AU2005218545B8 - Use of lipid conjugates in the treatment of disease - Google Patents

Use of lipid conjugates in the treatment of disease Download PDF

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Publication number
AU2005218545B8
AU2005218545B8 AU2005218545A AU2005218545A AU2005218545B8 AU 2005218545 B8 AU2005218545 B8 AU 2005218545B8 AU 2005218545 A AU2005218545 A AU 2005218545A AU 2005218545 A AU2005218545 A AU 2005218545A AU 2005218545 B8 AU2005218545 B8 AU 2005218545B8
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AU2005218545A1 (en
AU2005218545B2 (en
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Saul Yedgar
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Yissum Research Development Co of Hebrew University of Jerusalem
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Yissum Research Development Co of Hebrew University of Jerusalem
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    • C—CHEMISTRY; METALLURGY
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    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
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    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
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  • Neurology (AREA)
  • Dermatology (AREA)
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  • Biomedical Technology (AREA)
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  • Pulmonology (AREA)
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  • Communicable Diseases (AREA)
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  • Cardiology (AREA)
  • Diabetes (AREA)
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  • Biophysics (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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AU2005218545A 2004-03-02 2005-03-02 Use of lipid conjugates in the treatment of disease Ceased AU2005218545B8 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2011201154A AU2011201154B2 (en) 2004-03-02 2011-03-15 Use of lipid conjugates in the treatment of disease

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/790,182 2004-03-02
US10/790,182 US7141552B2 (en) 2000-01-10 2004-03-02 Use of lipid conjugates in the treatment of diseases
PCT/US2005/006591 WO2005084307A2 (en) 2004-03-02 2005-03-02 Use of lipid conjugates in the treatment of disease

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AU2011201154A Division AU2011201154B2 (en) 2004-03-02 2011-03-15 Use of lipid conjugates in the treatment of disease

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AU2005218545A1 AU2005218545A1 (en) 2005-09-15
AU2005218545B2 AU2005218545B2 (en) 2010-12-16
AU2005218545B8 true AU2005218545B8 (en) 2010-12-23

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AU2005218545A Ceased AU2005218545B8 (en) 2004-03-02 2005-03-02 Use of lipid conjugates in the treatment of disease
AU2011201154A Ceased AU2011201154B2 (en) 2004-03-02 2011-03-15 Use of lipid conjugates in the treatment of disease

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US (1) US7141552B2 (enExample)
EP (2) EP3354318A1 (enExample)
JP (2) JP2008509229A (enExample)
AU (2) AU2005218545B8 (enExample)
CA (1) CA2558416C (enExample)
IL (1) IL177847A0 (enExample)
WO (1) WO2005084307A2 (enExample)

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US7608598B2 (en) * 2000-01-10 2009-10-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of conjunctivitis
US8304395B2 (en) * 2000-01-10 2012-11-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Lipid conjugates in the treatment of disease
US8501701B2 (en) * 2000-01-10 2013-08-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Use of lipid conjugates in the treatment of disease
US7772196B2 (en) * 2000-01-10 2010-08-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases
US20060189568A1 (en) * 2000-01-10 2006-08-24 Saul Yedgar Use of lipid conjugates in the treatment of infection
US20090325876A1 (en) * 2004-09-29 2009-12-31 Saul Yedgar Use of lipid conjugates in the treatment of diseases associated with vasculature
US8076312B2 (en) * 2000-01-10 2011-12-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Use of lipid conjugates in the treatment of disease
US8916539B2 (en) * 2000-01-10 2014-12-23 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of disease
US7893226B2 (en) 2004-09-29 2011-02-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Use of lipid conjugates in the treatment of diseases
WO2006054304A2 (en) * 2004-11-17 2006-05-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of disease
US7141552B2 (en) * 2000-01-10 2006-11-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases
US7811999B2 (en) * 2000-01-10 2010-10-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Use of lipid conjugates in the treatment of diseases
US9040078B2 (en) * 2000-01-10 2015-05-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases of the nervous system
US8883761B2 (en) * 2001-01-10 2014-11-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases associated with vasculature
CN1742623A (zh) * 2005-07-13 2006-03-08 凌沛学 透明质酸磷脂复合物及其制备方法
JP5339905B2 (ja) * 2005-08-03 2013-11-13 モリア バイオファーマスーティカルズ 嚢胞性線維症における脂質複合体の使用及びその適用
DE102005045152A1 (de) * 2005-09-21 2007-03-22 Stremmel, Wolfgang, Prof. Dr. Verwendung von therapeutisch wirksamen Lipiden nebst Verfahren zur Herstellung von Organ-/Gewebe-spezifischen therapeutisch wirksamen Lipiden
US8859524B2 (en) 2005-11-17 2014-10-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Lipid conjugates in the treatment of chronic rhinosinusitis
US8906882B2 (en) 2005-11-17 2014-12-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Lipid conjugates in the treatment of allergic rhinitis
US20080183282A1 (en) * 2006-03-09 2008-07-31 Saul Yedgar Use of lipid conjugates for the coating of stents and catheters
AU2006344178A1 (en) 2006-06-09 2007-12-13 Erasmus University Medical Center Rotterdam Modulation of the immune system by inositol phospholipids
CA2705785A1 (en) * 2006-11-14 2008-05-22 Saul Yedgar Use of lipid conjugates in the treatment of diseases or disorders of the eye
EP2097086A4 (en) * 2006-11-14 2012-01-11 Yissum Res Dev Co CONTACT LENS COMPOSITIONS
US20090281065A1 (en) * 2008-05-09 2009-11-12 Kemin Industries, Inc. Use of Lysophospholipids to Treat Inflammation
AU2010247814B2 (en) * 2009-05-11 2015-08-13 Celsus Therapeutics Plc Lipid-polymer conjugates, their preparation and uses thereof
AU2010257181A1 (en) * 2009-06-02 2012-01-12 Brian Charles Keller Pure PEG-lipid conjugates
DK2706988T3 (da) 2011-05-12 2020-01-20 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd Liposomer omfattende polymer konjugerede lipider og relateret brug
EP2923710A1 (en) * 2014-03-27 2015-09-30 Universitätsklinikum Heidelberg Bacterial phospholipase inhibitors as modulator of colonic bacterial flora
WO2019147990A1 (en) * 2018-01-26 2019-08-01 The Regents Of The University Of California Methods and compositions concerning intestinal permeability
CN110183779B (zh) * 2019-06-06 2021-08-24 宁波一舟塑胶有限公司 羧甲基纤维素铈作为阻燃剂在高分子聚合物材料中的应用
CA3209491A1 (en) * 2021-03-15 2022-09-22 Saul Yedgar Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory disease

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0930970A (ja) * 1995-07-19 1997-02-04 Taisho Pharmaceut Co Ltd 抗菌剤

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL84252A (en) * 1987-10-23 1994-02-27 Yissum Res Dev Co Phospholipase inhibiting compositions
DK0478715T3 (da) * 1989-06-23 1996-08-05 Liposome Co Inc Målrettede liposomer og fremgangsmåder til liposom-protein-kobling
JPH0482893A (ja) * 1990-07-23 1992-03-16 Fuji Photo Film Co Ltd ペプチド誘導リン脂質化合物およびそれを用いたポリペブチドリポソームの製造方法
AU647814B2 (en) 1990-07-24 1994-03-31 Seikagaku Kogyo Kabushiki Kaisha Phospholipid- or lipid-combining glycosaminoglycan, production thereof, and cancer metastasis inhibitor
JP2997018B2 (ja) * 1990-07-24 2000-01-11 生化学工業株式会社 燐脂質又は脂質結合グリコサミノグリカン
US6022866A (en) 1991-07-03 2000-02-08 Hyal Pharmaceutical Corporation Use of hyaluronic acid and forms to prevent arterial restenosis
AU2782792A (en) * 1991-10-15 1993-05-21 Warner-Lambert Company Azabicyclo oxime and amine cholinergic agents and methods of treatment
JP3714683B2 (ja) 1992-07-30 2005-11-09 生化学工業株式会社 抗リウマチ剤
US6043231A (en) 1993-03-02 2000-03-28 The Research Foundation Of State Univ. Of New York Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines
EP0952841A4 (en) * 1994-08-05 2000-11-02 Molecular Structural Biotechno BIOMOLECULAR COMPLEXES FOR TARGETED TRANSPORTATION OF MEDICINAL PRODUCTS IN SPECIAL REGIONS
EP0871721A1 (en) 1995-03-09 1998-10-21 Novo Nordisk A/S A protein-lipid conjugate, consisting of heparin binding protein (hbp) and a ceramide analogue, and its pharmaceutical use in treatment of conditions involving stress injury to cells
JPH11504319A (ja) * 1995-04-20 1999-04-20 ジー．ディー．サール アンド カンパニー 酸化窒素シンターゼインヒビターとして有用な環状アミジノ薬剤
US6033645A (en) * 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
JP2001523216A (ja) 1995-06-26 2001-11-20 リサーチ．トライアングル．ファーマシューティカルズ 新規のアジュバント組成物と、それからなるワクチン製剤
US5785975A (en) * 1995-06-26 1998-07-28 Research Triangle Pharmaceuticals Adjuvant compositions and vaccine formulations comprising same
JP3942205B2 (ja) 1995-07-24 2007-07-11 生化学工業株式会社 神経疾患の治療剤
US6071532A (en) 1996-10-15 2000-06-06 Emory University Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof
WO1998051285A2 (en) * 1997-05-15 1998-11-19 Genzyme Corporation Cationic amphiphile formulations
US6162787A (en) 1999-04-02 2000-12-19 Immudyne, Inc. Methods for treating arthritis using collagen type II, glucosamine chondroitin sulfate, and compositions
EP1046394A3 (en) * 1999-04-19 2001-10-10 ImaRx Pharmaceutical Corp. Novel compositions useful for delivering compounds into a cell
US7101859B2 (en) * 2000-01-10 2006-09-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases
IL150628A0 (en) * 2000-01-10 2003-02-12 Yissum Res Dev Co Use of lipid conjugates in the treatment of disease
US7141552B2 (en) * 2000-01-10 2006-11-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases
US7109167B2 (en) * 2000-06-02 2006-09-19 Bracco International B.V. Compounds for targeting endothelial cells, compositions containing the same and methods for their use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0930970A (ja) * 1995-07-19 1997-02-04 Taisho Pharmaceut Co Ltd 抗菌剤

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