MX2009000934A - Inmunoterapia de vacuna. - Google Patents
Inmunoterapia de vacuna.Info
- Publication number
- MX2009000934A MX2009000934A MX2009000934A MX2009000934A MX2009000934A MX 2009000934 A MX2009000934 A MX 2009000934A MX 2009000934 A MX2009000934 A MX 2009000934A MX 2009000934 A MX2009000934 A MX 2009000934A MX 2009000934 A MX2009000934 A MX 2009000934A
- Authority
- MX
- Mexico
- Prior art keywords
- antigen
- producing
- patient
- lesion
- methods
- Prior art date
Links
- 238000009169 immunotherapy Methods 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 9
- 102000036639 antigens Human genes 0.000 abstract 9
- 108091007433 antigens Proteins 0.000 abstract 9
- 239000000203 mixture Substances 0.000 abstract 7
- 201000010099 disease Diseases 0.000 abstract 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 5
- 230000003902 lesion Effects 0.000 abstract 5
- 108090000695 Cytokines Proteins 0.000 abstract 3
- 102000004127 Cytokines Human genes 0.000 abstract 3
- 230000028993 immune response Effects 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 108010002352 Interleukin-1 Proteins 0.000 abstract 1
- 108010002350 Interleukin-2 Proteins 0.000 abstract 1
- 108090001005 Interleukin-6 Proteins 0.000 abstract 1
- 108090001007 Interleukin-8 Proteins 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 230000002085 persistent effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2006—IL-1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/204—IL-6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2053—IL-8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/217—IFN-gamma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
- A61K39/001195—Prostate specific membrane antigen [PSMA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Reproductive Health (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- AIDS & HIV (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
Abstract
La presente invención proporciona composiciones y métodos de inmunoterapia para tratar cáncer u otras enfermedades o lesiones que producen antígeno. De acuerdo con una modalidad de la invención, se proporciona una composición para inducir una respuesta inmune a por lo menos una antígeno en un paciente que tiene una enfermedad o lesión que produce antígeno, la composición que comprende una cantidad efectiva de una mezcla de citoquinas, de preferencia que comprende IL-1, IL-2, IL-6, IL-8, IFN-? (gamma) y TNF-a- (alfa). La mezcla de citoquinas actúa como un adyuvante con el antígeno asociado con la enfermedad o lesión que produce antígeno para aumentar la respuesta inmune del paciente al antígeno. Por lo tanto también se proporcionan métodos para inducir una respuesta inmune a por lo menos un antígeno en un paciente que tiene una enfermedad o lesión que produce antígeno utilizando la mezcla de citoquinas de la invención. Las composiciones y métodos son útiles en el tratamiento de enfermedades que producen antígeno tales como cáncer, enfermedades infecciosas o lesiones persistentes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/492,418 US20070025958A1 (en) | 2000-10-27 | 2006-07-25 | Vaccine immunotherapy |
PCT/US2007/074156 WO2008014220A2 (en) | 2006-07-25 | 2007-07-24 | Vaccine immunotherapy |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009000934A true MX2009000934A (es) | 2009-07-29 |
Family
ID=38982244
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009000934A MX2009000934A (es) | 2006-07-25 | 2007-07-24 | Inmunoterapia de vacuna. |
Country Status (7)
Country | Link |
---|---|
US (3) | US20070025958A1 (es) |
EP (2) | EP2056861A4 (es) |
JP (4) | JP2009544724A (es) |
AU (1) | AU2007276835B2 (es) |
CA (1) | CA2694428C (es) |
MX (1) | MX2009000934A (es) |
WO (1) | WO2008014220A2 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070025958A1 (en) | 2000-10-27 | 2007-02-01 | Hadden John W | Vaccine immunotherapy |
WO2002034119A2 (en) | 2000-10-27 | 2002-05-02 | Immuno-Rx, Inc. | Vaccine immunotherapy for immune suppressed patients |
US20070154399A1 (en) * | 2000-10-27 | 2007-07-05 | Hadden John W | Immunotherapy for immune suppressed patients |
CA2706445C (en) | 2007-11-28 | 2019-07-23 | Irx Therapeutics, Inc. | Production of apoptosis-resistant t-lymphocytes for use in cancer therapy |
JP5647601B2 (ja) * | 2008-04-14 | 2015-01-07 | アイ アール エックス セーラピューティクス, インコーポレイテッド | Irx−2の改良された作製方法 |
US9695397B2 (en) * | 2008-10-01 | 2017-07-04 | Immunovative Therapies Ltd. | Th1 vaccination priming for active immunotherapy |
AU2009251277A1 (en) * | 2008-05-29 | 2009-12-03 | Irx Therapeutics, Inc. | Mechanism of action of primary cell derived biologic |
AU2013203561B2 (en) * | 2009-05-15 | 2015-11-26 | Irx Therapeutics, Inc. | Vaccine immunotherapy |
US9539320B2 (en) * | 2009-05-15 | 2017-01-10 | Irx Therapeutics, Inc. | Vaccine immunotherapy |
AU2010307075B2 (en) | 2009-10-12 | 2014-12-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Granulysin in immunotherapy |
CN107050430B (zh) | 2009-12-08 | 2021-10-15 | 伊尔克斯治疗有限公司 | 逆转朗格汉斯细胞免疫抑制的方法 |
WO2012021609A2 (en) * | 2010-08-12 | 2012-02-16 | Ulrik Mouritzen | Neoadjuvant treatment of cancer with proleukin |
WO2012037551A2 (en) * | 2010-09-17 | 2012-03-22 | Irx Therapeutics, Inc. | Primary cell-derived biologic and wt1 synthetic long peptide vaccine |
JP6124460B2 (ja) * | 2012-02-16 | 2017-05-10 | 国立大学法人 岡山大学 | 融合タンパク質を含む癌治療用医薬組成物 |
CN104122710B (zh) * | 2013-04-27 | 2017-08-08 | 北京京东方光电科技有限公司 | 一种显示面板及其制造方法 |
US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
WO2018161038A1 (en) * | 2017-03-03 | 2018-09-07 | Obsidian Therapeutics, Inc. | Il12 compositions and methods for immunotherapy |
EP3621629A4 (en) | 2017-05-11 | 2021-03-17 | Theralase Biotech Inc. | VACCINE CONTAINING CANCER CELLS INACTIVATED BY PHOTODYNAMIC TREATMENT WITH METAL-BASED COORDINATION COMPLEXES, AND IMMUNOTHERAPY METHOD USING THE LATTER |
CN110101843A (zh) * | 2018-02-01 | 2019-08-09 | 北京科诺科服生物科技有限公司 | 一种抗肿瘤蛋白质及其应用 |
WO2020073044A1 (en) * | 2018-10-05 | 2020-04-09 | Czerniecki Brian J | Combination therapy for treating cancer |
Family Cites Families (103)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2160326B1 (es) | 1971-11-19 | 1975-02-07 | Anvar | |
US4079127A (en) * | 1976-10-28 | 1978-03-14 | Board Of Regents Of The University Of Texas | Thymosin alpha 1 |
US4116951A (en) * | 1977-04-22 | 1978-09-26 | Hoffmann-La Roche Inc. | [Asn2 ]-thymosin α1 and analogs thereof |
US4148788A (en) * | 1978-01-23 | 1979-04-10 | Hoffmann-La Roche Inc. | Synthesis of thymosin α1 |
DE2919592A1 (de) * | 1979-05-15 | 1981-01-15 | Max Planck Gesellschaft | Verfahren zur herstellung von thymosin- alpha 1 und derivaten davon |
US4470926A (en) * | 1980-01-18 | 1984-09-11 | Max-Planck-Gesellschaft zur F/o/ rderung der Wissenschaften e.V. | Medicaments containing thymosin alpha 1 fragments and having an immunostimulant action, and fragments of thymosin alpha 1 |
DE3100974A1 (de) * | 1980-01-18 | 1982-01-21 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Thymosin(alpha)(pfeil abwaerts)1(pfeil abwaerts)-fragmente enthaltende arzneimittel mit immunregulierender wirkung, und thymosin(alpha)(pfeil abwaerts)1(pfeil abwaerts)-fragmente |
US4612365A (en) * | 1980-03-25 | 1986-09-16 | Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften | Medicaments containing alpha 1-thymosin and having an immuno regulatory action and alpha 1-thymosin fragments |
US4293455A (en) * | 1980-04-07 | 1981-10-06 | Rockefeller University | N.sup.α -Desacetylthymosinα1 and process |
IL62903A0 (en) | 1980-05-22 | 1981-07-31 | Deutsches Krebsforsch | Method for the production of interferon ii and stimulated clones for the carrying out of the method |
US4390623A (en) * | 1980-10-02 | 1983-06-28 | Hooper Trading Company | Serum-free and mitogen-free T-cell growth factor and process for making same |
US4475196A (en) | 1981-03-06 | 1984-10-02 | Zor Clair G | Instrument for locating faults in aircraft passenger reading light and attendant call control system |
US4464355A (en) * | 1981-03-26 | 1984-08-07 | Hooper Trading Co. | Serum-free and mitogen-free T-cell growth factor and process for making same |
US4448879A (en) * | 1981-03-26 | 1984-05-15 | Hooper Trading Company | High yield process for in vitro production of serum-free and mitogen-free interleukin-2 |
US4447233A (en) | 1981-04-10 | 1984-05-08 | Parker-Hannifin Corporation | Medication infusion pump |
US4406830A (en) * | 1981-04-17 | 1983-09-27 | Shanksville Corporation, N.V. | Regulatory glycoprotein for immune response and the use thereof in the production of T-cell growth factor |
DE3120912A1 (de) | 1981-05-26 | 1982-12-16 | Hoechst Ag, 6000 Frankfurt | Verfahren zur herstellung von p-nitrophenetol |
US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
DE3377363D1 (en) | 1982-03-31 | 1988-08-18 | Ajinomoto Kk | Gene coding for interleukin-2 polypeptide, recombinant dna carrying said gene, cell lines possessing the recombinant dna,and method for producing interleukin-2 using said cells |
US4447224A (en) | 1982-09-20 | 1984-05-08 | Infusaid Corporation | Variable flow implantable infusion apparatus |
US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
US4504415A (en) * | 1983-04-04 | 1985-03-12 | Hoffman-La Roche Inc. | Synthesis of thymosin α1 and desacetyl thymosin α1 |
US4486194A (en) | 1983-06-08 | 1984-12-04 | James Ferrara | Therapeutic device for administering medicaments through the skin |
US4614731A (en) * | 1983-09-15 | 1986-09-30 | Hoffmann-La Roche Inc. | Peptide having immunopotentiating activity similar to thymosin alpha1 |
US4659694A (en) * | 1983-10-27 | 1987-04-21 | Hoffmann-La Roche Inc. | Prothymosin alpha |
US4716148A (en) * | 1984-08-13 | 1987-12-29 | Hoffman-La Roche Inc. | Prothymosin alpha |
US5100664A (en) * | 1985-09-20 | 1992-03-31 | Cetus Corporation | Human IL-2 as a vaccine adjuvant |
US5503841A (en) * | 1985-09-20 | 1996-04-02 | Cetus Oncology Corporation | Human IL-2 as a vaccine adjuvant |
US5643565A (en) * | 1985-09-20 | 1997-07-01 | Chiron Corporation | Human IL-2 as a vaccine adjuvant |
US5098702A (en) * | 1986-04-09 | 1992-03-24 | Cetus Corporation | Combination therapy using interleukin-2 and tumor necrosis factor |
JPS63503308A (ja) | 1986-05-09 | 1988-12-02 | スローン‐ケツテリング・インステイテユート・フオー・キヤンサー・リサーチ | 抗腫瘍療法のためのリポ多糖体及び天然因子の組成物及び治療方法 |
US4992367A (en) | 1986-05-12 | 1991-02-12 | Hoffmann-La Roche Inc. | Enhanced expression of human interleukin-2 in mammalian cells |
US4959217A (en) | 1986-05-22 | 1990-09-25 | Syntex (U.S.A.) Inc. | Delayed/sustained release of macromolecules |
US4925678A (en) | 1987-04-01 | 1990-05-15 | Ranney David F | Endothelial envelopment drug carriers |
US5080646A (en) | 1988-10-03 | 1992-01-14 | Alza Corporation | Membrane for electrotransport transdermal drug delivery |
US5376369A (en) | 1987-11-03 | 1994-12-27 | Syntex (U.S.A.) Inc. | Vaccine adjuvant |
SE8801426D0 (sv) | 1988-04-15 | 1988-04-15 | Ulf Rothman | Forfarande och medel for blodbehandling |
IL92382A (en) * | 1988-11-23 | 1994-12-29 | Univ Michigan | Use of a ligand specific for CD28 in the manufacture of medicament |
US6534055B1 (en) * | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
US5167616A (en) | 1989-12-14 | 1992-12-01 | Alza Corporation | Iontophoretic delivery method |
IT1238231B (it) | 1989-12-18 | 1993-07-12 | Consiglio Nazionale Ricerche | Impiego di immunomodulanti come agenti sinergici di chemioterapici nella terapia dei tumori |
US5225182A (en) | 1991-10-31 | 1993-07-06 | Sharma Yash P | Vectored drug delivery system using a cephaloplastin linking agent and a methed of using the system |
CA2129533A1 (en) * | 1992-02-10 | 1993-08-19 | Douglas Testa | Improved alpha interferon composition and method for its production from human peripheral blood leukocytes |
WO1994001133A1 (en) * | 1992-07-08 | 1994-01-20 | Schering Corporation | Use of gm-csf as a vaccine adjuvant |
CN1094310A (zh) | 1992-12-15 | 1994-11-02 | 托马斯·C·梅里根 | 人体免疫缺陷性病毒感染用组合式化学疗法 |
US5747024A (en) * | 1993-03-08 | 1998-05-05 | Immunex Corporation | Vaccine adjuvant comprising interleukin-15 |
DK0700430T3 (da) | 1993-06-04 | 2005-08-15 | Us Navy | Fremgangsmåder til selektivt af stimulere proliferation af T-celler |
ATE303160T1 (de) | 1993-08-11 | 2005-09-15 | Jenner Technologies | Impfstoff gegen prostatakrebs |
CN1044781C (zh) | 1994-02-05 | 1999-08-25 | 丹东市生物制品免疫技术应用研究中心 | 复方免疫抗生素 |
DE4412794A1 (de) * | 1994-04-14 | 1995-12-14 | Univ Ludwigs Albert | Verfahren zur Herstellung von dendritischen Zellen, so erhaltene Zellen und Behälter zur Durchführung dieses Verfahrens |
CA2205430C (en) * | 1994-11-17 | 2001-09-04 | University Of South Florida | Method for making a medicament for treating secondary immunodeficiency |
US5632983A (en) | 1994-11-17 | 1997-05-27 | University Of South Florida | Method for treating secondary immunodeficiency |
AU5673496A (en) | 1995-05-04 | 1996-11-21 | Arch Development Corporation | Methods for modulating t cell survival by modulating bcl-xl protein level |
US5788963A (en) * | 1995-07-31 | 1998-08-04 | Pacific Northwest Cancer Foundation | Isolation and/or preservation of dendritic cells for prostate cancer immunotherapy |
EP0882134B8 (en) | 1996-02-21 | 2009-09-02 | Genetic Immunity kft. | Methods and compositions for protective and therapeutic genetic immunization |
US5849589A (en) * | 1996-03-11 | 1998-12-15 | Duke University | Culturing monocytes with IL-4, TNF-α and GM-CSF TO induce differentiation to dendric cells |
US6017527A (en) * | 1996-07-10 | 2000-01-25 | Immunex Corporation | Activated dendritic cells and methods for their activation |
US5849307A (en) * | 1997-03-26 | 1998-12-15 | The Picower Institute For Medical Research | Vaccine adjuvant |
CA2307345A1 (en) * | 1997-10-17 | 1999-04-29 | University Of South Florida | Method to diagnose and monitor cellular immune deficiencies |
ATE428769T1 (de) * | 1997-10-27 | 2009-05-15 | Univ Rockefeller | Methode und zusammensetzung zur herstellung von reifen dendritischen zellen |
DK1053017T3 (da) | 1998-02-12 | 2004-11-22 | Wyeth Corp | Vacciner omfattende interleukin-12 og herpes simplex virusantigen |
US20050124645A1 (en) * | 1998-04-20 | 2005-06-09 | Finkel Terri H. | Methods and compositions for increasing CD4lymphocyte immune responsiveness |
EP0974357A1 (en) | 1998-07-16 | 2000-01-26 | Schering-Plough | Chemokines as adjuvants of immune response |
IL125608A0 (en) | 1998-07-30 | 1999-03-12 | Yeda Res & Dev | Tumor associated antigen peptides and use of same as anti-tumor vaccines |
GB9827103D0 (en) | 1998-12-10 | 1999-02-03 | Onyvax Ltd | New cancer treatments |
US6017537A (en) | 1998-12-18 | 2000-01-25 | Connaught Laboratories, Inc. | Formyl methionyl peptide vaccine adjuvant |
US6350589B1 (en) * | 1998-12-31 | 2002-02-26 | Viragen, Inc. | Compositions of highly-purified natural mixtures of type I interferon derived from leukocytes and methods |
US6667175B1 (en) | 1999-06-15 | 2003-12-23 | The Trustees Of Columbia University | Generation of antigen specific T suppressor cells for treatment of rejection |
US7056503B2 (en) * | 1999-08-19 | 2006-06-06 | Regents Of The University Of Michigan | Enclosures housing cell-coated supports for treating tumors |
US6406699B1 (en) | 1999-10-05 | 2002-06-18 | Gary W. Wood | Composition and method of cancer antigen immunotherapy |
MXPA02008265A (es) * | 2000-02-24 | 2004-09-10 | Xcyte Therapies Inc | Concentracion y estimulacion simultanea de calulas. |
AU2001270031B2 (en) * | 2000-06-22 | 2005-11-03 | Wyeth Holdings Corporation | QS-21 and IL-12 as an adjuvant combination |
US20060194242A1 (en) * | 2000-10-27 | 2006-08-31 | Hadden John W | Immunotherapy for immune suppressed patients |
US7182942B2 (en) | 2000-10-27 | 2007-02-27 | Irx Therapeutics, Inc. | Vaccine immunotherapy for immune suppressed patients |
WO2002034119A2 (en) * | 2000-10-27 | 2002-05-02 | Immuno-Rx, Inc. | Vaccine immunotherapy for immune suppressed patients |
US20070154399A1 (en) | 2000-10-27 | 2007-07-05 | Hadden John W | Immunotherapy for immune suppressed patients |
US20070031372A1 (en) * | 2004-08-05 | 2007-02-08 | Hadden John W | Vaccine immunotherapy for immune suppressed patients |
US20070025958A1 (en) | 2000-10-27 | 2007-02-01 | Hadden John W | Vaccine immunotherapy |
WO2003035004A2 (en) * | 2001-10-26 | 2003-05-01 | Immuno-Rx, Inc. | Immunotherapy for reversing immune suppression |
DE10154579A1 (de) * | 2001-11-07 | 2003-05-28 | Medigene Ag | Topikale Verwendung von Cytokinen und Chemokinen zur Behandlung von viralen oder mykotischen Hauterkrankungen oder Tumorerkrankungen |
EP1469860A4 (en) | 2002-01-24 | 2005-09-07 | Yissum Res Dev Co | ANTICANCER COMBINATION AND USE THEREOF |
WO2004060300A2 (en) * | 2002-12-26 | 2004-07-22 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity |
AU2004230328A1 (en) | 2003-04-15 | 2004-10-28 | Sanofi Pasteur Limited | Tumor antigens BFA5 for prevention and/or treatment of cancer |
US6896879B2 (en) * | 2003-07-03 | 2005-05-24 | Cel-Sci Corporation | Method of pre-sensitizing cancer prior to treatment with radiation and/or chemotherapy and a novel cytokine mixture |
WO2005077048A2 (en) | 2004-02-09 | 2005-08-25 | The Johns Hopkins University | Immune modulation by regulating expression of the “minor” gene in immune dendritic cells |
GB0409799D0 (en) * | 2004-04-30 | 2004-06-09 | Isis Innovation | Method of generating improved immune response |
ES2553133T3 (es) | 2004-06-04 | 2015-12-04 | Cel-Sci Corporation | Método de modificación de la proporción de CD4/CD8 y del infiltrado celular mononuclear en un tumor |
JP2008502605A (ja) | 2004-06-16 | 2008-01-31 | スマート ドラッグ システムズ インコーポレイティド | 徐放性ワクチン組成物 |
EP1814981A4 (en) | 2004-10-25 | 2009-09-30 | Baylor Res Inst | HEAT-SHOCK-TREATED MELANOMA CELLS LOAD DENDRITICAL CELLS |
US20070065415A1 (en) | 2005-09-16 | 2007-03-22 | Kleinsek Donald A | Compositions and methods for the augmentation and repair of defects in tissue |
AU2006292203A1 (en) | 2005-09-21 | 2007-03-29 | Dask Technologies, Llc | Methods and compositions for organ and tissue functionality |
EP1957634A4 (en) | 2005-12-08 | 2010-01-27 | Northwest Biotherapeutics Inc | COMPOSITIONS AND METHODS FOR INDUCING ACTIVATION OF IMMATURE MONOCYTIC DENDRITIC CELLS |
US20070259330A1 (en) | 2006-05-04 | 2007-11-08 | Ge Healthcare Bio-Sciences Ab | Separation of cells |
US20090181078A1 (en) * | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
US8802098B2 (en) | 2007-04-25 | 2014-08-12 | Immurx, Inc. | Methods of promoting antitumor immunity by administering CD40 agonists and alpha-galactosyl ceramide |
EP2167528B1 (en) * | 2007-06-21 | 2018-01-10 | Angelica Therapeutics, INC. | Modified toxins |
CA2706445C (en) * | 2007-11-28 | 2019-07-23 | Irx Therapeutics, Inc. | Production of apoptosis-resistant t-lymphocytes for use in cancer therapy |
JP5647601B2 (ja) | 2008-04-14 | 2015-01-07 | アイ アール エックス セーラピューティクス, インコーポレイテッド | Irx−2の改良された作製方法 |
AU2009251277A1 (en) | 2008-05-29 | 2009-12-03 | Irx Therapeutics, Inc. | Mechanism of action of primary cell derived biologic |
US9539320B2 (en) * | 2009-05-15 | 2017-01-10 | Irx Therapeutics, Inc. | Vaccine immunotherapy |
CN107050430B (zh) * | 2009-12-08 | 2021-10-15 | 伊尔克斯治疗有限公司 | 逆转朗格汉斯细胞免疫抑制的方法 |
WO2012037551A2 (en) | 2010-09-17 | 2012-03-22 | Irx Therapeutics, Inc. | Primary cell-derived biologic and wt1 synthetic long peptide vaccine |
US20130243423A1 (en) * | 2011-07-26 | 2013-09-19 | Ziqiang He | Ethernet hub and method of use |
-
2006
- 2006-07-25 US US11/492,418 patent/US20070025958A1/en not_active Abandoned
-
2007
- 2007-07-24 MX MX2009000934A patent/MX2009000934A/es not_active Application Discontinuation
- 2007-07-24 EP EP07799769A patent/EP2056861A4/en not_active Withdrawn
- 2007-07-24 CA CA2694428A patent/CA2694428C/en active Active
- 2007-07-24 WO PCT/US2007/074156 patent/WO2008014220A2/en active Application Filing
- 2007-07-24 EP EP13188131.0A patent/EP2684569A1/en active Pending
- 2007-07-24 JP JP2009521935A patent/JP2009544724A/ja active Pending
- 2007-07-24 US US12/374,732 patent/US9492517B2/en not_active Expired - Lifetime
- 2007-07-24 AU AU2007276835A patent/AU2007276835B2/en active Active
-
2013
- 2013-07-04 JP JP2013140691A patent/JP2013189480A/ja not_active Withdrawn
- 2013-07-12 US US13/940,635 patent/US9492519B2/en not_active Expired - Lifetime
-
2015
- 2015-11-12 JP JP2015222533A patent/JP6162778B2/ja active Active
-
2017
- 2017-06-15 JP JP2017117390A patent/JP2017155059A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP2056861A2 (en) | 2009-05-13 |
US20140030217A1 (en) | 2014-01-30 |
WO2008014220A3 (en) | 2008-05-02 |
CA2694428A1 (en) | 2008-01-31 |
US9492519B2 (en) | 2016-11-15 |
EP2056861A4 (en) | 2012-04-25 |
CA2694428C (en) | 2018-06-12 |
JP6162778B2 (ja) | 2017-07-12 |
US9492517B2 (en) | 2016-11-15 |
JP2016029100A (ja) | 2016-03-03 |
EP2684569A1 (en) | 2014-01-15 |
WO2008014220A2 (en) | 2008-01-31 |
JP2009544724A (ja) | 2009-12-17 |
JP2017155059A (ja) | 2017-09-07 |
US20100047205A1 (en) | 2010-02-25 |
US20070025958A1 (en) | 2007-02-01 |
JP2013189480A (ja) | 2013-09-26 |
AU2007276835B2 (en) | 2013-03-28 |
AU2007276835A1 (en) | 2008-01-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2009000934A (es) | Inmunoterapia de vacuna. | |
NO20061912L (no) | Vaksinesammensetninger omfattende et interleukin 18 og saponin adjuvant system | |
BR112018068748A2 (pt) | composto, composição farmacêutica e de vacina, métodos para indução ou promoção de uma resposta imunológica, para tratamento de câncer, de doenças infecciosas, de distúrbios imunológicos e de doenças imunológicas e para tratamento ou prevenção de uma doença, e, uso de um composto | |
MXPA06000619A (es) | Estimulacion sinergistica del sistema inmune usando oligonucleotidos inmunoestimuladores y/o compuestos inmunomeros en conjunto con citocinas y/o agentes quimioterapeuticos o terapia de radiacion. | |
Silveira et al. | Quillaja brasiliensis saponins are less toxic than Quil A and have similar properties when used as an adjuvant for a viral antigen preparation | |
WO2007063421A3 (en) | Compositions and methods relating to treatment of cancer and infectious diseases | |
WO2007054279A3 (en) | Cyclic-dinucleotides and its conjugates as adjuvants and their uses in pharmaceutical compositions | |
MX2013004817A (es) | Enfermedad inflamatoria. | |
HK1116073A1 (en) | Bendamustine pharmaceutical compositions for lyophilisation | |
EA200601761A1 (ru) | Композиции в качестве адъювантов для усиления иммунных ответов на вакцины и способы их применения | |
WO2009072767A3 (en) | A powerful vaccine composition comprising a lipopeptide and poly i:c as an adjuvant | |
WO2004087153A3 (en) | Use of organic compounds for immunopotentiation | |
MX2008013993A (es) | Combinación adyuvante sinergistica de anticuerpo agonista de cd40/interferona tipo 1, conjugados que la contienen y uso de los mismos como un terapeutico para aumentar la inmunidad celular. | |
DK2280721T3 (da) | Indoleamin-2, 3-dioxygenasebaseret immunterapi | |
UA94036C2 (ru) | Фармацевтическая композиция бендамустина, предназначенная для лиофилизации | |
BRPI0510570A (pt) | composição de vacina | |
WO2009060281A3 (en) | Immune stimulatory oligoribonucleotide analogs containing modified oligophosphate moieties | |
WO2014205199A3 (en) | Compositions and methods for potentiating immune response, enhancing immunotherapy, and increasing vaccine potency | |
EA200801411A1 (ru) | Новые адъюванты на основе конъюгатов и производных бис-ацилоксипропилцистеина и их применения в фармацевтических композициях | |
Ahmad et al. | Prime-boost and recombinant protein vaccination strategies using Sm-p80 protects against Schistosoma mansoni infection in the mouse model to levels previously attainable only by the irradiated cercarial vaccine | |
ATE458496T1 (de) | Hiv-vakzine und anwendungsverfahren | |
AR068984A1 (es) | Proceso para la obtencion de celulas presentadoras de antigenos activados, utiles en las terapias contra el cancer y enfermedades relacionadas del sistema inmunologico | |
EP1556513A4 (en) | COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASES MEDIATED BY THE HUMANE PAPILLOMA VIRUS | |
WO2008082719A3 (en) | Combined human papillomavirus vlp/gene delivery system and use thereof as a vaccine for prophylaxis and immunotherapy of infectious diseases and tumors | |
EA200700598A1 (ru) | Противоопухолевая вакцина, способ получения противоопухолевой вакцины и способ проведения противоопухолевой иммунотерапии |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |