AU2007275073B2 - Compound that can inhibit UBC13-UEV interactions, pharmaceutical compositions and therapeutic uses - Google Patents
Compound that can inhibit UBC13-UEV interactions, pharmaceutical compositions and therapeutic uses Download PDFInfo
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- AU2007275073B2 AU2007275073B2 AU2007275073A AU2007275073A AU2007275073B2 AU 2007275073 B2 AU2007275073 B2 AU 2007275073B2 AU 2007275073 A AU2007275073 A AU 2007275073A AU 2007275073 A AU2007275073 A AU 2007275073A AU 2007275073 B2 AU2007275073 B2 AU 2007275073B2
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- substituted
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- ethyl
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- fluorophenyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
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| ESP200601933 | 2006-07-20 | ||
| ES200601933A ES2293834B1 (es) | 2006-07-20 | 2006-07-20 | Compuesto con actividad inhibidora de las interacciones ubc13-uev, composiciones farmaceuticas que lo comprenden y sus aplicaciones terapeuticas. |
| PCT/ES2007/000120 WO2008009758A1 (es) | 2006-07-20 | 2007-03-07 | Compuestos con actividad inhibidora de las interacciones ubc13-uev, composiciones farmacéuticas y aplicaciones terapéuticas |
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| US9006487B2 (en) | 2005-06-15 | 2015-04-14 | Massachusetts Institute Of Technology | Amine-containing lipids and uses thereof |
| ES2646630T3 (es) | 2008-11-07 | 2017-12-14 | Massachusetts Institute Of Technology | Lipidoides aminoalcohólicos y usos de los mismos |
| BR112012002134B8 (pt) * | 2009-07-30 | 2021-05-25 | Salvat Lab Sa | compostos inibidores de apaf-1 |
| HUE042177T2 (hu) | 2009-12-01 | 2019-06-28 | Translate Bio Inc | Szteroidszármazék mRNS szállítására humán genetikai betegségekben |
| EP2609135A4 (en) | 2010-08-26 | 2015-05-20 | Massachusetts Inst Technology | POLY (BETA AMINO ALCOHOLS), THEIR PREPARATION AND USES THEREOF |
| CN103619331A (zh) * | 2011-03-23 | 2014-03-05 | 印第安纳大学研究及科技公司 | 抗癌治疗剂 |
| US9238716B2 (en) | 2011-03-28 | 2016-01-19 | Massachusetts Institute Of Technology | Conjugated lipomers and uses thereof |
| PL3586861T3 (pl) | 2011-06-08 | 2022-05-23 | Translate Bio, Inc. | Kompozycje nanocząstek lipidowych i sposoby dostarczania mrna |
| KR102451116B1 (ko) * | 2011-10-27 | 2022-10-06 | 메사추세츠 인스티튜트 오브 테크놀로지 | 약물 캡슐화 마이크로스피어를 형성할 수 있는, ｎ-말단 상에 관능화된 아미노산 유도체 |
| US20130236504A1 (en) * | 2012-03-06 | 2013-09-12 | Medical University Of South Carolina | Delivery System for Enhancing Drug Efficacy |
| EP3536787A1 (en) | 2012-06-08 | 2019-09-11 | Translate Bio, Inc. | Nuclease resistant polynucleotides and uses thereof |
| EP2882706A1 (en) | 2012-08-13 | 2015-06-17 | Massachusetts Institute of Technology | Amine-containing lipidoids and uses thereof |
| PL3467108T3 (pl) | 2013-03-14 | 2024-09-30 | Translate Bio, Inc. | Sposoby oczyszczania informacyjnego rna |
| KR20210122917A (ko) | 2013-03-14 | 2021-10-12 | 샤이어 휴먼 지네틱 테라피즈 인크. | Cftr mrna 조성물 및 관련 방법 및 사용 |
| WO2014179562A1 (en) | 2013-05-01 | 2014-11-06 | Massachusetts Institute Of Technology | 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof |
| EA034103B1 (ru) | 2013-10-22 | 2019-12-27 | Транслейт Био, Инк. | СПОСОБ ЛЕЧЕНИЯ ФЕНИЛКЕТОНУРИИ С ПРИМЕНЕНИЕМ мРНК |
| MX2016005238A (es) | 2013-10-22 | 2016-08-12 | Shire Human Genetic Therapies | Formulaciones de lipidos para la administracion de acido ribonucleico mensajero. |
| ES2707966T3 (es) | 2013-10-22 | 2019-04-08 | Translate Bio Inc | Terapia de ARNm para la deficiencia en síntesis de argininosuccinato |
| JP6295767B2 (ja) | 2014-03-25 | 2018-03-20 | 富士通株式会社 | スイッチ装置、情報処理システムおよびスイッチ装置の制御方法 |
| PT3134506T (pt) | 2014-04-25 | 2019-10-31 | Translate Bio Inc | Métodos de purificação de rna mensageiro |
| JP6557722B2 (ja) | 2014-05-30 | 2019-08-07 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | 核酸の送達のための生分解性脂質 |
| EP3160959B1 (en) | 2014-06-24 | 2023-08-30 | Translate Bio, Inc. | Stereochemically enriched compositions for delivery of nucleic acids |
| US9840479B2 (en) | 2014-07-02 | 2017-12-12 | Massachusetts Institute Of Technology | Polyamine-fatty acid derived lipidoids and uses thereof |
| ES2949540T3 (es) | 2015-06-19 | 2023-09-29 | Massachusetts Inst Technology | 2,5-piperazinadionas sustituidas con alquenilo y su uso en composiciones para suministrar un agente a un sujeto o una célula |
| EA201991747A1 (ru) | 2017-02-27 | 2020-06-04 | Транслейт Био, Инк. | НОВАЯ КОДОН-ОПТИМИЗИРОВАННАЯ мРНК CFTR |
| MX2019013752A (es) | 2017-05-16 | 2020-07-20 | Translate Bio Inc | Tratamiento de la fibrosis quística mediante el suministro de arnm que codifica cftr optimizado en codones. |
| CA3108544A1 (en) | 2018-08-24 | 2020-02-27 | Translate Bio, Inc. | Methods for purification of messenger rna |
| MX2021005969A (es) | 2018-11-21 | 2021-09-14 | Translate Bio Inc | Tratamiento de la fibrosis quística mediante el suministro de arnm que codifica cftr nebulizado. |
| EP3983533B1 (en) * | 2019-06-14 | 2025-01-08 | Children's Hospital Medical Center | Ube2n inhibitors for use in the treatment of acute myelomonocytic leukemia (aml-m4) and/or acute monocytic leukemia (aml-m5). |
| KR20220017075A (ko) | 2020-08-04 | 2022-02-11 | 삼성전자주식회사 | 홈 화면을 복원하는 방법 및 이를 적용한 전자 장치 |
| WO2023225277A1 (en) * | 2022-05-19 | 2023-11-23 | Ohio State Innovation Foundation | Peptidyl flavor modifiers |
Citations (1)
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| DE4234295A1 (de) * | 1992-10-12 | 1994-04-14 | Thomae Gmbh Dr K | Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| US6271199B2 (en) * | 1997-02-15 | 2001-08-07 | Millennium Pharmaceuticals, Inc. | Treatment of infarcts |
| AU2001281392A1 (en) * | 2000-08-08 | 2002-02-18 | The Government Of The United States Of America, As Represented By The Secretary Of Health And Human | Prevention of beta-amyloid neurotoxicity by blockade of the ubiquitin-proteasome proteolytic pathway |
| TW200538149A (en) | 2004-05-20 | 2005-12-01 | Telik Inc | Sensitization to another anticancer therapy and/or amelioration of a side effect of another anticancer therapy by treatment with a GST-activated anticancer compound |
| ES2296484B1 (es) * | 2005-11-23 | 2009-04-01 | Fundacion De La Comunidad Valenciana Centro De Investigacion Principe Felipe (90%) | Composicion farmaceutica para inhibir la apoptosis. |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20040029811A1 (en) * | 2000-10-06 | 2004-02-12 | Orts Vicente Felipo | N-alkylglycine trimeres capable of protecting neurons against excitotoxic aggressions and compositions containing such trimeres |
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| EP2045251A4 (en) | 2010-12-01 |
| EP2045251B1 (en) | 2015-11-18 |
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| AU2007275073A1 (en) | 2008-01-24 |
| MX2009000672A (es) | 2009-02-04 |
| US20130237529A1 (en) | 2013-09-12 |
| JP2009544600A (ja) | 2009-12-17 |
| ES2293834B1 (es) | 2009-02-16 |
| ES2293834A1 (es) | 2008-03-16 |
| WO2008009758A1 (es) | 2008-01-24 |
| CN101506196B (zh) | 2013-11-20 |
| EP2045251A1 (en) | 2009-04-08 |
| CN101506196A (zh) | 2009-08-12 |
| US20110160189A1 (en) | 2011-06-30 |
| US8785430B2 (en) | 2014-07-22 |
| JP5203363B2 (ja) | 2013-06-05 |
| CA2658327C (en) | 2013-12-03 |
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