AU2005224043B2 - Novel use for PDE5 inhibitors - Google Patents
Novel use for PDE5 inhibitors Download PDFInfo
- Publication number
- AU2005224043B2 AU2005224043B2 AU2005224043A AU2005224043A AU2005224043B2 AU 2005224043 B2 AU2005224043 B2 AU 2005224043B2 AU 2005224043 A AU2005224043 A AU 2005224043A AU 2005224043 A AU2005224043 A AU 2005224043A AU 2005224043 B2 AU2005224043 B2 AU 2005224043B2
- Authority
- AU
- Australia
- Prior art keywords
- methyl
- dihydro
- pyrimidin
- triazolo
- phenylbutyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000002590 phosphodiesterase V inhibitor Substances 0.000 title claims abstract description 54
- 229940123333 Phosphodiesterase 5 inhibitor Drugs 0.000 title claims abstract description 52
- 239000003814 drug Substances 0.000 claims abstract description 8
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- 229960003310 sildenafil Drugs 0.000 claims description 41
- 238000011282 treatment Methods 0.000 claims description 36
- 150000003839 salts Chemical class 0.000 claims description 22
- SECKRCOLJRRGGV-UHFFFAOYSA-N Vardenafil Chemical compound CCCC1=NC(C)=C(C(N=2)=O)N1NC=2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(CC)CC1 SECKRCOLJRRGGV-UHFFFAOYSA-N 0.000 claims description 20
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- VDXZLVXFVYDBNH-UHFFFAOYSA-N 4-[(3-chloro-4-methoxyphenyl)methylamino]-1-(4-hydroxypiperidin-1-yl)phthalazine-6-carbonitrile Chemical compound C1=C(Cl)C(OC)=CC=C1CNC(C1=CC(=CC=C11)C#N)=NN=C1N1CCC(O)CC1 VDXZLVXFVYDBNH-UHFFFAOYSA-N 0.000 claims description 3
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- OOOBGFAUGXVKGI-UHFFFAOYSA-N 5,6-dihydropyrazolo[3,4-d]pyrimidin-4-one Chemical compound O=C1NCN=C2N=NC=C12 OOOBGFAUGXVKGI-UHFFFAOYSA-N 0.000 claims description 3
- UYBVXOPUCHLFBB-UHFFFAOYSA-N 5-(1,3-benzodioxol-5-ylmethyl)-3-(5-phenylpentan-2-yl)-6H-triazolo[4,5-d]pyrimidin-7-one Chemical compound N1=NC(C(NC(CC=2C=C3OCOC3=CC=2)=N2)=O)=C2N1C(C)CCCC1=CC=CC=C1 UYBVXOPUCHLFBB-UHFFFAOYSA-N 0.000 claims description 3
- YRVSSAHNWIKBOO-UHFFFAOYSA-N 5-[(3,4-dichlorophenyl)methyl]-3-(5-phenylpentan-2-yl)-6H-triazolo[4,5-d]pyrimidin-7-one Chemical compound N1=NC(C(NC(CC=2C=C(Cl)C(Cl)=CC=2)=N2)=O)=C2N1C(C)CCCC1=CC=CC=C1 YRVSSAHNWIKBOO-UHFFFAOYSA-N 0.000 claims description 3
- BLWMVGBZGHLKMW-UHFFFAOYSA-N 5-[(4-bromophenyl)methyl]-3-(5-phenylpentan-2-yl)-6H-triazolo[4,5-d]pyrimidin-7-one Chemical compound N1=NC(C(NC(CC=2C=CC(Br)=CC=2)=N2)=O)=C2N1C(C)CCCC1=CC=CC=C1 BLWMVGBZGHLKMW-UHFFFAOYSA-N 0.000 claims description 3
- ASGAJEZWBBMWJS-UHFFFAOYSA-N 5-benzyl-3-(5-phenylpentan-2-yl)-6H-triazolo[4,5-d]pyrimidin-7-one Chemical compound N1=NC(C(NC(CC=2C=CC=CC=2)=N2)=O)=C2N1C(C)CCCC1=CC=CC=C1 ASGAJEZWBBMWJS-UHFFFAOYSA-N 0.000 claims description 3
- FFCZQVKVWGGQFB-UHFFFAOYSA-N 9h-pyrido[3,4-b]indole-1,4-dione Chemical compound N1C2=CC=CC=C2C2=C1C(=O)N=CC2=O FFCZQVKVWGGQFB-UHFFFAOYSA-N 0.000 claims description 3
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- ORZROTLRYOYVPB-UHFFFAOYSA-N methyl 2-(4-aminophenyl)-1-oxo-7-(pyridin-2-ylmethoxy)-4-(3,4,5-trimethoxyphenyl)isoquinoline-3-carboxylate Chemical compound C12=CC=C(OCC=3N=CC=CC=3)C=C2C(=O)N(C=2C=CC(N)=CC=2)C(C(=O)OC)=C1C1=CC(OC)=C(OC)C(OC)=C1 ORZROTLRYOYVPB-UHFFFAOYSA-N 0.000 claims description 3
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| EP04100909 | 2004-03-05 | ||
| EP04100909.3 | 2004-03-05 | ||
| PCT/EP2005/050958 WO2005089766A1 (en) | 2004-03-05 | 2005-03-03 | Novel use for pde5 inhibitors |
Publications (2)
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| AU2005224043A1 AU2005224043A1 (en) | 2005-09-29 |
| AU2005224043B2 true AU2005224043B2 (en) | 2010-06-24 |
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Country Status (9)
| Country | Link |
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| US (2) | US7666872B2 (sr) |
| EP (1) | EP1740183B8 (sr) |
| JP (1) | JP4838792B2 (sr) |
| AT (1) | ATE445402T1 (sr) |
| AU (1) | AU2005224043B2 (sr) |
| CA (1) | CA2557792C (sr) |
| DE (1) | DE602005017135D1 (sr) |
| ES (1) | ES2334682T3 (sr) |
| WO (1) | WO2005089766A1 (sr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8841300B2 (en) * | 2006-10-02 | 2014-09-23 | Jerry M. Held | Treatment for Parkinson's disease—combination high dose serotonergic synaptic reuptake inhibitor with phosphodiesterase inhibitor |
| EP2079739A2 (en) | 2006-10-04 | 2009-07-22 | Pfizer Products Inc. | Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists |
| AU2008254424B2 (en) * | 2007-05-18 | 2012-12-20 | Vivus, Inc. | Novel combinations comprising a phosphodiesterase-5 inhibitor and their use |
| KR101002490B1 (ko) * | 2007-06-09 | 2010-12-17 | 동아제약주식회사 | 유데나필을 유효성분으로 함유하는 만성 심부전증 치료용약학적 조성물 |
| AU2012201640B2 (en) * | 2007-06-13 | 2014-09-04 | Vivus, Inc. | Treatment of pulmonary hypertension with carbonic anhydrase inhibitors in combination with a sympathomimetic amine |
| AU2014213552B2 (en) * | 2007-06-13 | 2016-11-24 | Vivus, Inc. | Treatment of pulmonary hypertension with carbonic anhydrase inhibitors in combination with a sympathomimetic amine |
| US8071557B2 (en) * | 2007-06-13 | 2011-12-06 | Vivus, Inc. | Treatment of pulmonary hypertension with carbonic anhydrase inhibitors |
| AU2009242127B2 (en) * | 2008-04-29 | 2014-03-27 | Pharnext | New therapeutic approaches for treating Alzheimer disease and related disorders through a modulation of cell stress response |
| US8507491B2 (en) | 2008-08-25 | 2013-08-13 | Irm Llc | Compounds and compositions as hedgehog pathway inhibitors |
| US8962770B2 (en) | 2009-12-30 | 2015-02-24 | Sabic Global Technologies B.V. | Blends of isosorbide-based copolycarbonate, method of making, and articles formed therefrom |
| US8888802B2 (en) * | 2010-12-21 | 2014-11-18 | Alcon Research, Ltd. | Vitrectomy probe with adjustable cutter port size |
| EP2535049A1 (en) * | 2011-06-17 | 2012-12-19 | Proyecto de Biomedicina Cima, S.L. | Tadalafil for the treatment of dementia |
| AT512084A1 (de) | 2011-10-20 | 2013-05-15 | Univ Wien Tech | Diazabicyclo- und diazaspiro-alkanderivate als phosphodiesterase-5 inhibitoren |
| RU2497203C2 (ru) * | 2012-02-13 | 2013-10-27 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Курский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации | Способ фармакологической коррекции ишемии скелетной мышцы силденафилом, в том числе при l-name-индуцированном дефиците оксида азота |
| CA2908482A1 (en) * | 2013-03-01 | 2014-09-04 | Fundacion Para La Investigacion Medica Aplicada | Novel compounds as dual inhibitors of phosphodiesterases and histone deacetylases |
| IT201700085714A1 (it) * | 2017-07-26 | 2019-01-26 | Luigi Maiuri | Approccio terapeutico per il trattamento e/o prevenzione di condizioni di sensibilità al glutine. |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998038168A1 (en) * | 1997-02-27 | 1998-09-03 | Tanabe Seiyaku Co., Ltd. | Isoquinolinone derivatives, process for preparing the same, and their use as phosphodiesterase inhibitors |
| WO2001027112A1 (en) * | 1999-10-11 | 2001-04-19 | Pfizer Limited | 5-(2-substituted-5-heterocyclylsulphonylpyrid-3-yl)-dihydropyrazolo[4,3-d]pyrimidin-7-ones as phosphodiesterase inhibitors |
| WO2002089808A1 (de) * | 2001-05-09 | 2002-11-14 | Bayer Healthcare Ag | Neue verwendung von 2-phenyl-substituierten imidazotriazinonen |
| EP1317924A1 (en) * | 2001-12-06 | 2003-06-11 | Pfizer Limited | Kit for reducing aching caused by pde-v inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2189355A1 (en) | 1995-03-01 | 1996-09-06 | Yasuo Onoda | Imidazoquinazoline derivatives |
| EP0985671B1 (en) * | 1996-05-31 | 2003-04-02 | Mochida Pharmaceutical Co., Ltd. | PYRIDOCARBAZOLE DERIVATIVES HAVING cGMP-PDE INHIBITORY EFFECT |
| JPH10298164A (ja) * | 1997-02-27 | 1998-11-10 | Tanabe Seiyaku Co Ltd | イソキノリノン誘導体、その製法及びその合成中間体 |
| IL139073A0 (en) * | 1999-10-21 | 2001-11-25 | Pfizer | Treatment of neuropathy |
| WO2003051346A2 (en) | 2001-12-17 | 2003-06-26 | Altana Pharma Ag | Use of selective pde5 inhibitors for treating partial and global respiratory failure |
-
2005
- 2005-03-03 AU AU2005224043A patent/AU2005224043B2/en not_active Ceased
- 2005-03-03 US US10/590,992 patent/US7666872B2/en not_active Expired - Fee Related
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- 2005-03-03 AT AT05716901T patent/ATE445402T1/de not_active IP Right Cessation
- 2005-03-03 JP JP2007501295A patent/JP4838792B2/ja not_active Expired - Fee Related
- 2005-03-03 DE DE602005017135T patent/DE602005017135D1/de active Active
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2010
- 2010-01-04 US US12/654,787 patent/US8278300B2/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998038168A1 (en) * | 1997-02-27 | 1998-09-03 | Tanabe Seiyaku Co., Ltd. | Isoquinolinone derivatives, process for preparing the same, and their use as phosphodiesterase inhibitors |
| WO2001027112A1 (en) * | 1999-10-11 | 2001-04-19 | Pfizer Limited | 5-(2-substituted-5-heterocyclylsulphonylpyrid-3-yl)-dihydropyrazolo[4,3-d]pyrimidin-7-ones as phosphodiesterase inhibitors |
| WO2002089808A1 (de) * | 2001-05-09 | 2002-11-14 | Bayer Healthcare Ag | Neue verwendung von 2-phenyl-substituierten imidazotriazinonen |
| EP1317924A1 (en) * | 2001-12-06 | 2003-06-11 | Pfizer Limited | Kit for reducing aching caused by pde-v inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2557792C (en) | 2012-12-18 |
| DE602005017135D1 (de) | 2009-11-26 |
| EP1740183B1 (en) | 2009-10-14 |
| ES2334682T3 (es) | 2010-03-15 |
| AU2005224043A1 (en) | 2005-09-29 |
| US20100179152A1 (en) | 2010-07-15 |
| US8278300B2 (en) | 2012-10-02 |
| US20070185114A1 (en) | 2007-08-09 |
| EP1740183A1 (en) | 2007-01-10 |
| EP1740183B8 (en) | 2009-11-25 |
| ATE445402T1 (de) | 2009-10-15 |
| JP2007526285A (ja) | 2007-09-13 |
| JP4838792B2 (ja) | 2011-12-14 |
| US7666872B2 (en) | 2010-02-23 |
| CA2557792A1 (en) | 2005-09-29 |
| WO2005089766A1 (en) | 2005-09-29 |
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