemical compound Cl.CCN(CC)CC ILWRPSCZWQJDMK-UHFFFAOYSA-N 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7729308P | 2008-07-01 | 2008-07-01 | |
| US61/077,293 | 2008-07-01 | ||
| PCT/US2008/075549 WO2010002415A1 (en) | 2008-07-01 | 2008-09-08 | Treatment of antibiotic-resistant bacteria infection |
Publications (2)
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| AU2008358909A1 AU2008358909A1 (en) | 2010-01-07 |
| AU2008358909B2 true AU2008358909B2 (en) | 2012-12-13 |
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|---|---|---|---|
| AU2008358909A Active AU2008358909B2 (en) | 2008-07-01 | 2008-09-08 | Treatment of antibiotic-resistant bacteria infection |
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|---|---|
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| EP (1) | EP2303271B1 (enExample) |
| JP (1) | JP2011526887A (enExample) |
| KR (2) | KR20150006080A (enExample) |
| CN (1) | CN101618038B (enExample) |
| AU (1) | AU2008358909B2 (enExample) |
| CA (1) | CA2728328C (enExample) |
| EA (1) | EA018653B1 (enExample) |
| NZ (1) | NZ588898A (enExample) |
| TR (1) | TR201820964T4 (enExample) |
| TW (1) | TWI375558B (enExample) |
| WO (1) | WO2010002415A1 (enExample) |
| ZA (1) | ZA201100616B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101392808B1 (ko) * | 2011-12-30 | 2014-05-12 | 순천대학교 산학협력단 | 식물 추출물 또는 이의 분획물을 포함하는 항균용 조성물 |
| CN103145615B (zh) * | 2013-03-20 | 2015-07-29 | 浙江医药股份有限公司 | 一种奈诺沙星螯合物的后处理方法 |
| KR101392810B1 (ko) * | 2013-09-25 | 2014-05-12 | 순천대학교 산학협력단 | 된장풀 추출물 또는 이의 분획물을 포함하는 항균용 조성물 |
| US9492374B2 (en) | 2015-03-25 | 2016-11-15 | Jose Rafael Salinas Andrade | Composition and method for treatment of ulcers |
| CN105368825B (zh) * | 2015-10-14 | 2019-09-10 | 华东医院 | 幽门螺杆菌抗生素耐药性分析试剂盒及耐药性检测方法 |
| US12358902B2 (en) * | 2017-12-11 | 2025-07-15 | Denovamed Inc. | 5-(2,5-bis(4-chloro-2-isopropylphenyl)thiophen-3-yl)-1H-tetrazole for the topical treatment of bacterial infections |
| CN111979292B (zh) * | 2020-07-27 | 2022-08-05 | 广东省微生物研究所（广东省微生物分析检测中心） | 一种同时携带多重耐药基因cfr和lsa(E)的MRSA的用途 |
| CN114437026A (zh) * | 2021-10-26 | 2022-05-06 | 浙江医药股份有限公司新昌制药厂 | 一种低组合物杂质的苹果酸奈诺沙星原料药及其制备方法 |
| CN118852222B (zh) * | 2024-06-27 | 2025-09-05 | 南京桦冠生物技术有限公司 | 一种奈诺沙星中间体及其制备方法和应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999014214A1 (en) * | 1997-09-15 | 1999-03-25 | The Procter & Gamble Company | Antimicrobial quinolones, their compositions and uses |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US100800A (en) | 1870-03-15 | Improvement in riding attachments for plows | ||
| US3989816A (en) | 1975-06-19 | 1976-11-02 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacycloheptan-2-ones |
| US4444762A (en) | 1980-04-04 | 1984-04-24 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacyclopentan-2-ones |
| US6387928B1 (en) * | 1997-09-15 | 2002-05-14 | The Procter & Gamble Co. | Antimicrobial quinolones, their compositions and uses |
| US6348624B1 (en) | 1998-01-09 | 2002-02-19 | The Procter & Gamble Co. | Process for making certain benzoic acid compounds |
| DK1343766T3 (da) | 2000-12-14 | 2005-10-31 | Procter & Gamble | Procestrin med cyklisering ved fremstilling af quinoloner og naphthyridiner |
| US6900224B2 (en) * | 2002-07-31 | 2005-05-31 | The Procter & Gamble Company | Antimicrobial quinolones, their compositions and uses |
| US6803469B2 (en) | 2002-08-05 | 2004-10-12 | The Procter & Gamble Company | Process for preparing quinolone antibiotic intermediates |
| WO2005026145A2 (en) * | 2003-09-12 | 2005-03-24 | Warner-Lambert Company Llc | Quinolone antibacterial agents |
| DK2001862T3 (da) | 2006-03-28 | 2011-08-08 | Warner Chilcott Co Llc | Malatsalte og polymorfe af (3S,5S)-7-[3-amino-5-methyl-piperidinyl]-1-cyklopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolincarboxylsyre |
| JP4876165B2 (ja) | 2006-03-28 | 2012-02-15 | ザ プロクター アンド ギャンブル カンパニー | キノロン中間体を調製するための水素化物還元法 |
| BRPI0709220A2 (pt) * | 2006-03-28 | 2011-07-12 | Procter & Gamble | processo de acoplamento para preparo de intermediários de quinolona |
| US8658183B2 (en) | 2007-08-09 | 2014-02-25 | Taigen Biotechnology Company, Ltd. | Antimicrobial parenteral formulation |
| US20120157492A1 (en) | 2008-07-15 | 2012-06-21 | Taigen Biotechnology Co., Ltd. | Antibiotic drug |
-
2008
- 2008-09-08 WO PCT/US2008/075549 patent/WO2010002415A1/en not_active Ceased
- 2008-09-08 US US12/206,060 patent/US8211909B2/en active Active
- 2008-09-08 CA CA2728328A patent/CA2728328C/en active Active
- 2008-09-08 AU AU2008358909A patent/AU2008358909B2/en active Active
- 2008-09-08 EP EP08821583.5A patent/EP2303271B1/en active Active
- 2008-09-08 NZ NZ588898A patent/NZ588898A/xx unknown
- 2008-09-08 TR TR2018/20964T patent/TR201820964T4/tr unknown
- 2008-09-08 KR KR1020147036073A patent/KR20150006080A/ko not_active Ceased
- 2008-09-08 EA EA201170121A patent/EA018653B1/ru unknown
- 2008-09-08 KR KR1020107025547A patent/KR20110044168A/ko not_active Ceased
- 2008-09-08 JP JP2011516261A patent/JP2011526887A/ja active Pending
- 2008-09-09 TW TW097134583A patent/TWI375558B/zh active
- 2008-09-26 CN CN2008101700068A patent/CN101618038B/zh active Active
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2011
- 2011-01-25 ZA ZA2011/00616A patent/ZA201100616B/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999014214A1 (en) * | 1997-09-15 | 1999-03-25 | The Procter & Gamble Company | Antimicrobial quinolones, their compositions and uses |
| US6329391B1 (en) * | 1997-09-15 | 2001-12-11 | The Procter & Gamble Co. | Antimicrobial quinolones, their compositions and uses |
Non-Patent Citations (1)
| Title |
|---|
| International Journal of Antimicrobial Agents (2004) Vol.24 pages 32-34 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EA201170121A1 (ru) | 2011-06-30 |
| EP2303271B1 (en) | 2018-11-07 |
| ZA201100616B (en) | 2011-10-26 |
| US8211909B2 (en) | 2012-07-03 |
| JP2011526887A (ja) | 2011-10-20 |
| HK1139049A1 (en) | 2010-09-10 |
| TWI375558B (en) | 2012-11-01 |
| EP2303271A1 (en) | 2011-04-06 |
| CN101618038A (zh) | 2010-01-06 |
| EA018653B1 (ru) | 2013-09-30 |
| NZ588898A (en) | 2012-09-28 |
| TR201820964T4 (tr) | 2019-01-21 |
| EP2303271A4 (en) | 2012-01-25 |
| TW201002322A (en) | 2010-01-16 |
| CA2728328C (en) | 2015-02-24 |
| WO2010002415A1 (en) | 2010-01-07 |
| CN101618038B (zh) | 2011-12-07 |
| US20100004282A1 (en) | 2010-01-07 |
| KR20110044168A (ko) | 2011-04-28 |
| CA2728328A1 (en) | 2010-01-07 |
| KR20150006080A (ko) | 2015-01-15 |
| AU2008358909A1 (en) | 2010-01-07 |
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Legal Events
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| FGA | Letters patent sealed or granted (standard patent) |