AU2007330996C1 - Formation of nanometric core-shell particles having a metal oxide shell - Google Patents
Formation of nanometric core-shell particles having a metal oxide shell Download PDFInfo
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- AU2007330996C1 AU2007330996C1 AU2007330996A AU2007330996A AU2007330996C1 AU 2007330996 C1 AU2007330996 C1 AU 2007330996C1 AU 2007330996 A AU2007330996 A AU 2007330996A AU 2007330996 A AU2007330996 A AU 2007330996A AU 2007330996 C1 AU2007330996 C1 AU 2007330996C1
- Authority
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- Australia
- Prior art keywords
- nanocapsules
- emulsion
- shell
- alkyl
- core material
- Prior art date
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- 239000002245 particle Substances 0.000 title claims abstract description 57
- 229910044991 metal oxide Inorganic materials 0.000 title claims abstract description 22
- 150000004706 metal oxides Chemical class 0.000 title claims abstract description 22
- 239000011258 core-shell material Substances 0.000 title claims abstract description 15
- 230000015572 biosynthetic process Effects 0.000 title description 7
- 239000002088 nanocapsule Substances 0.000 claims abstract description 119
- 239000011162 core material Substances 0.000 claims abstract description 60
- 239000000203 mixture Substances 0.000 claims abstract description 59
- 239000007908 nanoemulsion Substances 0.000 claims abstract description 42
- 239000000839 emulsion Substances 0.000 claims abstract description 38
- 238000009826 distribution Methods 0.000 claims abstract description 36
- 239000012071 phase Substances 0.000 claims abstract description 32
- 239000012703 sol-gel precursor Substances 0.000 claims abstract description 28
- 239000008346 aqueous phase Substances 0.000 claims abstract description 21
- 238000004945 emulsification Methods 0.000 claims abstract description 11
- 238000004519 manufacturing process Methods 0.000 claims abstract description 9
- 238000000265 homogenisation Methods 0.000 claims abstract description 6
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- 239000004480 active ingredient Substances 0.000 claims description 49
- -1 dental agents Substances 0.000 claims description 44
- 238000000034 method Methods 0.000 claims description 43
- 230000008569 process Effects 0.000 claims description 37
- 239000004094 surface-active agent Substances 0.000 claims description 37
- 229910052751 metal Inorganic materials 0.000 claims description 23
- 239000000178 monomer Substances 0.000 claims description 23
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 22
- 239000000725 suspension Substances 0.000 claims description 22
- 239000002184 metal Substances 0.000 claims description 19
- 239000003054 catalyst Substances 0.000 claims description 17
- 125000000217 alkyl group Chemical group 0.000 claims description 16
- 239000002243 precursor Substances 0.000 claims description 14
- 125000003118 aryl group Chemical group 0.000 claims description 12
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- 125000001424 substituent group Chemical group 0.000 claims description 11
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- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 6
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- 125000004104 aryloxy group Chemical group 0.000 claims description 6
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- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 5
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- XLOMVQKBTHCTTD-UHFFFAOYSA-N zinc oxide Inorganic materials [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 3
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- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 2
- 125000005372 silanol group Chemical group 0.000 claims description 2
- 150000001356 alkyl thiols Chemical class 0.000 claims 2
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 claims 1
- 229910052725 zinc Inorganic materials 0.000 claims 1
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- BOTDANWDWHJENH-UHFFFAOYSA-N Tetraethyl orthosilicate Chemical compound CCO[Si](OCC)(OCC)OCC BOTDANWDWHJENH-UHFFFAOYSA-N 0.000 description 14
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- LFQCEHFDDXELDD-UHFFFAOYSA-N tetramethyl orthosilicate Chemical group CO[Si](OC)(OC)OC LFQCEHFDDXELDD-UHFFFAOYSA-N 0.000 description 5
- 230000032683 aging Effects 0.000 description 4
- 125000000129 anionic group Chemical group 0.000 description 4
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- 239000002904 solvent Substances 0.000 description 4
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 3
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 description 3
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- DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 description 3
- 229960001173 oxybenzone Drugs 0.000 description 3
- ZXDDPOHVAMWLBH-UHFFFAOYSA-N 2,4-Dihydroxybenzophenone Chemical compound OC1=CC(O)=CC=C1C(=O)C1=CC=CC=C1 ZXDDPOHVAMWLBH-UHFFFAOYSA-N 0.000 description 2
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
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- OCWYEMOEOGEQAN-UHFFFAOYSA-N bumetrizole Chemical compound CC(C)(C)C1=CC(C)=CC(N2N=C3C=C(Cl)C=CC3=N2)=C1O OCWYEMOEOGEQAN-UHFFFAOYSA-N 0.000 description 2
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
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- TVWTZAGVNBPXHU-FOCLMDBBSA-N dioctyl (e)-but-2-enedioate Chemical compound CCCCCCCCOC(=O)\C=C\C(=O)OCCCCCCCC TVWTZAGVNBPXHU-FOCLMDBBSA-N 0.000 description 1
- TVWTZAGVNBPXHU-NXVVXOECSA-N dioctyl (z)-but-2-enedioate Chemical compound CCCCCCCCOC(=O)\C=C/C(=O)OCCCCCCCC TVWTZAGVNBPXHU-NXVVXOECSA-N 0.000 description 1
- CNHQWLUGXFIDAT-UHFFFAOYSA-N dioctyl 2-hydroxybutanedioate Chemical compound CCCCCCCCOC(=O)CC(O)C(=O)OCCCCCCCC CNHQWLUGXFIDAT-UHFFFAOYSA-N 0.000 description 1
- DLAHAXOYRFRPFQ-UHFFFAOYSA-N dodecyl benzoate Chemical compound CCCCCCCCCCCCOC(=O)C1=CC=CC=C1 DLAHAXOYRFRPFQ-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
- SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 description 1
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 1
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- GVEPBJHOBDJJJI-UHFFFAOYSA-N fluoranthrene Natural products C1=CC(C2=CC=CC=C22)=C3C2=CC=CC3=C1 GVEPBJHOBDJJJI-UHFFFAOYSA-N 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 125000005417 glycidoxyalkyl group Chemical group 0.000 description 1
- 239000004009 herbicide Substances 0.000 description 1
- 229940100463 hexyl laurate Drugs 0.000 description 1
- 238000010316 high energy milling Methods 0.000 description 1
- 229960004881 homosalate Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000000976 ink Substances 0.000 description 1
- 229920000592 inorganic polymer Polymers 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 229920000831 ionic polymer Polymers 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000010907 mechanical stirring Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 229940035363 muscle relaxants Drugs 0.000 description 1
- 239000003158 myorelaxant agent Substances 0.000 description 1
- NJWBAJNKROKYMV-UHFFFAOYSA-N n-(6-bromo-2-methoxyacridin-9-yl)-n',n'-dimethylbutane-1,4-diamine;dihydrochloride Chemical compound Cl.Cl.C1=C(Br)C=CC2=C(NCCCCN(C)C)C3=CC(OC)=CC=C3N=C21 NJWBAJNKROKYMV-UHFFFAOYSA-N 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 125000000962 organic group Chemical group 0.000 description 1
- 229920000620 organic polymer Polymers 0.000 description 1
- 125000002524 organometallic group Chemical group 0.000 description 1
- 150000003961 organosilicon compounds Chemical class 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 125000002080 perylenyl group Chemical group C1(=CC=C2C=CC=C3C4=CC=CC5=CC=CC(C1=C23)=C45)* 0.000 description 1
- CSHWQDPOILHKBI-UHFFFAOYSA-N peryrene Natural products C1=CC(C2=CC=CC=3C2=C2C=CC=3)=C3C2=CC=CC3=C1 CSHWQDPOILHKBI-UHFFFAOYSA-N 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 238000006068 polycondensation reaction Methods 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229940116422 propylene glycol dicaprate Drugs 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 235000021067 refined food Nutrition 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- CXVGEDCSTKKODG-UHFFFAOYSA-N sulisobenzone Chemical compound C1=C(S(O)(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC=CC=C1 CXVGEDCSTKKODG-UHFFFAOYSA-N 0.000 description 1
- 229960000368 sulisobenzone Drugs 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 238000007669 thermal treatment Methods 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/14—Polymerisation; cross-linking
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Colloid Chemistry (AREA)
- Catalysts (AREA)
- Silicon Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87426806P | 2006-12-12 | 2006-12-12 | |
| US60/874,268 | 2006-12-12 | ||
| PCT/IL2007/001541 WO2008072239A2 (en) | 2006-12-12 | 2007-12-12 | Formation of nanometric core-shell particles having a metal oxide shell |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| AU2007330996A1 AU2007330996A1 (en) | 2008-06-19 |
| AU2007330996B2 AU2007330996B2 (en) | 2013-02-28 |
| AU2007330996C1 true AU2007330996C1 (en) | 2014-07-03 |
Family
ID=39414445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2007330996A Ceased AU2007330996C1 (en) | 2006-12-12 | 2007-12-12 | Formation of nanometric core-shell particles having a metal oxide shell |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10525433B2 (enExample) |
| EP (1) | EP2104558A2 (enExample) |
| JP (2) | JP2010512244A (enExample) |
| AU (1) | AU2007330996C1 (enExample) |
| BR (1) | BRPI0720068A2 (enExample) |
| WO (1) | WO2008072239A2 (enExample) |
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| US9786910B2 (en) | 2015-11-16 | 2017-10-10 | HHeLI, LLC | Synthesized, surface-functionalized, acidified metal oxide materials for energy storage, catalytic, photovoltaic and sensor applications |
| US10553861B2 (en) | 2017-04-10 | 2020-02-04 | HHeLI, LLC | Battery with novel components |
| US10566620B2 (en) | 2017-05-17 | 2020-02-18 | HHeLI, LLC | Battery with acidified cathode and lithium anode |
| US10978731B2 (en) | 2017-06-21 | 2021-04-13 | HHeLI, LLC | Ultra high capacity performance battery cell |
| US11283267B2 (en) | 2018-09-10 | 2022-03-22 | HHeLI, LLC | Methods of use of ultra high capacity performance battery cell |
| US11641014B2 (en) | 2017-05-17 | 2023-05-02 | HHeLI, LLC | Battery cell with anode or cathode with nanomaterial including acidic surface |
| US12278342B2 (en) | 2019-06-12 | 2025-04-15 | HHeLI, LLC | Alkaline and acidified metal oxide blended active materials |
| US12401018B2 (en) | 2019-06-12 | 2025-08-26 | HHeLI, LLC | Blended active materials for battery cells |
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| JP5382723B2 (ja) | 2007-02-01 | 2014-01-08 | ソル − ゲル テクノロジーズ リミテッド | 金属酸化物コーティングを含む粒子の製造方法及び金属酸化物コーティングを有する粒子 |
| BRPI0915006B1 (pt) * | 2008-06-10 | 2018-02-06 | Unilever N.V. | Processo para a produção de partículas do tipo núcleo-casca |
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| GB2416524A (en) | 2004-07-24 | 2006-02-01 | Dow Corning | Microcapsules with siloxane walls formed in situ |
| JP2008546848A (ja) | 2005-06-29 | 2008-12-25 | ディーエスエム アイピー アセッツ ビー．ブイ． | 日焼け止め剤を含有する堅固なカプセルを有する組成物 |
| EP2038053B1 (en) * | 2006-06-27 | 2017-05-17 | Dow Corning Corporation | Microcapsules from emulsion polymerization of tetraalkoxysilane |
-
2007
- 2007-12-12 WO PCT/IL2007/001541 patent/WO2008072239A2/en not_active Ceased
- 2007-12-12 AU AU2007330996A patent/AU2007330996C1/en not_active Ceased
- 2007-12-12 BR BRPI0720068-4A2A patent/BRPI0720068A2/pt not_active IP Right Cessation
- 2007-12-12 JP JP2009540970A patent/JP2010512244A/ja active Pending
- 2007-12-12 US US12/518,743 patent/US10525433B2/en active Active
- 2007-12-12 EP EP07849567A patent/EP2104558A2/en not_active Withdrawn
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- 2013-08-09 JP JP2013165717A patent/JP2013237051A/ja active Pending
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| WO2000009652A2 (en) * | 1998-08-13 | 2000-02-24 | Sol-Gel Technologies Ltd. | Method for the preparation of oxide microcapsules loaded with functional molecules and the products obtained thereof |
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2008072239A2 (en) | 2008-06-19 |
| EP2104558A2 (en) | 2009-09-30 |
| AU2007330996B2 (en) | 2013-02-28 |
| AU2007330996A1 (en) | 2008-06-19 |
| JP2010512244A (ja) | 2010-04-22 |
| WO2008072239A3 (en) | 2008-08-21 |
| US10525433B2 (en) | 2020-01-07 |
| JP2013237051A (ja) | 2013-11-28 |
| US20100203121A1 (en) | 2010-08-12 |
| BRPI0720068A2 (pt) | 2013-12-24 |
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