AU2008279509B2 - Stabilized immune modulatory RNA (SIMRA) compounds - Google Patents
Stabilized immune modulatory RNA (SIMRA) compounds Download PDFInfo
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- AU2008279509B2 AU2008279509B2 AU2008279509A AU2008279509A AU2008279509B2 AU 2008279509 B2 AU2008279509 B2 AU 2008279509B2 AU 2008279509 A AU2008279509 A AU 2008279509A AU 2008279509 A AU2008279509 A AU 2008279509A AU 2008279509 B2 AU2008279509 B2 AU 2008279509B2
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- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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- C12N2310/3183—Diol linkers, e.g. glycols or propanediols
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- C12N2320/00—Applications; Uses
- C12N2320/50—Methods for regulating/modulating their activity
- C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance
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| US94852907P | 2007-07-09 | 2007-07-09 | |
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| US95719507P | 2007-08-22 | 2007-08-22 | |
| US60/957,195 | 2007-08-22 | ||
| US98116107P | 2007-10-19 | 2007-10-19 | |
| US60/981,161 | 2007-10-19 | ||
| US1528407P | 2007-12-20 | 2007-12-20 | |
| US61/015,284 | 2007-12-20 | ||
| PCT/US2008/069335 WO2009014887A2 (en) | 2007-07-09 | 2008-07-07 | Stabilized immune modulatory rna (simra) compounds |
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| EP2371834B1 (en) * | 2003-06-11 | 2016-02-17 | Idera Pharmaceuticals, Inc. | Stabilized immunomodulatory oligonucleotides |
| US20060074040A1 (en) * | 2003-07-15 | 2006-04-06 | Hybridon, Inc. | Synergistic stimulation of the immune system using immunostimulatory oligonucleotides and/or immunomer compounds in conjunction with cytokines and/or chemotherapeutic agents or radiation therapy |
| CN102282155B (zh) | 2008-12-02 | 2017-06-09 | 日本波涛生命科学公司 | 磷原子修饰的核酸的合成方法 |
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- 2008-07-07 EP EP11002685.3A patent/EP2348112B1/en not_active Not-in-force
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| WO2007117686A2 (en) * | 2006-04-07 | 2007-10-18 | Idera Pharmaceuticals, Inc. | Stabilized immune modulatory rna (simra) compounds for tlr7 and tlr8 |
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| JP5737937B2 (ja) | 2015-06-17 |
| EP2178567A4 (en) | 2010-11-03 |
| EP2348112B1 (en) | 2018-11-28 |
| CA2692161A1 (en) | 2009-01-29 |
| CA2692161C (en) | 2015-09-29 |
| KR101343489B1 (ko) | 2013-12-20 |
| US20120183530A1 (en) | 2012-07-19 |
| EP2348112A3 (en) | 2015-09-02 |
| WO2009014887A2 (en) | 2009-01-29 |
| EP2178567A2 (en) | 2010-04-28 |
| EP2357231A2 (en) | 2011-08-17 |
| CN102921003A (zh) | 2013-02-13 |
| KR20100055413A (ko) | 2010-05-26 |
| CN101795715A (zh) | 2010-08-04 |
| WO2009014887A3 (en) | 2009-12-30 |
| AU2008279509A1 (en) | 2009-01-29 |
| US20090053205A1 (en) | 2009-02-26 |
| US8362233B2 (en) | 2013-01-29 |
| CN102921003B (zh) | 2014-11-26 |
| US8188261B2 (en) | 2012-05-29 |
| EP2348112A2 (en) | 2011-07-27 |
| JP2010532996A (ja) | 2010-10-21 |
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