AU2005235419B2 - Pharmaceutical combinations containing benzoxazine for treating respiratory diseases - Google Patents

Pharmaceutical combinations containing benzoxazine for treating respiratory diseases Download PDF

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Publication number
AU2005235419B2
AU2005235419B2 AU2005235419A AU2005235419A AU2005235419B2 AU 2005235419 B2 AU2005235419 B2 AU 2005235419B2 AU 2005235419 A AU2005235419 A AU 2005235419A AU 2005235419 A AU2005235419 A AU 2005235419A AU 2005235419 B2 AU2005235419 B2 AU 2005235419B2
Authority
AU
Australia
Prior art keywords
amino
phenyl
hydroxy
quinazoline
methoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active, expires
Application number
AU2005235419A
Other languages
English (en)
Other versions
AU2005235419A1 (en
Inventor
Thierry Bouyssou
Christoph Hoenke
Ingo Konetzki
Philipp Lustenberger
Michel Pairet
Sabine Pestel
Michael P. Pieper
Klaus Rudolf
Andreas Schnapp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34966478&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2005235419(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE102004019540A external-priority patent/DE102004019540A1/de
Priority claimed from DE102004052987A external-priority patent/DE102004052987A1/de
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Publication of AU2005235419A1 publication Critical patent/AU2005235419A1/en
Application granted granted Critical
Publication of AU2005235419B2 publication Critical patent/AU2005235419B2/en
Active legal-status Critical Current
Adjusted expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/5381,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06Antiabortive agents; Labour repressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/10Anthelmintics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2005235419A 2004-04-22 2005-04-18 Pharmaceutical combinations containing benzoxazine for treating respiratory diseases Active 2030-04-18 AU2005235419B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
DE102004019540.4 2004-04-22
DE102004019540A DE102004019540A1 (de) 2004-04-22 2004-04-22 Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen
DE102004052987A DE102004052987A1 (de) 2004-11-03 2004-11-03 Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen
DE102004052987.6 2004-11-03
EP05002496 2005-02-07
EP05002496.7 2005-02-07
PCT/EP2005/004073 WO2005102349A1 (de) 2004-04-22 2005-04-18 Arzneinmittelkombinationen enthaltend benzoxazine zur behandlung von atemwegserkrankungen

Publications (2)

Publication Number Publication Date
AU2005235419A1 AU2005235419A1 (en) 2005-11-03
AU2005235419B2 true AU2005235419B2 (en) 2010-11-04

Family

ID=34966478

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005235419A Active 2030-04-18 AU2005235419B2 (en) 2004-04-22 2005-04-18 Pharmaceutical combinations containing benzoxazine for treating respiratory diseases

Country Status (33)

Country Link
EP (2) EP1781298B1 (enrdf_load_stackoverflow)
JP (1) JP2007533683A (enrdf_load_stackoverflow)
KR (2) KR20130049840A (enrdf_load_stackoverflow)
AR (1) AR049262A1 (enrdf_load_stackoverflow)
AT (1) ATE539754T1 (enrdf_load_stackoverflow)
AU (1) AU2005235419B2 (enrdf_load_stackoverflow)
BE (1) BE2015C065I2 (enrdf_load_stackoverflow)
BR (1) BRPI0510080B8 (enrdf_load_stackoverflow)
CA (1) CA2559699C (enrdf_load_stackoverflow)
CY (3) CY1113890T1 (enrdf_load_stackoverflow)
DK (2) DK2422786T3 (enrdf_load_stackoverflow)
EA (1) EA013157B1 (enrdf_load_stackoverflow)
EC (1) ECSP066947A (enrdf_load_stackoverflow)
ES (2) ES2380370T3 (enrdf_load_stackoverflow)
FI (1) FIC20170005I1 (enrdf_load_stackoverflow)
FR (1) FR16C0029I2 (enrdf_load_stackoverflow)
HU (1) HUS1500058I1 (enrdf_load_stackoverflow)
IL (2) IL177685A (enrdf_load_stackoverflow)
LT (1) LTC1781298I2 (enrdf_load_stackoverflow)
LU (1) LU93066I2 (enrdf_load_stackoverflow)
MY (1) MY148945A (enrdf_load_stackoverflow)
NL (1) NL300779I2 (enrdf_load_stackoverflow)
NO (2) NO337714B1 (enrdf_load_stackoverflow)
NZ (1) NZ550797A (enrdf_load_stackoverflow)
PE (1) PE20060462A1 (enrdf_load_stackoverflow)
PL (2) PL2422786T3 (enrdf_load_stackoverflow)
PT (2) PT1781298E (enrdf_load_stackoverflow)
SG (1) SG152237A1 (enrdf_load_stackoverflow)
SI (2) SI2422786T1 (enrdf_load_stackoverflow)
TW (2) TWI374739B (enrdf_load_stackoverflow)
UY (1) UY28861A1 (enrdf_load_stackoverflow)
WO (1) WO2005102349A1 (enrdf_load_stackoverflow)
ZA (1) ZA200606624B (enrdf_load_stackoverflow)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
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US7056916B2 (en) 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
DE102004024452A1 (de) * 2004-05-14 2005-12-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolformulierung für die Inhalation von Betaagonisten
US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
US7923455B2 (en) * 2005-01-28 2011-04-12 Boehringer Ingelheim International Gmbh Medicaments for the prevention or treatment of heart failure comprising administration of an anticholinergic
CA2597942A1 (en) * 2005-02-16 2006-08-24 Boehringer Ingelheim International Gmbh Pharmaceutical compositions comprising anticholinergics and etiprednol
EP1917253B1 (de) 2005-08-15 2015-01-07 Boehringer Ingelheim International Gmbh Verfahren zur herstellung von betamimetika
TWI389692B (zh) 2005-10-10 2013-03-21 Boehringer Ingelheim Int 用以吸入β-共效劑的氣溶膠調配物
US20070086957A1 (en) * 2005-10-10 2007-04-19 Thierry Bouyssou Combination of medicaments for the treatment of respiratory diseases
AU2006315657B2 (en) * 2005-11-10 2011-12-01 Shell Internationale Research Maatschappij B.V. Soft anticholinergic esters
WO2007093608A1 (de) * 2006-02-16 2007-08-23 Boehringer Ingelheim International Gmbh Arzneimittelkombinationen zur behandlung von atemwegserkrankungen
EP2051714B1 (de) 2006-08-07 2011-04-13 Boehringer Ingelheim International GmbH Arzneimittelkombinationen zur behandlung von atemwegserkrankungen
UY30542A1 (es) * 2006-08-18 2008-03-31 Boehringer Ingelheim Int Formulacion de aerosol para la inhalacion de agonistas beta
UY30543A1 (es) * 2006-08-18 2008-03-31 Boehringer Ingelheim Int Formulacion de aerosol para la inhalacion de beta- agonistas
US20100099651A1 (en) * 2006-10-26 2010-04-22 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
EP1921070A1 (de) 2006-11-10 2008-05-14 Boehringer Ingelheim Pharma GmbH & Co. KG Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung
CN101939316B (zh) 2008-02-07 2013-10-02 贝林格尔.英格海姆国际有限公司 螺环杂环化合物、含有所述化合物的药物、其用途及其制备方法
JP5539351B2 (ja) 2008-08-08 2014-07-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング シクロヘキシルオキシ置換ヘテロ環、これらの化合物を含有する医薬、およびそれらを生成するための方法
WO2010060875A1 (de) * 2008-11-27 2010-06-03 Boehringer Ingelheim International Gmbh Neue pulverförmige kristalline arzneimittel zur inhalation
WO2014016548A2 (en) * 2012-07-27 2014-01-30 Cipla Limited Pharmaceutical composition
WO2014056840A1 (en) 2012-10-09 2014-04-17 Boehringer Ingelheim International Gmbh Beta-2-adrenoceptor agonist for the treatment of cough

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4460581A (en) * 1982-10-12 1984-07-17 Boehringer Ingelheim Kg (1-Hydroxy-2-amino-alkyl)-substituted benzoxazinones and benzoxazolinones
WO2001083462A1 (de) * 2000-04-27 2001-11-08 Boehringer Ingelheim Pharma Kg Neue, langwirksame betamimetika, verfahren zu deren herstellung und deren verwendung als arzneimittel
AU2003285326A1 (en) * 2002-11-15 2004-06-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Novel medicaments for the treatment of chronic obstructive pulmonary diseases

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US4570630A (en) 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
EP0211595B1 (en) 1985-07-30 1991-11-13 Glaxo Group Limited Devices for administering medicaments to patients
SE453566B (sv) 1986-03-07 1988-02-15 Draco Ab Anordning vid pulverinhalatorer
SG45171A1 (en) 1990-03-21 1998-01-16 Boehringer Ingelheim Int Atomising devices and methods
DE4318455A1 (de) 1993-06-03 1994-12-08 Boehringer Ingelheim Kg Kapselhalterung
DE19536902A1 (de) 1995-10-04 1997-04-10 Boehringer Ingelheim Int Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung
CN100519558C (zh) 2000-10-12 2009-07-29 贝林格尔英格海姆法玛两合公司 结晶单水合物、其制备方法及其在制备药物组合中的用途
JP2005504015A (ja) 2001-06-22 2005-02-10 ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト 抗コリン作用薬、その製造方法及び医薬組成物を製造するためのその使用
DE10130371A1 (de) * 2001-06-23 2003-01-02 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Anticholinergika, Corticosteroiden und Betamimetika
ES2203327B1 (es) * 2002-06-21 2005-06-16 Almirall Prodesfarma, S.A. Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen.
DE10230751A1 (de) * 2002-07-09 2004-01-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittelkompositionen auf der Basis neuer Anticholinergika und EGFR-Kinase-Hemmern
DE10246374A1 (de) * 2002-10-04 2004-04-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Betamimetika mit verlängerter Wirkungsdauer, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4460581A (en) * 1982-10-12 1984-07-17 Boehringer Ingelheim Kg (1-Hydroxy-2-amino-alkyl)-substituted benzoxazinones and benzoxazolinones
WO2001083462A1 (de) * 2000-04-27 2001-11-08 Boehringer Ingelheim Pharma Kg Neue, langwirksame betamimetika, verfahren zu deren herstellung und deren verwendung als arzneimittel
AU2003285326A1 (en) * 2002-11-15 2004-06-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Novel medicaments for the treatment of chronic obstructive pulmonary diseases

Also Published As

Publication number Publication date
ES2523518T3 (es) 2014-11-26
FR16C0029I1 (enrdf_load_stackoverflow) 2016-08-26
UY28861A1 (es) 2005-11-30
DK2422786T3 (da) 2014-11-17
NO337714B1 (no) 2016-06-06
TW201231055A (en) 2012-08-01
EP1781298A1 (de) 2007-05-09
NZ550797A (en) 2010-08-27
BRPI0510080A (pt) 2007-10-16
SG152237A1 (en) 2009-05-29
TWI372056B (en) 2012-09-11
CA2559699A1 (en) 2005-11-03
NO2016022I1 (no) 2016-12-01
CY1115719T1 (el) 2017-01-25
CY2017014I2 (el) 2017-11-14
DK1781298T3 (da) 2012-05-07
WO2005102349A1 (de) 2005-11-03
HUS1500058I1 (hu) 2016-01-28
SI2422786T1 (sl) 2014-12-31
BE2015C065I2 (enrdf_load_stackoverflow) 2024-08-08
MY148945A (en) 2013-06-14
EA013157B1 (ru) 2010-02-26
EP1781298B1 (de) 2012-01-04
CY1113890T1 (el) 2016-07-27
EA200601846A1 (ru) 2007-04-27
KR101287460B1 (ko) 2013-07-23
NO20065060L (no) 2006-11-21
FIC20170005I1 (fi) 2017-01-13
AR049262A1 (es) 2006-07-12
PT2422786E (pt) 2014-11-12
JP2007533683A (ja) 2007-11-22
ES2380370T3 (es) 2012-05-11
AU2005235419A1 (en) 2005-11-03
PL1781298T3 (pl) 2012-06-29
CA2559699C (en) 2012-06-19
NO2016022I2 (no) 2016-12-01
LTC1781298I2 (lt) 2018-09-25
ECSP066947A (es) 2007-01-26
ATE539754T1 (de) 2012-01-15
FR16C0029I2 (fr) 2017-01-27
BRPI0510080B8 (pt) 2021-05-25
PE20060462A1 (es) 2006-06-19
IL226562A0 (en) 2013-06-27
PL1781298T4 (pl) 2017-07-31
KR20130049840A (ko) 2013-05-14
PT1781298E (pt) 2012-02-03
SI1781298T1 (sl) 2012-04-30
EP2422786B1 (de) 2014-08-13
CY2017014I1 (el) 2017-11-14
KR20070015592A (ko) 2007-02-05
EP2422786A1 (de) 2012-02-29
IL177685A0 (en) 2006-12-31
PL2422786T3 (pl) 2015-02-27
BRPI0510080B1 (pt) 2020-08-18
TWI374739B (en) 2012-10-21
IL177685A (en) 2013-10-31
ZA200606624B (en) 2008-01-08
NL300779I2 (nl) 2017-11-02
LU93066I2 (fr) 2016-07-11

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Free format text: PRODUCT NAME: SPIOLTO RESPIMAT TIOTROPIUM (AS BROMIDE MONOHYDRATE)/OLODATEROL (AS HYDROCHLORIDE)

Filing date: 20150610

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Extension date: 20300418