AU2008293381B2 - pH gradients controlled by electrolysis, and their use in isoelectric focusing - Google Patents
pH gradients controlled by electrolysis, and their use in isoelectric focusing Download PDFInfo
- Publication number
- AU2008293381B2 AU2008293381B2 AU2008293381A AU2008293381A AU2008293381B2 AU 2008293381 B2 AU2008293381 B2 AU 2008293381B2 AU 2008293381 A AU2008293381 A AU 2008293381A AU 2008293381 A AU2008293381 A AU 2008293381A AU 2008293381 B2 AU2008293381 B2 AU 2008293381B2
- Authority
- AU
- Australia
- Prior art keywords
- proton concentration
- volume
- proton
- environment
- topography
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000005868 electrolysis reaction Methods 0.000 title claims description 68
- 238000001155 isoelectric focusing Methods 0.000 title abstract description 73
- 238000012876 topography Methods 0.000 claims description 172
- 239000003792 electrolyte Substances 0.000 claims description 65
- 238000000034 method Methods 0.000 claims description 45
- 150000002500 ions Chemical class 0.000 claims description 32
- 239000012530 fluid Substances 0.000 claims description 26
- 230000008859 change Effects 0.000 claims description 22
- 230000004888 barrier function Effects 0.000 claims description 17
- 238000004519 manufacturing process Methods 0.000 claims description 15
- 238000004891 communication Methods 0.000 claims description 7
- 230000004044 response Effects 0.000 claims description 5
- 238000012544 monitoring process Methods 0.000 claims description 3
- 238000001962 electrophoresis Methods 0.000 abstract description 9
- 239000000499 gel Substances 0.000 description 73
- 239000012491 analyte Substances 0.000 description 30
- 102000004169 proteins and genes Human genes 0.000 description 24
- 108090000623 proteins and genes Proteins 0.000 description 24
- 230000006870 function Effects 0.000 description 22
- 239000000463 material Substances 0.000 description 18
- 239000000203 mixture Substances 0.000 description 15
- 239000008151 electrolyte solution Substances 0.000 description 14
- 238000004458 analytical method Methods 0.000 description 12
- 239000012528 membrane Substances 0.000 description 11
- -1 hydroxyl anions Chemical class 0.000 description 9
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 8
- 238000000926 separation method Methods 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 230000003247 decreasing effect Effects 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 230000007423 decrease Effects 0.000 description 5
- 230000008901 benefit Effects 0.000 description 4
- 230000001419 dependent effect Effects 0.000 description 4
- 230000005684 electric field Effects 0.000 description 4
- 239000007793 ph indicator Substances 0.000 description 4
- 229910052697 platinum Inorganic materials 0.000 description 4
- 230000003213 activating effect Effects 0.000 description 3
- 230000004069 differentiation Effects 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
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- 229920005439 Perspex® Polymers 0.000 description 2
- 235000019647 acidic taste Nutrition 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 230000037230 mobility Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
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- 230000004001 molecular interaction Effects 0.000 description 2
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- 229920002401 polyacrylamide Polymers 0.000 description 2
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- 229920000515 polycarbonate Polymers 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 238000007873 sieving Methods 0.000 description 2
- 229920000936 Agarose Polymers 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/46—Treatment of water, waste water, or sewage by electrochemical methods
- C02F1/461—Treatment of water, waste water, or sewage by electrochemical methods by electrolysis
- C02F1/46104—Devices therefor; Their operating or servicing
- C02F1/46109—Electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44795—Isoelectric focusing
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/66—Treatment of water, waste water, or sewage by neutralisation; pH adjustment
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44743—Introducing samples
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/46—Treatment of water, waste water, or sewage by electrochemical methods
- C02F1/461—Treatment of water, waste water, or sewage by electrochemical methods by electrolysis
- C02F1/46104—Devices therefor; Their operating or servicing
- C02F1/4618—Devices therefor; Their operating or servicing for producing "ionised" acidic or basic water
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/46—Treatment of water, waste water, or sewage by electrochemical methods
- C02F1/461—Treatment of water, waste water, or sewage by electrochemical methods by electrolysis
- C02F1/46104—Devices therefor; Their operating or servicing
- C02F1/46109—Electrodes
- C02F2001/46152—Electrodes characterised by the shape or form
- C02F2001/46157—Perforated or foraminous electrodes
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2201/00—Apparatus for treatment of water, waste water or sewage
- C02F2201/46—Apparatus for electrochemical processes
- C02F2201/461—Electrolysis apparatus
- C02F2201/46105—Details relating to the electrolytic devices
- C02F2201/46115—Electrolytic cell with membranes or diaphragms
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2201/00—Apparatus for treatment of water, waste water or sewage
- C02F2201/46—Apparatus for electrochemical processes
- C02F2201/461—Electrolysis apparatus
- C02F2201/46105—Details relating to the electrolytic devices
- C02F2201/4612—Controlling or monitoring
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2201/00—Apparatus for treatment of water, waste water or sewage
- C02F2201/46—Apparatus for electrochemical processes
- C02F2201/461—Electrolysis apparatus
- C02F2201/46105—Details relating to the electrolytic devices
- C02F2201/4612—Controlling or monitoring
- C02F2201/46125—Electrical variables
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2201/00—Apparatus for treatment of water, waste water or sewage
- C02F2201/46—Apparatus for electrochemical processes
- C02F2201/461—Electrolysis apparatus
- C02F2201/46105—Details relating to the electrolytic devices
- C02F2201/4612—Controlling or monitoring
- C02F2201/46125—Electrical variables
- C02F2201/4614—Current
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2209/00—Controlling or monitoring parameters in water treatment
- C02F2209/06—Controlling or monitoring parameters in water treatment pH
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Environmental & Geological Engineering (AREA)
- Engineering & Computer Science (AREA)
- Hydrology & Water Resources (AREA)
- Water Supply & Treatment (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Electrolytic Production Of Non-Metals, Compounds, Apparatuses Therefor (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93569807P | 2007-08-27 | 2007-08-27 | |
| US60/935,698 | 2007-08-27 | ||
| US3925708P | 2008-03-25 | 2008-03-25 | |
| US61/039,257 | 2008-03-25 | ||
| PCT/IL2008/001159 WO2009027970A2 (en) | 2007-08-27 | 2008-08-26 | Ph gradients controlled by electrolysis, and their use in isoelectric focusing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2008293381A1 AU2008293381A1 (en) | 2009-03-05 |
| AU2008293381B2 true AU2008293381B2 (en) | 2012-07-19 |
Family
ID=40254551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2008293381A Ceased AU2008293381B2 (en) | 2007-08-27 | 2008-08-26 | pH gradients controlled by electrolysis, and their use in isoelectric focusing |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9274082B2 (enExample) |
| EP (2) | EP2193100B1 (enExample) |
| JP (1) | JP5702142B2 (enExample) |
| KR (1) | KR20100053672A (enExample) |
| CN (2) | CN101868425B (enExample) |
| AU (1) | AU2008293381B2 (enExample) |
| CA (1) | CA2697649C (enExample) |
| WO (1) | WO2009027970A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2193100B1 (en) | 2007-08-27 | 2014-05-07 | Technion Research and Development Foundation, Limited | pH gradients controlled by electrolysis, and their use in isoelectric focusing |
| US10107782B2 (en) * | 2008-01-25 | 2018-10-23 | ProteinSimple | Method to perform limited two dimensional separation of proteins and other biologicals |
| CA2770270C (en) * | 2009-08-18 | 2018-08-14 | Technion Research & Development Foundation Ltd. | Proton concentration topographies, methods and devices for producing the same |
| US8864970B2 (en) | 2009-08-18 | 2014-10-21 | Technion Research & Development Foundation Limited | Methods and devices of separating molecular analytes |
| JP5950429B2 (ja) * | 2011-05-13 | 2016-07-13 | シャープ株式会社 | 電気泳動方法、及び電気泳動装置 |
| CN104024856B (zh) * | 2011-11-04 | 2018-10-26 | 生物辐射实验室股份有限公司 | 基于pI的蛋白质分级 |
| US9766207B2 (en) | 2011-11-04 | 2017-09-19 | Bio-Rad Laboratories, Inc. | Affinity methods and compositions employing electronic control of pH |
| WO2013067509A1 (en) | 2011-11-04 | 2013-05-10 | Bio-Rad Laboratories, Inc. | Simultaneous purification of cell components |
| CN104024396A (zh) | 2011-11-04 | 2014-09-03 | 生物辐射实验室股份有限公司 | 采用pH的电子控制的亲和方法及组合物 |
| CN102565171A (zh) * | 2012-01-05 | 2012-07-11 | 厦门大学 | 一种用于等电聚焦分离的微流控芯片 |
| US9658195B2 (en) | 2012-02-15 | 2017-05-23 | Bio-Rad Laboratories, Inc. | Electronic control of pH and ionic strength |
| US9321012B2 (en) | 2012-04-04 | 2016-04-26 | Bio-Rad Laboratories, Inc. | Electronic protein fractionation |
| CN104034789A (zh) * | 2013-04-02 | 2014-09-10 | 上海交通大学 | 蛋白质等电聚焦电泳的装置 |
| CN106267304B (zh) * | 2015-06-09 | 2019-10-18 | 海南光宇生物科技有限公司 | 具有酸碱性的生物纤维素凝胶膜及由其制备的医用敷料 |
| CN106260992B (zh) * | 2015-06-09 | 2020-02-18 | 海南椰国食品有限公司 | 一种含有酸性椰果和/或碱性椰果的食品 |
| EP3653121A1 (en) * | 2018-11-14 | 2020-05-20 | Koninklijke Philips N.V. | Sensor unit, body fluid monitoring device and method for detecting an analyte |
| CN119470588A (zh) * | 2024-11-18 | 2025-02-18 | 中国科学院空天信息创新研究院 | 集成式多种重金属检测微传感器 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050189237A1 (en) * | 2004-02-27 | 2005-09-01 | Yoichi Sano | Production of electrolytic water |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2591738B2 (ja) | 1985-08-21 | 1997-03-19 | ベーリンガー マンヘイム コーポレイション | 特異的結合アッセイにおける成分の分離，混合および検出のための方法および装置 |
| US4670119A (en) * | 1985-10-25 | 1987-06-02 | Hurd Stanley M | Isoelectric focusing device and process |
| US4900414A (en) * | 1988-08-19 | 1990-02-13 | Drug Delivery Systems Inc. | Commercial separation system and method using electrokinetic techniques |
| US5160594A (en) | 1989-03-08 | 1992-11-03 | Board Of Regents Of The University Of Texas System | Apparatus and methods for isoelectric focusing of amphoteric substances incorporating ion selective membranes in electrode chambers |
| DE3929137C1 (enExample) | 1989-09-01 | 1991-02-28 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung Ev, 8000 Muenchen, De | |
| US5110434A (en) | 1990-12-20 | 1992-05-05 | Bio-Rad Laboratories, Inc. | Use of zwitterions to mobilize isoelectrically focused ampholyte zones |
| US5646001A (en) | 1991-03-25 | 1997-07-08 | Immunivest Corporation | Affinity-binding separation and release of one or more selected subset of biological entities from a mixed population thereof |
| GB2275974B (en) | 1993-03-10 | 1996-01-10 | Curty Payen Sa | Improvements in and relating to gaskets |
| US6129828A (en) * | 1996-09-06 | 2000-10-10 | Nanogen, Inc. | Apparatus and methods for active biological sample preparation |
| JPH0933479A (ja) * | 1995-07-18 | 1997-02-07 | Mizu Kk | センサカバー及びこれを用いた電解水生成装置 |
| US5993627A (en) | 1997-06-24 | 1999-11-30 | Large Scale Biology Corporation | Automated system for two-dimensional electrophoresis |
| US6296752B1 (en) * | 1998-06-05 | 2001-10-02 | Sarnoff Corporation | Apparatus for separating molecules |
| JP3113645B2 (ja) * | 1999-03-01 | 2000-12-04 | ファースト・オーシャン株式会社 | 電解水製造法 |
| AU4773400A (en) | 1999-05-28 | 2000-12-18 | Leisamon (Israel), Ltd. | Methods and apparatus for nonlinear mobility electrophoresis separation |
| DE10047088C2 (de) * | 2000-09-21 | 2002-10-17 | Gerhard Weber | Medium für analytische und präparative Elektrophorese |
| JP2002265494A (ja) | 2001-03-06 | 2002-09-18 | Tokuyama Corp | 混合物から高純度化された目的物を製造する方法 |
| WO2003008977A2 (en) | 2001-07-16 | 2003-01-30 | Protein, Forest, Inc. | Arrays of buffers for analysing biomolecules by their isoelectric point |
| GB0121189D0 (en) * | 2001-08-31 | 2001-10-24 | Diagnoswiss Sa | Apparatus and method for separating an analyte |
| SE0203773D0 (sv) | 2002-12-19 | 2002-12-19 | Capture Device Ab | Method and device for capturing charged molecules traveling in a flow stream |
| US7150813B2 (en) * | 2003-06-12 | 2006-12-19 | Palo Alto Research Center Incorporated | Isoelectric focusing (IEF) of proteins with sequential and oppositely directed traveling waves in gel electrophoresis |
| AU2004269196B2 (en) | 2003-09-03 | 2010-03-04 | Shmuel Bukshpan | Methods and apparatus for rapid crystallization of biomolecules |
| JP2006213932A (ja) * | 2004-05-07 | 2006-08-17 | Honda Motor Co Ltd | 電解水生成用電極 |
| CN1258828C (zh) * | 2004-02-13 | 2006-06-07 | 清华大学 | 一种质子交换膜燃料电池多元催化剂的制备方法 |
| EP1776581B1 (en) | 2004-07-19 | 2015-05-06 | ProteinSimple | Method for protein detection |
| US7749370B2 (en) | 2005-02-03 | 2010-07-06 | Osao Sumita | Manufacturing method of oxidative water to be employed for sterilization |
| JP5129442B2 (ja) * | 2005-02-08 | 2013-01-30 | エア・ウォーター株式会社 | 液体の帯電物質の濃度調節装置 |
| JP4856530B2 (ja) | 2005-12-21 | 2012-01-18 | ミドリ安全株式会社 | 電解水の有効塩素濃度調節方法、電解水のｐＨ調節方法および電解水生成装置。 |
| EP1986959B1 (de) | 2006-02-17 | 2010-10-27 | Actides Gmbh | Verfahren zur herstellung eines desinfektionsmittels durch elektrochemische aktivierung (eca) von wasser |
| JP3163188U (ja) | 2007-03-13 | 2010-10-07 | シーメンス ウォーター テクノロジース コーポレイション | 酸及び塩基生成のための装置及び方法 |
| US20110100821A1 (en) | 2007-04-20 | 2011-05-05 | Brian Furmanski | Mineral oil free isoelectric focusing apparatus for immobilized ph gradient strips |
| CN101294930B (zh) | 2007-04-27 | 2013-08-14 | 杨春 | 一种整体型固定化pH梯度的制备方法及其应用 |
| US8366899B2 (en) | 2007-06-22 | 2013-02-05 | Massachusetts Institute Of Technology | Isoelectric focusing systems and methods |
| EP2193100B1 (en) | 2007-08-27 | 2014-05-07 | Technion Research and Development Foundation, Limited | pH gradients controlled by electrolysis, and their use in isoelectric focusing |
| CA2770270C (en) | 2009-08-18 | 2018-08-14 | Technion Research & Development Foundation Ltd. | Proton concentration topographies, methods and devices for producing the same |
| US8864970B2 (en) | 2009-08-18 | 2014-10-21 | Technion Research & Development Foundation Limited | Methods and devices of separating molecular analytes |
| CN104024856B (zh) | 2011-11-04 | 2018-10-26 | 生物辐射实验室股份有限公司 | 基于pI的蛋白质分级 |
-
2008
- 2008-08-26 EP EP08789831.8A patent/EP2193100B1/en not_active Not-in-force
- 2008-08-26 EP EP12177368.3A patent/EP2559666B1/en not_active Not-in-force
- 2008-08-26 CN CN2008801146906A patent/CN101868425B/zh not_active Expired - Fee Related
- 2008-08-26 US US12/675,794 patent/US9274082B2/en active Active
- 2008-08-26 JP JP2010522513A patent/JP5702142B2/ja not_active Expired - Fee Related
- 2008-08-26 KR KR1020107006740A patent/KR20100053672A/ko not_active Ceased
- 2008-08-26 CN CN201210450797.6A patent/CN103134843B/zh not_active Expired - Fee Related
- 2008-08-26 WO PCT/IL2008/001159 patent/WO2009027970A2/en not_active Ceased
- 2008-08-26 AU AU2008293381A patent/AU2008293381B2/en not_active Ceased
- 2008-08-26 CA CA2697649A patent/CA2697649C/en active Active
-
2016
- 2016-02-28 US US15/055,601 patent/US10132776B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050189237A1 (en) * | 2004-02-27 | 2005-09-01 | Yoichi Sano | Production of electrolytic water |
Also Published As
| Publication number | Publication date |
|---|---|
| US20160178578A1 (en) | 2016-06-23 |
| EP2193100B1 (en) | 2014-05-07 |
| WO2009027970A2 (en) | 2009-03-05 |
| US10132776B2 (en) | 2018-11-20 |
| EP2193100A2 (en) | 2010-06-09 |
| US20100307920A1 (en) | 2010-12-09 |
| CN103134843B (zh) | 2014-11-12 |
| KR20100053672A (ko) | 2010-05-20 |
| EP2559666A2 (en) | 2013-02-20 |
| US9274082B2 (en) | 2016-03-01 |
| JP5702142B2 (ja) | 2015-04-15 |
| AU2008293381A1 (en) | 2009-03-05 |
| CN101868425A (zh) | 2010-10-20 |
| CN103134843A (zh) | 2013-06-05 |
| CN101868425B (zh) | 2013-01-02 |
| EP2559666A3 (en) | 2013-04-03 |
| WO2009027970A3 (en) | 2009-05-14 |
| EP2559666B1 (en) | 2014-07-23 |
| JP2010538255A (ja) | 2010-12-09 |
| CA2697649C (en) | 2016-08-09 |
| CA2697649A1 (en) | 2009-03-05 |
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