AU2005244115A1 - Pharmaceutical solution formulations containing 17-AAG - Google Patents
Pharmaceutical solution formulations containing 17-AAG Download PDFInfo
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- AU2005244115A1 AU2005244115A1 AU2005244115A AU2005244115A AU2005244115A1 AU 2005244115 A1 AU2005244115 A1 AU 2005244115A1 AU 2005244115 A AU2005244115 A AU 2005244115A AU 2005244115 A AU2005244115 A AU 2005244115A AU 2005244115 A1 AU2005244115 A1 AU 2005244115A1
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| US11/123,570 US20050256097A1 (en) | 2004-05-11 | 2005-05-05 | Pharmaceutical solution formulations containing 17-AAG |
| PCT/US2005/016010 WO2005110398A2 (en) | 2004-05-11 | 2005-05-06 | Pharmaceutical solution formulations containing 17-aag |
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| US20090197852A9 (en) * | 2001-08-06 | 2009-08-06 | Johnson Robert G Jr | Method of treating breast cancer using 17-AAG or 17-AG or a prodrug of either in combination with a HER2 inhibitor |
| US20050232981A1 (en) | 2004-04-15 | 2005-10-20 | Ben-Sasson Shmuel A | Compositions capable of facilitating penetration across a biological barrier |
| MX2007013499A (es) * | 2005-04-29 | 2008-01-24 | Kosan Biosciences Inc | Metodo para tratar mieloma multiple utilizando 17-aag o 17-ag o un profarmaco de ya sea 17-aag o 17-ag en combinacion con un inhibidor de proteasoma. |
| KR20080000682A (ko) * | 2005-04-29 | 2008-01-02 | 코산 바이오사이언시즈, 인코포레이티드 | 17-ａａｇ 또는 17-ａｇ, 또는 이들의 프로드럭을 사용한다발성 골수종의 치료 방법 |
| US20090042847A1 (en) * | 2005-11-23 | 2009-02-12 | Kosan Biosciences Incorporated | 17-allylamino-17-demethoxygeldanamycin polymorphs and formulations |
| US7648976B2 (en) * | 2005-11-23 | 2010-01-19 | Bristol-Myers Squibb Company | 17-allylamino-17-demethoxygeldanamycin polymorphs and formulations |
| US20070167422A1 (en) * | 2006-01-18 | 2007-07-19 | Yu Kwok S | Pharmaceutical compositions comprising 17-allylamino-17-demethoxygeldanamycin |
| EP2073807A1 (en) | 2006-10-12 | 2009-07-01 | Astex Therapeutics Limited | Pharmaceutical combinations |
| JP5528806B2 (ja) | 2006-10-12 | 2014-06-25 | アステックス、セラピューティックス、リミテッド | 複合薬剤 |
| WO2008055386A1 (fr) * | 2006-11-10 | 2008-05-15 | Shenzhen Shengeryimei Biotech Co., Ltd. | Composition pharmaceutique hydrosoluble pour injection de 17-allyl amino-17-déméthoxy geldanamycine (17-aag) |
| PE20081506A1 (es) * | 2006-12-12 | 2008-12-09 | Infinity Discovery Inc | Formulaciones de ansamicina |
| WO2008094438A1 (en) | 2007-01-26 | 2008-08-07 | Kosan Biosciences Incorporated | Macrolactams by engineered biosynthesis |
| US20100203114A1 (en) * | 2007-07-09 | 2010-08-12 | Warf - Wisconsin Alumni Research Foundation | Micelle encapsulation of therapeutic agents |
| WO2009046967A1 (en) * | 2007-10-08 | 2009-04-16 | Fovea Pharmaceuticals Sa | Aqueous ophthalmic formulations |
| US20090258869A1 (en) * | 2008-02-08 | 2009-10-15 | The Regents Of The University Of California | Methods and compounds for treatment or prevention of substance-related disorders |
| BRPI0918652B1 (pt) | 2008-09-17 | 2021-10-19 | Chiasma, Inc. | Composição farmacêutica compreendendo um meio hidrofóbico e uma forma sólida que compreende polipeptídeo e sal de ácido graxo de cadeia média, processo de produção da mesma e forma de dosagem oral |
| WO2011038278A2 (en) | 2009-09-25 | 2011-03-31 | Wisconsin Alumni Research Foundation | Micelle encapsulation of therapeutic agents |
| WO2011116286A2 (en) * | 2010-03-18 | 2011-09-22 | Innopharma, Llc | Stable bortezomib formulations |
| US8945627B2 (en) | 2011-05-05 | 2015-02-03 | Wisconsin Alumni Research Foundation | Micelles for the solubilization of gossypol |
| US10682415B2 (en) | 2013-07-22 | 2020-06-16 | Wisconsin Alumni Research Foundation | Thermogel formulation for combination drug delivery |
| EP3230322B1 (en) | 2014-12-11 | 2020-10-07 | University of Utah Research Foundation | Bi-functional allosteric protein-drug molecules for targeted therapy |
| US10238709B2 (en) | 2015-02-03 | 2019-03-26 | Chiasma, Inc. | Method of treating diseases |
| JP2018008922A (ja) * | 2015-08-04 | 2018-01-18 | わかもと製薬株式会社 | ステロイド白内障の予防及び治療 |
| US11141457B1 (en) | 2020-12-28 | 2021-10-12 | Amryt Endo, Inc. | Oral octreotide therapy and contraceptive methods |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US553153A (en) * | 1896-01-14 | Type-writing machine | ||
| US4261989A (en) * | 1979-02-19 | 1981-04-14 | Kaken Chemical Co. Ltd. | Geldanamycin derivatives and antitumor drug |
| US6262022B1 (en) * | 1992-06-25 | 2001-07-17 | Novartis Ag | Pharmaceutical compositions containing cyclosporin as the active agent |
| US5932556A (en) * | 1995-09-17 | 1999-08-03 | Tam; Robert C | Methods and compositions for regulation of CD28 expression |
| EP1014953B1 (en) * | 1997-03-05 | 2012-04-25 | Sugen, Inc. | Formulations for hydrophobic pharmaceutical agents |
| US20030044434A1 (en) * | 1997-07-29 | 2003-03-06 | Ping Gao | Self-emulsifying formulation for lipophilic compounds |
| US6121323A (en) * | 1997-12-03 | 2000-09-19 | 3M Innovative Properties Company | Bishydroxyureas |
| US5925776A (en) * | 1997-12-24 | 1999-07-20 | Schein Pharmacetical, Inc. | Polyethoxylated castor oil, process of making the same and formulations thereof |
| US6682758B1 (en) * | 1998-12-22 | 2004-01-27 | The United States Of America As Represented By The Department Of Health And Human Services | Water-insoluble drug delivery system |
| TW471968B (en) * | 1999-08-25 | 2002-01-11 | Committee On Chinese Medicine | Solamargine pharmaceutical composition for killing cancer cells |
| US20020037855A1 (en) * | 2000-05-05 | 2002-03-28 | Fritz Stanislaus | Stabilized medicament containing cysteinyl derivatives |
| US6946456B2 (en) * | 2000-07-28 | 2005-09-20 | Sloan-Kettering Institute For Cancer Research | Methods for treating cell proliferative disorders and viral infections |
| EE200300201A (et) * | 2000-10-31 | 2003-08-15 | Boehringer Ingelheim Pharmaceuticals, Inc. | Püranoonsete proteaasi inhibiitorite iseemulgeeruva kompositsiooni oraalne doos |
| US7025992B2 (en) * | 2001-02-14 | 2006-04-11 | Gw Pharma Limited | Pharmaceutical formulations |
| SI21369A (sl) * | 2001-03-30 | 2004-06-30 | The United States Of America, Represented By The Secretary, | Geldanamicinski derivat in postopek zdravljenja raka z uporabo le-tega |
| WO2002092076A1 (en) * | 2001-05-16 | 2002-11-21 | Cytovia, Inc. | Substituted coumarins and quinolines as caspases activators |
| US6962944B2 (en) * | 2001-07-31 | 2005-11-08 | Arqule, Inc. | Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same |
| US6872715B2 (en) * | 2001-08-06 | 2005-03-29 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
| US6653319B1 (en) * | 2001-08-10 | 2003-11-25 | University Of Kentucky Research Foundation | Pharmaceutical formulation for poorly water soluble camptothecin analogues |
| US8071133B2 (en) * | 2001-08-20 | 2011-12-06 | Stiefel Laboratories, Inc. | Oral dosage forms of water insoluble drugs and methods of making the same |
| EP1435910B9 (en) * | 2001-10-19 | 2010-02-03 | Isotechnika Inc. | Novel cyclosporin analog microemulsion preconcentrates |
| NZ533060A (en) * | 2001-12-19 | 2006-03-31 | Alza Corp | Formulation and dosage form for increasing oral bioavailability of hydrophilic macromolecules |
| CA2471081A1 (en) * | 2001-12-19 | 2003-07-03 | Alza Corporation | Formulation & dosage form for the controlled delivery of therapeutic agents |
| US6803046B2 (en) * | 2002-08-16 | 2004-10-12 | Bracco International B.V. | Sincalide formulations |
| US7649006B2 (en) * | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
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- 2005-05-06 JP JP2007513239A patent/JP2007537258A/ja not_active Abandoned
- 2005-05-06 MX MXPA06012935A patent/MXPA06012935A/es active IP Right Grant
- 2005-05-06 CA CA002565583A patent/CA2565583A1/en not_active Abandoned
- 2005-05-06 RU RU2006143666/15A patent/RU2382643C2/ru not_active IP Right Cessation
- 2005-05-06 WO PCT/US2005/016010 patent/WO2005110398A2/en active Application Filing
- 2005-05-06 AU AU2005244115A patent/AU2005244115A1/en not_active Abandoned
- 2005-05-06 EP EP05779076A patent/EP1744743A2/en not_active Withdrawn
- 2005-05-06 BR BRPI0511036-0A patent/BRPI0511036A/pt not_active IP Right Cessation
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2006
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| WO2005110398A2 (en) | 2005-11-24 |
| BRPI0511036A (pt) | 2007-11-27 |
| EP1744743A2 (en) | 2007-01-24 |
| RU2006143666A (ru) | 2008-06-20 |
| RU2382643C2 (ru) | 2010-02-27 |
| WO2005110398A3 (en) | 2006-05-04 |
| US20050256097A1 (en) | 2005-11-17 |
| MXPA06012935A (es) | 2007-01-26 |
| IL178689A0 (en) | 2007-02-11 |
| JP2007537258A (ja) | 2007-12-20 |
| CA2565583A1 (en) | 2005-11-24 |
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