AU2007276835B2 - Vaccine immunotherapy - Google Patents
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- AU2007276835B2 AU2007276835B2 AU2007276835A AU2007276835A AU2007276835B2 AU 2007276835 B2 AU2007276835 B2 AU 2007276835B2 AU 2007276835 A AU2007276835 A AU 2007276835A AU 2007276835 A AU2007276835 A AU 2007276835A AU 2007276835 B2 AU2007276835 B2 AU 2007276835B2
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/492,418 US20070025958A1 (en) | 2000-10-27 | 2006-07-25 | Vaccine immunotherapy |
| US11/492,418 | 2006-07-25 | ||
| PCT/US2007/074156 WO2008014220A2 (en) | 2006-07-25 | 2007-07-24 | Vaccine immunotherapy |
Publications (2)
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| AU2007276835A1 AU2007276835A1 (en) | 2008-01-31 |
| AU2007276835B2 true AU2007276835B2 (en) | 2013-03-28 |
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| Application Number | Title | Priority Date | Filing Date |
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| AU2007276835A Ceased AU2007276835B2 (en) | 2006-07-25 | 2007-07-24 | Vaccine immunotherapy |
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| US (3) | US20070025958A1 (enExample) |
| EP (2) | EP2684569A1 (enExample) |
| JP (4) | JP2009544724A (enExample) |
| AU (1) | AU2007276835B2 (enExample) |
| CA (1) | CA2694428C (enExample) |
| MX (1) | MX2009000934A (enExample) |
| WO (1) | WO2008014220A2 (enExample) |
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|---|---|---|---|---|
| US20070025958A1 (en) * | 2000-10-27 | 2007-02-01 | Hadden John W | Vaccine immunotherapy |
| US20070154399A1 (en) * | 2000-10-27 | 2007-07-05 | Hadden John W | Immunotherapy for immune suppressed patients |
| AU2002232560A1 (en) | 2000-10-27 | 2002-05-06 | Immuno-Rx, Inc | Vaccine immunotherapy for immune suppressed patients |
| DK2234642T3 (en) | 2007-11-28 | 2018-01-08 | Irx Therapeutics Inc | PROCEDURE FOR INCREASING AN IMMUNOLOGICAL EFFECT |
| EP2276850B9 (en) * | 2008-04-14 | 2013-10-30 | IRX Therapeutics, Inc. | Irx-2 modified manufacturing process |
| US9695397B2 (en) | 2008-10-01 | 2017-07-04 | Immunovative Therapies Ltd. | Th1 vaccination priming for active immunotherapy |
| AU2009251277A1 (en) * | 2008-05-29 | 2009-12-03 | Irx Therapeutics, Inc. | Mechanism of action of primary cell derived biologic |
| EP2429585B1 (en) * | 2009-05-15 | 2018-04-18 | IRX Therapeutics, Inc. | Vaccine immunotherapy |
| AU2013203561B2 (en) * | 2009-05-15 | 2015-11-26 | Irx Therapeutics, Inc. | Vaccine immunotherapy |
| EP2498795B1 (en) | 2009-10-12 | 2016-12-07 | The United States Of America, As Represented By The Secretary, Department of Health and Human Services | Granulysin in immunotherapy |
| CN103097543A (zh) | 2009-12-08 | 2013-05-08 | 伊尔克斯治疗有限公司 | 逆转朗格汉斯细胞免疫抑制的方法 |
| WO2012021609A2 (en) * | 2010-08-12 | 2012-02-16 | Ulrik Mouritzen | Neoadjuvant treatment of cancer with proleukin |
| WO2012037551A2 (en) * | 2010-09-17 | 2012-03-22 | Irx Therapeutics, Inc. | Primary cell-derived biologic and wt1 synthetic long peptide vaccine |
| US20150284444A1 (en) * | 2012-02-16 | 2015-10-08 | Masami Watanabe | Pharmaceutical composition for cancer treatment including fusion protein |
| CN104122710B (zh) * | 2013-04-27 | 2017-08-08 | 北京京东方光电科技有限公司 | 一种显示面板及其制造方法 |
| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| WO2018161038A1 (en) * | 2017-03-03 | 2018-09-07 | Obsidian Therapeutics, Inc. | Il12 compositions and methods for immunotherapy |
| US11464798B2 (en) | 2017-05-11 | 2022-10-11 | Theralase Technologies Inc. | Vaccine containing cancer cells inactivated by photodynamic treatment with metal-based coordination complexes, and immunotherapy method using same |
| CN110101843A (zh) * | 2018-02-01 | 2019-08-09 | 北京科诺科服生物科技有限公司 | 一种抗肿瘤蛋白质及其应用 |
| WO2020073044A1 (en) * | 2018-10-05 | 2020-04-09 | Czerniecki Brian J | Combination therapy for treating cancer |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6977072B2 (en) * | 2000-10-27 | 2005-12-20 | Irx Therapeutics, Inc. | Vaccine immunotherapy for immune suppressed patients |
Family Cites Families (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2160326B1 (enExample) * | 1971-11-19 | 1975-02-07 | Anvar | |
| US4079127A (en) * | 1976-10-28 | 1978-03-14 | Board Of Regents Of The University Of Texas | Thymosin alpha 1 |
| US4116951A (en) * | 1977-04-22 | 1978-09-26 | Hoffmann-La Roche Inc. | [Asn2 ]-thymosin α1 and analogs thereof |
| US4148788A (en) * | 1978-01-23 | 1979-04-10 | Hoffmann-La Roche Inc. | Synthesis of thymosin α1 |
| DE2919592A1 (de) * | 1979-05-15 | 1981-01-15 | Max Planck Gesellschaft | Verfahren zur herstellung von thymosin- alpha 1 und derivaten davon |
| US4470926A (en) * | 1980-01-18 | 1984-09-11 | Max-Planck-Gesellschaft zur F/o/ rderung der Wissenschaften e.V. | Medicaments containing thymosin alpha 1 fragments and having an immunostimulant action, and fragments of thymosin alpha 1 |
| DE3100974A1 (de) * | 1980-01-18 | 1982-01-21 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Thymosin(alpha)(pfeil abwaerts)1(pfeil abwaerts)-fragmente enthaltende arzneimittel mit immunregulierender wirkung, und thymosin(alpha)(pfeil abwaerts)1(pfeil abwaerts)-fragmente |
| US4612365A (en) * | 1980-03-25 | 1986-09-16 | Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften | Medicaments containing alpha 1-thymosin and having an immuno regulatory action and alpha 1-thymosin fragments |
| US4293455A (en) * | 1980-04-07 | 1981-10-06 | Rockefeller University | N.sup.α -Desacetylthymosinα1 and process |
| GR74132B (enExample) | 1980-05-22 | 1984-06-06 | Deutsches Krebsforsch | |
| US4390623A (en) * | 1980-10-02 | 1983-06-28 | Hooper Trading Company | Serum-free and mitogen-free T-cell growth factor and process for making same |
| US4475196A (en) * | 1981-03-06 | 1984-10-02 | Zor Clair G | Instrument for locating faults in aircraft passenger reading light and attendant call control system |
| US4448879A (en) * | 1981-03-26 | 1984-05-15 | Hooper Trading Company | High yield process for in vitro production of serum-free and mitogen-free interleukin-2 |
| US4464355A (en) * | 1981-03-26 | 1984-08-07 | Hooper Trading Co. | Serum-free and mitogen-free T-cell growth factor and process for making same |
| US4447233A (en) * | 1981-04-10 | 1984-05-08 | Parker-Hannifin Corporation | Medication infusion pump |
| US4406830A (en) * | 1981-04-17 | 1983-09-27 | Shanksville Corporation, N.V. | Regulatory glycoprotein for immune response and the use thereof in the production of T-cell growth factor |
| DE3120912A1 (de) * | 1981-05-26 | 1982-12-16 | Hoechst Ag, 6000 Frankfurt | Verfahren zur herstellung von p-nitrophenetol |
| US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
| US4738927A (en) | 1982-03-31 | 1988-04-19 | Ajinomoto Co. Inc. | Gene coded for interleukin-2 polypeptide, recombinant DNA carrying the said gene, a living cell line possessing the recombinant DNA, and method for producing interleukin-2 using the said cell |
| US4447224A (en) * | 1982-09-20 | 1984-05-08 | Infusaid Corporation | Variable flow implantable infusion apparatus |
| US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
| US4504415A (en) * | 1983-04-04 | 1985-03-12 | Hoffman-La Roche Inc. | Synthesis of thymosin α1 and desacetyl thymosin α1 |
| US4486194A (en) | 1983-06-08 | 1984-12-04 | James Ferrara | Therapeutic device for administering medicaments through the skin |
| US4614731A (en) * | 1983-09-15 | 1986-09-30 | Hoffmann-La Roche Inc. | Peptide having immunopotentiating activity similar to thymosin alpha1 |
| US4659694A (en) * | 1983-10-27 | 1987-04-21 | Hoffmann-La Roche Inc. | Prothymosin alpha |
| US4716148A (en) * | 1984-08-13 | 1987-12-29 | Hoffman-La Roche Inc. | Prothymosin alpha |
| US5100664A (en) * | 1985-09-20 | 1992-03-31 | Cetus Corporation | Human IL-2 as a vaccine adjuvant |
| US5643565A (en) * | 1985-09-20 | 1997-07-01 | Chiron Corporation | Human IL-2 as a vaccine adjuvant |
| US5503841A (en) * | 1985-09-20 | 1996-04-02 | Cetus Oncology Corporation | Human IL-2 as a vaccine adjuvant |
| US5098702A (en) * | 1986-04-09 | 1992-03-24 | Cetus Corporation | Combination therapy using interleukin-2 and tumor necrosis factor |
| WO1987006830A1 (en) | 1986-05-09 | 1987-11-19 | Sloan-Kettering Institute For Cancer Research | Lipopolysaccharide and natural factor compositions for anti-tumor therapy and method of treatment |
| US4992367A (en) | 1986-05-12 | 1991-02-12 | Hoffmann-La Roche Inc. | Enhanced expression of human interleukin-2 in mammalian cells |
| US4959217A (en) | 1986-05-22 | 1990-09-25 | Syntex (U.S.A.) Inc. | Delayed/sustained release of macromolecules |
| US4925678A (en) * | 1987-04-01 | 1990-05-15 | Ranney David F | Endothelial envelopment drug carriers |
| US5080646A (en) | 1988-10-03 | 1992-01-14 | Alza Corporation | Membrane for electrotransport transdermal drug delivery |
| US5376369A (en) * | 1987-11-03 | 1994-12-27 | Syntex (U.S.A.) Inc. | Vaccine adjuvant |
| SE8801426D0 (sv) | 1988-04-15 | 1988-04-15 | Ulf Rothman | Forfarande och medel for blodbehandling |
| IL92382A (en) * | 1988-11-23 | 1994-12-29 | Univ Michigan | Use of a ligand specific for CD28 in the manufacture of medicament |
| US6534055B1 (en) * | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US5167616A (en) * | 1989-12-14 | 1992-12-01 | Alza Corporation | Iontophoretic delivery method |
| IT1238231B (it) | 1989-12-18 | 1993-07-12 | Consiglio Nazionale Ricerche | Impiego di immunomodulanti come agenti sinergici di chemioterapici nella terapia dei tumori |
| US5225182A (en) | 1991-10-31 | 1993-07-06 | Sharma Yash P | Vectored drug delivery system using a cephaloplastin linking agent and a methed of using the system |
| DE69324671D1 (de) * | 1992-02-10 | 1999-06-02 | Interferon Sciences Inc | Verbesserte alpha-interferon-zusammensetzung und verfahren zu ihrer herstellung aus leukocyten des menschlichen peripheren blute |
| CA2139756A1 (en) * | 1992-07-08 | 1994-01-20 | Eric M. Bonnem | Use of gm-csf as a vaccine adjuvant |
| CN1094310A (zh) | 1992-12-15 | 1994-11-02 | 托马斯·C·梅里根 | 人体免疫缺陷性病毒感染用组合式化学疗法 |
| US5747024A (en) * | 1993-03-08 | 1998-05-05 | Immunex Corporation | Vaccine adjuvant comprising interleukin-15 |
| JPH08511166A (ja) | 1993-06-04 | 1996-11-26 | アメリカ合衆国 | T細胞の増殖を選択的に刺激する方法 |
| DE69434475T2 (de) * | 1993-08-11 | 2006-05-18 | Jenner Technologies, Tiburon | Impfstoff gegen prostatakrebs |
| CN1044781C (zh) | 1994-02-05 | 1999-08-25 | 丹东市生物制品免疫技术应用研究中心 | 复方免疫抗生素 |
| DE4412794A1 (de) * | 1994-04-14 | 1995-12-14 | Univ Ludwigs Albert | Verfahren zur Herstellung von dendritischen Zellen, so erhaltene Zellen und Behälter zur Durchführung dieses Verfahrens |
| EP0789588B1 (en) | 1994-11-17 | 2005-01-19 | University Of South Florida | Method for making a medicament for treating secondary immunodeficiency |
| US5632983A (en) | 1994-11-17 | 1997-05-27 | University Of South Florida | Method for treating secondary immunodeficiency |
| DE69628921T2 (de) | 1995-05-04 | 2004-04-22 | The Government Of The United States Of America As Represented By The Secretary Of The Navy | Verfahren zur modulation der t-zell-überlebensrate durch von bcl-xl protein-spiegels |
| US5788963A (en) * | 1995-07-31 | 1998-08-04 | Pacific Northwest Cancer Foundation | Isolation and/or preservation of dendritic cells for prostate cancer immunotherapy |
| AP964A (en) | 1996-02-21 | 2001-05-11 | Julianna Lisziewicz | Methods and compositions for protective and therapeutic genetic immunisation. |
| US5849589A (en) * | 1996-03-11 | 1998-12-15 | Duke University | Culturing monocytes with IL-4, TNF-α and GM-CSF TO induce differentiation to dendric cells |
| US6017527A (en) * | 1996-07-10 | 2000-01-25 | Immunex Corporation | Activated dendritic cells and methods for their activation |
| US5849307A (en) * | 1997-03-26 | 1998-12-15 | The Picower Institute For Medical Research | Vaccine adjuvant |
| EP1027453A4 (en) * | 1997-10-17 | 2004-12-01 | Univ South Florida | METHOD FOR DIAGNOSIS AND MONITORING OF CELLULAR IMMUNE FUNCTIONS |
| ATE428769T1 (de) * | 1997-10-27 | 2009-05-15 | Univ Rockefeller | Methode und zusammensetzung zur herstellung von reifen dendritischen zellen |
| PT1053017E (pt) | 1998-02-12 | 2004-12-31 | Wyeth Corp | Vacinas compreendendo interleucina-12 e antigenio de virus herpes simplex |
| US20050124645A1 (en) * | 1998-04-20 | 2005-06-09 | Finkel Terri H. | Methods and compositions for increasing CD4lymphocyte immune responsiveness |
| EP0974357A1 (en) | 1998-07-16 | 2000-01-26 | Schering-Plough | Chemokines as adjuvants of immune response |
| IL125608A0 (en) | 1998-07-30 | 1999-03-12 | Yeda Res & Dev | Tumor associated antigen peptides and use of same as anti-tumor vaccines |
| GB9827103D0 (en) | 1998-12-10 | 1999-02-03 | Onyvax Ltd | New cancer treatments |
| US6017537A (en) * | 1998-12-18 | 2000-01-25 | Connaught Laboratories, Inc. | Formyl methionyl peptide vaccine adjuvant |
| US6350589B1 (en) * | 1998-12-31 | 2002-02-26 | Viragen, Inc. | Compositions of highly-purified natural mixtures of type I interferon derived from leukocytes and methods |
| US6667175B1 (en) | 1999-06-15 | 2003-12-23 | The Trustees Of Columbia University | Generation of antigen specific T suppressor cells for treatment of rejection |
| US7056503B2 (en) * | 1999-08-19 | 2006-06-06 | Regents Of The University Of Michigan | Enclosures housing cell-coated supports for treating tumors |
| US6406699B1 (en) | 1999-10-05 | 2002-06-18 | Gary W. Wood | Composition and method of cancer antigen immunotherapy |
| KR20030032922A (ko) * | 2000-02-24 | 2003-04-26 | 싸이트 테라피스 인코포레이티드 | 세포의 동시 자극 및 농축 |
| CN1437481A (zh) * | 2000-06-22 | 2003-08-20 | 美国氰胺公司 | 作为佐剂组合的qs-21和il-12 |
| US20060194242A1 (en) * | 2000-10-27 | 2006-08-31 | Hadden John W | Immunotherapy for immune suppressed patients |
| US7182942B2 (en) * | 2000-10-27 | 2007-02-27 | Irx Therapeutics, Inc. | Vaccine immunotherapy for immune suppressed patients |
| US20070031372A1 (en) * | 2004-08-05 | 2007-02-08 | Hadden John W | Vaccine immunotherapy for immune suppressed patients |
| US20070154399A1 (en) | 2000-10-27 | 2007-07-05 | Hadden John W | Immunotherapy for immune suppressed patients |
| US20070025958A1 (en) | 2000-10-27 | 2007-02-01 | Hadden John W | Vaccine immunotherapy |
| US7731945B2 (en) * | 2001-10-26 | 2010-06-08 | Immuno-Rx, Inc. | Immunotherapy for reversing immune suppression |
| DE10154579A1 (de) * | 2001-11-07 | 2003-05-28 | Medigene Ag | Topikale Verwendung von Cytokinen und Chemokinen zur Behandlung von viralen oder mykotischen Hauterkrankungen oder Tumorerkrankungen |
| EP1469860A4 (en) | 2002-01-24 | 2005-09-07 | Yissum Res Dev Co | ANTICANCER COMBINATION AND USE THEREOF |
| MXPA05006945A (es) * | 2002-12-26 | 2005-12-14 | Mountain View Pharmaceuticals | Conjugados polimericos de citoquinas, quimiocinas, factores de crecimiento, hormonas polipeptidicas y sus antagonistas con actividad conservada de union al receptor. |
| CN1802174A (zh) * | 2003-04-15 | 2006-07-12 | 圣诺菲·帕斯图尔有限公司 | 用于预防和/或治疗癌症的肿瘤抗原bfa5 |
| US6896879B2 (en) * | 2003-07-03 | 2005-05-24 | Cel-Sci Corporation | Method of pre-sensitizing cancer prior to treatment with radiation and/or chemotherapy and a novel cytokine mixture |
| US20070196335A1 (en) | 2004-02-09 | 2007-08-23 | The Johns Hopkins University | Immune Modulation By Regulating Expression Of The "Minor" Gene In Immune Dendritic Cells |
| GB0409799D0 (en) * | 2004-04-30 | 2004-06-09 | Isis Innovation | Method of generating improved immune response |
| CN101005760A (zh) | 2004-06-04 | 2007-07-25 | 塞尔-赛公司 | 改变cd4/cd8和进入肿瘤的单核细胞浸润液的方法 |
| WO2005123120A1 (en) | 2004-06-16 | 2005-12-29 | Smart Drug Systems Inc. | Sustained release vaccine composition |
| US20060140983A1 (en) | 2004-10-25 | 2006-06-29 | Baylor Research Institute | Dendritic cells loaded with heat shocked melanoma cell bodies |
| US20070065415A1 (en) | 2005-09-16 | 2007-03-22 | Kleinsek Donald A | Compositions and methods for the augmentation and repair of defects in tissue |
| AU2006292203A1 (en) | 2005-09-21 | 2007-03-29 | Dask Technologies, Llc | Methods and compositions for organ and tissue functionality |
| KR20220113543A (ko) | 2005-12-08 | 2022-08-12 | 노쓰웨스트 바이오써라퓨틱스, 인크. | 미성숙 단핵구성 수지상 세포의 활성화를 유도하기 위한 조성물 및 방법 |
| US20070259330A1 (en) * | 2006-05-04 | 2007-11-08 | Ge Healthcare Bio-Sciences Ab | Separation of cells |
| US20090181078A1 (en) * | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| US8802098B2 (en) | 2007-04-25 | 2014-08-12 | Immurx, Inc. | Methods of promoting antitumor immunity by administering CD40 agonists and alpha-galactosyl ceramide |
| CA2691539C (en) * | 2007-06-21 | 2014-08-26 | Angelica Therapeutics, Inc. | Modified toxins |
| DK2234642T3 (en) * | 2007-11-28 | 2018-01-08 | Irx Therapeutics Inc | PROCEDURE FOR INCREASING AN IMMUNOLOGICAL EFFECT |
| EP2276850B9 (en) | 2008-04-14 | 2013-10-30 | IRX Therapeutics, Inc. | Irx-2 modified manufacturing process |
| AU2009251277A1 (en) | 2008-05-29 | 2009-12-03 | Irx Therapeutics, Inc. | Mechanism of action of primary cell derived biologic |
| EP2429585B1 (en) | 2009-05-15 | 2018-04-18 | IRX Therapeutics, Inc. | Vaccine immunotherapy |
| CN103097543A (zh) * | 2009-12-08 | 2013-05-08 | 伊尔克斯治疗有限公司 | 逆转朗格汉斯细胞免疫抑制的方法 |
| WO2012037551A2 (en) | 2010-09-17 | 2012-03-22 | Irx Therapeutics, Inc. | Primary cell-derived biologic and wt1 synthetic long peptide vaccine |
| US20130243423A1 (en) * | 2011-07-26 | 2013-09-19 | Ziqiang He | Ethernet hub and method of use |
-
2006
- 2006-07-25 US US11/492,418 patent/US20070025958A1/en not_active Abandoned
-
2007
- 2007-07-24 WO PCT/US2007/074156 patent/WO2008014220A2/en not_active Ceased
- 2007-07-24 JP JP2009521935A patent/JP2009544724A/ja active Pending
- 2007-07-24 CA CA2694428A patent/CA2694428C/en active Active
- 2007-07-24 MX MX2009000934A patent/MX2009000934A/es not_active Application Discontinuation
- 2007-07-24 EP EP13188131.0A patent/EP2684569A1/en not_active Withdrawn
- 2007-07-24 EP EP07799769A patent/EP2056861A4/en not_active Withdrawn
- 2007-07-24 US US12/374,732 patent/US9492517B2/en not_active Expired - Fee Related
- 2007-07-24 AU AU2007276835A patent/AU2007276835B2/en not_active Ceased
-
2013
- 2013-07-04 JP JP2013140691A patent/JP2013189480A/ja not_active Withdrawn
- 2013-07-12 US US13/940,635 patent/US9492519B2/en not_active Expired - Fee Related
-
2015
- 2015-11-12 JP JP2015222533A patent/JP6162778B2/ja not_active Expired - Fee Related
-
2017
- 2017-06-15 JP JP2017117390A patent/JP2017155059A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6977072B2 (en) * | 2000-10-27 | 2005-12-20 | Irx Therapeutics, Inc. | Vaccine immunotherapy for immune suppressed patients |
Non-Patent Citations (2)
| Title |
|---|
| Meneses et al, Arch. Path Lab Med. (1998), Vol 122 pages 447-454 * |
| Verastegui E, et al Int J Immunopharmacol. (1997), Vol 19, No:(11-12) pages 619-27 * |
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| EP2056861A2 (en) | 2009-05-13 |
| JP2013189480A (ja) | 2013-09-26 |
| JP2016029100A (ja) | 2016-03-03 |
| JP2017155059A (ja) | 2017-09-07 |
| WO2008014220A3 (en) | 2008-05-02 |
| US9492517B2 (en) | 2016-11-15 |
| MX2009000934A (es) | 2009-07-29 |
| US9492519B2 (en) | 2016-11-15 |
| CA2694428C (en) | 2018-06-12 |
| EP2056861A4 (en) | 2012-04-25 |
| US20140030217A1 (en) | 2014-01-30 |
| JP6162778B2 (ja) | 2017-07-12 |
| CA2694428A1 (en) | 2008-01-31 |
| JP2009544724A (ja) | 2009-12-17 |
| EP2684569A1 (en) | 2014-01-15 |
| AU2007276835A1 (en) | 2008-01-31 |
| US20100047205A1 (en) | 2010-02-25 |
| WO2008014220A2 (en) | 2008-01-31 |
| US20070025958A1 (en) | 2007-02-01 |
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