AU2006269261B2 - Melanocortin receptor ligands - Google Patents

Melanocortin receptor ligands Download PDF

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Publication number
AU2006269261B2
AU2006269261B2 AU2006269261A AU2006269261A AU2006269261B2 AU 2006269261 B2 AU2006269261 B2 AU 2006269261B2 AU 2006269261 A AU2006269261 A AU 2006269261A AU 2006269261 A AU2006269261 A AU 2006269261A AU 2006269261 B2 AU2006269261 B2 AU 2006269261B2
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cys
arg
disease
seq
phe
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AU2006269261A1 (en
Inventor
Zheng Xin Dong
Jacques-Pierre Moreau
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Ipsen Pharma SAS
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Ipsen Pharma SAS
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Assigned to SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A.S. reassignment SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A.S. Alteration of Name(s) of Applicant(s) under S113 Assignors: DONG, ZHENG XIN, MOREAU, JACQUES-PIERRE, SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A.S.
Assigned to IPSEN PHARMA S.A.S reassignment IPSEN PHARMA S.A.S Alteration of Name(s) of Applicant(s) under S113 Assignors: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES, S.A.S.
Priority to AU2009230799A priority Critical patent/AU2009230799B2/en
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    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
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AU2006269261A 2005-07-08 2006-07-10 Melanocortin receptor ligands Active AU2006269261B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2009230799A AU2009230799B2 (en) 2005-07-08 2009-10-28 Melanocortin receptor ligands

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Application Number Priority Date Filing Date Title
US69777905P 2005-07-08 2005-07-08
US60/697,779 2005-07-08
US74885005P 2005-12-09 2005-12-09
US60/748,850 2005-12-09
PCT/US2006/026586 WO2007008704A2 (en) 2005-07-08 2006-07-10 Melanocortin receptor ligands

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AU2009230799A Division AU2009230799B2 (en) 2005-07-08 2009-10-28 Melanocortin receptor ligands

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AU2006269261A1 AU2006269261A1 (en) 2007-01-18
AU2006269261B2 true AU2006269261B2 (en) 2009-12-17

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AU2006269261A Active AU2006269261B2 (en) 2005-07-08 2006-07-10 Melanocortin receptor ligands
AU2009230799A Active AU2009230799B2 (en) 2005-07-08 2009-10-28 Melanocortin receptor ligands

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US (9) US8039435B2 (2)
EP (6) EP1915167A4 (2)
JP (4) JP4734411B2 (2)
KR (2) KR101232201B1 (2)
CN (5) CN103755786B (2)
AU (2) AU2006269261B2 (2)
BE (1) BE2021C557I2 (2)
CA (4) CA3228910A1 (2)
DK (4) DK3354273T3 (2)
ES (4) ES2663916T3 (2)
FR (1) FR21C1060I2 (2)
HU (4) HUE037147T2 (2)
IL (3) IL188545A (2)
NL (1) NL301150I2 (2)
NZ (2) NZ565217A (2)
PL (4) PL2286825T3 (2)
PT (4) PT3354273T (2)
RU (2) RU2439079C2 (2)
SG (1) SG163585A1 (2)
SI (1) SI3354273T1 (2)
WO (1) WO2007008704A2 (2)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2286825T3 (pl) * 2005-07-08 2017-06-30 Ipsen Pharma Ligandy receptora melanokortyny
DE102007020152A1 (de) * 2007-04-26 2008-10-30 Charité - Universitätsmedizin Berlin Mittel zur antiinfektiven Behandlung eines Patienten
ES2618315T3 (es) 2007-05-25 2017-06-21 Ipsen Pharma S.A.S. Ligandos del receptor de melanocortina modificados con hidantoína
AR066175A1 (es) * 2007-06-15 2009-08-05 Sod Conseils Rech Applic Ligandos del receptor de melanocortina de peptidos ciclicos
NZ585131A (en) * 2007-11-05 2012-10-26 Ipsen Pharma Sas Use melanocortins to treat insulin sensitivity
DK2297178T3 (da) 2008-05-27 2014-09-01 Genzyme Corp Peptidanaloger af alpha-melanocytstimulerende hormon
KR101687037B1 (ko) 2008-06-09 2016-12-15 팔라틴 테크놀로지스 인코포레이티드 성기능 장애 치료용 멜라노코르틴 수용체-특이적 펩티드
UY32690A (es) 2009-06-08 2011-01-31 Astrazeneca Ab Péptidos específicos para receptores de melanocortina
KR101726893B1 (ko) 2009-06-08 2017-04-13 팔라틴 테크놀로지스 인코포레이티드 멜라노코르틴 수용체-특이적 펩티드
WO2010144341A2 (en) 2009-06-08 2010-12-16 Palatin Technologies, Inc. Lactam-bridged melanocortin receptor-specific peptides
BR112012002445A2 (pt) * 2009-08-05 2015-10-13 Ipsen Pharma Sas uso de um agonista do receptor 4 de melanocortina.
CN102574894A (zh) * 2009-08-31 2012-07-11 张力控制股份有限公司 稳定化的黑皮质素配体
US9314509B2 (en) 2009-11-16 2016-04-19 Ipsen Pharma S.A.S. Pharmaceutical compositions of melanocortin receptor ligands
US20120226018A1 (en) * 2009-11-16 2012-09-06 Ipsen Pharma, S.A.S. Process for the Synthesis of Ac-Arg-Cyclo(Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NH2
JP2013511554A (ja) 2009-11-23 2013-04-04 パラティン テクノロジーズ,インコーポレイテッド メラノコルチン−1受容体特異的線状ペプチド
WO2011063366A1 (en) 2009-11-23 2011-05-26 Palatin Technologies, Inc. Melanocortin-1 receptor-specific cyclic peptides
CA2833676C (en) * 2011-06-14 2019-04-23 Ipsen Pharma S.A.S. A sustained-release composition containing peptides as active ingredient
CA2862444A1 (en) 2011-12-29 2013-07-04 Rhythm Metabolic, Inc. Method of treating melanocortin-4 receptor-associated disorders in heterozygous carriers
EP2705835A1 (en) 2012-06-08 2014-03-12 Ipsen Pharma S.A.S. Aqueous gelling compositions of soluble active pharmaceutical peptides providing modified release
US9217023B2 (en) * 2012-10-19 2015-12-22 Txp Pharma Gmbh Alpha- and gamma-MSH analogues
US10232018B2 (en) 2013-03-14 2019-03-19 Mallinckrodt Ard Ip Limited ACTH for treatment of acute respiratory distress syndrome
PL2970389T3 (pl) * 2013-03-15 2021-03-08 Rhythm Pharmaceuticals, Inc. Kompozycje farmaceutyczne
RU2020120797A (ru) 2013-03-15 2020-07-02 Ритм Фармасьютикалз, Инк. Пептидные композиции
EP3838285A1 (en) 2014-04-22 2021-06-23 TXP Pharma GmbH Peptide analogues with branched amino acid probe(s)
MA43040A (fr) * 2015-09-30 2018-08-08 Univ Berlin Charite Méthode de traitement de troubles associés à la voie du récepteur de la mélanocortine 4
WO2017066754A1 (en) * 2015-10-15 2017-04-20 The Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for the treatment of depression and anxiety
US11542302B2 (en) 2015-10-15 2023-01-03 Arizona Board Of Regents On Behalf Of The University Of Arizona Modulators of melanocortin receptors for the treatment of depression and anxiety
US20190255142A1 (en) * 2016-10-17 2019-08-22 Arizona Board Of Regents On Behalf Of The University Of Arizona Novel modulators of melanocortin receptors for the treatment of depression and anxiety
JP2020514365A (ja) * 2017-03-15 2020-05-21 ノヴォ ノルディスク アー/エス メラノコルチン4受容体に結合可能な二環式化合物
EP3773897A1 (en) 2018-04-06 2021-02-17 Rhythm Pharmaceuticals, Inc. Compositions for treating kidney disease
WO2019219714A1 (en) * 2018-05-15 2019-11-21 Novo Nordisk A/S Compounds capable of binding to melanocortin 4 receptor
US11992537B2 (en) * 2018-05-23 2024-05-28 Provincial Health Services Authority Radiolabeled melanocortin 1 receptor-specific alpha-melanocyte-stimulating hormone analogues for imaging or therapy
US11396535B2 (en) 2019-03-01 2022-07-26 Provincial Health Services Authority Cyclic peptide analogs of melanocortin and amanitin and methods of making such
EP4216979A4 (en) * 2020-09-24 2024-11-06 Rhythm Pharmaceuticals, Inc. Methods of treating melanocortin-4 receptor pathway-associated disorders
MX2023011157A (es) * 2021-03-24 2024-01-25 Glo Pharma Inc Peptidos y metodos para reducir la pigmentacion de la piel.
US20240287154A1 (en) * 2021-05-27 2024-08-29 The Regents Of The University Of Michigan Mc3r agonist peptides
EP4605077A1 (en) 2022-10-18 2025-08-27 Confo Therapeutics N.V. Amino acid sequences directed against the melanocortin 4 receptor and polypeptides comprising the same for the treatment of mc4r-related diseases and disorders
WO2025123059A1 (en) * 2023-12-07 2025-06-12 Endevica Bio, Inc. Non-naturally occurring melanocortin analogs and uses thereof for treating substance use disorders
WO2025245288A1 (en) * 2024-05-22 2025-11-27 Endevica Bio, Inc. Non-naturally occurring melanocortin analogs and uses thereof
CN120699097A (zh) * 2024-09-03 2025-09-26 万邦德制药集团有限公司 一种二硫环肽化合物及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6613874B1 (en) * 1999-03-29 2003-09-02 The Procter & Gamble Company Melanocortin receptor ligands
US20030212002A1 (en) * 2002-05-07 2003-11-13 University Of Florida Peptides and methods for the control of obesity
US20040128136A1 (en) * 2002-09-20 2004-07-01 Irani Pourang Polad Internet voice browser

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US613874A (en) 1898-11-08 George e
US1613874A (en) 1922-03-29 1927-01-11 Miner Inc W H Friction draft gear
US5652214A (en) 1989-06-05 1997-07-29 Cephalon, Inc. Treating disorders by application of insulin-like growth factors and analogs
US5672659A (en) 1993-01-06 1997-09-30 Kinerton Limited Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides
US5595760A (en) 1994-09-02 1997-01-21 Delab Sustained release of peptides from pharmaceutical compositions
US5665702A (en) 1995-06-06 1997-09-09 Biomeasure Incorporated Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides
US5916883A (en) 1996-11-01 1999-06-29 Poly-Med, Inc. Acylated cyclodextrin derivatives
SE9700620D0 (sv) 1997-02-21 1997-02-21 Wapharm Ab Cykliska peptider med selektivitet för MSH-receptor subtyper
AU7464998A (en) 1997-10-27 1999-05-17 Trega Biosciences, Inc. Melanocortin receptor ligands and methods of using same
AU3768799A (en) * 1998-04-28 1999-11-16 Trega Biosciences, Inc. Isoquinoline compound melanocortin receptor ligands and methods of using same
JP3790102B2 (ja) * 1998-07-27 2006-06-28 アイオワ ステイト ユニバーシティ リサーチ ファウンデーション,インコーポレイティド メラノコルチン−4レセプター遺伝子、並びに動物における脂質含量、体重増加及び/又は食物消費量のマーカーとしての使用
WO2000010507A2 (en) 1998-08-21 2000-03-02 The Children's Medical Center Corporation Use of melanin for inhibition of angiogenesis and macular degeneration
US6716810B1 (en) 1998-12-09 2004-04-06 Eleanor Roosevelt Institute Composition and method for regulation of body weight and associated conditions
US6603058B1 (en) 1998-12-09 2003-08-05 Oklahoma Medical Research Foundation Non-human animal model for obesity and uses thereof
US7176279B2 (en) * 2000-06-28 2007-02-13 Palatin Technologies, Inc. Cyclic peptide compositions and methods for treatment of sexual dysfunction
US6579968B1 (en) * 1999-06-29 2003-06-17 Palatin Technologies, Inc. Compositions and methods for treatment of sexual dysfunction
JP2003513645A (ja) 1999-11-12 2003-04-15 メルク エンド カムパニー インコーポレーテッド メラノコルチン−3レセプター欠失細胞、非ヒトトランスジェニック動物及び体重を調節する化合物の選択方法
US6600015B2 (en) 2000-04-04 2003-07-29 Hoffmann-La Roche Inc. Selective linear peptides with melanocortin-4 receptor (MC4-R) agonist activity
AP2001002196A0 (en) * 2000-06-28 2002-12-21 Pfizer Prod Inc Melanocortin receptor ligands.
US6720324B2 (en) 2000-07-05 2004-04-13 Synaptic Pharmaceutical Corporation Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof
EP1322954A4 (en) 2000-09-13 2005-08-03 Eleanor Roosevelt Inst PROCESS FOR TREATING INSULIN RESISTANCE IN OBESITY AND DIABETES
US20030113263A1 (en) 2001-02-13 2003-06-19 Oregon Health And Sciences University, A Non-Profit Organization Methods and reagents for using mammalian melanocortin receptor antagonists to treat cachexia
JP2004532838A (ja) 2001-03-02 2004-10-28 ブリストル−マイヤーズ スクイブ カンパニー メラノコルチン受容体のモデュレーターとして有用な化合物及びそれを含む製薬組成物
US6770645B2 (en) * 2001-03-16 2004-08-03 Pfizer Inc. Pharmaceutically active compounds
AU2002322466B2 (en) * 2001-07-11 2007-08-30 Palatin Technologies, Inc. Linear and cyclic melanocortin receptor-specific peptides
CA2530024A1 (en) * 2003-06-19 2005-01-06 Eli Lilly And Company Melanocortin receptor 4(mc4) agonists and their uses
WO2005000338A1 (en) 2003-06-19 2005-01-06 Eli Lilly And Company Uses of melanocortin-3 receptor (mc3r) agonist peptides
US7084111B2 (en) 2003-06-23 2006-08-01 University Of Florida Research Foundation, Inc. Melanocortin receptor templates, peptides, and use thereof
CA2532026C (en) * 2003-08-20 2012-04-17 Eli Lilly And Company Compounds, methods and formulations for the oral delivery of a glucagon like peptide (glp)-1 compound or an melanocortin 4 receptor (mc4) agonist peptide
ATE361294T1 (de) * 2003-08-20 2007-05-15 Lilly Co Eli Verbindungen, verfahren und formulierungen zur oralen verabreichung einer glucagonartigen peptid (glp)-1-verbindung oder eines melanocortin-4- rezeptor-(mc4-)agonistschen peptids
US20050192286A1 (en) * 2003-10-22 2005-09-01 Neurocrine Biosciences, Inc. Ligands of melanocortin receptors and compositions and methods related thereto
DE10355559A1 (de) 2003-11-21 2005-06-23 Orthogen Ag Transskin
US20070155660A1 (en) 2003-12-10 2007-07-05 Marsh Donald J Inhibition of voluntary ethanol consumption with selective melanocortin 4-receptor agonists
US20070123453A1 (en) 2004-03-29 2007-05-31 Heiman Mark L Uses of melanocortin-4 receptor (mc4r) agonist peptides administered by continuous infusion
EP1812034A4 (en) 2004-10-08 2009-07-29 Clinuvel Pharmaceuticals Ltd COMPOSITIONS AND METHODS OF INDUCING MELANOESEES IN ONE PERSON
WO2006073772A1 (en) 2005-01-05 2006-07-13 Eli Lilly And Company Polyethylene glycol linked mc4r or mc3r agonist peptides
WO2006073771A2 (en) 2005-01-05 2006-07-13 Eli Lilly And Company Polyethylene glycol linked mc4r or mc3r agonist peptides
PL2286825T3 (pl) * 2005-07-08 2017-06-30 Ipsen Pharma Ligandy receptora melanokortyny
EP1919947B1 (en) 2005-08-26 2013-02-27 AbbVie Inc. Therapeutically active alpha-msh analogues

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6613874B1 (en) * 1999-03-29 2003-09-02 The Procter & Gamble Company Melanocortin receptor ligands
US20030212002A1 (en) * 2002-05-07 2003-11-13 University Of Florida Peptides and methods for the control of obesity
US20040128136A1 (en) * 2002-09-20 2004-07-01 Irani Pourang Polad Internet voice browser

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