AU2005271372B2 - Optimizing expression of active botulinum toxin type A - Google Patents
Optimizing expression of active botulinum toxin type A Download PDFInfo
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- AU2005271372B2 AU2005271372B2 AU2005271372A AU2005271372A AU2005271372B2 AU 2005271372 B2 AU2005271372 B2 AU 2005271372B2 AU 2005271372 A AU2005271372 A AU 2005271372A AU 2005271372 A AU2005271372 A AU 2005271372A AU 2005271372 B2 AU2005271372 B2 AU 2005271372B2
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- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
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| CA2588758C (en) * | 2004-11-22 | 2017-01-03 | New York University | Genetically engineered clostridial genes, proteins encoded by the engineered genes, and uses thereof |
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| EP2218783A1 (en) | 2009-02-05 | 2010-08-18 | Merz Pharma GmbH & Co. KGaA | Novel method for the manufacturing of neurotoxins |
| CN102422158B (zh) | 2009-03-13 | 2015-04-08 | 阿勒根公司 | 基于免疫的重靶向内肽酶活性测定 |
| SG181772A1 (en) | 2009-12-16 | 2012-07-30 | Allergan Inc | Modified clostridial toxins comprising an integrated protease cleavage site-binding domain |
| EP2684890B1 (en) | 2010-01-25 | 2016-04-20 | Allergan, Inc. | Methods of intracellular conversion of single-chain proteins into their di-chain form |
| EP2528941A4 (en) * | 2010-01-25 | 2013-05-29 | Univ New York | FOR TRANSPORT STUDIES AND NEURONAL ADMINISTRATION, MANIPULATED RECOMBINANT DERIVATIVES FROM BOTULINUM NEUROTOXINES |
| ES2553149T3 (es) | 2010-11-23 | 2015-12-04 | Allergan, Inc. | Composiciones y métodos para producir enterocinasa en la levadura |
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| US20120251574A1 (en) | 2011-03-28 | 2012-10-04 | Allergan, Inc. | Endopeptidase and Neurotoxin Combination Treatment of Multiple Medical Conditions |
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| US20120258132A1 (en) | 2011-03-29 | 2012-10-11 | Allergan, Inc. | Vagal Nerve-Based Disorders |
| US20120251519A1 (en) | 2011-03-29 | 2012-10-04 | Allergan, Inc. | Endopeptidase Treatment of Smooth Muscle Disorders |
| US20120251515A1 (en) | 2011-03-29 | 2012-10-04 | Allergan, Inc. | Endopeptidase Treatment of Cosmesis Disorders |
| US20120251518A1 (en) | 2011-03-29 | 2012-10-04 | Allergan, Inc. | Endopeptidase Treatment of Sexual Dysfunction Disorders |
| AU2012255746B2 (en) * | 2011-05-17 | 2016-04-28 | Boston Scientific Neuromodulation Corporation | User-defined graphical shapes used as a visualization aid for stimulator programming |
| WO2012174123A1 (en) | 2011-06-13 | 2012-12-20 | Allergan, Inc. | Treatment of psychological trauma |
| US20140377248A1 (en) | 2011-12-23 | 2014-12-25 | Merz Pharma Gmbh & Co. Kgaa | Method for the manufacturing of di-chain proteins for use in humans |
| US20130171122A1 (en) | 2011-12-29 | 2013-07-04 | Allergan, Inc. | Endopeptidase and neurotoxin combination treatment of bladder disorders |
| RU2673910C2 (ru) | 2012-11-21 | 2018-12-03 | Ипсен Байоинновейшн Лимитед | Способ производства протеолитически процессированного полипептида |
| EP2948174B1 (en) | 2013-01-28 | 2019-09-11 | New York University | Treatment methods using atoxic neurotoxin derivatives |
| KR20150127585A (ko) | 2013-03-15 | 2015-11-17 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 보툴리누스균의 혈청형으로부터의 중쇄를 사용한 1가 또는 다가 보툴리늄 신경독소 기반 백신 |
| WO2015132004A1 (en) | 2014-03-05 | 2015-09-11 | Merz Pharma Gmbh & Co. Kgaa | Novel recombinant clostridial neurotoxins with increased duration of effect |
| EP3230457B1 (en) | 2014-12-09 | 2021-06-30 | New York University | Clostridial neurotoxin fusion proteins, propeptide fusions, their expression, and use |
| EP3233911B1 (en) | 2014-12-19 | 2020-10-14 | Merz Pharma GmbH & Co. KGaA | Means and methods for the determination of the biological activity of bont/e in cells |
| PT3242884T (pt) * | 2015-01-09 | 2021-04-22 | Ipsen Bioinnovation Ltd | Neurotoxinas catiónicas |
| TW201718627A (zh) | 2015-06-11 | 2017-06-01 | 梅茲製藥有限兩合公司 | 重組梭菌神經毒素及其使用與形成方法、包括其之醫藥組合物及對應其之前驅物、編碼前驅物之核酸序列及其獲得方法與前驅物之形成方法、載體與包括核酸序列之重組宿主細胞 |
| US11078472B2 (en) | 2016-01-20 | 2021-08-03 | Merz Pharma Gmbh & Co., Kgaa | Recombinant clostridial neurotoxins with increased duration of effect |
| US11969461B2 (en) | 2016-03-02 | 2024-04-30 | Merz Pharma Gmbh & Co. Kgaa | Composition comprising botulinum toxin |
| EP3290437A1 (en) | 2016-08-31 | 2018-03-07 | Merz Pharma GmbH & Co. KGaA | Novel recombinant clostridial neurotoxins with decreased duration of effect |
| PL3432916T3 (pl) | 2016-09-13 | 2020-04-30 | Allergan, Inc. | Niebiałkowo stabilzowane kompozycje toksyny clostridium |
| EP3312193A1 (en) | 2016-10-19 | 2018-04-25 | Merz Pharma GmbH & Co. KGaA | Novel recombinant botulinum neurotoxins with accelerated onset of effect |
| EP3333179A1 (en) | 2016-12-07 | 2018-06-13 | Merz Pharma GmbH & Co. KGaA | Novel recombinant botulinum toxin with accelarated onset of effect |
| EP3335719A1 (en) | 2016-12-14 | 2018-06-20 | Merz Pharma GmbH & Co. KGaA | Novel recombinant botulinum neurotoxins with a stabilized light chain |
| EP3642222A1 (en) | 2017-06-20 | 2020-04-29 | Merz Pharma GmbH & Co. KGaA | Novel recombinant botulinum toxin with increased duration of effect |
| EP3649143B1 (en) | 2017-07-06 | 2022-08-31 | Merz Pharma GmbH & Co. KGaA | Novel recombinant botulinum neurotoxins with increased duration of effect |
| US20210008156A1 (en) | 2017-10-26 | 2021-01-14 | Merz Pharma Gmbh & Co. Kgaa | Novel recombinant botulinum neurotoxins with increased duration of effect |
| US20200354706A1 (en) | 2017-11-22 | 2020-11-12 | Merz Pharma Gmbh & Co. Kgaa | Novel recombinant botulinum toxin with increased duration of effect |
| WO2019152380A1 (en) * | 2018-01-30 | 2019-08-08 | Children's Medical Center Corporation | Production of botulinum neurotoxins using bacillus systems |
| US11707510B2 (en) * | 2018-02-16 | 2023-07-25 | Preclinics Discovery Gmbh | Nucleic acid-based botulinum neurotoxin for therapeutic use |
| WO2020174079A1 (en) * | 2019-02-28 | 2020-09-03 | Proteonic Biotechnology Ip B.V. | Self-immolative plasmid backbone |
| WO2022197623A1 (en) * | 2021-03-15 | 2022-09-22 | Children's Medical Center Corporation | Engineered botulinum neurotoxin a protease domain with improved efficacy |
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| US20030009025A1 (en) * | 1993-09-21 | 2003-01-09 | Smith Leonard A. | Recombinant vaccine against botulinum neurotoxin |
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| CA2003383A1 (en) * | 1988-11-23 | 1990-05-23 | Sushil G. Devare | Synthetic dna derived recombinant hiv antigens |
| UA48104C2 (uk) * | 1991-10-04 | 2002-08-15 | Новартіс Аг | Фрагмент днк, який містить послідовність,що кодує інсектицидний протеїн, оптимізовану для кукурудзи,фрагмент днк, який забезпечує направлену бажану для серцевини стебла експресію зв'язаного з нею структурного гена в рослині, фрагмент днк, який забезпечує специфічну для пилку експресію зв`язаного з нею структурного гена в рослині, рекомбінантна молекула днк, спосіб одержання оптимізованої для кукурудзи кодуючої послідовності інсектицидного протеїну, спосіб захисту рослин кукурудзи щонайменше від однієї комахи-шкідника |
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- 2005-08-03 AU AU2005271372A patent/AU2005271372B2/en not_active Ceased
- 2005-08-03 EP EP05778839A patent/EP1773874B1/en not_active Revoked
- 2005-08-03 JP JP2007525034A patent/JP2008508886A/ja active Pending
- 2005-08-03 CA CA002575994A patent/CA2575994A1/en not_active Abandoned
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2008
- 2008-08-15 US US12/192,873 patent/US20090023198A1/en not_active Abandoned
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2575994A1 (en) | 2006-02-16 |
| EP1773874B1 (en) | 2012-10-24 |
| JP2008508886A (ja) | 2008-03-27 |
| WO2006017749A2 (en) | 2006-02-16 |
| US20090023198A1 (en) | 2009-01-22 |
| AU2005271372A1 (en) | 2006-02-16 |
| WO2006017749A3 (en) | 2006-03-30 |
| EP1773874A2 (en) | 2007-04-18 |
| US20080057575A1 (en) | 2008-03-06 |
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