AU2004283425B2 - Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an acetylcholinesterase inhibitor - Google Patents

Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an acetylcholinesterase inhibitor Download PDF

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Publication number
AU2004283425B2
AU2004283425B2 AU2004283425A AU2004283425A AU2004283425B2 AU 2004283425 B2 AU2004283425 B2 AU 2004283425B2 AU 2004283425 A AU2004283425 A AU 2004283425A AU 2004283425 A AU2004283425 A AU 2004283425A AU 2004283425 B2 AU2004283425 B2 AU 2004283425B2
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AU
Australia
Prior art keywords
dementia
tropane
disease
pharmaceutically acceptable
solvate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2004283425A
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English (en)
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AU2004283425A1 (en
Inventor
Thomas Friedl
Joachim Mierau
Andreas Raschig
Jurgen Reess
Jorgen Scheel-Kruger
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NTG Nordic Transport Group AS
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Neurosearch AS
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Publication of AU2004283425A1 publication Critical patent/AU2004283425A1/en
Assigned to NEUROSEARCH A/S reassignment NEUROSEARCH A/S Request for Assignment Assignors: BOEHRINGER INGELHEIM INTERNATIONAL GMBH, NEUROSEARCH A/S
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Publication of AU2004283425B2 publication Critical patent/AU2004283425B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
AU2004283425A 2003-10-16 2004-10-05 Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an acetylcholinesterase inhibitor Ceased AU2004283425B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP03023635 2003-10-16
EP03023635.0 2003-10-16
EP04005819 2004-03-11
EP04005819.0 2004-03-11
PCT/EP2004/011093 WO2005039580A1 (en) 2003-10-16 2004-10-05 Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an acetylcholinesterase inhibitor

Publications (2)

Publication Number Publication Date
AU2004283425A1 AU2004283425A1 (en) 2005-05-06
AU2004283425B2 true AU2004283425B2 (en) 2010-07-08

Family

ID=34524707

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2004283425A Ceased AU2004283425B2 (en) 2003-10-16 2004-10-05 Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an acetylcholinesterase inhibitor

Country Status (10)

Country Link
US (2) US20050154009A1 (https=)
EP (2) EP1675591B1 (https=)
JP (1) JP2007508336A (https=)
AT (1) ATE519486T1 (https=)
AU (1) AU2004283425B2 (https=)
CA (1) CA2542442C (https=)
DK (1) DK1675591T3 (https=)
MX (1) MXPA06003762A (https=)
NZ (1) NZ547152A (https=)
WO (1) WO2005039580A1 (https=)

Families Citing this family (28)

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US20070053976A1 (en) * 2002-05-17 2007-03-08 Eisai R & D Management Co., Ltd. Novel combination of drugs as antidepressant
JP2007508336A (ja) * 2003-10-16 2007-04-05 ニューロサーチ、アクティーゼルスカブ モノアミン神経伝達物質再取り込みインヒビター及びアセチルコリンエステラーゼインヒビターを含む医薬組成物
NZ547880A (en) * 2003-11-18 2010-02-26 Boehringer Ingelheim Int Solid pharmaceutical preparation form
WO2005070427A1 (en) * 2004-01-22 2005-08-04 Neurosearch A/S Compounds for the sustained reduction of body weight
AU2005205882A1 (en) * 2004-01-22 2005-08-04 Neurosearch A/S Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an N-methyl-D-aspartate (NMDA) receptors antagonist
JP2008501656A (ja) * 2004-06-04 2008-01-24 ノイロサーチ アクティーゼルスカブ β−アミロイド（Ａβ４０及びＡβ４２）生成阻害のためのモノアミン神経伝達物質再取り込み阻害剤
WO2007028769A1 (en) * 2005-09-05 2007-03-15 Neurosearch A/S Monoamine neurotransmitter re-uptake inhibitor for neuroprotection
EP2089383B1 (en) 2006-11-09 2015-09-16 Probiodrug AG 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
US9126987B2 (en) 2006-11-30 2015-09-08 Probiodrug Ag Inhibitors of glutaminyl cyclase
JP5237112B2 (ja) * 2006-12-01 2013-07-17 日東電工株式会社 経皮吸収製剤
US20100048628A1 (en) * 2006-12-01 2010-02-25 Sumiyo Nishi Method for suppressing discoloration over time of adhesive preparation containing donepezil
AU2008220785B2 (en) 2007-03-01 2013-02-21 Vivoryon Therapeutics N.V. New use of glutaminyl cyclase inhibitors
JP5667440B2 (ja) 2007-04-18 2015-02-12 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体
KR20110020788A (ko) * 2008-05-30 2011-03-03 에자이 알앤드디 매니지먼트 가부시키가이샤 경피 흡수 제제
WO2009145177A1 (ja) * 2008-05-30 2009-12-03 日東電工株式会社 ドネペジル含有貼付製剤およびその包装体
JP5934645B2 (ja) 2009-09-11 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体
EA202092673A3 (ru) 2010-02-09 2021-05-31 Дзе Джонс Хопкинс Юниверсити Способы и композиции для улучшения когнитивной функции
WO2011107530A2 (en) 2010-03-03 2011-09-09 Probiodrug Ag Novel inhibitors
JP5688745B2 (ja) 2010-03-10 2015-03-25 プロビオドルグ エージー グルタミニルシクラーゼ（ｑｃ、ｅｃ２．３．２．５）の複素環阻害剤
WO2011131748A2 (en) 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
EP2686313B1 (en) 2011-03-16 2016-02-03 Probiodrug AG Benzimidazole derivatives as inhibitors of glutaminyl cyclase
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
WO2014085367A1 (en) * 2012-11-30 2014-06-05 P2D Inc. Substituted benztropine analogs for treatment of dementia
AU2014228512A1 (en) 2013-03-15 2015-10-01 Agenebio, Inc. Methods and compositions for improving cognitive function
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
CA2986598C (en) 2015-05-22 2023-09-26 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam
ES2812698T3 (es) 2017-09-29 2021-03-18 Probiodrug Ag Inhibidores de glutaminil ciclasa
US20220218689A1 (en) * 2018-10-24 2022-07-14 Saniona A/S Transdermal tropane compositions and methods for using the same

Citations (7)

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Publication number Priority date Publication date Assignee Title
EP0604352A2 (en) * 1992-12-23 1994-06-29 Neurosearch A/S Aryl substituted heterocyclic compounds
EP0604354A2 (en) * 1992-12-23 1994-06-29 Neurosearch A/S Antidepressant and antiparkinsonian compounds
EP0604355A2 (en) * 1992-12-23 1994-06-29 Neurosearch A/S Akyl Substituted heterocyclic compounds
US5444070A (en) * 1992-12-23 1995-08-22 Neurosearch A/S Phenyl substituted heterocyclic compounds
WO1995028401A1 (en) * 1994-04-19 1995-10-26 Neurosearch A/S Tropane-2-aldoxine derivatives as neurotransmitter reuptake inhibitors
WO1997030997A1 (en) * 1996-02-22 1997-08-28 Neurosearch A/S Tropane-derivatives, their preparation and use
WO2002002549A1 (en) * 2000-07-05 2002-01-10 Taisho Pharmaceutical Co., Ltd. Tetrahydropyridino or piperidino heterocyclic derivatives

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JP2006517567A (ja) * 2003-02-12 2006-07-27 ニューロサーチ、アクティーゼルスカブ 新規８−アザ−ビシクロ［３．２．１］オクタン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害薬として使用する方法
JP2007508336A (ja) * 2003-10-16 2007-04-05 ニューロサーチ、アクティーゼルスカブ モノアミン神経伝達物質再取り込みインヒビター及びアセチルコリンエステラーゼインヒビターを含む医薬組成物
WO2005070427A1 (en) * 2004-01-22 2005-08-04 Neurosearch A/S Compounds for the sustained reduction of body weight
AU2005205882A1 (en) * 2004-01-22 2005-08-04 Neurosearch A/S Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an N-methyl-D-aspartate (NMDA) receptors antagonist
JP2008501656A (ja) * 2004-06-04 2008-01-24 ノイロサーチ アクティーゼルスカブ β−アミロイド（Ａβ４０及びＡβ４２）生成阻害のためのモノアミン神経伝達物質再取り込み阻害剤

Patent Citations (7)

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EP0604352A2 (en) * 1992-12-23 1994-06-29 Neurosearch A/S Aryl substituted heterocyclic compounds
EP0604354A2 (en) * 1992-12-23 1994-06-29 Neurosearch A/S Antidepressant and antiparkinsonian compounds
EP0604355A2 (en) * 1992-12-23 1994-06-29 Neurosearch A/S Akyl Substituted heterocyclic compounds
US5444070A (en) * 1992-12-23 1995-08-22 Neurosearch A/S Phenyl substituted heterocyclic compounds
WO1995028401A1 (en) * 1994-04-19 1995-10-26 Neurosearch A/S Tropane-2-aldoxine derivatives as neurotransmitter reuptake inhibitors
WO1997030997A1 (en) * 1996-02-22 1997-08-28 Neurosearch A/S Tropane-derivatives, their preparation and use
WO2002002549A1 (en) * 2000-07-05 2002-01-10 Taisho Pharmaceutical Co., Ltd. Tetrahydropyridino or piperidino heterocyclic derivatives

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Also Published As

Publication number Publication date
AU2004283425A1 (en) 2005-05-06
DK1675591T3 (da) 2011-11-14
ATE519486T1 (de) 2011-08-15
US20050154009A1 (en) 2005-07-14
NZ547152A (en) 2009-12-24
WO2005039580A1 (en) 2005-05-06
MXPA06003762A (es) 2006-06-14
EP1675591A1 (en) 2006-07-05
EP2269608A3 (en) 2011-02-16
EP2269608A2 (en) 2011-01-05
CA2542442C (en) 2012-08-21
CA2542442A1 (en) 2005-05-06
US20100210626A1 (en) 2010-08-19
EP1675591B1 (en) 2011-08-10
JP2007508336A (ja) 2007-04-05

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