AU2008228768A1 - N-heterocyclic compounds useful as inhibitors of Janus Kinases - Google Patents

N-heterocyclic compounds useful as inhibitors of Janus Kinases Download PDF

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Publication number
AU2008228768A1
AU2008228768A1 AU2008228768A AU2008228768A AU2008228768A1 AU 2008228768 A1 AU2008228768 A1 AU 2008228768A1 AU 2008228768 A AU2008228768 A AU 2008228768A AU 2008228768 A AU2008228768 A AU 2008228768A AU 2008228768 A1 AU2008228768 A1 AU 2008228768A1
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Australia
Prior art keywords
aliphatic
compound according
optionally substituted
ring
occurrences
Prior art date
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Abandoned
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AU2008228768A
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English (en)
Inventor
Alexander Aronov
Randy Bethiel
Luc Farmer
Mark Ledeboer
Brian Ledford
Gabriel Martinez-Botella
Albert Pierce
Emilie Porter
Francesco Salituro
Jian Wang
Tiansheng Wang
Marion Wannamaker
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of AU2008228768A1 publication Critical patent/AU2008228768A1/en
Abandoned legal-status Critical Current

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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AU2008228768A 2007-03-22 2008-03-21 N-heterocyclic compounds useful as inhibitors of Janus Kinases Abandoned AU2008228768A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91946907P 2007-03-22 2007-03-22
US60/919,469 2007-03-22
PCT/US2008/057797 WO2008116139A2 (en) 2007-03-22 2008-03-21 N-heterocyclic compounds useful as inhibitors of janus kinases

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AU2008228768A1 true AU2008228768A1 (en) 2008-09-25

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AU2008228768A Abandoned AU2008228768A1 (en) 2007-03-22 2008-03-21 N-heterocyclic compounds useful as inhibitors of Janus Kinases

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US (3) US20100160287A1 (enExample)
EP (1) EP2144878A2 (enExample)
JP (2) JP5642973B2 (enExample)
KR (1) KR20090129488A (enExample)
CN (1) CN101778825A (enExample)
AU (1) AU2008228768A1 (enExample)
CA (1) CA2681516A1 (enExample)
IL (1) IL201064A0 (enExample)
MX (1) MX2009010127A (enExample)
WO (1) WO2008116139A2 (enExample)

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TW201100441A (en) 2009-06-01 2011-01-01 Osi Pharm Inc Amino pyrimidine anticancer compounds
CN102471345A (zh) * 2009-07-15 2012-05-23 雅培制药有限公司 激酶的吡咯并吡嗪抑制剂
CA2788450A1 (en) 2009-12-30 2011-07-07 Arqule, Inc. Substituted naphthalenyl-pyrimidine compounds
JP2013147428A (ja) * 2010-04-27 2013-08-01 Dainippon Sumitomo Pharma Co Ltd 新規２−ヘテロアリール単環ピリミジン誘導体
EP2611789A1 (en) 2010-09-01 2013-07-10 Ambit Biosciences Corporation Quinazoline compounds and methods of use thereof
WO2012074951A1 (en) 2010-11-29 2012-06-07 OSI Pharmaceuticals, LLC Macrocyclic kinase inhibitors
JP2014500277A (ja) 2010-12-09 2014-01-09 アムジエン・インコーポレーテツド Ｐｉｍ阻害剤としての二環式化合物
WO2012129338A1 (en) 2011-03-22 2012-09-27 Amgen Inc. Azole compounds as pim inhibitors
ES2698847T3 (es) 2011-07-07 2019-02-06 Merck Patent Gmbh Azaheterociclos sustituidos para el tratamiento del cáncer
US9089574B2 (en) 2011-11-30 2015-07-28 Emory University Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections
WO2014126954A1 (en) * 2013-02-13 2014-08-21 OSI Pharmaceuticals, LLC Regioselective synthesis of substituted pyrimidines
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US8686143B2 (en) 2014-04-01
CA2681516A1 (en) 2008-09-25
IL201064A0 (en) 2010-05-17
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JP2010522210A (ja) 2010-07-01
US20100160287A1 (en) 2010-06-24
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EP2144878A2 (en) 2010-01-20
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US20140221336A1 (en) 2014-08-07

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