AU2006218132B2 - Phosphate salts of 6-dimethylaminomethyl-l-(3-methoxyphenyl) -1,3-dihydroxycyclohexane compounds - Google Patents

Phosphate salts of 6-dimethylaminomethyl-l-(3-methoxyphenyl) -1,3-dihydroxycyclohexane compounds Download PDF

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Publication number
AU2006218132B2
AU2006218132B2 AU2006218132A AU2006218132A AU2006218132B2 AU 2006218132 B2 AU2006218132 B2 AU 2006218132B2 AU 2006218132 A AU2006218132 A AU 2006218132A AU 2006218132 A AU2006218132 A AU 2006218132A AU 2006218132 B2 AU2006218132 B2 AU 2006218132B2
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Australia
Prior art keywords
polymorph
dimethylaminomethyl
methoxyphenyl
cyclohexane
approx
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Ceased
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AU2006218132A
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AU2006218132A1 (en
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Andreas Fischer
Michael Gruss
Wolfgang Hell
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Gruenenthal GmbH
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Gruenenthal GmbH
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biomedical Technology (AREA)
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  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
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  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
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  • Obesity (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2006218132A 2005-02-25 2006-02-21 Phosphate salts of 6-dimethylaminomethyl-l-(3-methoxyphenyl) -1,3-dihydroxycyclohexane compounds Ceased AU2006218132B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102005009217.9 2005-02-25
DE102005009217A DE102005009217A1 (de) 2005-02-25 2005-02-25 Phosphatsalze der 6-Dimethylaminomethyl-1-(3-methoxyphenyl)-1,3-dihydroxy-cyclohexanverbindungen
PCT/EP2006/001547 WO2006089707A1 (de) 2005-02-25 2006-02-21 Phosphatsalze der 6-dimethylaminomethyl-l- (3-methoxyphenyl) -1,3-dihydroxy- cyclohexanverbindungen

Publications (2)

Publication Number Publication Date
AU2006218132A1 AU2006218132A1 (en) 2006-08-31
AU2006218132B2 true AU2006218132B2 (en) 2011-10-06

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AU2006218132A Ceased AU2006218132B2 (en) 2005-02-25 2006-02-21 Phosphate salts of 6-dimethylaminomethyl-l-(3-methoxyphenyl) -1,3-dihydroxycyclohexane compounds

Country Status (18)

Country Link
EP (1) EP1851191A1 (zh)
JP (1) JP2008531510A (zh)
KR (1) KR20070107162A (zh)
CN (1) CN101137615A (zh)
AR (1) AR053145A1 (zh)
AU (1) AU2006218132B2 (zh)
BR (1) BRPI0606146A2 (zh)
CA (1) CA2598845A1 (zh)
DE (1) DE102005009217A1 (zh)
IL (1) IL185468A0 (zh)
MX (1) MX2007010361A (zh)
NO (1) NO20074673L (zh)
NZ (1) NZ556338A (zh)
PE (1) PE20061100A1 (zh)
RU (1) RU2007135271A (zh)
TW (1) TW200640840A (zh)
WO (1) WO2006089707A1 (zh)
ZA (1) ZA200708153B (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007008752A2 (en) 2005-07-07 2007-01-18 Farnam Companies, Inc. Sustained release pharmaceutical compositions for highly water soluble drugs
DE102007022790A1 (de) * 2007-05-11 2008-11-20 Grünenthal GmbH Axomadol zur Schmerzbehandlung bei Arthrose
EP2477960A1 (en) * 2009-09-14 2012-07-25 Grünenthal GmbH Crystalline modifications of 6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0753506A1 (de) * 1995-07-11 1997-01-15 Grünenthal GmbH 6-dimethylaminomethyl-1-phenyl-cyclo-hexanverbindungen als pharmazeutische Wirkstoffe
US20040242617A1 (en) * 2001-09-18 2004-12-02 Gruenenthal Gmbh Combination of selected opioids with muscarine antagonists for treating urinary incontinence
WO2005009329A2 (de) * 2003-07-24 2005-02-03 Grünenthal GmbH 6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol enthaltendes arzneimittel mit verzögerter wirkstofffreisetzung

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0753506A1 (de) * 1995-07-11 1997-01-15 Grünenthal GmbH 6-dimethylaminomethyl-1-phenyl-cyclo-hexanverbindungen als pharmazeutische Wirkstoffe
USRE37355E1 (en) * 1995-07-11 2001-09-04 Gruenenthal Gmbh 6-dimethylaminomethyl-1-phenyl-cyclohexane compounds as pharmaceutical active ingredients
US20040242617A1 (en) * 2001-09-18 2004-12-02 Gruenenthal Gmbh Combination of selected opioids with muscarine antagonists for treating urinary incontinence
WO2005009329A2 (de) * 2003-07-24 2005-02-03 Grünenthal GmbH 6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol enthaltendes arzneimittel mit verzögerter wirkstofffreisetzung

Also Published As

Publication number Publication date
BRPI0606146A2 (pt) 2009-06-02
CA2598845A1 (en) 2006-08-31
CN101137615A (zh) 2008-03-05
NZ556338A (en) 2009-11-27
TW200640840A (en) 2006-12-01
WO2006089707A1 (de) 2006-08-31
AR053145A1 (es) 2007-04-25
EP1851191A1 (de) 2007-11-07
MX2007010361A (es) 2008-02-21
KR20070107162A (ko) 2007-11-06
PE20061100A1 (es) 2007-01-04
AU2006218132A1 (en) 2006-08-31
RU2007135271A (ru) 2010-02-27
IL185468A0 (en) 2008-01-06
ZA200708153B (en) 2008-10-29
JP2008531510A (ja) 2008-08-14
DE102005009217A1 (de) 2006-08-31
NO20074673L (no) 2007-10-19

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