AU2007271504B2 - Indazole derivatives for treating HSP90-induced diseases - Google Patents

Indazole derivatives for treating HSP90-induced diseases Download PDF

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Publication number
AU2007271504B2
AU2007271504B2 AU2007271504A AU2007271504A AU2007271504B2 AU 2007271504 B2 AU2007271504 B2 AU 2007271504B2 AU 2007271504 A AU2007271504 A AU 2007271504A AU 2007271504 A AU2007271504 A AU 2007271504A AU 2007271504 B2 AU2007271504 B2 AU 2007271504B2
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AU
Australia
Prior art keywords
hydroxy
indazole
methylaminocarbonyl
methylbenzyl
indlazole
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Ceased
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AU2007271504A
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AU2007271504A1 (en
Inventor
Hans-Peter Buchstaller
Hans-Michael Eggenweiler
Christian Sirrenberg
Michael Wolf
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Merck Patent GmbH
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Merck Patent GmbH
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
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  • Oncology (AREA)
  • Communicable Diseases (AREA)
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  • Immunology (AREA)
  • Biomedical Technology (AREA)
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  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • AIDS & HIV (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
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AU2007271504A 2006-07-01 2007-06-18 Indazole derivatives for treating HSP90-induced diseases Ceased AU2007271504B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102006030479.9 2006-07-01
DE102006030479A DE102006030479A1 (de) 2006-07-01 2006-07-01 Indazolderivate
PCT/EP2007/005338 WO2008003396A1 (de) 2006-07-01 2007-06-18 Indazolderivate zur behandlung von hsp90-induzierten krankheiten

Publications (2)

Publication Number Publication Date
AU2007271504A1 AU2007271504A1 (en) 2008-01-10
AU2007271504B2 true AU2007271504B2 (en) 2012-05-24

Family

ID=38289949

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007271504A Ceased AU2007271504B2 (en) 2006-07-01 2007-06-18 Indazole derivatives for treating HSP90-induced diseases

Country Status (16)

Country Link
US (1) US8722903B2 (de)
EP (1) EP2035391B1 (de)
JP (1) JP5303456B2 (de)
KR (1) KR20090025371A (de)
CN (1) CN101484425A (de)
AR (1) AR061735A1 (de)
AT (1) ATE534633T1 (de)
AU (1) AU2007271504B2 (de)
BR (1) BRPI0713977A2 (de)
CA (1) CA2656458C (de)
DE (1) DE102006030479A1 (de)
ES (1) ES2376043T3 (de)
IL (1) IL196202A (de)
MX (1) MX2008015442A (de)
WO (1) WO2008003396A1 (de)
ZA (1) ZA200900750B (de)

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DE102007028521A1 (de) * 2007-06-21 2008-12-24 Merck Patent Gmbh Indazolamidderivate
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
KR101630432B1 (ko) * 2009-08-28 2016-06-15 한국생명공학연구원 2, 6-위치가 치환된 3-니트로피리딘 유도체 화합물 또는 이의 약제학적으로 허용되는 염을 포함하는 암 예방 또는 치료용 약학 조성물
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
US9487506B2 (en) * 2011-04-13 2016-11-08 Merck Sharp & Dohme Corp. Mineralocorticoid receptor antagonists
JP6396210B2 (ja) 2011-05-12 2018-09-26 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ キナーゼ阻害剤として活性な置換インダゾール誘導体
TWI672141B (zh) 2014-02-20 2019-09-21 美商醫科泰生技 投予ｒｏｓ１突變癌細胞之分子
JP6744309B2 (ja) 2014-12-02 2020-08-19 イグニタ，インコーポレイテッド 神経芽細胞腫の治療のための併用
US10336707B2 (en) 2014-12-16 2019-07-02 Eudendron S.R.L. Heterocyclic derivatives modulating activity of certain protein kinases
CN105541720A (zh) * 2015-12-18 2016-05-04 青岛友诚高新技术有限公司 一种可用于制备抗乳腺导管癌药物的化合物及其制备方法、用途
AU2016370846B2 (en) 2015-12-18 2022-08-25 Ignyta, Inc. Combinations for the treatment of cancer
KR20200031115A (ko) 2017-07-19 2020-03-23 이그니타, 인코포레이티드 엔트렉티닙을 포함하는 약학적 조성물
WO2019077506A1 (en) 2017-10-17 2019-04-25 Ignyta, Inc. PHARMACEUTICAL COMPOSITIONS AND SOLID GALENIC FORMS
EP4076444A4 (de) * 2019-12-18 2024-01-10 Merck Sharp & Dohme Llc Indazolderivate und verfahren zur verwendung davon für die behandlung von herpesviren
IL299303A (en) * 2021-02-25 2023-02-01 Aptabio Therapeutics Inc New hacking derivatives
KR20240050921A (ko) * 2022-10-12 2024-04-19 고려대학교 산학협력단 신규 인다졸 유도체 또는 이의 약학적으로 허용가능한 염 및 이의 용도

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US20040127538A1 (en) * 2001-04-16 2004-07-01 Hitoshi Oinuma Novel 1h-indazole compound
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US6897231B2 (en) 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
WO2002100833A1 (fr) 2001-06-12 2002-12-19 Sumitomo Pharmaceuticals Company, Limited Inhibiteurs de rho kinase
KR20040047869A (ko) 2001-09-26 2004-06-05 파마시아 이탈리아 에스.피.에이. 키나제 억제제로서 활성인 아미노인다졸 유도체, 이의제조방법 및 이를 함유하는 약제학적 조성물
EP1441725A1 (de) 2001-10-26 2004-08-04 Aventis Pharmaceuticals Inc. Benzimidazole und analoga und ihre verwendung als proteinkinase-hemmer
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FR2845382A1 (fr) 2002-10-02 2004-04-09 Sanofi Synthelabo Derives d'indazolecarboxamides, leur preparation et leur utilisation en therapeutique
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WO2005063222A1 (ja) 2003-12-26 2005-07-14 Kyowa Hakko Kogyo Co., Ltd. Hsp90ファミリー蛋白質阻害剤
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US20040127538A1 (en) * 2001-04-16 2004-07-01 Hitoshi Oinuma Novel 1h-indazole compound
WO2003037896A1 (en) * 2001-10-26 2003-05-08 Pharmacia & Upjohn Company N-azabicyclo-substituted hetero-bicyclic carboxamides as nachr agonists
US6897208B2 (en) * 2001-10-26 2005-05-24 Aventis Pharmaceuticals Inc. Benzimidazoles
US6908916B2 (en) * 2001-11-14 2005-06-21 Bristol Myers Squibb Company C-5 modified indazolylpyrrolotriazines

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CA2656458C (en) 2014-10-07
US20090197882A1 (en) 2009-08-06
IL196202A (en) 2014-03-31
JP2009541377A (ja) 2009-11-26
EP2035391B1 (de) 2011-11-23
US8722903B2 (en) 2014-05-13
EP2035391A1 (de) 2009-03-18
CA2656458A1 (en) 2008-01-10
WO2008003396A1 (de) 2008-01-10
ZA200900750B (en) 2009-12-30
JP5303456B2 (ja) 2013-10-02
DE102006030479A1 (de) 2008-03-20
ATE534633T1 (de) 2011-12-15
CN101484425A (zh) 2009-07-15
KR20090025371A (ko) 2009-03-10
IL196202A0 (en) 2009-09-22
MX2008015442A (es) 2008-12-12
AR061735A1 (es) 2008-09-17
BRPI0713977A2 (pt) 2012-11-27
ES2376043T3 (es) 2012-03-08
AU2007271504A1 (en) 2008-01-10

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