AU2005239989B2 - Naltrexone long acting formulations and methods of use - Google Patents
Naltrexone long acting formulations and methods of use Download PDFInfo
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- AU2005239989B2 AU2005239989B2 AU2005239989A AU2005239989A AU2005239989B2 AU 2005239989 B2 AU2005239989 B2 AU 2005239989B2 AU 2005239989 A AU2005239989 A AU 2005239989A AU 2005239989 A AU2005239989 A AU 2005239989A AU 2005239989 B2 AU2005239989 B2 AU 2005239989B2
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- naltrexone
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- HUNXMJYCHXQEGX-UHFFFAOYSA-N zaleplon Chemical compound CCN(C(C)=O)C1=CC=CC(C=2N3N=CC(=C3N=CC=2)C#N)=C1 HUNXMJYCHXQEGX-UHFFFAOYSA-N 0.000 description 1
- 229960004010 zaleplon Drugs 0.000 description 1
- 229960005111 zolpidem tartrate Drugs 0.000 description 1
- 229960000820 zopiclone Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Addiction (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56454204P | 2004-04-22 | 2004-04-22 | |
| US60/564,542 | 2004-04-22 | ||
| US11/083,167 US7919499B2 (en) | 2004-04-22 | 2005-03-17 | Naltrexone long acting formulations and methods of use |
| US11/083,167 | 2005-03-17 | ||
| PCT/US2005/009133 WO2005107753A2 (en) | 2004-04-22 | 2005-03-18 | Naltrexone long acting formulations and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2005239989A1 AU2005239989A1 (en) | 2005-11-17 |
| AU2005239989B2 true AU2005239989B2 (en) | 2008-05-29 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2005239989A Expired AU2005239989B2 (en) | 2004-04-22 | 2005-03-18 | Naltrexone long acting formulations and methods of use |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US7919499B2 (enExample) |
| EP (2) | EP2386269A3 (enExample) |
| JP (2) | JP5426094B2 (enExample) |
| KR (2) | KR20070005722A (enExample) |
| CN (1) | CN103251597A (enExample) |
| AU (1) | AU2005239989B2 (enExample) |
| CA (1) | CA2563086C (enExample) |
| NZ (1) | NZ549976A (enExample) |
| RU (1) | RU2370257C2 (enExample) |
| WO (1) | WO2005107753A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2818973B2 (ja) | 1990-10-22 | 1998-10-30 | 株式会社藤井鉄工所 | スキップ式水路用スクリーン除塵機 |
| US20100196436A1 (en) * | 2009-01-30 | 2010-08-05 | Gooberman Lance L | Implants containing disulfiram and an anti-inflammatory agent |
| US8791093B2 (en) * | 2009-05-29 | 2014-07-29 | Lance L. Gooberman | Pharmaceutical delivery systems for treatment of substance abuse and other addictions |
| RU2471478C1 (ru) * | 2011-12-08 | 2013-01-10 | Станислав Анатольевич Кедик | Фармацевтическая композиция для лечения алкоголизма, наркомании и токсикомании с улучшенным профилем высвобождения налтрексона |
| WO2016160715A1 (en) * | 2015-03-27 | 2016-10-06 | Markel Dan | Method for treating addiction |
| BR112021006747A2 (pt) | 2018-10-15 | 2021-07-13 | Chong Kun Dang Pharmaceutical Corp. | composições injetáveis de micropartícula de naltrexona de longa ação |
| WO2020135576A1 (en) * | 2018-12-27 | 2020-07-02 | Alar Pharmaceuticals Inc. | Naltrexone injectable sustained release formulation |
| GR1009871B (el) * | 2019-07-30 | 2020-11-12 | Φαρματεν Α.Β.Ε.Ε. | Φαρμακευτικο σκευασμα που περιλαμβανει μικροσφαιριδια ναλτρεξονης και μεθοδος παρασκευης αυτου |
| US11752143B2 (en) | 2020-12-31 | 2023-09-12 | Soin Therapeutics Llc | Methods of using low dose naltrexone to treat chronic pain |
| US12343340B2 (en) | 2020-12-31 | 2025-07-01 | Soin Therapeutics Llc | Methods of using low dose naltrexone to treat chronic pain |
| US11197819B1 (en) | 2021-04-09 | 2021-12-14 | Drug Delivery Company, Llc | Extended release bioabsorbable subcutaneous medicinal dosage delivery implant system |
| WO2023114557A2 (en) * | 2021-12-17 | 2023-06-22 | Journey Colab Corp. | METHODS OF TREATING SUBSTANCE USE DISORDERS USING 5-MeO-DMT |
| US12303604B1 (en) | 2024-10-16 | 2025-05-20 | Currax Pharmaceuticals Llc | Pharmaceutical formulations comprising naltrexone and/or bupropion |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4882335A (en) * | 1988-06-13 | 1989-11-21 | Alko Limited | Method for treating alcohol-drinking response |
| US6306425B1 (en) * | 1999-04-09 | 2001-10-23 | Southern Research Institute | Injectable naltrexone microsphere compositions and their use in reducing consumption of heroin and alcohol |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4719219A (en) * | 1982-03-30 | 1988-01-12 | Per A. E. Carlsson | Phenyl-azacycloalkanes and use thereof in treatment of central nervous system disorders |
| ATE133087T1 (de) * | 1989-05-04 | 1996-02-15 | Southern Res Inst | Einkapselungsverfahren |
| US5512593A (en) * | 1993-03-02 | 1996-04-30 | John S. Nagle | Composition and method of treating depression using natoxone or naltrexone in combination with a serotonin reuptake inhibitor |
| JPH09505308A (ja) * | 1993-11-19 | 1997-05-27 | アルカーミズ・コントロールド・セラピューティクス・インコーポレイテッド・トゥー | 生物学的活性剤を含有する生分解性微粒子の製造 |
| US5922253A (en) * | 1995-05-18 | 1999-07-13 | Alkermes Controlled Therapeutics, Inc. | Production scale method of forming microparticles |
| WO1997033581A1 (en) * | 1996-03-13 | 1997-09-18 | Yale University | Smoking cessation treatments using naltrexone and related compounds |
| US5792477A (en) * | 1996-05-07 | 1998-08-11 | Alkermes Controlled Therapeutics, Inc. Ii | Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent |
| US6143314A (en) * | 1998-10-28 | 2000-11-07 | Atrix Laboratories, Inc. | Controlled release liquid delivery compositions with low initial drug burst |
| IL148343A0 (en) | 1999-08-27 | 2002-09-12 | Southern Res Inst | Injectable buprenorphine microparticle compositions and their use |
| US20020034534A1 (en) * | 1999-12-16 | 2002-03-21 | Barr Deborah P. | System and method for delivering a therapeutic agent over an extended period of time in conjuction with a receptor loading dose of the therapeutic agent |
| US6264987B1 (en) * | 2000-05-19 | 2001-07-24 | Alkermes Controlled Therapeutics Inc. Ii | Method for preparing microparticles having a selected polymer molecular weight |
| AU2003286796A1 (en) | 2002-10-31 | 2004-06-07 | Umd, Inc. | Therapeutic compositions for drug delivery to and through covering epithelia |
| CN1166360C (zh) * | 2002-11-07 | 2004-09-15 | 上海医药工业研究院 | 一种纳曲酮长效注射微球组合物及制备方法和应用 |
| US7658998B2 (en) | 2003-01-22 | 2010-02-09 | Alkermes Controlled Therapeutics, Inc. | Method of preparing sustained release microparticles |
| US7279579B2 (en) | 2003-06-04 | 2007-10-09 | Alkermes, Inc. | Polymorphic forms of naltrexone |
-
2005
- 2005-03-17 US US11/083,167 patent/US7919499B2/en active Active
- 2005-03-18 EP EP11161854A patent/EP2386269A3/en not_active Withdrawn
- 2005-03-18 EP EP05728952A patent/EP1740120A4/en not_active Ceased
- 2005-03-18 CN CN2013101596188A patent/CN103251597A/zh active Pending
- 2005-03-18 AU AU2005239989A patent/AU2005239989B2/en not_active Expired
- 2005-03-18 KR KR1020067023387A patent/KR20070005722A/ko not_active Ceased
- 2005-03-18 NZ NZ549976A patent/NZ549976A/en not_active IP Right Cessation
- 2005-03-18 WO PCT/US2005/009133 patent/WO2005107753A2/en not_active Ceased
- 2005-03-18 RU RU2006137349/14A patent/RU2370257C2/ru active
- 2005-03-18 CA CA2563086A patent/CA2563086C/en not_active Expired - Lifetime
- 2005-03-18 JP JP2007509472A patent/JP5426094B2/ja not_active Expired - Fee Related
- 2005-03-18 KR KR1020097009360A patent/KR20090050111A/ko not_active Ceased
-
2011
- 2011-03-01 US US13/037,713 patent/US20110212985A1/en not_active Abandoned
- 2011-07-15 JP JP2011156813A patent/JP2011225600A/ja active Pending
-
2013
- 2013-04-26 US US13/871,534 patent/US20140155424A1/en not_active Abandoned
-
2017
- 2017-04-13 US US15/486,869 patent/US20180064814A1/en not_active Abandoned
-
2021
- 2021-04-29 US US17/244,110 patent/US20210244818A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4882335A (en) * | 1988-06-13 | 1989-11-21 | Alko Limited | Method for treating alcohol-drinking response |
| US6306425B1 (en) * | 1999-04-09 | 2001-10-23 | Southern Research Institute | Injectable naltrexone microsphere compositions and their use in reducing consumption of heroin and alcohol |
Non-Patent Citations (1)
| Title |
|---|
| Bartus, R.T. et al 2003 Neuropsychopharmacology 28:1973-1982 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011225600A (ja) | 2011-11-10 |
| US20210244818A1 (en) | 2021-08-12 |
| US20140155424A1 (en) | 2014-06-05 |
| EP1740120A4 (en) | 2008-06-25 |
| US20110212985A1 (en) | 2011-09-01 |
| EP2386269A3 (en) | 2012-04-25 |
| RU2006137349A (ru) | 2009-04-20 |
| NZ549976A (en) | 2009-11-27 |
| KR20070005722A (ko) | 2007-01-10 |
| JP5426094B2 (ja) | 2014-02-26 |
| CN103251597A (zh) | 2013-08-21 |
| US7919499B2 (en) | 2011-04-05 |
| WO2005107753A3 (en) | 2005-12-29 |
| AU2005239989A1 (en) | 2005-11-17 |
| KR20090050111A (ko) | 2009-05-19 |
| WO2005107753A2 (en) | 2005-11-17 |
| JP2007533738A (ja) | 2007-11-22 |
| RU2370257C2 (ru) | 2009-10-20 |
| CA2563086C (en) | 2018-04-17 |
| EP2386269A2 (en) | 2011-11-16 |
| CA2563086A1 (en) | 2005-11-17 |
| US20050245558A1 (en) | 2005-11-03 |
| US20180064814A1 (en) | 2018-03-08 |
| EP1740120A2 (en) | 2007-01-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| PC | Assignment registered |
Owner name: ALKERMES PHARMA IRELAND LIMITED Free format text: FORMER OWNER(S): ALKERMES, INC. |
|
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |