AU2005314151B2 - Method of molding a microneedle - Google Patents
Method of molding a microneedle Download PDFInfo
- Publication number
- AU2005314151B2 AU2005314151B2 AU2005314151A AU2005314151A AU2005314151B2 AU 2005314151 B2 AU2005314151 B2 AU 2005314151B2 AU 2005314151 A AU2005314151 A AU 2005314151A AU 2005314151 A AU2005314151 A AU 2005314151A AU 2005314151 B2 AU2005314151 B2 AU 2005314151B2
- Authority
- AU
- Australia
- Prior art keywords
- mold
- microneedle
- mold insert
- polymeric material
- microneedles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000000034 method Methods 0.000 title claims abstract description 51
- 238000000465 moulding Methods 0.000 title claims abstract description 28
- 239000000463 material Substances 0.000 claims abstract description 76
- 230000006835 compression Effects 0.000 claims abstract description 62
- 238000007906 compression Methods 0.000 claims abstract description 62
- 239000007924 injection Substances 0.000 claims abstract description 32
- 238000002347 injection Methods 0.000 claims abstract description 30
- 239000000758 substrate Substances 0.000 claims description 21
- 238000003491 array Methods 0.000 claims description 20
- 238000012876 topography Methods 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 6
- 229920000515 polycarbonate Polymers 0.000 claims description 5
- 239000004417 polycarbonate Substances 0.000 claims description 5
- 239000004697 Polyetherimide Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 229920001601 polyetherimide Polymers 0.000 claims description 2
- -1 polyethylene terephthalate Polymers 0.000 claims description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 claims description 2
- 239000005020 polyethylene terephthalate Substances 0.000 claims description 2
- 210000003491 skin Anatomy 0.000 description 14
- 239000003814 drug Substances 0.000 description 8
- 229940079593 drug Drugs 0.000 description 6
- 229910052751 metal Inorganic materials 0.000 description 5
- 239000002184 metal Substances 0.000 description 5
- 239000012768 molten material Substances 0.000 description 5
- 230000037317 transdermal delivery Effects 0.000 description 5
- 238000007796 conventional method Methods 0.000 description 4
- 238000007516 diamond turning Methods 0.000 description 4
- 238000001746 injection moulding Methods 0.000 description 4
- 238000000748 compression moulding Methods 0.000 description 3
- 230000002708 enhancing effect Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 150000002605 large molecules Chemical class 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 239000002831 pharmacologic agent Substances 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- 101100269871 Acinetobacter nosocomialis anoI gene Proteins 0.000 description 1
- 244000226021 Anacardium occidentale Species 0.000 description 1
- 229940122361 Bisphosphonate Drugs 0.000 description 1
- 229910001369 Brass Inorganic materials 0.000 description 1
- 229910000906 Bronze Inorganic materials 0.000 description 1
- 108010041986 DNA Vaccines Proteins 0.000 description 1
- 229940021995 DNA vaccine Drugs 0.000 description 1
- 108091092889 HOTTIP Proteins 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 229920004142 LEXAN™ Polymers 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- DCSBSVSZJRSITC-UHFFFAOYSA-M alendronate sodium trihydrate Chemical compound O.O.O.[Na+].NCCCC(O)(P(O)(O)=O)P(O)([O-])=O DCSBSVSZJRSITC-UHFFFAOYSA-M 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 150000004663 bisphosphonates Chemical class 0.000 description 1
- 239000010951 brass Substances 0.000 description 1
- 239000010974 bronze Substances 0.000 description 1
- 235000020226 cashew nut Nutrition 0.000 description 1
- 229960004755 ceftriaxone Drugs 0.000 description 1
- VAAUVRVFOQPIGI-SPQHTLEESA-N ceftriaxone Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1CSC1=NC(=O)C(=O)NN1C VAAUVRVFOQPIGI-SPQHTLEESA-N 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- KUNSUQLRTQLHQQ-UHFFFAOYSA-N copper tin Chemical compound [Cu].[Sn] KUNSUQLRTQLHQQ-UHFFFAOYSA-N 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000005323 electroforming Methods 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000001000 micrograph Methods 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 235000012771 pancakes Nutrition 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 150000003839 salts Chemical group 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000005382 thermal cycling Methods 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 229920001187 thermosetting polymer Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 239000012646 vaccine adjuvant Substances 0.000 description 1
- 229940124931 vaccine adjuvant Drugs 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/17—Component parts, details or accessories; Auxiliary operations
- B29C45/46—Means for plasticising or homogenising the moulding material or forcing it into the mould
- B29C45/56—Means for plasticising or homogenising the moulding material or forcing it into the mould using mould parts movable during or after injection, e.g. injection-compression moulding
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/17—Component parts, details or accessories; Auxiliary operations
- B29C45/46—Means for plasticising or homogenising the moulding material or forcing it into the mould
- B29C45/56—Means for plasticising or homogenising the moulding material or forcing it into the mould using mould parts movable during or after injection, e.g. injection-compression moulding
- B29C45/568—Applying vibrations to the mould parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/17—Component parts, details or accessories; Auxiliary operations
- B29C45/46—Means for plasticising or homogenising the moulding material or forcing it into the mould
- B29C45/56—Means for plasticising or homogenising the moulding material or forcing it into the mould using mould parts movable during or after injection, e.g. injection-compression moulding
- B29C45/561—Injection-compression moulding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C2045/0094—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor injection moulding of small-sized articles, e.g. microarticles, ultra thin articles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C2791/00—Shaping characteristics in general
- B29C2791/004—Shaping under special conditions
- B29C2791/008—Using vibrations during moulding
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/17—Component parts, details or accessories; Auxiliary operations
- B29C45/26—Moulds
- B29C45/2669—Moulds with means for removing excess material, e.g. with overflow cavities
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/17—Component parts, details or accessories; Auxiliary operations
- B29C45/26—Moulds
- B29C45/34—Moulds having venting means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2031/00—Other particular articles
- B29L2031/753—Medical equipment; Accessories therefor
- B29L2031/7544—Injection needles, syringes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2031/00—Other particular articles
- B29L2031/756—Microarticles, nanoarticles
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Mechanical Engineering (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medical Informatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Moulds For Moulding Plastics Or The Like (AREA)
- Injection Moulding Of Plastics Or The Like (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63431904P | 2004-12-07 | 2004-12-07 | |
| US60/634,319 | 2004-12-07 | ||
| PCT/US2005/044121 WO2006062974A2 (en) | 2004-12-07 | 2005-12-07 | Method of molding a microneedle |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2005314151A1 AU2005314151A1 (en) | 2006-06-15 |
| AU2005314151B2 true AU2005314151B2 (en) | 2011-09-08 |
Family
ID=36168440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2005314151A Ceased AU2005314151B2 (en) | 2004-12-07 | 2005-12-07 | Method of molding a microneedle |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US8088321B2 (enExample) |
| EP (2) | EP2067599B1 (enExample) |
| JP (1) | JP2008522875A (enExample) |
| KR (1) | KR20070098851A (enExample) |
| CN (2) | CN101072668B (enExample) |
| AT (1) | ATE468961T1 (enExample) |
| AU (1) | AU2005314151B2 (enExample) |
| CA (1) | CA2589733C (enExample) |
| DE (1) | DE602005021541D1 (enExample) |
| IL (1) | IL183556A (enExample) |
| WO (1) | WO2006062974A2 (enExample) |
Families Citing this family (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0517749A (pt) * | 2004-11-18 | 2008-10-21 | 3M Innovative Properties Co | dispositivo de aplicação para aplicar um dispositivo de micro-agulha a uma superfìcie de pele, e, método para usar um dispositivo de aplicação |
| CA2589733C (en) * | 2004-12-07 | 2014-02-11 | 3M Innovative Properties Company | Method of molding a microneedle |
| WO2007112309A2 (en) * | 2006-03-24 | 2007-10-04 | 3M Innovative Properties Company | Process for making microneedles, microneedle arrays, masters, and replication tools |
| WO2007124411A1 (en) * | 2006-04-20 | 2007-11-01 | 3M Innovative Properties Company | Device for applying a microneedle array |
| WO2007127976A2 (en) * | 2006-05-01 | 2007-11-08 | Georgia Tech Research Corporation | Particle based molding |
| KR101450939B1 (ko) | 2007-06-20 | 2014-10-14 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 웨브 상에서의 초음파 사출 성형 |
| CN101340784A (zh) * | 2007-07-04 | 2009-01-07 | 深圳富泰宏精密工业有限公司 | 电子装置机壳及其制造方法 |
| CN102105108B (zh) * | 2008-05-21 | 2013-12-04 | 谢拉杰克特股份有限公司 | 制作固体溶液穿孔器贴剂的方法及其使用 |
| CN105999538A (zh) | 2008-11-18 | 2016-10-12 | 3M创新有限公司 | 空心微针阵列和方法 |
| EP2416835B1 (en) | 2009-04-10 | 2019-05-15 | 3M Innovative Properties Company | Methods of making hollow microneedle arrays |
| US8834423B2 (en) | 2009-10-23 | 2014-09-16 | University of Pittsburgh—of the Commonwealth System of Higher Education | Dissolvable microneedle arrays for transdermal delivery to human skin |
| US20110172638A1 (en) * | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Drug delivery device including multi-functional cover |
| US20110172639A1 (en) * | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Device and method for delivery of microneedle to desired depth within the skin |
| US20110172637A1 (en) * | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Drug delivery device including tissue support structure |
| USD638534S1 (en) | 2010-01-08 | 2011-05-24 | Ratio, Inc. | Drug delivery device |
| USD619245S1 (en) | 2010-01-08 | 2010-07-06 | Ratio, Inc. | Drug delivery device |
| US20110172609A1 (en) * | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Microneedle component assembly for drug delivery device |
| US20110172645A1 (en) * | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Wearable drug delivery device including integrated pumping and activation elements |
| PT2563450T (pt) | 2010-04-28 | 2017-08-28 | Kimberly Clark Co | Dispositivo para entrega de medicação para a artrite reumatóide |
| EP2563454A4 (en) * | 2010-04-28 | 2014-01-22 | Kimberly Clark Co | INJECTION MICRONADEL ARRAY AND METHOD FOR FORMING THE MICRONADEL ARRAY |
| US10245421B2 (en) | 2010-04-28 | 2019-04-02 | Sorrento Therapeutics, Inc. | Nanopatterned medical device with enhanced cellular interaction |
| RU2585138C2 (ru) | 2010-04-28 | 2016-05-27 | Кимберли-Кларк Ворлдвайд, Инк. | Медицинские устройства для доставки кирнк |
| CA2796965C (en) | 2010-04-28 | 2019-04-16 | Kimberly-Clark Worldwide, Inc. | Method for increasing permeability of an epithelial barrier |
| US8668675B2 (en) | 2010-11-03 | 2014-03-11 | Flugen, Inc. | Wearable drug delivery device having spring drive and sliding actuation mechanism |
| ES2580834T3 (es) * | 2010-12-02 | 2016-08-29 | 3M Innovative Properties Company | Microagujas de polímero cristalino líquido |
| US8696637B2 (en) | 2011-02-28 | 2014-04-15 | Kimberly-Clark Worldwide | Transdermal patch containing microneedles |
| EP2686152B1 (en) * | 2011-03-15 | 2016-04-27 | 3M Innovative Properties Company | Method for ultrasonic-assisted injection molding of precisely-shaped articles |
| USD687550S1 (en) | 2011-06-09 | 2013-08-06 | 3M Innovative Properties Company | Handle for a micro-needle device |
| US8636696B2 (en) | 2011-06-10 | 2014-01-28 | Kimberly-Clark Worldwide, Inc. | Transdermal device containing microneedles |
| US20170246439A9 (en) | 2011-10-27 | 2017-08-31 | Kimberly-Clark Worldwide, Inc. | Increased Bioavailability of Transdermally Delivered Agents |
| EP3542851B1 (en) | 2011-10-27 | 2021-12-15 | Sorrento Therapeutics, Inc. | Implantable devices for delivery of bioactive agents |
| CN104039382B (zh) | 2011-10-27 | 2018-01-12 | 金伯利-克拉克环球有限公司 | 高粘度生物活性剂的经皮递送 |
| US10155332B2 (en) * | 2011-12-09 | 2018-12-18 | National Taiwan University Of Science And Technology | In-mold vibratile injection compression molding method and molding apparatus thereof |
| CN103301092B (zh) | 2012-03-06 | 2014-12-03 | 中国科学院理化技术研究所 | 聚合物微针阵列芯片及其制备方法和应用 |
| HK1209658A1 (en) | 2012-05-01 | 2016-04-08 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Tip-loaded microneedle arrays for transdermal insertion |
| US8663537B2 (en) | 2012-05-18 | 2014-03-04 | 3M Innovative Properties Company | Injection molding apparatus and method |
| EP2938390A1 (en) | 2012-12-27 | 2015-11-04 | 3M Innovative Properties Company | Article with hollow microneedles and method of making |
| US9872975B2 (en) | 2013-05-31 | 2018-01-23 | 3M Innovative Properties Company | Microneedle injection and infusion apparatus and method of using same |
| EP3003459B1 (en) | 2013-05-31 | 2018-06-20 | 3M Innovative Properties Company | Microneedle injection apparatus comprising an inverted actuator |
| JP6494602B2 (ja) | 2013-05-31 | 2019-04-03 | スリーエム イノベイティブ プロパティズ カンパニー | 二重カバーを備えるマイクロニードル注射装置 |
| SG11201600330XA (en) | 2013-07-16 | 2016-02-26 | 3M Innovative Properties Co | Article comprising a microneedle |
| WO2015009524A1 (en) | 2013-07-16 | 2015-01-22 | 3M Innovative Properties Company | Hollow microneedle with beveled tip |
| US10099043B2 (en) | 2013-07-16 | 2018-10-16 | 3M Innovative Properties Company | Hollow microneedle array article |
| US10384047B2 (en) | 2013-07-16 | 2019-08-20 | 3M Innovative Properties Company | Hollow microneedle with bevel opening |
| US9933387B1 (en) | 2014-09-07 | 2018-04-03 | Biolinq, Inc. | Miniaturized sub-nanoampere sensitivity low-noise potentiostat system |
| KR102021212B1 (ko) * | 2014-10-17 | 2019-09-11 | 카오카부시키가이샤 | 미세 중공 돌기물의 제조 방법 |
| AU2016209496B2 (en) | 2015-01-21 | 2018-06-28 | Kindeva Drug Delivery L.P. | Microneedle array and method of use |
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| US8246893B2 (en) | 2012-08-21 |
| CA2589733A1 (en) | 2006-06-15 |
| CA2589733C (en) | 2014-02-11 |
| CN101072668A (zh) | 2007-11-14 |
| WO2006062974A3 (en) | 2006-09-28 |
| EP2067599A3 (en) | 2010-01-27 |
| EP1824655B1 (en) | 2010-05-26 |
| WO2006062974A2 (en) | 2006-06-15 |
| JP2008522875A (ja) | 2008-07-03 |
| DE602005021541D1 (de) | 2010-07-08 |
| US8821779B2 (en) | 2014-09-02 |
| IL183556A (en) | 2011-11-30 |
| CN101072668B (zh) | 2011-08-31 |
| IL183556A0 (en) | 2007-09-20 |
| CN102358015A (zh) | 2012-02-22 |
| KR20070098851A (ko) | 2007-10-05 |
| US20110163479A1 (en) | 2011-07-07 |
| AU2005314151A1 (en) | 2006-06-15 |
| EP1824655A2 (en) | 2007-08-29 |
| US20120280428A1 (en) | 2012-11-08 |
| ATE468961T1 (de) | 2010-06-15 |
| EP2067599B1 (en) | 2016-10-26 |
| US20080088066A1 (en) | 2008-04-17 |
| US8088321B2 (en) | 2012-01-03 |
| EP2067599A2 (en) | 2009-06-10 |
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