AU2005247467B2 - Compounds, formulations, and methods for treating or preventing inflammatory skin disorders - Google Patents
Compounds, formulations, and methods for treating or preventing inflammatory skin disorders Download PDFInfo
- Publication number
- AU2005247467B2 AU2005247467B2 AU2005247467A AU2005247467A AU2005247467B2 AU 2005247467 B2 AU2005247467 B2 AU 2005247467B2 AU 2005247467 A AU2005247467 A AU 2005247467A AU 2005247467 A AU2005247467 A AU 2005247467A AU 2005247467 B2 AU2005247467 B2 AU 2005247467B2
- Authority
- AU
- Australia
- Prior art keywords
- alkyl
- compounds
- independently hydrogen
- pharmaceutically acceptable
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- 238000000034 method Methods 0.000 title claims description 25
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
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- Animal Behavior & Ethology (AREA)
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| PCT/US2005/018288 WO2005115395A2 (en) | 2004-05-25 | 2005-05-25 | Compounds, formulations, and methods for treating or preventing inflammatory skin disorders |
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| US20040266776A1 (en) | 2003-06-25 | 2004-12-30 | Gil Daniel W. | Methods of preventing and reducing the severity of stress-associated conditions |
| US7439241B2 (en) * | 2003-05-27 | 2008-10-21 | Galderma Laboratories, Inc. | Compounds, formulations, and methods for treating or preventing rosacea |
| US8410102B2 (en) | 2003-05-27 | 2013-04-02 | Galderma Laboratories Inc. | Methods and compositions for treating or preventing erythema |
| US20050020600A1 (en) * | 2003-07-23 | 2005-01-27 | Scherer Warren J. | Methods of treating cutaneous flushing using selective alpha-2-adrenergic receptor agonists |
| GB0611241D0 (en) * | 2006-06-07 | 2006-07-19 | Daniolabs Ltd | The treatment of increased sebum production |
| CA2779063A1 (en) * | 2009-10-26 | 2011-05-05 | Galderma Pharma S.A. | Methods of treating or preventing acute erythema |
| EP2329849B1 (en) | 2009-11-18 | 2015-04-29 | Galderma Research & Development | Combination of alpha-2 adrenergic receptor agonist and non-steroidal anti-inflammatory agent for treating or preventing an inflammatory skin disorder |
| US8394800B2 (en) | 2009-11-19 | 2013-03-12 | Galderma Laboratories, L.P. | Method for treating psoriasis |
| US8513247B2 (en) | 2010-03-26 | 2013-08-20 | Galderma Laboratories, L.P. | Methods and compositions for safe and effective treatment of erythema |
| MX2012010823A (es) | 2010-03-26 | 2012-10-10 | Galderma Res & Dev | Metodos y composiciones mejoradas para tratamiento seguro y efectivo de telangiectasia. |
| US8492557B2 (en) * | 2010-09-16 | 2013-07-23 | Allergan, Inc. | Ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol |
| US20120076738A1 (en) * | 2010-09-28 | 2012-03-29 | Michael Graeber | Combination treatment for dermatological conditions |
| US20120082625A1 (en) * | 2010-09-28 | 2012-04-05 | Michael Graeber | Combination treatment for rosacea |
| RU2571277C2 (ru) | 2010-10-21 | 2015-12-20 | Галдерма С.А. | Композиции геля с бримонидином и способы применения |
| KR20130101552A (ko) * | 2010-10-21 | 2013-09-13 | 갈데르마 소시에떼아노님 | 국소용 겔 조성물 |
| CN101972272B (zh) * | 2010-10-31 | 2012-07-04 | 无锡龙腾画材有限公司 | 一种二氧化氯皮肤凝胶及其制备方法 |
| KR102050187B1 (ko) * | 2010-11-16 | 2019-11-28 | 알러간, 인코포레이티드 | (3-(1-(1h-이미다졸-4-일)에틸)-2-메틸페닐)메탄올을 포함하는 약제학적 조성물 |
| BR112013020770A2 (pt) * | 2011-02-15 | 2019-08-27 | Allergan, Inc. | composições de creme farmacêutico de oximetazolina para tratamento de sintomas de rosácea |
| FR2977493B1 (fr) * | 2011-07-05 | 2014-02-14 | Galderma Res & Dev | Nouvelle composition anesthesique stable pour la reduction des reactions cutanees |
| PH12014500783A1 (en) * | 2011-10-19 | 2014-05-12 | Galderma Sa | Method of reducing facial flushing associated with systemic use of phosphodiesterase type 5 inhibitors |
| US9283217B2 (en) | 2011-11-10 | 2016-03-15 | Allergan, Inc. | Pharmaceutical compositions comprising 7-(1 H-imidazol-4-ylmethyl)-5,6,7,8-tetrahydro-quinoline for treating skin diseases and conditions |
| UA109359C2 (xx) * | 2011-11-10 | 2015-08-10 | Лікування захворювань і станів шкіри 7-(1h-імідазол-4-ілметил)-5,6,7,8-тетрагідрохіноліном | |
| EP2782569A1 (en) | 2011-11-21 | 2014-10-01 | Allergan, Inc. | Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3h-imidazole derivatives for treating retinal diseases |
| BR112015027984A2 (pt) * | 2013-05-06 | 2017-09-05 | Allergan Inc | Agonistas alfa adrenérgicos para o tratamento de lesão de tecido |
| EP3024462A2 (en) * | 2013-07-26 | 2016-06-01 | Galderma Research & Development | Method for treating skin thickening |
| BR112016006848A2 (pt) | 2013-10-07 | 2017-08-01 | Teikoku Pharma Usa Inc | métodos e composições para distribuição transdérmica de uma quantidade não sedativa de dexmedetomidina |
| CA2924233C (en) | 2013-10-07 | 2018-10-23 | Teikoku Pharma Usa, Inc. | Methods and compositions for treating attention deficit hyperactivity disorder, anxiety and insomnia using dexmedetomidine transdermal compositions |
| KR101827980B1 (ko) | 2013-10-07 | 2018-02-13 | 테이코쿠 팔마 유에스에이, 인코포레이티드 | 덱스메데토미딘 경피 전달 장치 및 이의 사용 방법 |
| EP3319607A4 (en) * | 2015-07-09 | 2019-04-03 | Galderma S.A. | METHOD FOR REDUCING HAIR LOSS IN CONNECTION WITH CHEMOTHERAPY |
| JP2017052723A (ja) * | 2015-09-10 | 2017-03-16 | 株式会社Ｌｔｔバイオファーマ | ドライアイ改善剤 |
| TWI764951B (zh) | 2016-10-31 | 2022-05-21 | 美商帝國製藥美國股份有限公司 | 用於處理疼痛之右美托咪啶經皮遞送裝置 |
| CN106727462B (zh) * | 2016-11-14 | 2019-04-09 | 四川省人民医院 | 一种治疗面部皮炎的药物及其应用 |
| WO2020144546A1 (en) * | 2019-01-12 | 2020-07-16 | Cellix Bio Private Limited | Combination of selective alpha-adrenergic receptor agonist or an anticholinergic agent and lipoic acid and uses thereof |
| US20220218590A1 (en) * | 2019-05-14 | 2022-07-14 | Abend Fritz Ventures Llc | Compositions and methods for removal of skin adhesive patches, products, and residual adhesives |
| JP2023539595A (ja) * | 2020-08-26 | 2023-09-15 | オティカラ，インコーポレーテッド | 鼻、耳及び他の組織の感染症及び／又は炎症を処置するための組成物、デバイス及び方法 |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4164570A (en) * | 1973-09-24 | 1979-08-14 | David Clough | Stabilized aqueous catecholamine solutions |
| US5442053A (en) * | 1982-09-28 | 1995-08-15 | Fidia, S.P.A. | Salts and mixtures of hyaluronic acid with pharmaceutically active substances, pharmaceutical compositions containing the same and methods for administration of such compositions |
| US5720962A (en) * | 1995-10-04 | 1998-02-24 | Au Pharmaceuticals, Inc. | Analgesic lotion for hemorrhoids and method of making such lotion |
| US6284765B1 (en) * | 2000-04-27 | 2001-09-04 | The University Of North Texas Health Science Center At Fort Worth | (+) naloxone and epinephrine combination therapy |
| US6441047B2 (en) * | 1995-11-17 | 2002-08-27 | Alcon Manufacturing Ltd.. | Combination therapy for treating glaucoma |
| US20020197300A1 (en) * | 1999-02-22 | 2002-12-26 | Schultz Clyde L. | Drug delivery system for anti-glaucomatous medication |
| WO2005010025A2 (en) * | 2003-07-23 | 2005-02-03 | Scherer Warren J | Methods of treating cutaneous flushing using selective alpha-2-adrenergic receptor agonists |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3278447A (en) | 1963-12-02 | 1966-10-11 | Cloro Bac Products Inc | Process for stabilizing chlorine dioxide solution |
| BE795970A (fr) | 1972-02-29 | 1973-08-27 | Pfizer | Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant |
| US4029792A (en) | 1972-02-29 | 1977-06-14 | Pfizer Inc. | (2-Imidazolin-2-ylamino) substituted -quinoxalines and -quinazolines as antihypertensive agents |
| US4285967A (en) * | 1978-06-30 | 1981-08-25 | Estee Lauder Inc. | Cosmetic preparation for reducing redness of blemishes |
| US4256763A (en) * | 1978-09-19 | 1981-03-17 | Mchugh John E | Treatment of herpes simplex infections and acne |
| US4908387A (en) * | 1988-06-06 | 1990-03-13 | The Regents Of The University Of California | Use of beta2 antagonists in the treatment of inflammatory diseases, in particular, rheumatoid arthritis |
| CA2003198C (en) | 1988-11-29 | 1995-03-21 | Anthony J. Dziabo, Jr. | Aqueous ophthalmic solutions and method for preserving same |
| IT1252692B (it) * | 1991-11-27 | 1995-06-23 | Zambon Spa | Composizione farmaceutica per uso oftalmico contenente un antiinfiammatorio non steroideo ed un decongestionante come principi attivi |
| US5736165A (en) | 1993-05-25 | 1998-04-07 | Allergan | In-the-eye use of chlorine dioxide-containing compositions |
| US6194415B1 (en) | 1995-06-28 | 2001-02-27 | Allergan Sales, Inc. | Method of using (2-imidazolin-2-ylamino) quinoxoalines in treating neural injury |
| US5916574A (en) | 1996-10-09 | 1999-06-29 | Ideal Ideas, Inc. | Method of treating natural poison skin conditions |
| US5910312A (en) * | 1996-10-09 | 1999-06-08 | Ideal Ideas, Inc. | Acne treatment composition with vasoconstrictor |
| JPH1129482A (ja) * | 1997-05-14 | 1999-02-02 | Taisho Pharmaceut Co Ltd | 医薬組成物 |
| SK7792000A3 (en) * | 1997-11-24 | 2001-01-18 | Procter & Gamble | 5-(2-imidazolinylamino)-benzimidazole derivatives, their preparation and their use as alpha-adrenoceptor agonists with improved metabolic stability |
| US6159944A (en) * | 1998-02-27 | 2000-12-12 | Synchroneuron, Llc | Method for treating painful conditions of the anal region and compositions therefor |
| IN185228B (https=) | 1999-02-03 | 2000-12-09 | Bakulesh Mafatlal Dr Khamar | |
| US6468989B1 (en) | 2000-07-13 | 2002-10-22 | Dow Pharmaceutical Sciences | Gel compositions containing metronidazole |
| PL360707A1 (en) * | 2000-07-14 | 2004-09-20 | Allergan Inc. | Compositions containing alpha-2-adrenergic agonist components |
| US6387383B1 (en) | 2000-08-03 | 2002-05-14 | Dow Pharmaceutical Sciences | Topical low-viscosity gel composition |
| JP3520076B2 (ja) * | 2001-10-02 | 2004-04-19 | 憲司 中村 | 皮膚外用剤 |
| US20040266776A1 (en) * | 2003-06-25 | 2004-12-30 | Gil Daniel W. | Methods of preventing and reducing the severity of stress-associated conditions |
| US7439241B2 (en) * | 2003-05-27 | 2008-10-21 | Galderma Laboratories, Inc. | Compounds, formulations, and methods for treating or preventing rosacea |
-
2005
- 2005-05-25 JP JP2007515279A patent/JP4955543B2/ja not_active Expired - Fee Related
- 2005-05-25 SI SI200531745T patent/SI1761266T1/sl unknown
- 2005-05-25 CA CA2824612A patent/CA2824612C/en not_active Expired - Fee Related
- 2005-05-25 KR KR1020067027124A patent/KR101257046B1/ko not_active Expired - Fee Related
- 2005-05-25 DK DK05754754.9T patent/DK1761266T3/da active
- 2005-05-25 EP EP05754754.9A patent/EP1761266B1/en not_active Expired - Lifetime
- 2005-05-25 EP EP12165557.5A patent/EP2481412B1/en not_active Expired - Lifetime
- 2005-05-25 WO PCT/US2005/018288 patent/WO2005115395A2/en not_active Ceased
- 2005-05-25 CN CNA2005800223827A patent/CN101426502A/zh active Pending
- 2005-05-25 BR BRPI0511519-1A patent/BRPI0511519A/pt not_active Application Discontinuation
- 2005-05-25 ES ES05754754T patent/ES2424644T3/es not_active Expired - Lifetime
- 2005-05-25 PL PL05754754T patent/PL1761266T3/pl unknown
- 2005-05-25 PT PT57547549T patent/PT1761266E/pt unknown
- 2005-05-25 CA CA2567401A patent/CA2567401C/en not_active Expired - Fee Related
- 2005-05-25 ES ES12165557.5T patent/ES2647618T3/es not_active Expired - Lifetime
- 2005-05-25 NZ NZ552325A patent/NZ552325A/en not_active IP Right Cessation
- 2005-05-25 CN CN201410590016.2A patent/CN104490884A/zh active Pending
- 2005-05-25 MX MXPA06013649A patent/MXPA06013649A/es not_active Application Discontinuation
- 2005-05-25 AU AU2005247467A patent/AU2005247467B2/en not_active Ceased
-
2011
- 2011-12-01 JP JP2011263425A patent/JP5547705B2/ja not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4164570A (en) * | 1973-09-24 | 1979-08-14 | David Clough | Stabilized aqueous catecholamine solutions |
| US5442053A (en) * | 1982-09-28 | 1995-08-15 | Fidia, S.P.A. | Salts and mixtures of hyaluronic acid with pharmaceutically active substances, pharmaceutical compositions containing the same and methods for administration of such compositions |
| US5720962A (en) * | 1995-10-04 | 1998-02-24 | Au Pharmaceuticals, Inc. | Analgesic lotion for hemorrhoids and method of making such lotion |
| US6441047B2 (en) * | 1995-11-17 | 2002-08-27 | Alcon Manufacturing Ltd.. | Combination therapy for treating glaucoma |
| US20020197300A1 (en) * | 1999-02-22 | 2002-12-26 | Schultz Clyde L. | Drug delivery system for anti-glaucomatous medication |
| US6284765B1 (en) * | 2000-04-27 | 2001-09-04 | The University Of North Texas Health Science Center At Fort Worth | (+) naloxone and epinephrine combination therapy |
| WO2005010025A2 (en) * | 2003-07-23 | 2005-02-03 | Scherer Warren J | Methods of treating cutaneous flushing using selective alpha-2-adrenergic receptor agonists |
Also Published As
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|---|---|
| ES2647618T3 (es) | 2017-12-22 |
| CA2567401A1 (en) | 2005-12-08 |
| MXPA06013649A (es) | 2007-07-09 |
| SI1761266T1 (sl) | 2013-08-30 |
| NZ552325A (en) | 2010-11-26 |
| CA2824612A1 (en) | 2005-12-08 |
| EP2481412A1 (en) | 2012-08-01 |
| JP2012072176A (ja) | 2012-04-12 |
| PL1761266T3 (pl) | 2013-09-30 |
| KR20070032716A (ko) | 2007-03-22 |
| JP4955543B2 (ja) | 2012-06-20 |
| CN104490884A (zh) | 2015-04-08 |
| DK1761266T3 (da) | 2013-08-05 |
| ES2424644T3 (es) | 2013-10-07 |
| PT1761266E (pt) | 2013-06-04 |
| JP2008500356A (ja) | 2008-01-10 |
| WO2005115395A2 (en) | 2005-12-08 |
| EP1761266A2 (en) | 2007-03-14 |
| AU2005247467A1 (en) | 2005-12-08 |
| CN101426502A (zh) | 2009-05-06 |
| BRPI0511519A (pt) | 2007-12-26 |
| JP5547705B2 (ja) | 2014-07-16 |
| CA2824612C (en) | 2016-08-16 |
| EP1761266A4 (en) | 2009-11-11 |
| EP2481412B1 (en) | 2017-09-27 |
| EP1761266B1 (en) | 2013-05-08 |
| KR101257046B1 (ko) | 2013-04-22 |
| WO2005115395A3 (en) | 2009-04-09 |
| CA2567401C (en) | 2013-11-12 |
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Owner name: GALDERMA PHARMA S.A. Free format text: FORMER APPLICANT(S): SANSROSA PHARMACEUTICAL DEVELOPMENT, INC. |
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| FGA | Letters patent sealed or granted (standard patent) | ||
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