AU2005303961A1 - Macrolones - Amino substituted quinolones - Google Patents

Macrolones - Amino substituted quinolones Download PDF

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Publication number
AU2005303961A1
AU2005303961A1 AU2005303961A AU2005303961A AU2005303961A1 AU 2005303961 A1 AU2005303961 A1 AU 2005303961A1 AU 2005303961 A AU2005303961 A AU 2005303961A AU 2005303961 A AU2005303961 A AU 2005303961A AU 2005303961 A1 AU2005303961 A1 AU 2005303961A1
Authority
AU
Australia
Prior art keywords
dihydro
oxo
dimethylamino
carboxy
erythromycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2005303961A
Other languages
English (en)
Inventor
Desmond John Best
John Stephen Elder
Andrea Fajdetic
Andrew Keith Forrest
Robert John Sheppard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Fidelta doo
Original Assignee
Glaxo Group Ltd
GlaxoSmithKline Istrazivacki Centar Zagreb doo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd, GlaxoSmithKline Istrazivacki Centar Zagreb doo filed Critical Glaxo Group Ltd
Publication of AU2005303961A1 publication Critical patent/AU2005303961A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2005303961A 2004-11-11 2005-11-09 Macrolones - Amino substituted quinolones Abandoned AU2005303961A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0424959A GB0424959D0 (en) 2004-11-11 2004-11-11 Novel compounds
GB0424959.5 2004-11-11
PCT/EP2005/012038 WO2006050942A1 (en) 2004-11-11 2005-11-09 Macrolones - amino substituted quinolones

Publications (1)

Publication Number Publication Date
AU2005303961A1 true AU2005303961A1 (en) 2006-05-18

Family

ID=33523587

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005303961A Abandoned AU2005303961A1 (en) 2004-11-11 2005-11-09 Macrolones - Amino substituted quinolones

Country Status (19)

Country Link
US (2) US7718621B2 (https=)
EP (1) EP1824870A1 (https=)
JP (1) JP2008519788A (https=)
KR (1) KR20070085919A (https=)
CN (1) CN101098881A (https=)
AR (1) AR053311A1 (https=)
AU (1) AU2005303961A1 (https=)
BR (1) BRPI0517792A (https=)
CA (1) CA2587413A1 (https=)
GB (1) GB0424959D0 (https=)
IL (1) IL182978A0 (https=)
MA (1) MA29213B1 (https=)
MX (1) MX2007005776A (https=)
NO (1) NO20072939L (https=)
PE (1) PE20061137A1 (https=)
RU (1) RU2007121581A (https=)
TW (1) TW200630378A (https=)
WO (1) WO2006050942A1 (https=)
ZA (1) ZA200703603B (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2552682T3 (es) 2003-03-10 2015-12-01 Merck Sharp & Dohme Corp. Agentes antibacterianos novedosos
WO2007054295A1 (en) * 2005-11-09 2007-05-18 Glaxo Group Limited New 4*-substituted erythromycin derivative
WO2006120545A1 (en) * 2005-05-10 2006-11-16 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 4' amino linked macrolides useful for the treatment of microbial infections
EP1945652A1 (en) * 2005-11-09 2008-07-23 Glaxo Group Limited Macrolones
EP2201010B1 (en) 2007-09-14 2013-11-06 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
CN105732745A (zh) 2007-10-25 2016-07-06 森普拉制药公司 大环内酯类抗菌剂的制备方法
TW200946109A (en) * 2008-05-09 2009-11-16 Enanta Pharm Inc Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides
AU2009308182B2 (en) 2008-10-24 2016-05-19 Cempra Pharmaceuticals, Inc. Biodefenses using triazole-containing macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
US9480679B2 (en) 2009-09-10 2016-11-01 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
CN105198944B (zh) 2010-05-20 2018-06-01 森普拉制药公司 制备大环内酯和酮内酯及其中间体的方法
EP2613630A4 (en) 2010-09-10 2014-01-15 Cempra Pharmaceuticals Inc HYDROGEN BOND FOR THE PREPARATION OF FLUOROCHETOLIDES FOR THE TREATMENT OF DISEASES
MX2014011537A (es) 2012-03-27 2015-02-10 Cempra Pharmaceuticals Inc Formulaciones parenterales para la administracion de antibioticos macrolidos.
HK1217665A1 (zh) 2013-03-14 2017-01-20 森普拉制药公司 用於治療呼吸道疾病的方法及其製劑
RU2015138797A (ru) 2013-03-15 2017-04-24 Семпра Фармасьютикалс, Инк. Конвергентные способы получения макролидных антибактериальных агентов
CN106589023A (zh) * 2016-11-22 2017-04-26 宜昌东阳光药业股份有限公司 一种罗红霉素杂质及其合成方法
EP3601282B1 (en) 2017-03-30 2021-07-21 F. Hoffmann-La Roche AG Novel pyrido[2,3-b]indole compounds for the treatment and prophylaxis of bacterial infection

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2808070A1 (de) 1978-02-24 1979-08-30 Bayer Ag Verfahren zur herstellung von 4-pyridon-3-carbonsaeuren und/oder deren derivaten
GB0127349D0 (en) * 2001-11-14 2002-01-02 Glaxo Group Ltd Macrolides
GB0225384D0 (en) 2002-10-31 2002-12-11 Glaxo Group Ltd Novel compounds

Also Published As

Publication number Publication date
TW200630378A (en) 2006-09-01
US20080090773A1 (en) 2008-04-17
MX2007005776A (es) 2007-07-16
JP2008519788A (ja) 2008-06-12
ZA200703603B (en) 2008-07-30
GB0424959D0 (en) 2004-12-15
AR053311A1 (es) 2007-05-02
EP1824870A1 (en) 2007-08-29
KR20070085919A (ko) 2007-08-27
BRPI0517792A (pt) 2008-10-21
RU2007121581A (ru) 2008-12-20
PE20061137A1 (es) 2006-12-13
US20080269146A1 (en) 2008-10-30
CA2587413A1 (en) 2006-05-18
NO20072939L (no) 2007-08-08
WO2006050942A1 (en) 2006-05-18
CN101098881A (zh) 2008-01-02
IL182978A0 (en) 2007-08-19
US7718621B2 (en) 2010-05-18
MA29213B1 (fr) 2008-02-01

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Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted