AU2007328210B2 - Intermediate duration neuromuscular blocking agents and antagonists thereof - Google Patents

Intermediate duration neuromuscular blocking agents and antagonists thereof Download PDF

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Publication number
AU2007328210B2
AU2007328210B2 AU2007328210A AU2007328210A AU2007328210B2 AU 2007328210 B2 AU2007328210 B2 AU 2007328210B2 AU 2007328210 A AU2007328210 A AU 2007328210A AU 2007328210 A AU2007328210 A AU 2007328210A AU 2007328210 B2 AU2007328210 B2 AU 2007328210B2
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AU
Australia
Prior art keywords
neuromuscular
cysteine
och
glutathione
blocking agent
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AU2007328210A
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English (en)
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AU2007328210A2 (en
AU2007328210A1 (en
Inventor
John J. Savarese
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Cornell Research Foundation Inc
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Cornell Research Foundation Inc
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Publication of AU2007328210A2 publication Critical patent/AU2007328210A2/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2007328210A 2006-12-06 2007-12-05 Intermediate duration neuromuscular blocking agents and antagonists thereof Active AU2007328210B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87313206P 2006-12-06 2006-12-06
US60/873,132 2006-12-06
PCT/US2007/024914 WO2008070121A1 (en) 2006-12-06 2007-12-05 Intermediate duration neuromuscular blocking agents and antagonists thereof

Publications (3)

Publication Number Publication Date
AU2007328210A1 AU2007328210A1 (en) 2008-06-12
AU2007328210A2 AU2007328210A2 (en) 2011-06-09
AU2007328210B2 true AU2007328210B2 (en) 2012-11-22

Family

ID=39492558

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007328210A Active AU2007328210B2 (en) 2006-12-06 2007-12-05 Intermediate duration neuromuscular blocking agents and antagonists thereof

Country Status (8)

Country Link
US (1) US8148398B2 (enExample)
EP (1) EP2101772B1 (enExample)
JP (1) JP5213137B2 (enExample)
CN (1) CN101588803B (enExample)
AT (1) ATE554769T1 (enExample)
AU (1) AU2007328210B2 (enExample)
CA (1) CA2671904C (enExample)
WO (1) WO2008070121A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101588803B (zh) 2006-12-06 2013-03-20 康乃尔研究基金会有限公司 中等持续时间神经肌肉阻断剂及其拮抗剂
AU2008222298A1 (en) * 2007-03-08 2008-09-12 Chemagis Ltd. (1R,1'R)-atracurium salts separation process
EP2125743A1 (en) * 2007-03-26 2009-12-02 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
WO2008132748A1 (en) * 2007-05-01 2008-11-06 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
US8357807B2 (en) * 2007-05-01 2013-01-22 Chemagis Ltd. Isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
AU2008264802A1 (en) * 2007-06-18 2008-12-24 Chemagis Ltd. (1R,1'R)-atracurium salts separation process
CA2692636A1 (en) * 2007-07-09 2009-01-15 Chemagis Ltd. Process for producing cisatracurium and associated intermediates
EP2197848A1 (en) * 2007-10-29 2010-06-23 Chemagis Ltd. Novel r,r'-atracurium salts
EP2283005A4 (en) * 2008-05-01 2011-08-31 Chemagis Ltd CISATRACURIUM DERIVATIVES, PREPARATION AND USES THEREOF
US8592451B2 (en) 2009-03-17 2013-11-26 Cornell University Reversible nondepolarizing neuromuscular blockade agents and methods for their use
WO2011022491A1 (en) * 2009-08-19 2011-02-24 Cornell University Cysteine for physiological injection
WO2014005122A2 (en) 2012-06-29 2014-01-03 Savarese John J Asymmetrical reversible neuromuscular blocking agents of ultra-short, short, or intermediate duration
WO2014210369A2 (en) * 2013-06-28 2014-12-31 Cornell University Reversal of cysteine-inactivated neuromuscular blocking drugs with combinations of reversal agents
CN108375644B (zh) * 2016-12-07 2021-11-30 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂中间体的分析方法
CN110776481B (zh) 2018-07-24 2023-06-16 四川大学华西医院 一类双阳离子化合物及其制备方法和用途
CN108727248B (zh) 2018-07-25 2021-05-25 四川大学华西医院 一类双季铵化合物及其制备方法和用途
TW202128628A (zh) * 2019-12-11 2021-08-01 大陸商江蘇恆瑞醫藥股份有限公司 神經肌肉阻滯劑及其製備方法
US20230381192A1 (en) 2020-10-17 2023-11-30 Cornell University Methods for controlling and predicting recovery after nmba administration

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005041960A2 (en) * 2003-10-28 2005-05-12 Cornell Research Foundation, Inc. Neuromuscular blocking agents and antagonists thereof

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3004031A (en) 1958-07-03 1961-10-10 Allen & Hauburys Ltd Diquaternary salts of papaverino esters
US4036959A (en) * 1974-10-29 1977-07-19 Millmaster Onyx Corporation Microbiocidal capped polymers
AU506657B2 (en) * 1975-12-10 1980-01-17 Wellcome Foundation Limited, The Isoquinoline derivatives
US4039682A (en) * 1976-03-29 1977-08-02 Baxter Travenol Laboratories, Inc. Method and composition for relief of back pain
NL7808067A (nl) * 1977-08-01 1979-02-05 Massachusetts Gen Hospital Werkwijze voor het bereiden van een middel dat zenuw- spieren blokkeert.
US4192877A (en) * 1977-08-01 1980-03-11 Massachusetts General Hospital Neuromuscular blocking agents
US4235906A (en) * 1978-07-21 1980-11-25 Massachusetts General Hospital Bis-isoquinolinium compounds, compositions and methods of use
ATE921T1 (de) 1978-09-05 1982-05-15 Akzo N.V. Saeureadditionssalze von 2-beta, 16-beta-bis-piperidino-an drostan-16-beta-monoquaternaeren ammoniumderivaten und diese enthaltende pharmazeutische zusammensetzungen.
US4491665A (en) * 1979-10-19 1985-01-01 Burroughs Wellcome Co. Method of preparing isomers of bis isoquinolinium compounds
US4727146A (en) * 1980-07-03 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Synthesis of chiral 1-benzyl-1,2,3,4-tetra-hydroisoquinolines by asymmetric reduction
US4556712A (en) * 1981-05-20 1985-12-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Preparation and racemization of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines
US4701460A (en) * 1980-12-17 1987-10-20 Burroughs Wellcome Co. Long duration neuromuscular blocking agents
GR79603B (enExample) * 1982-07-24 1984-10-31 Pfizer
BG38182A1 (en) * 1983-06-21 1985-11-15 Ivanova Tocolytic means
GB8418303D0 (en) * 1984-07-18 1984-08-22 Wellcome Found Compounds
DE3436179A1 (de) * 1984-10-03 1986-04-10 Merck Patent Gmbh, 6100 Darmstadt Verfahren zur herstellung optisch aktiver amine
GB8518634D0 (en) * 1985-07-23 1985-08-29 Smithkline Beckman Corp Chemical compounds
US5453510A (en) * 1990-07-13 1995-09-26 Burroughs Wellcome Co. Neuromuscular blocking agents
DE4135710A1 (de) * 1991-10-30 1993-05-06 Basf Ag, 6700 Ludwigshafen, De Cyclische ammoniumverbindungen und ihre verwendung als glanzmittel fuer waessrig-saure galvanische nickelbaeder
US5240939A (en) * 1991-10-31 1993-08-31 Anaquest, Inc. Nitrogen bridge tetrahydroisoquinolines
US5739170A (en) * 1992-09-11 1998-04-14 The Regents Of The University Of California Inhibitors of metazoan parasite proteases
US5684154A (en) * 1996-02-16 1997-11-04 Abbott Laboratories Process for the preparation and isolation of atracurium besylate
EP1526130A1 (en) * 1997-03-25 2005-04-27 Avera Pharmaceuticals, Inc. Substituted isoquinolines as ultra short acting neuromuscular blockers
EP0971743B1 (de) * 1997-04-18 2006-07-12 Fritz Stanislaus Stabilisiertes arzneimittel enthaltend cysteinylderivate
US7897598B2 (en) * 1998-06-09 2011-03-01 Alexandros Makriyannis Inhibitors of the anandamide transporter
US6562836B1 (en) * 1999-05-24 2003-05-13 Queen's University Of Kingston Methods and compounds for inhibiting amyloid deposits
DE60035613T2 (de) * 1999-12-21 2008-04-10 Kao Corp. Topische,kosmetische und pharmazeutische Mittel,enthaltend spezifische alkoxylierte Diester der Fumarsäure
DE10000577A1 (de) * 2000-01-10 2001-07-26 Fumapharm Ag Muri Verwendung von Fumarsäurederivaten zur Behandlung mitochondrialer Krankheiten
US7763263B2 (en) * 2000-03-30 2010-07-27 Kao Corporation Skin external agents and drugs
US20040180925A1 (en) * 2000-12-27 2004-09-16 Kenji Matsuno Dipeptidylpeptidase-IV inhibitor
DE10101307A1 (de) * 2001-01-12 2002-08-01 Fumapharm Ag Muri Fumarsäurederivate als NF-kappaB-Inhibitor
CA2776023A1 (en) * 2001-01-12 2002-07-18 Fumapharm Ag Fumaric acid amides
TWI320039B (en) * 2001-09-21 2010-02-01 Lactam-containing compounds and derivatives thereof as factor xa inhibitors
JP4463206B2 (ja) * 2003-08-12 2010-05-19 日本臓器製薬株式会社 グリチルリチン高濃度製剤
US8197808B2 (en) * 2005-12-27 2012-06-12 Ramot At Tel-Aviv University Ltd. Stable enzymatic preparations and methods of use thereof
CN101588803B (zh) 2006-12-06 2013-03-20 康乃尔研究基金会有限公司 中等持续时间神经肌肉阻断剂及其拮抗剂
US8592451B2 (en) * 2009-03-17 2013-11-26 Cornell University Reversible nondepolarizing neuromuscular blockade agents and methods for their use
WO2011022491A1 (en) * 2009-08-19 2011-02-24 Cornell University Cysteine for physiological injection

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005041960A2 (en) * 2003-10-28 2005-05-12 Cornell Research Foundation, Inc. Neuromuscular blocking agents and antagonists thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Boros, E. E. et al., Journal of Medicinal Chemistry, 1999, vol. 42, pages 206-209 *
Boros, E. E. et al., Journal of Medicinal Chemistry, 2003, vol. 46, pages 2502-2515 *

Also Published As

Publication number Publication date
AU2007328210A2 (en) 2011-06-09
CA2671904C (en) 2012-07-03
AU2007328210A1 (en) 2008-06-12
WO2008070121A1 (en) 2008-06-12
CN101588803A (zh) 2009-11-25
US8148398B2 (en) 2012-04-03
EP2101772B1 (en) 2012-04-25
JP2010511715A (ja) 2010-04-15
JP5213137B2 (ja) 2013-06-19
EP2101772A1 (en) 2009-09-23
CN101588803B (zh) 2013-03-20
EP2101772A4 (en) 2010-12-01
CA2671904A1 (en) 2008-06-12
US20080139482A1 (en) 2008-06-12
ATE554769T1 (de) 2012-05-15

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