AU2008335080B2 - Benzylphenyl cyclohexane derivatives and methods of use - Google Patents

Benzylphenyl cyclohexane derivatives and methods of use Download PDF

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Publication number
AU2008335080B2
AU2008335080B2 AU2008335080A AU2008335080A AU2008335080B2 AU 2008335080 B2 AU2008335080 B2 AU 2008335080B2 AU 2008335080 A AU2008335080 A AU 2008335080A AU 2008335080 A AU2008335080 A AU 2008335080A AU 2008335080 B2 AU2008335080 B2 AU 2008335080B2
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AU
Australia
Prior art keywords
alkyl
cycloalkyl
compound
group
alkyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2008335080A
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English (en)
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AU2008335080A1 (en
Inventor
Yuanwei Chen
Jiajia Dong
Jiyan Du
Yan Feng
Binhua Lv
Kun Peng
Vasanthakumar Rajappan
Brian Seed
Baihua Xu
Ge Xu
Lili Zhang
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Theracos Inc
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Theracos Inc
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Publication of AU2008335080A1 publication Critical patent/AU2008335080A1/en
Application granted granted Critical
Publication of AU2008335080B2 publication Critical patent/AU2008335080B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
AU2008335080A 2007-12-13 2008-12-11 Benzylphenyl cyclohexane derivatives and methods of use Ceased AU2008335080B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1351707P 2007-12-13 2007-12-13
US61/013,517 2007-12-13
PCT/US2008/086472 WO2009076550A1 (en) 2007-12-13 2008-12-11 Benzylphenyl cyclohexane derivatives and methods of use

Publications (2)

Publication Number Publication Date
AU2008335080A1 AU2008335080A1 (en) 2009-06-18
AU2008335080B2 true AU2008335080B2 (en) 2014-06-05

Family

ID=40754059

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008335080A Ceased AU2008335080B2 (en) 2007-12-13 2008-12-11 Benzylphenyl cyclohexane derivatives and methods of use

Country Status (16)

Country Link
US (1) US8129434B2 (enExample)
EP (1) EP2230907B1 (enExample)
JP (1) JP5507464B2 (enExample)
KR (1) KR101567969B1 (enExample)
CN (1) CN101938902B (enExample)
AR (2) AR071268A1 (enExample)
AU (1) AU2008335080B2 (enExample)
BR (1) BRPI0819930A2 (enExample)
CA (1) CA2707909C (enExample)
IL (1) IL206234A0 (enExample)
NZ (1) NZ586639A (enExample)
RU (1) RU2505521C2 (enExample)
TW (1) TWI426081B (enExample)
UA (1) UA101004C2 (enExample)
WO (1) WO2009076550A1 (enExample)
ZA (1) ZA201004400B (enExample)

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WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
CN103649033B (zh) * 2011-05-26 2016-02-24 Tf化学公司 芳基、杂芳基、o-芳基和o-杂芳基碳环糖家族
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
CN103570671B (zh) * 2012-09-26 2016-03-30 上海天慈生物谷生物工程有限公司 一种降糖化合物及其制法和应用
WO2015051484A1 (en) 2013-10-12 2015-04-16 Theracos, Inc. Preparation of hydroxy-benzylbenzene derivatives
EP3082829B1 (en) 2013-12-17 2021-02-17 Boehringer Ingelheim Vetmedica GmbH Sglt2 inhibitors for the treatment of metabolic disorders in feline animals
US10759729B2 (en) * 2016-11-07 2020-09-01 The Chinese University Of Hong Kong Compounds for treating diabetes
CN116785268A (zh) * 2022-03-14 2023-09-22 江苏万邦生化医药集团有限责任公司 一种sglt-2抑制剂的药物组合物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1783110A1 (en) * 2004-07-26 2007-05-09 Chugai Seiyaku Kabushiki Kaisha Novel cyclohexane derivative, prodrug thereof and salt thereof, and therapeutic agent containing the same for diabetes

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Also Published As

Publication number Publication date
ZA201004400B (en) 2014-10-29
JP2011506469A (ja) 2011-03-03
US8129434B2 (en) 2012-03-06
TW200932755A (en) 2009-08-01
CA2707909A1 (en) 2009-06-18
KR20100098690A (ko) 2010-09-08
AR071268A1 (es) 2010-06-09
CA2707909C (en) 2016-10-18
UA101004C2 (en) 2013-02-25
RU2505521C2 (ru) 2014-01-27
AU2008335080A1 (en) 2009-06-18
EP2230907B1 (en) 2018-05-09
JP5507464B2 (ja) 2014-05-28
NZ586639A (en) 2011-06-30
AR113211A2 (es) 2020-02-19
US20090156516A1 (en) 2009-06-18
CN101938902A (zh) 2011-01-05
RU2010128940A (ru) 2012-01-20
BRPI0819930A2 (pt) 2016-05-17
TWI426081B (zh) 2014-02-11
WO2009076550A1 (en) 2009-06-18
EP2230907A1 (en) 2010-09-29
CN101938902B (zh) 2014-07-02
KR101567969B1 (ko) 2015-11-10
IL206234A0 (en) 2010-12-30
EP2230907A4 (en) 2015-04-08

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