AU2005245104B2 - Novel cylopenta[b]benzofuran derivatives and the utilization thereof - Google Patents

Novel cylopenta[b]benzofuran derivatives and the utilization thereof Download PDF

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Publication number
AU2005245104B2
AU2005245104B2 AU2005245104A AU2005245104A AU2005245104B2 AU 2005245104 B2 AU2005245104 B2 AU 2005245104B2 AU 2005245104 A AU2005245104 A AU 2005245104A AU 2005245104 A AU2005245104 A AU 2005245104A AU 2005245104 B2 AU2005245104 B2 AU 2005245104B2
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Prior art keywords
hydrogen
formula
alkylamino
ethoxy
substituted
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AU2005245104A
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English (en)
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AU2005245104A1 (en
Inventor
Nicole Diedrichs
Thomas Fahrig
Irene Gerlach
Ervin Horvath
Jacques Ragot
Joachim Schuhmacher
Kai Thede
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Intermed Discovery GmbH
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Intermed Discovery GmbH
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Publication of AU2005245104B2 publication Critical patent/AU2005245104B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Pulmonology (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
AU2005245104A 2004-05-18 2005-05-14 Novel cylopenta[b]benzofuran derivatives and the utilization thereof Ceased AU2005245104B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102004024504A DE102004024504A1 (de) 2004-05-18 2004-05-18 Neue Cylopenta[b]benzofuran-Derivate und ihre Verwendung
DE102004024504.5 2004-05-18
PCT/EP2005/005298 WO2005113529A2 (de) 2004-05-18 2005-05-14 Neue cylopenta[b]benzofuran-derivate und ihre verwendung

Publications (2)

Publication Number Publication Date
AU2005245104A1 AU2005245104A1 (en) 2005-12-01
AU2005245104B2 true AU2005245104B2 (en) 2011-07-28

Family

ID=35207782

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005245104A Ceased AU2005245104B2 (en) 2004-05-18 2005-05-14 Novel cylopenta[b]benzofuran derivatives and the utilization thereof

Country Status (14)

Country Link
US (1) US8030347B2 (US07794700-20100914-C00152.png)
EP (1) EP1751127B1 (US07794700-20100914-C00152.png)
JP (1) JP2007538031A (US07794700-20100914-C00152.png)
KR (1) KR101215164B1 (US07794700-20100914-C00152.png)
CN (1) CN1989122B (US07794700-20100914-C00152.png)
AU (1) AU2005245104B2 (US07794700-20100914-C00152.png)
BR (1) BRPI0510403A (US07794700-20100914-C00152.png)
CA (1) CA2567404C (US07794700-20100914-C00152.png)
DE (1) DE102004024504A1 (US07794700-20100914-C00152.png)
IL (1) IL179257A (US07794700-20100914-C00152.png)
MX (1) MXPA06013182A (US07794700-20100914-C00152.png)
RU (1) RU2415847C9 (US07794700-20100914-C00152.png)
WO (1) WO2005113529A2 (US07794700-20100914-C00152.png)
ZA (1) ZA200609444B (US07794700-20100914-C00152.png)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
EP1771169A1 (en) 2004-07-14 2007-04-11 PTC Therapeutics, Inc. Methods for treating hepatitis c
EP1693059A1 (en) * 2005-02-22 2006-08-23 Deutsches Krebsforschungszentrum Use of rocaglamide derivatives as NF-AT-specific inhibitors for the treatment of certain inflammatory diseases
EP2189453A1 (en) * 2008-11-25 2010-05-26 Université Louis Pasteur Rocaglaol derivatives as cardioprotectant agents
EP2457907A1 (en) * 2010-11-16 2012-05-30 Université de Strasbourg Flavagline derivatives as neuroprotective agents
WO2013016658A1 (en) * 2011-07-27 2013-01-31 The Ohio State University Research Foundation Silvestrol, silvestrol analogs and uses thereof
FR3023290B1 (fr) 2014-07-04 2016-08-19 Pf Medicament Derives de flavaglines
MX2018006443A (es) 2015-11-25 2019-08-01 Effector Therapeutics Inc Compuestos que inhiben eif4a y métodos relacionados a los mismos.
EP3639820A1 (en) * 2018-10-16 2020-04-22 Universitätsmedizin der Johannes Gutenberg-Universität Mainz Flavagline derivatives for inhibition of kras oncogene activation
CN110646616B (zh) * 2019-09-05 2023-05-30 桂林理工大学 一种检测血清中人cTnI的超敏荧光猝灭免疫传感器及检测方法
CN110776486B (zh) * 2019-10-23 2022-05-20 中国药科大学 一种苯并呋喃类小分子p2y14受体抑制剂，及其制备和应用
WO2023030685A1 (en) 2021-09-01 2023-03-09 KHR Biotec GmbH (I. GR.) Novel ras inhibitors
CN115385924B (zh) * 2022-10-06 2023-10-13 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 一种具有抗肿瘤活性的环戊烷苯并呋喃类化合物及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000007579A2 (de) * 1998-08-05 2000-02-17 Bayer Aktiengesellschaft VERWENDUNG VON CYCLOPENTABENZOFURANDERIVATEN ZUR BEKÄMPFUNG VON NF-λB-ABHÄNGIGEN KRANKHEITEN
WO2000008007A2 (de) * 1998-08-05 2000-02-17 Bayer Aktiengesellschaft Cyclopentabenzofuran-derivate und ihre verwendung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19934952A1 (de) * 1998-07-30 2000-02-03 Novartis Ag Cyclopentabenzofuran-Derivate
DE10158561A1 (de) * 2001-11-29 2003-06-12 Bayer Ag Neue Verwendung von Cyclopentabenzofuranen

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000007579A2 (de) * 1998-08-05 2000-02-17 Bayer Aktiengesellschaft VERWENDUNG VON CYCLOPENTABENZOFURANDERIVATEN ZUR BEKÄMPFUNG VON NF-λB-ABHÄNGIGEN KRANKHEITEN
WO2000008007A2 (de) * 1998-08-05 2000-02-17 Bayer Aktiengesellschaft Cyclopentabenzofuran-derivate und ihre verwendung

Also Published As

Publication number Publication date
JP2007538031A (ja) 2007-12-27
IL179257A (en) 2013-02-28
RU2415847C9 (ru) 2011-08-10
EP1751127A2 (de) 2007-02-14
BRPI0510403A (pt) 2007-10-23
ZA200609444B (en) 2008-01-30
MXPA06013182A (es) 2007-02-14
IL179257A0 (en) 2007-03-08
CN1989122B (zh) 2013-07-24
CN1989122A (zh) 2007-06-27
US20090018113A1 (en) 2009-01-15
CA2567404C (en) 2014-04-01
WO2005113529A2 (de) 2005-12-01
EP1751127B1 (de) 2012-07-11
US8030347B2 (en) 2011-10-04
KR20070011522A (ko) 2007-01-24
DE102004024504A1 (de) 2006-02-16
CA2567404A1 (en) 2005-12-01
AU2005245104A1 (en) 2005-12-01
WO2005113529A3 (de) 2006-02-09
RU2006144710A (ru) 2008-06-27
RU2415847C2 (ru) 2011-04-10
KR101215164B1 (ko) 2012-12-24

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