AU2004225527B2 - Proteomic analysis of biological fluids - Google Patents

Info

Publication number

AU2004225527B2

AU2004225527B2 AU2004225527A AU2004225527A AU2004225527B2 AU 2004225527 B2 AU2004225527 B2 AU 2004225527B2 AU 2004225527 A AU2004225527 A AU 2004225527A AU 2004225527 A AU2004225527 A AU 2004225527A AU 2004225527 B2 AU2004225527 B2 AU 2004225527B2

Authority

AU

Australia

Prior art keywords

protein

precursor

calgranulin

human

infection

Prior art date

2003-03-25

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

Links

• Espacenet
• Global Dossier
• Discuss

• 239000013060 biological fluid Substances 0.000 title claims abstract description 35
• 238000000575 proteomic method Methods 0.000 title description 8
• 210000004381 amniotic fluid Anatomy 0.000 claims abstract description 166
• 208000008158 Chorioamnionitis Diseases 0.000 claims abstract description 95
• 108090000623 proteins and genes Proteins 0.000 claims description 204
• 102000004169 proteins and genes Human genes 0.000 claims description 198
• 239000002243 precursor Substances 0.000 claims description 158
• 238000000034 method Methods 0.000 claims description 56
• 210000002966 serum Anatomy 0.000 claims description 49
• 238000004458 analytical method Methods 0.000 claims description 47
• 241000282414 Homo sapiens Species 0.000 claims description 44
• 238000012360 testing method Methods 0.000 claims description 42
• 102000004375 Insulin-like growth factor-binding protein 1 Human genes 0.000 claims description 37
• 108090000957 Insulin-like growth factor-binding protein 1 Proteins 0.000 claims description 37
• 238000003745 diagnosis Methods 0.000 claims description 26
• 238000004949 mass spectrometry Methods 0.000 claims description 24
• 102000001109 Leukocyte L1 Antigen Complex Human genes 0.000 claims description 22
• 108010069316 Leukocyte L1 Antigen Complex Proteins 0.000 claims description 22
• 102100030009 Azurocidin Human genes 0.000 claims description 18
• 239000012634 fragment Substances 0.000 claims description 17
• 101710154607 Azurocidin Proteins 0.000 claims description 15
• 230000002797 proteolythic effect Effects 0.000 claims description 15
• 108010039659 FALL 39 Proteins 0.000 claims description 13
• 108010052495 Calgranulin B Proteins 0.000 claims description 12
• 102100032420 Protein S100-A9 Human genes 0.000 claims description 12
• 238000003498 protein array Methods 0.000 claims description 12
• 238000001262 western blot Methods 0.000 claims description 12
• 230000027455 binding Effects 0.000 claims description 11
• 238000003018 immunoassay Methods 0.000 claims description 11
• 239000007787 solid Substances 0.000 claims description 10
• 102100037362 Fibronectin Human genes 0.000 claims description 9
• 108010067306 Fibronectins Proteins 0.000 claims description 9
• 102000016453 Macrophage-capping proteins Human genes 0.000 claims description 9
• 108050006096 Macrophage-capping proteins Proteins 0.000 claims description 9
• 102100035182 Plastin-2 Human genes 0.000 claims description 9
• 230000000844 anti-bacterial effect Effects 0.000 claims description 9
• 108010049148 plastin Proteins 0.000 claims description 8
• 108010059886 Apolipoprotein A-I Proteins 0.000 claims description 7
• 102000005666 Apolipoprotein A-I Human genes 0.000 claims description 7
• 102000004878 Gelsolin Human genes 0.000 claims description 7
• 108090001064 Gelsolin Proteins 0.000 claims description 7
• 102000011195 Profilin Human genes 0.000 claims description 7
• 108050001408 Profilin Proteins 0.000 claims description 7
• 102000008847 Serpin Human genes 0.000 claims description 7
• 108050000761 Serpin Proteins 0.000 claims description 7
• 108010071525 moesin Proteins 0.000 claims description 7
• 210000002381 plasma Anatomy 0.000 claims description 7
• 108010088201 squamous cell carcinoma-related antigen Proteins 0.000 claims description 7
• 102100027869 Moesin Human genes 0.000 claims description 6
• 102100038608 Cathelicidin antimicrobial peptide Human genes 0.000 claims description 5
• 102100033299 Glia-derived nexin Human genes 0.000 claims description 5
• 101710183811 Glia-derived nexin Proteins 0.000 claims description 5
• 108010063045 Lactoferrin Proteins 0.000 claims description 5
• 210000001175 cerebrospinal fluid Anatomy 0.000 claims description 5
• 235000020256 human milk Nutrition 0.000 claims description 5
• 210000004251 human milk Anatomy 0.000 claims description 5
• 210000003097 mucus Anatomy 0.000 claims description 5
• 210000003296 saliva Anatomy 0.000 claims description 5
• 239000003001 serine protease inhibitor Substances 0.000 claims description 5
• 210000002700 urine Anatomy 0.000 claims description 5
• 108050008974 14-3-3 protein sigma Proteins 0.000 claims description 4
• 102100040685 14-3-3 protein zeta/delta Human genes 0.000 claims description 4
• 101710183121 14-3-3 protein zeta/delta Proteins 0.000 claims description 4
• 108090000668 Annexin A2 Proteins 0.000 claims description 4
• 102000004149 Annexin A2 Human genes 0.000 claims description 4
• 108010052500 Calgranulin A Proteins 0.000 claims description 4
• 108010061635 Cystatin B Proteins 0.000 claims description 4
• 102100031237 Cystatin-A Human genes 0.000 claims description 4
• 102100026891 Cystatin-B Human genes 0.000 claims description 4
• 108010051335 Lipocalin-2 Proteins 0.000 claims description 4
• 102000013519 Lipocalin-2 Human genes 0.000 claims description 4
• 108090000235 Myeloperoxidases Proteins 0.000 claims description 4
• 102100032442 Protein S100-A8 Human genes 0.000 claims description 4
• 102100036383 Serpin B3 Human genes 0.000 claims description 4
• 102000000454 14-3-3 protein sigma Human genes 0.000 claims description 3
• 108010038798 Actin Depolymerizing Factors Proteins 0.000 claims description 3
• 102000015693 Actin Depolymerizing Factors Human genes 0.000 claims description 3
• 108010061641 Cystatin A Proteins 0.000 claims description 3
• 108010061642 Cystatin C Proteins 0.000 claims description 3
• 102100026897 Cystatin-C Human genes 0.000 claims description 3
• 102100030635 Leukocyte elastase inhibitor Human genes 0.000 claims description 3
• 101710091916 Leukocyte elastase inhibitor Proteins 0.000 claims description 3
• 102100028251 Phosphoglycerate kinase 1 Human genes 0.000 claims description 3
• 101710139464 Phosphoglycerate kinase 1 Proteins 0.000 claims description 3
• 102100037389 Phosphoglycerate mutase 1 Human genes 0.000 claims description 3
• 108050006040 Phosphoglycerate mutase 1 Proteins 0.000 claims description 3
• 102100030326 Serpin B4 Human genes 0.000 claims description 3
• 102000014701 Transketolase Human genes 0.000 claims description 3
• 108010043652 Transketolase Proteins 0.000 claims description 3
• 239000003591 leukocyte elastase inhibitor Substances 0.000 claims description 3
• 102000004411 Antithrombin III Human genes 0.000 claims description 2
• 108090000935 Antithrombin III Proteins 0.000 claims description 2
• 102000001848 Salivary Proteins and Peptides Human genes 0.000 claims description 2
• 108010029987 Salivary Proteins and Peptides Proteins 0.000 claims description 2
• 229960005348 antithrombin iii Drugs 0.000 claims description 2
• 102000012174 Lactotransferrin Human genes 0.000 claims 1
• 102000003896 Myeloperoxidases Human genes 0.000 claims 1
• 229930003316 Vitamin D Natural products 0.000 claims 1
• QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 1
• 235000019166 vitamin D Nutrition 0.000 claims 1
• 239000011710 vitamin D Substances 0.000 claims 1
• 150000003710 vitamin D derivatives Chemical class 0.000 claims 1
• 229940046008 vitamin d Drugs 0.000 claims 1
• 230000008774 maternal effect Effects 0.000 abstract description 88
• 230000001605 fetal effect Effects 0.000 abstract description 37
• 108010026552 Proteome Proteins 0.000 abstract description 20
• 230000002759 chromosomal effect Effects 0.000 abstract description 20
• 208000036878 aneuploidy Diseases 0.000 abstract description 17
• 231100001075 aneuploidy Toxicity 0.000 abstract description 16
• 208000022471 Fetal disease Diseases 0.000 abstract description 2
• 230000004578 fetal growth Effects 0.000 abstract description 2
• 230000035800 maturation Effects 0.000 abstract description 2
• 102000014702 Haptoglobin Human genes 0.000 abstract 1
• 108050005077 Haptoglobin Proteins 0.000 abstract 1
• 235000018102 proteins Nutrition 0.000 description 158
• 239000000523 sample Substances 0.000 description 55
• 208000015181 infectious disease Diseases 0.000 description 51
• 108090000765 processed proteins & peptides Proteins 0.000 description 41
• 206010056254 Intrauterine infection Diseases 0.000 description 36
• 238000012384 transportation and delivery Methods 0.000 description 31
• 108010029485 Protein Isoforms Proteins 0.000 description 29
• 102000001708 Protein Isoforms Human genes 0.000 description 29
• 238000001514 detection method Methods 0.000 description 29
• 239000000499 gel Substances 0.000 description 28
• 102000004196 processed proteins & peptides Human genes 0.000 description 28
• 238000001228 spectrum Methods 0.000 description 27
• 230000001575 pathological effect Effects 0.000 description 26
• 230000035935 pregnancy Effects 0.000 description 22
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 21
• 208000006399 Premature Obstetric Labor Diseases 0.000 description 19
• 238000011282 treatment Methods 0.000 description 18
• 238000001819 mass spectrum Methods 0.000 description 17
• 201000011461 pre-eclampsia Diseases 0.000 description 16
• 238000012216 screening Methods 0.000 description 16
• 201000010374 Down Syndrome Diseases 0.000 description 14
• 239000000090 biomarker Substances 0.000 description 14
• 201000010099 disease Diseases 0.000 description 14
• 150000002500 ions Chemical class 0.000 description 14
• 206010060937 Amniotic cavity infection Diseases 0.000 description 13
• 238000003491 array Methods 0.000 description 13
• 230000004044 response Effects 0.000 description 13
• WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 12
• 102100039457 Inter-alpha-trypsin inhibitor heavy chain H4 Human genes 0.000 description 12
• 238000013459 approach Methods 0.000 description 12
• 239000012528 membrane Substances 0.000 description 12
• 229920001184 polypeptide Polymers 0.000 description 12
• 238000004885 tandem mass spectrometry Methods 0.000 description 12
• 102000004889 Interleukin-6 Human genes 0.000 description 11
• 108090001005 Interleukin-6 Proteins 0.000 description 11
• 239000012472 biological sample Substances 0.000 description 11
• 229940100601 interleukin-6 Drugs 0.000 description 11
• 210000004379 membrane Anatomy 0.000 description 11
• 241001465754 Metazoa Species 0.000 description 10
• 241000288906 Primates Species 0.000 description 10
• 238000011081 inoculation Methods 0.000 description 10
• 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 10
• 241000894006 Bacteria Species 0.000 description 9
• 206010044688 Trisomy 21 Diseases 0.000 description 9
• 108090000631 Trypsin Proteins 0.000 description 9
• 102000004142 Trypsin Human genes 0.000 description 9
• 230000001580 bacterial effect Effects 0.000 description 9
• 102000028416 insulin-like growth factor binding Human genes 0.000 description 9
• 108091022911 insulin-like growth factor binding Proteins 0.000 description 9
• 210000000440 neutrophil Anatomy 0.000 description 9
• 238000012163 sequencing technique Methods 0.000 description 9
• 239000012588 trypsin Substances 0.000 description 9
• 101710083924 Inter-alpha-trypsin inhibitor heavy chain H4 Proteins 0.000 description 8
• 208000005107 Premature Birth Diseases 0.000 description 8
• 230000028993 immune response Effects 0.000 description 8
• 230000004054 inflammatory process Effects 0.000 description 8
• 238000012544 monitoring process Methods 0.000 description 8
• 102000015833 Cystatin Human genes 0.000 description 7
• 102000050760 Vitamin D-binding protein Human genes 0.000 description 7
• 101710179590 Vitamin D-binding protein Proteins 0.000 description 7
• 108050004038 cystatin Proteins 0.000 description 7
• 208000035475 disorder Diseases 0.000 description 7
• 230000000694 effects Effects 0.000 description 7
• 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 description 7
• 238000005259 measurement Methods 0.000 description 7
• 239000013074 reference sample Substances 0.000 description 7
• 238000002604 ultrasonography Methods 0.000 description 7
• 108010035532 Collagen Proteins 0.000 description 6
• 102000008186 Collagen Human genes 0.000 description 6
• 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 6
• 241000282560 Macaca mulatta Species 0.000 description 6
• CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 6
• 238000002669 amniocentesis Methods 0.000 description 6
• 210000004027 cell Anatomy 0.000 description 6
• 229920001436 collagen Polymers 0.000 description 6
• 239000000284 extract Substances 0.000 description 6
• 238000002560 therapeutic procedure Methods 0.000 description 6
• DTQVDTLACAAQTR-UHFFFAOYSA-N trifluoroacetic acid Substances OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 6
• 238000000539 two dimensional gel electrophoresis Methods 0.000 description 6
• 102000009027 Albumins Human genes 0.000 description 5
• 108010088751 Albumins Proteins 0.000 description 5
• 108010075016 Ceruloplasmin Proteins 0.000 description 5
• 102100023321 Ceruloplasmin Human genes 0.000 description 5
• 102100025682 Dystroglycan 1 Human genes 0.000 description 5
• 108010071885 Dystroglycans Proteins 0.000 description 5
• 206010061218 Inflammation Diseases 0.000 description 5
• 208000006816 Neonatal Sepsis Diseases 0.000 description 5
• 102000035195 Peptidases Human genes 0.000 description 5
• 108091005804 Peptidases Proteins 0.000 description 5
• 102100032859 Protein AMBP Human genes 0.000 description 5
• 206010037660 Pyrexia Diseases 0.000 description 5
• 230000001154 acute effect Effects 0.000 description 5
• 108010026331 alpha-Fetoproteins Proteins 0.000 description 5
• 102000013529 alpha-Fetoproteins Human genes 0.000 description 5
• 238000003556 assay Methods 0.000 description 5
• 150000001875 compounds Chemical class 0.000 description 5
• 230000007547 defect Effects 0.000 description 5
• 238000011161 development Methods 0.000 description 5
• 230000018109 developmental process Effects 0.000 description 5
• 238000001962 electrophoresis Methods 0.000 description 5
• 210000002219 extraembryonic membrane Anatomy 0.000 description 5
• 239000012530 fluid Substances 0.000 description 5
• 230000006870 function Effects 0.000 description 5
• 238000002493 microarray Methods 0.000 description 5
• 239000000203 mixture Substances 0.000 description 5
• 238000011809 primate model Methods 0.000 description 5
• 238000011160 research Methods 0.000 description 5
• 230000035945 sensitivity Effects 0.000 description 5
• 238000000756 surface-enhanced laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 description 5
• 108010085238 Actins Proteins 0.000 description 4
• 102000007469 Actins Human genes 0.000 description 4
• 102000000412 Annexin Human genes 0.000 description 4
• 108050008874 Annexin Proteins 0.000 description 4
• 102000005701 Calcium-Binding Proteins Human genes 0.000 description 4
• 108010045403 Calcium-Binding Proteins Proteins 0.000 description 4
• 108020004414 DNA Proteins 0.000 description 4
• 102100031262 Deleted in malignant brain tumors 1 protein Human genes 0.000 description 4
• 101000844721 Homo sapiens Deleted in malignant brain tumors 1 protein Proteins 0.000 description 4
• 101000609413 Homo sapiens Inter-alpha-trypsin inhibitor heavy chain H4 Proteins 0.000 description 4
• 102000010445 Lactoferrin Human genes 0.000 description 4
• 108010028275 Leukocyte Elastase Proteins 0.000 description 4
• 102100033174 Neutrophil elastase Human genes 0.000 description 4
• 239000004365 Protease Substances 0.000 description 4
• 238000010847 SEQUEST Methods 0.000 description 4
• 102000013275 Somatomedins Human genes 0.000 description 4
• 101710172711 Structural protein Proteins 0.000 description 4
• 208000037280 Trisomy Diseases 0.000 description 4
• 150000001413 amino acids Chemical group 0.000 description 4
• 230000033228 biological regulation Effects 0.000 description 4
• 230000008602 contraction Effects 0.000 description 4
• 230000007123 defense Effects 0.000 description 4
• 230000029087 digestion Effects 0.000 description 4
• 238000000132 electrospray ionisation Methods 0.000 description 4
• 238000005516 engineering process Methods 0.000 description 4
• 238000001502 gel electrophoresis Methods 0.000 description 4
• 238000004128 high performance liquid chromatography Methods 0.000 description 4
• 210000003630 histaminocyte Anatomy 0.000 description 4
• 206010024378 leukocytosis Diseases 0.000 description 4
• 239000000463 material Substances 0.000 description 4
• 239000011159 matrix material Substances 0.000 description 4
• 230000007246 mechanism Effects 0.000 description 4
• 238000009629 microbiological culture Methods 0.000 description 4
• 239000000137 peptide hydrolase inhibitor Substances 0.000 description 4
• 239000002953 phosphate buffered saline Substances 0.000 description 4
• 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 4
• 230000001105 regulatory effect Effects 0.000 description 4
• 238000007423 screening assay Methods 0.000 description 4
• 238000000926 separation method Methods 0.000 description 4
• 239000000243 solution Substances 0.000 description 4
• 230000003595 spectral effect Effects 0.000 description 4
• 238000000672 surface-enhanced laser desorption--ionisation Methods 0.000 description 4
• 208000024891 symptom Diseases 0.000 description 4
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
• QFVHZQCOUORWEI-UHFFFAOYSA-N 4-[(4-anilino-5-sulfonaphthalen-1-yl)diazenyl]-5-hydroxynaphthalene-2,7-disulfonic acid Chemical compound C=12C(O)=CC(S(O)(=O)=O)=CC2=CC(S(O)(=O)=O)=CC=1N=NC(C1=CC=CC(=C11)S(O)(=O)=O)=CC=C1NC1=CC=CC=C1 QFVHZQCOUORWEI-UHFFFAOYSA-N 0.000 description 3
• CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
• 208000031404 Chromosome Aberrations Diseases 0.000 description 3
• 102000016918 Complement C3 Human genes 0.000 description 3
• 108010028780 Complement C3 Proteins 0.000 description 3
• 102100034622 Complement factor B Human genes 0.000 description 3
• 108090000056 Complement factor B Proteins 0.000 description 3
• 108050003114 Coronin 1A Proteins 0.000 description 3
• 102100028233 Coronin-1A Human genes 0.000 description 3
• 102000004127 Cytokines Human genes 0.000 description 3
• 108090000695 Cytokines Proteins 0.000 description 3
• 102000004237 Decorin Human genes 0.000 description 3
• 108090000738 Decorin Proteins 0.000 description 3
• 208000034423 Delivery Diseases 0.000 description 3
• 241000588724 Escherichia coli Species 0.000 description 3
• 102100031812 Fibulin-1 Human genes 0.000 description 3
• 101710170731 Fibulin-1 Proteins 0.000 description 3
• 102000013382 Gelatinases Human genes 0.000 description 3
• 108010026132 Gelatinases Proteins 0.000 description 3
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
• 102000004240 Glycodelin Human genes 0.000 description 3
• 108010081520 Glycodelin Proteins 0.000 description 3
• 101000793686 Homo sapiens Azurocidin Proteins 0.000 description 3
• 206010020772 Hypertension Diseases 0.000 description 3
• 101800001691 Inter-alpha-trypsin inhibitor light chain Proteins 0.000 description 3
• 102100035792 Kininogen-1 Human genes 0.000 description 3
• 208000035752 Live birth Diseases 0.000 description 3
• 208000034702 Multiple pregnancies Diseases 0.000 description 3
• 102400000569 Myeloperoxidase Human genes 0.000 description 3
• 239000002033 PVDF binder Substances 0.000 description 3
• 108010071690 Prealbumin Proteins 0.000 description 3
• 102000007584 Prealbumin Human genes 0.000 description 3
• 206010036595 Premature delivery Diseases 0.000 description 3
• 206010036600 Premature labour Diseases 0.000 description 3
• 241000193990 Streptococcus sp. 'group B' Species 0.000 description 3
• 241000935255 Ureaplasma parvum Species 0.000 description 3
• 206010046827 Uterine tenderness Diseases 0.000 description 3
• 102100040334 Zinc finger protein 354B Human genes 0.000 description 3
• 230000005856 abnormality Effects 0.000 description 3
• 239000002253 acid Substances 0.000 description 3
• 102000015395 alpha 1-Antitrypsin Human genes 0.000 description 3
• 108010050122 alpha 1-Antitrypsin Proteins 0.000 description 3
• 229940024142 alpha 1-antitrypsin Drugs 0.000 description 3
• 230000008901 benefit Effects 0.000 description 3
• 210000004369 blood Anatomy 0.000 description 3
• 239000008280 blood Substances 0.000 description 3
• 239000000872 buffer Substances 0.000 description 3
• 206010008129 cerebral palsy Diseases 0.000 description 3
• 230000008859 change Effects 0.000 description 3
• 239000013068 control sample Substances 0.000 description 3
• NKLPQNGYXWVELD-UHFFFAOYSA-M coomassie brilliant blue Chemical compound [Na+].C1=CC(OCC)=CC=C1NC1=CC=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C=CC(=CC=2)N(CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=C1 NKLPQNGYXWVELD-UHFFFAOYSA-M 0.000 description 3
• 230000008878 coupling Effects 0.000 description 3
• 238000010168 coupling process Methods 0.000 description 3
• 238000005859 coupling reaction Methods 0.000 description 3
• 230000006378 damage Effects 0.000 description 3
• 238000002405 diagnostic procedure Methods 0.000 description 3
• 230000004069 differentiation Effects 0.000 description 3
• 230000002357 endometrial effect Effects 0.000 description 3
• 210000004696 endometrium Anatomy 0.000 description 3
• 210000003754 fetus Anatomy 0.000 description 3
• 102000006640 gamma-Glutamyltransferase Human genes 0.000 description 3
• 239000008103 glucose Substances 0.000 description 3
• 230000012010 growth Effects 0.000 description 3
• 238000005040 ion trap Methods 0.000 description 3
• 238000009533 lab test Methods 0.000 description 3
• 210000000265 leukocyte Anatomy 0.000 description 3
• 108010000849 leukocyte esterase Proteins 0.000 description 3
• 210000002540 macrophage Anatomy 0.000 description 3
• 229910052943 magnesium sulfate Inorganic materials 0.000 description 3
• 235000019341 magnesium sulphate Nutrition 0.000 description 3
• 238000007726 management method Methods 0.000 description 3
• 244000005700 microbiome Species 0.000 description 3
• 230000004048 modification Effects 0.000 description 3
• 238000012986 modification Methods 0.000 description 3
• 230000037361 pathway Effects 0.000 description 3
• 230000009984 peri-natal effect Effects 0.000 description 3
• 229920002981 polyvinylidene fluoride Polymers 0.000 description 3
• 208000026440 premature labor Diseases 0.000 description 3
• 150000003180 prostaglandins Chemical class 0.000 description 3
• 238000011002 quantification Methods 0.000 description 3
• 150000003839 salts Chemical class 0.000 description 3
• 238000001356 surgical procedure Methods 0.000 description 3
• 230000009885 systemic effect Effects 0.000 description 3
• 230000036642 wellbeing Effects 0.000 description 3
• 108700020469 14-3-3 Proteins 0.000 description 2
• 102000004899 14-3-3 Proteins Human genes 0.000 description 2
• HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
• 206010001052 Acute respiratory distress syndrome Diseases 0.000 description 2
• 102100022524 Alpha-1-antichymotrypsin Human genes 0.000 description 2
• 102100033326 Alpha-1B-glycoprotein Human genes 0.000 description 2
• 101710104910 Alpha-1B-glycoprotein Proteins 0.000 description 2
• 108010064733 Angiotensins Proteins 0.000 description 2
• 102000015427 Angiotensins Human genes 0.000 description 2
• 102100040432 Ankyrin repeat and BTB/POZ domain-containing protein 1 Human genes 0.000 description 2
• 241000222122 Candida albicans Species 0.000 description 2
• 108010078791 Carrier Proteins Proteins 0.000 description 2
• 102100038530 Chorionic somatomammotropin hormone 2 Human genes 0.000 description 2
• 206010008805 Chromosomal abnormalities Diseases 0.000 description 2
• 206010010356 Congenital anomaly Diseases 0.000 description 2
• 201000006360 Edwards syndrome Diseases 0.000 description 2
• 108020004206 Gamma-glutamyltransferase Proteins 0.000 description 2
• 102100027685 Hemoglobin subunit alpha Human genes 0.000 description 2
• 108091005902 Hemoglobin subunit alpha Proteins 0.000 description 2
• 102100021519 Hemoglobin subunit beta Human genes 0.000 description 2
• 108091005904 Hemoglobin subunit beta Proteins 0.000 description 2
• 101000964352 Homo sapiens Ankyrin repeat and BTB/POZ domain-containing protein 1 Proteins 0.000 description 2
• 101000840257 Homo sapiens Immunoglobulin kappa constant Proteins 0.000 description 2
• 101001081567 Homo sapiens Insulin-like growth factor-binding protein 1 Proteins 0.000 description 2
• 101000797623 Homo sapiens Protein AMBP Proteins 0.000 description 2
• 101000964396 Homo sapiens Zinc finger protein 354B Proteins 0.000 description 2
• 108060003951 Immunoglobulin Proteins 0.000 description 2
• 102100029572 Immunoglobulin kappa constant Human genes 0.000 description 2
• 102000004218 Insulin-Like Growth Factor I Human genes 0.000 description 2
• 108090001117 Insulin-Like Growth Factor II Proteins 0.000 description 2
• 102000048143 Insulin-Like Growth Factor II Human genes 0.000 description 2
• 102100027636 Insulin-like growth factor-binding protein 1 Human genes 0.000 description 2
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
• 102000011782 Keratins Human genes 0.000 description 2
• 108010076876 Keratins Proteins 0.000 description 2
• 108010077861 Kininogens Proteins 0.000 description 2
• 208000017924 Klinefelter Syndrome Diseases 0.000 description 2
• 102000016267 Leptin Human genes 0.000 description 2
• 108010092277 Leptin Proteins 0.000 description 2
• 102100026046 Mannan-binding lectin serine protease 2 Human genes 0.000 description 2
• 101710117460 Mannan-binding lectin serine protease 2 Proteins 0.000 description 2
• 241000204048 Mycoplasma hominis Species 0.000 description 2
• PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
• 102000007079 Peptide Fragments Human genes 0.000 description 2
• 108010033276 Peptide Fragments Proteins 0.000 description 2
• 102000003867 Phospholipid Transfer Proteins Human genes 0.000 description 2
• 108090000216 Phospholipid Transfer Proteins Proteins 0.000 description 2
• 102100035846 Pigment epithelium-derived factor Human genes 0.000 description 2
• 102100038124 Plasminogen Human genes 0.000 description 2
• 108010051456 Plasminogen Proteins 0.000 description 2
• 101710081231 Plastin-2 Proteins 0.000 description 2
• 206010036590 Premature baby Diseases 0.000 description 2
• 208000013616 Respiratory Distress Syndrome Diseases 0.000 description 2
• 108010071390 Serum Albumin Proteins 0.000 description 2
• 102000007562 Serum Albumin Human genes 0.000 description 2
• 108010089417 Sex Hormone-Binding Globulin Proteins 0.000 description 2
• 102000034755 Sex Hormone-Binding Globulin Human genes 0.000 description 2
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
• 102100036427 Spondin-2 Human genes 0.000 description 2
• 101710092169 Spondin-2 Proteins 0.000 description 2
• 239000006180 TBST buffer Substances 0.000 description 2
• 206010043074 Tachycardia foetal Diseases 0.000 description 2
• 102000004338 Transferrin Human genes 0.000 description 2
• 108090000901 Transferrin Proteins 0.000 description 2
• 208000007159 Trisomy 18 Syndrome Diseases 0.000 description 2
• 206010054094 Tumour necrosis Diseases 0.000 description 2
• 208000026928 Turner syndrome Diseases 0.000 description 2
• LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 2
• TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 2
• 208000036029 Uterine contractions during pregnancy Diseases 0.000 description 2
• 208000027418 Wounds and injury Diseases 0.000 description 2
• 108010039309 actin-modulating proteins Proteins 0.000 description 2
• 230000009471 action Effects 0.000 description 2
• 108010091628 alpha 1-Antichymotrypsin Proteins 0.000 description 2
• 208000019812 amnionitis Diseases 0.000 description 2
• 238000000540 analysis of variance Methods 0.000 description 2
• 230000001773 anti-convulsant effect Effects 0.000 description 2
• 230000000845 anti-microbial effect Effects 0.000 description 2
• 239000001961 anticonvulsive agent Substances 0.000 description 2
• 229960003965 antiepileptics Drugs 0.000 description 2
• 229940019748 antifibrinolytic proteinase inhibitors Drugs 0.000 description 2
• 239000000427 antigen Substances 0.000 description 2
• 108091007433 antigens Proteins 0.000 description 2
• 102000036639 antigens Human genes 0.000 description 2
• 230000003385 bacteriostatic effect Effects 0.000 description 2
• 239000011324 bead Substances 0.000 description 2
• 210000001185 bone marrow Anatomy 0.000 description 2
• 229940095731 candida albicans Drugs 0.000 description 2
• 125000002091 cationic group Chemical group 0.000 description 2
• 238000005119 centrifugation Methods 0.000 description 2
• 238000012512 characterization method Methods 0.000 description 2
• 238000006243 chemical reaction Methods 0.000 description 2
• 239000005482 chemotactic factor Substances 0.000 description 2
• DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
• 230000001086 cytosolic effect Effects 0.000 description 2
• 238000007405 data analysis Methods 0.000 description 2
• 238000003795 desorption Methods 0.000 description 2
• UQLDLKMNUJERMK-UHFFFAOYSA-L di(octadecanoyloxy)lead Chemical compound [Pb+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O UQLDLKMNUJERMK-UHFFFAOYSA-L 0.000 description 2
• 206010012601 diabetes mellitus Diseases 0.000 description 2
• 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 description 2
• 229940079593 drug Drugs 0.000 description 2
• 239000003814 drug Substances 0.000 description 2
• 229940000406 drug candidate Drugs 0.000 description 2
• 238000013399 early diagnosis Methods 0.000 description 2
• 238000001378 electrochemiluminescence detection Methods 0.000 description 2
• 239000002158 endotoxin Substances 0.000 description 2
• 239000006167 equilibration buffer Substances 0.000 description 2
• 238000005194 fractionation Methods 0.000 description 2
• 230000002068 genetic effect Effects 0.000 description 2
• 230000002962 histologic effect Effects 0.000 description 2
• 229960004336 human antithrombin iii Drugs 0.000 description 2
• 230000002519 immonomodulatory effect Effects 0.000 description 2
• 102000018358 immunoglobulin Human genes 0.000 description 2
• 229940072221 immunoglobulins Drugs 0.000 description 2
• 239000002955 immunomodulating agent Substances 0.000 description 2
• 229940121354 immunomodulator Drugs 0.000 description 2
• 238000001114 immunoprecipitation Methods 0.000 description 2
• 230000004957 immunoregulator effect Effects 0.000 description 2
• 238000000338 in vitro Methods 0.000 description 2
• 238000011534 incubation Methods 0.000 description 2
• 230000002458 infectious effect Effects 0.000 description 2
• 230000009545 invasion Effects 0.000 description 2
• CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 description 2
• 229940078795 lactoferrin Drugs 0.000 description 2
• 235000021242 lactoferrin Nutrition 0.000 description 2
• NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 description 2
• 229940039781 leptin Drugs 0.000 description 2
• 229920006008 lipopolysaccharide Polymers 0.000 description 2
• 238000001294 liquid chromatography-tandem mass spectrometry Methods 0.000 description 2
• 210000004072 lung Anatomy 0.000 description 2
• 230000014759 maintenance of location Effects 0.000 description 2
• 230000036244 malformation Effects 0.000 description 2
• 238000010208 microarray analysis Methods 0.000 description 2
• 210000003632 microfilament Anatomy 0.000 description 2
• 108010008217 nidogen Proteins 0.000 description 2
• 210000004789 organ system Anatomy 0.000 description 2
• 230000001991 pathophysiological effect Effects 0.000 description 2
• 210000002826 placenta Anatomy 0.000 description 2
• 230000003169 placental effect Effects 0.000 description 2
• 230000003389 potentiating effect Effects 0.000 description 2
• 238000004393 prognosis Methods 0.000 description 2
• 238000011321 prophylaxis Methods 0.000 description 2
• 201000001474 proteinuria Diseases 0.000 description 2
• 230000002829 reductive effect Effects 0.000 description 2
• 230000014493 regulation of gene expression Effects 0.000 description 2
• 230000002441 reversible effect Effects 0.000 description 2
• 238000012552 review Methods 0.000 description 2
• 102000014452 scavenger receptors Human genes 0.000 description 2
• 108010078070 scavenger receptors Proteins 0.000 description 2
• PCMORTLOPMLEFB-ONEGZZNKSA-N sinapic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC(OC)=C1O PCMORTLOPMLEFB-ONEGZZNKSA-N 0.000 description 2
• PCMORTLOPMLEFB-UHFFFAOYSA-N sinapinic acid Natural products COC1=CC(C=CC(O)=O)=CC(OC)=C1O PCMORTLOPMLEFB-UHFFFAOYSA-N 0.000 description 2
• 230000002269 spontaneous effect Effects 0.000 description 2
• 238000007619 statistical method Methods 0.000 description 2
• 210000002536 stromal cell Anatomy 0.000 description 2
• 230000004083 survival effect Effects 0.000 description 2
• 210000001550 testis Anatomy 0.000 description 2
• 230000001225 therapeutic effect Effects 0.000 description 2
• 206010053884 trisomy 18 Diseases 0.000 description 2
• 229940116269 uric acid Drugs 0.000 description 2
• 238000012795 verification Methods 0.000 description 2
• 239000003643 water by type Substances 0.000 description 2
• 230000036266 weeks of gestation Effects 0.000 description 2
• PROQIPRRNZUXQM-UHFFFAOYSA-N (16alpha,17betaOH)-Estra-1,3,5(10)-triene-3,16,17-triol Natural products OC1=CC=C2C3CCC(C)(C(C(O)C4)O)C4C3CCC2=C1 PROQIPRRNZUXQM-UHFFFAOYSA-N 0.000 description 1
• YMXHPSHLTSZXKH-RVBZMBCESA-N (2,5-dioxopyrrolidin-1-yl) 5-[(3as,4s,6ar)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoate Chemical compound C([C@H]1[C@H]2NC(=O)N[C@H]2CS1)CCCC(=O)ON1C(=O)CCC1=O YMXHPSHLTSZXKH-RVBZMBCESA-N 0.000 description 1
• NHSJCIBSNKLAMA-UHFFFAOYSA-N (2Z)-1-ethyl-2-[(2E,4E)-5-[1-[6-[2-(4-hydroxyphenyl)ethylamino]-6-oxohexyl]-3,3-dimethyl-5-sulfoindol-1-ium-2-yl]penta-2,4-dienylidene]-3,3-dimethylindole-5-sulfonate Chemical compound CC[N+]1=C(\C=C\C=C\C=C2/N(CCCCCC(=O)NCCC3=CC=C(O)C=C3)C3=CC=C(C=C3C2(C)C)S(O)(=O)=O)C(C)(C)C2=C1C=CC(=C2)S([O-])(=O)=O NHSJCIBSNKLAMA-UHFFFAOYSA-N 0.000 description 1
• JWICNZAGYSIBAR-LEEGLKINSA-N (4s)-4-[[2-[[(2s)-2-[[(2s)-2-[[(2s)-2-aminopropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]-5-[[2-[[(2s)-3-carboxy-1-[[(2s)-1-[[1-[[(2s)-1-[[(2s)-4-carboxy-1-[[2-[[2-[[2-[[(2s)-1-[[(1s)-1-carboxy-4-(diaminomethylideneamino Chemical compound NC(N)=NCCC[C@@H](C(O)=O)NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)C(CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)N)CC1=CC=CC=C1 JWICNZAGYSIBAR-LEEGLKINSA-N 0.000 description 1
• 102100027832 14-3-3 protein gamma Human genes 0.000 description 1
• 102100027833 14-3-3 protein sigma Human genes 0.000 description 1
• QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
• 238000004780 2D liquid chromatography Methods 0.000 description 1
• BIHPYCDDPGNWQO-UHFFFAOYSA-N 5-iai Chemical compound C1=C(I)C=C2CC(N)CC2=C1 BIHPYCDDPGNWQO-UHFFFAOYSA-N 0.000 description 1
• 102000017304 72kDa type IV collagenases Human genes 0.000 description 1
• 108050005269 72kDa type IV collagenases Proteins 0.000 description 1
• 208000009206 Abruptio Placentae Diseases 0.000 description 1
• HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
• 102100026656 Actin, alpha skeletal muscle Human genes 0.000 description 1
• 101710090617 Actin, alpha skeletal muscle Proteins 0.000 description 1
• 102100036732 Actin, aortic smooth muscle Human genes 0.000 description 1
• 101710192004 Actin, aortic smooth muscle Proteins 0.000 description 1
• 102100022900 Actin, cytoplasmic 1 Human genes 0.000 description 1
• 101710119043 Actin, cytoplasmic 1 Proteins 0.000 description 1
• 102100030374 Actin, cytoplasmic 2 Human genes 0.000 description 1
• 101710119042 Actin, cytoplasmic 2 Proteins 0.000 description 1
• 102100036774 Afamin Human genes 0.000 description 1
• 101710149366 Afamin Proteins 0.000 description 1
• 102100022460 Alpha-1-acid glycoprotein 2 Human genes 0.000 description 1
• 101710186699 Alpha-1-acid glycoprotein 2 Proteins 0.000 description 1
• 102400001364 Alpha-1-microglobulin Human genes 0.000 description 1
• 101800001761 Alpha-1-microglobulin Proteins 0.000 description 1
• 102100033312 Alpha-2-macroglobulin Human genes 0.000 description 1
• 102000009131 Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 3 Human genes 0.000 description 1
• 108010087979 Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 3 Proteins 0.000 description 1
• 208000024827 Alzheimer disease Diseases 0.000 description 1
• ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 1
• 229910000013 Ammonium bicarbonate Inorganic materials 0.000 description 1
• 206010002023 Amyloidoses Diseases 0.000 description 1
• 102400000068 Angiostatin Human genes 0.000 description 1
• 108010079709 Angiostatins Proteins 0.000 description 1
• QMMRCKSBBNJCMR-KMZPNFOHSA-N Angiotensin III Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCN=C(N)N)C(C)C)C1=CC=C(O)C=C1 QMMRCKSBBNJCMR-KMZPNFOHSA-N 0.000 description 1
• 102400000344 Angiotensin-1 Human genes 0.000 description 1
• 101800000734 Angiotensin-1 Proteins 0.000 description 1
• 102400000348 Angiotensin-3 Human genes 0.000 description 1
• 101800000738 Angiotensin-3 Proteins 0.000 description 1
• 102000004881 Angiotensinogen Human genes 0.000 description 1
• 108090001067 Angiotensinogen Proteins 0.000 description 1
• 108090000663 Annexin A1 Proteins 0.000 description 1
• 102100040006 Annexin A1 Human genes 0.000 description 1
• 102100022977 Antithrombin-III Human genes 0.000 description 1
• 102100037320 Apolipoprotein A-IV Human genes 0.000 description 1
• 108010071619 Apolipoproteins Proteins 0.000 description 1
• 102000007592 Apolipoproteins Human genes 0.000 description 1
• 101100410782 Arabidopsis thaliana PXG1 gene Proteins 0.000 description 1
• 208000002109 Argyria Diseases 0.000 description 1
• 208000031504 Asymptomatic Infections Diseases 0.000 description 1
• 102100021523 BPI fold-containing family A member 1 Human genes 0.000 description 1
• 241000194107 Bacillus megaterium Species 0.000 description 1
• 208000031729 Bacteremia Diseases 0.000 description 1
• 208000035143 Bacterial infection Diseases 0.000 description 1
• 102100036597 Basement membrane-specific heparan sulfate proteoglycan core protein Human genes 0.000 description 1
• 101710151712 Basement membrane-specific heparan sulfate proteoglycan core protein Proteins 0.000 description 1
• 102100030802 Beta-2-glycoprotein 1 Human genes 0.000 description 1
• 102100031680 Beta-catenin-interacting protein 1 Human genes 0.000 description 1
• 102100026189 Beta-galactosidase Human genes 0.000 description 1
• 102100026044 Biotinidase Human genes 0.000 description 1
• 108010039206 Biotinidase Proteins 0.000 description 1
• 108010029692 Bisphosphoglycerate mutase Proteins 0.000 description 1
• 102000004506 Blood Proteins Human genes 0.000 description 1
• 108010017384 Blood Proteins Proteins 0.000 description 1
• 102100028728 Bone morphogenetic protein 1 Human genes 0.000 description 1
• 108090000654 Bone morphogenetic protein 1 Proteins 0.000 description 1
• 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
• 208000014644 Brain disease Diseases 0.000 description 1
• 102100021935 C-C motif chemokine 26 Human genes 0.000 description 1
• 108010074051 C-Reactive Protein Proteins 0.000 description 1
• 102100032752 C-reactive protein Human genes 0.000 description 1
• 102400000631 C3a anaphylatoxin Human genes 0.000 description 1
• 101800001577 C3a anaphylatoxin Proteins 0.000 description 1
• 102400000126 C4a anaphylatoxin Human genes 0.000 description 1
• 101800001547 C4a anaphylatoxin Proteins 0.000 description 1
• 108010049990 CD13 Antigens Proteins 0.000 description 1
• 102000000905 Cadherin Human genes 0.000 description 1
• 108050007957 Cadherin Proteins 0.000 description 1
• 102000014818 Cadherin-13 Human genes 0.000 description 1
• 102100029968 Calreticulin Human genes 0.000 description 1
• 108090000549 Calreticulin Proteins 0.000 description 1
• 101710132601 Capsid protein Proteins 0.000 description 1
• 101800001318 Capsid protein VP4 Proteins 0.000 description 1
• 102000014914 Carrier Proteins Human genes 0.000 description 1
• 102100027473 Cartilage oligomeric matrix protein Human genes 0.000 description 1
• 101710176668 Cartilage oligomeric matrix protein Proteins 0.000 description 1
• 108010066813 Chitinase-3-Like Protein 1 Proteins 0.000 description 1
• 102100038196 Chitinase-3-like protein 1 Human genes 0.000 description 1
• 101100219384 Chlamydomonas reinhardtii CAH2 gene Proteins 0.000 description 1
• 102100030556 Coagulation factor XII Human genes 0.000 description 1
• 108090000996 Cofilin 1 Proteins 0.000 description 1
• 102100027466 Cofilin-1 Human genes 0.000 description 1
• 102000012432 Collagen Type V Human genes 0.000 description 1
• 108010022514 Collagen Type V Proteins 0.000 description 1
• 102100031611 Collagen alpha-1(III) chain Human genes 0.000 description 1
• 102000029816 Collagenase Human genes 0.000 description 1
• 108060005980 Collagenase Proteins 0.000 description 1
• 108090000909 Collectins Proteins 0.000 description 1
• 102000004405 Collectins Human genes 0.000 description 1
• 108010028778 Complement C4 Proteins 0.000 description 1
• 102100033777 Complement C4-B Human genes 0.000 description 1
• 108010077762 Complement C4b Proteins 0.000 description 1
• 102000016550 Complement Factor H Human genes 0.000 description 1
• 108010053085 Complement Factor H Proteins 0.000 description 1
• 108090000044 Complement Factor I Proteins 0.000 description 1
• 102000008929 Complement component C9 Human genes 0.000 description 1
• 108050000891 Complement component C9 Proteins 0.000 description 1
• 102100035436 Complement factor D Human genes 0.000 description 1
• 108090000059 Complement factor D Proteins 0.000 description 1
• 102100040132 Complement factor H-related protein 1 Human genes 0.000 description 1
• 101710101151 Complement factor H-related protein 1 Proteins 0.000 description 1
• 102100035431 Complement factor I Human genes 0.000 description 1
• 206010010904 Convulsion Diseases 0.000 description 1
• 102000014196 Coronin 1A Human genes 0.000 description 1
• FBPFZTCFMRRESA-ZXXMMSQZSA-N D-iditol Chemical compound OC[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-ZXXMMSQZSA-N 0.000 description 1
• 230000004544 DNA amplification Effects 0.000 description 1
• 238000000018 DNA microarray Methods 0.000 description 1
• 101710119265 DNA topoisomerase 1 Proteins 0.000 description 1
• 206010012289 Dementia Diseases 0.000 description 1
• 102100036912 Desmin Human genes 0.000 description 1
• 108010044052 Desmin Proteins 0.000 description 1
• 101100117236 Drosophila melanogaster speck gene Proteins 0.000 description 1
• 208000032274 Encephalopathy Diseases 0.000 description 1
• 206010014759 Endometrial neoplasm Diseases 0.000 description 1
• 208000004145 Endometritis Diseases 0.000 description 1
• 102000004190 Enzymes Human genes 0.000 description 1
• 108090000790 Enzymes Proteins 0.000 description 1
• 102400000102 Eosinophil granule major basic protein Human genes 0.000 description 1
• 101800000338 Eosinophil granule major basic protein Proteins 0.000 description 1
• 102100027186 Extracellular superoxide dismutase [Cu-Zn] Human genes 0.000 description 1
• 108700001268 Extracellular superoxide dismutase [Cu-Zn] Proteins 0.000 description 1
• 108010080865 Factor XII Proteins 0.000 description 1
• 208000001362 Fetal Growth Retardation Diseases 0.000 description 1
• 108010049003 Fibrinogen Proteins 0.000 description 1
• 102000008946 Fibrinogen Human genes 0.000 description 1
• 102400001064 Fibrinogen beta chain Human genes 0.000 description 1
• 101710170765 Fibrinogen beta chain Proteins 0.000 description 1
• 102400000525 Fibrinopeptide A Human genes 0.000 description 1
• 101800000974 Fibrinopeptide A Proteins 0.000 description 1
• 102400001063 Fibrinopeptide B Human genes 0.000 description 1
• 101800003778 Fibrinopeptide B Proteins 0.000 description 1
• 102100029379 Follistatin-related protein 3 Human genes 0.000 description 1
• 102000013446 GTP Phosphohydrolases Human genes 0.000 description 1
• 108091006109 GTPases Proteins 0.000 description 1
• 102100040510 Galectin-3-binding protein Human genes 0.000 description 1
• 101710197901 Galectin-3-binding protein Proteins 0.000 description 1
• 102100028652 Gamma-enolase Human genes 0.000 description 1
• 101710191797 Gamma-enolase Proteins 0.000 description 1
• 101710107035 Gamma-glutamyltranspeptidase Proteins 0.000 description 1
• 102100023364 Ganglioside GM2 activator Human genes 0.000 description 1
• 101710201362 Ganglioside GM2 activator Proteins 0.000 description 1
• 101710205562 Glutathione hydrolase 1 proenzyme Proteins 0.000 description 1
• 102100033366 Glutathione hydrolase 1 proenzyme Human genes 0.000 description 1
• 102100025527 Glutathione hydrolase light chain 2 Human genes 0.000 description 1
• 101710173228 Glutathione hydrolase proenzyme Proteins 0.000 description 1
• 102000003886 Glycoproteins Human genes 0.000 description 1
• 108090000288 Glycoproteins Proteins 0.000 description 1
• 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 description 1
• 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 description 1
• 108010066705 H-cadherin Proteins 0.000 description 1
• 102100027772 Haptoglobin-related protein Human genes 0.000 description 1
• 101710122541 Haptoglobin-related protein Proteins 0.000 description 1
• 102100029100 Hematopoietic prostaglandin D synthase Human genes 0.000 description 1
• 102100039894 Hemoglobin subunit delta Human genes 0.000 description 1
• 108091005903 Hemoglobin subunit delta Proteins 0.000 description 1
• 102100038614 Hemoglobin subunit gamma-1 Human genes 0.000 description 1
• 101710195291 Hemoglobin subunit gamma-1 Proteins 0.000 description 1
• 108010054147 Hemoglobins Proteins 0.000 description 1
• 102000001554 Hemoglobins Human genes 0.000 description 1
• 102000013271 Hemopexin Human genes 0.000 description 1
• 108010026027 Hemopexin Proteins 0.000 description 1
• 208000032843 Hemorrhage Diseases 0.000 description 1
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
• 102100027619 Histidine-rich glycoprotein Human genes 0.000 description 1
• 102000017286 Histone H2A Human genes 0.000 description 1
• 108050005231 Histone H2A Proteins 0.000 description 1
• 102100030687 Histone H2B type 1-B Human genes 0.000 description 1
• 102100034523 Histone H4 Human genes 0.000 description 1
• 108010033040 Histones Proteins 0.000 description 1
• 241000282412 Homo Species 0.000 description 1
• 101000760079 Homo sapiens 14-3-3 protein epsilon Proteins 0.000 description 1
• 101000723517 Homo sapiens 14-3-3 protein gamma Proteins 0.000 description 1
• 101000936405 Homo sapiens A disintegrin and metalloproteinase with thrombospondin motifs 1 Proteins 0.000 description 1
• 101000757319 Homo sapiens Antithrombin-III Proteins 0.000 description 1
• 101000899089 Homo sapiens BPI fold-containing family A member 1 Proteins 0.000 description 1
• 101000937544 Homo sapiens Beta-2-microglobulin Proteins 0.000 description 1
• 101000993469 Homo sapiens Beta-catenin-interacting protein 1 Proteins 0.000 description 1
• 101000897493 Homo sapiens C-C motif chemokine 26 Proteins 0.000 description 1
• 101000984015 Homo sapiens Cadherin-1 Proteins 0.000 description 1
• 101000760643 Homo sapiens Carbonic anhydrase 2 Proteins 0.000 description 1
• 101000895818 Homo sapiens Chorionic somatomammotropin hormone 1 Proteins 0.000 description 1
• 101000956228 Homo sapiens Chorionic somatomammotropin hormone 2 Proteins 0.000 description 1
• 101000942697 Homo sapiens Clusterin Proteins 0.000 description 1
• 101000993285 Homo sapiens Collagen alpha-1(III) chain Proteins 0.000 description 1
• 101000993321 Homo sapiens Complement C2 Proteins 0.000 description 1
• 101000909486 Homo sapiens Complement component C7 Proteins 0.000 description 1
• 101000868967 Homo sapiens Corticosteroid-binding globulin Proteins 0.000 description 1
• 101000921786 Homo sapiens Cystatin-A Proteins 0.000 description 1
• 101001062529 Homo sapiens Follistatin-related protein 3 Proteins 0.000 description 1
• 101001059150 Homo sapiens Gelsolin Proteins 0.000 description 1
• 101000856496 Homo sapiens Glutathione hydrolase light chain 2 Proteins 0.000 description 1
• 101000871067 Homo sapiens Glutathione peroxidase 3 Proteins 0.000 description 1
• 101001068136 Homo sapiens Hepatitis A virus cellular receptor 1 Proteins 0.000 description 1
• 101001084691 Homo sapiens Histone H2B type 1-B Proteins 0.000 description 1
• 101000977638 Homo sapiens Immunoglobulin superfamily containing leucine-rich repeat protein Proteins 0.000 description 1
• 101000760817 Homo sapiens Macrophage-capping protein Proteins 0.000 description 1
• 101000904196 Homo sapiens Pancreatic secretory granule membrane major glycoprotein GP2 Proteins 0.000 description 1
• 101001081555 Homo sapiens Plasma protease C1 inhibitor Proteins 0.000 description 1
• 101000595925 Homo sapiens Plasminogen-like protein B Proteins 0.000 description 1
• 101000831286 Homo sapiens Protein timeless homolog Proteins 0.000 description 1
• 101000651439 Homo sapiens Prothrombin Proteins 0.000 description 1
• 101000752245 Homo sapiens Rho guanine nucleotide exchange factor 5 Proteins 0.000 description 1
• 101000652153 Homo sapiens Ribosome biogenesis protein SLX9 homolog Proteins 0.000 description 1
• 101000831940 Homo sapiens Stathmin Proteins 0.000 description 1
• 101000712600 Homo sapiens Thyroid hormone receptor beta Proteins 0.000 description 1
• 101000837639 Homo sapiens Thyroxine-binding globulin Proteins 0.000 description 1
• 101000818517 Homo sapiens Zinc-alpha-2-glycoprotein Proteins 0.000 description 1
• 108091006905 Human Serum Albumin Proteins 0.000 description 1
• 102000008100 Human Serum Albumin Human genes 0.000 description 1
• 208000023105 Huntington disease Diseases 0.000 description 1
• 101710138871 Ig gamma-1 chain C region Proteins 0.000 description 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
• 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
• 102100039345 Immunoglobulin heavy constant gamma 1 Human genes 0.000 description 1
• 102100023538 Immunoglobulin superfamily containing leucine-rich repeat protein Human genes 0.000 description 1
• 108090000964 Insulin-like growth factor binding protein 2 Proteins 0.000 description 1
• 102100022710 Insulin-like growth factor-binding protein 2 Human genes 0.000 description 1
• 102100039440 Inter-alpha-trypsin inhibitor heavy chain H2 Human genes 0.000 description 1
• 101710083919 Inter-alpha-trypsin inhibitor heavy chain H2 Proteins 0.000 description 1
• 102100030131 Interferon regulatory factor 5 Human genes 0.000 description 1
• 101710157897 Interferon regulatory factor 5 Proteins 0.000 description 1
• 108010002352 Interleukin-1 Proteins 0.000 description 1
• 102000000589 Interleukin-1 Human genes 0.000 description 1
• 108090001007 Interleukin-8 Proteins 0.000 description 1
• 102000004890 Interleukin-8 Human genes 0.000 description 1
• 102000015696 Interleukins Human genes 0.000 description 1
• 108010063738 Interleukins Proteins 0.000 description 1
• 206010022840 Intraventricular haemorrhage Diseases 0.000 description 1
• 206010022998 Irritability Diseases 0.000 description 1
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
• 102000004856 Lectins Human genes 0.000 description 1
• 108090001090 Lectins Proteins 0.000 description 1
• 102100035987 Leucine-rich alpha-2-glycoprotein Human genes 0.000 description 1
• 101710083711 Leucine-rich alpha-2-glycoprotein Proteins 0.000 description 1
• 102000019298 Lipocalin Human genes 0.000 description 1
• 108050006654 Lipocalin Proteins 0.000 description 1
• 101500021084 Locusta migratoria 5 kDa peptide Proteins 0.000 description 1
• 102100032114 Lumican Human genes 0.000 description 1
• 108010076371 Lumican Proteins 0.000 description 1
• 102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 description 1
• 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
• 108010015302 Matrix metalloproteinase-9 Proteins 0.000 description 1
• 102100030412 Matrix metalloproteinase-9 Human genes 0.000 description 1
• 201000009906 Meningitis Diseases 0.000 description 1
• NPPQSCRMBWNHMW-UHFFFAOYSA-N Meprobamate Chemical compound NC(=O)OCC(C)(CCC)COC(N)=O NPPQSCRMBWNHMW-UHFFFAOYSA-N 0.000 description 1
• 101710170181 Metalloproteinase inhibitor Proteins 0.000 description 1
• 102100039364 Metalloproteinase inhibitor 1 Human genes 0.000 description 1
• 241001430197 Mollicutes Species 0.000 description 1
• 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 description 1
• 101710095845 Monocyte differentiation antigen CD14 Proteins 0.000 description 1
• 206010065783 Musculoskeletal deformity Diseases 0.000 description 1
• 241000204003 Mycoplasmatales Species 0.000 description 1
• 101710143335 Myosin light chain 3, skeletal muscle isoform Proteins 0.000 description 1
• 101710202896 Myosin light chain alkali Proteins 0.000 description 1
• 101710182483 Myosin, essential light chain Proteins 0.000 description 1
• 102100037371 Nidogen-2 Human genes 0.000 description 1
• 101710091705 Nidogen-2 Proteins 0.000 description 1
• 239000000020 Nitrocellulose Substances 0.000 description 1
• 108091028043 Nucleic acid sequence Proteins 0.000 description 1
• 206010030113 Oedema Diseases 0.000 description 1
• 108091034117 Oligonucleotide Proteins 0.000 description 1
• 108010061952 Orosomucoid Proteins 0.000 description 1
• 102000012404 Orosomucoid Human genes 0.000 description 1
• 241000283973 Oryctolagus cuniculus Species 0.000 description 1
• 102100024019 Pancreatic secretory granule membrane major glycoprotein GP2 Human genes 0.000 description 1
• 208000001300 Perinatal Death Diseases 0.000 description 1
• 102100037765 Periostin Human genes 0.000 description 1
• 101710199268 Periostin Proteins 0.000 description 1
• 102000011025 Phosphoglycerate Mutase Human genes 0.000 description 1
• 208000036216 Placenta Previa Diseases 0.000 description 1
• 108010003044 Placental Lactogen Proteins 0.000 description 1
• 102000004576 Placental Lactogen Human genes 0.000 description 1
• 239000000381 Placental Lactogen Substances 0.000 description 1
• 102100035195 Plasminogen-like protein B Human genes 0.000 description 1
• 206010035664 Pneumonia Diseases 0.000 description 1
• 206010036049 Polycystic ovaries Diseases 0.000 description 1
• 108010015078 Pregnancy-Associated alpha 2-Macroglobulins Proteins 0.000 description 1
• 206010036608 Premature separation of placenta Diseases 0.000 description 1
• 108091000054 Prion Proteins 0.000 description 1
• 102000029797 Prion Human genes 0.000 description 1
• 102100024819 Prolactin Human genes 0.000 description 1
• 108010057464 Prolactin Proteins 0.000 description 1
• 108030003866 Prostaglandin-D synthases Proteins 0.000 description 1
• 102100040823 Protein FAM3C Human genes 0.000 description 1
• 108050003995 Protein FAM3C Proteins 0.000 description 1
• 102000016611 Proteoglycans Human genes 0.000 description 1
• 108010067787 Proteoglycans Proteins 0.000 description 1
• 102100038246 Retinol-binding protein 4 Human genes 0.000 description 1
• 101710137011 Retinol-binding protein 4 Proteins 0.000 description 1
• 108091078243 Rho family Proteins 0.000 description 1
• 102000042463 Rho family Human genes 0.000 description 1
• 102100021688 Rho guanine nucleotide exchange factor 5 Human genes 0.000 description 1
• 102100027609 Rho-related GTP-binding protein RhoD Human genes 0.000 description 1
• 102100030570 Ribosome biogenesis protein SLX9 homolog Human genes 0.000 description 1
• 229920002684 Sepharose Polymers 0.000 description 1
• 208000027583 Serpinopathy Diseases 0.000 description 1
• 239000000589 Siderophore Substances 0.000 description 1
• 208000032023 Signs and Symptoms Diseases 0.000 description 1
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
• 102100024237 Stathmin Human genes 0.000 description 1
• 241000194017 Streptococcus Species 0.000 description 1
• 229930006000 Sucrose Natural products 0.000 description 1
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
• QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
• 102100024554 Tetranectin Human genes 0.000 description 1
• 108060008245 Thrombospondin Proteins 0.000 description 1
• 102000002938 Thrombospondin Human genes 0.000 description 1
• 102100033451 Thyroid hormone receptor beta Human genes 0.000 description 1
• 108010031374 Tissue Inhibitor of Metalloproteinase-1 Proteins 0.000 description 1
• 101710120037 Toxin CcdB Proteins 0.000 description 1
• 108090001012 Transforming Growth Factor beta Proteins 0.000 description 1
• 102000004887 Transforming Growth Factor beta Human genes 0.000 description 1
• 102000010208 Transforming growth factor-beta-induced protein ig-h3 Human genes 0.000 description 1
• 108050001894 Transforming growth factor-beta-induced protein ig-h3 Proteins 0.000 description 1
• 102100033598 Triosephosphate isomerase Human genes 0.000 description 1
• 101710194411 Triosephosphate isomerase 1 Proteins 0.000 description 1
• 239000007976 Tris-NaCl-Tween buffer Substances 0.000 description 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
• 102400000757 Ubiquitin Human genes 0.000 description 1
• 108090000848 Ubiquitin Proteins 0.000 description 1
• 241000202921 Ureaplasma urealyticum Species 0.000 description 1
• 102100025455 Vesicular integral-membrane protein VIP36 Human genes 0.000 description 1
• 101710144407 Vesicular integral-membrane protein VIP36 Proteins 0.000 description 1
• 108010031318 Vitronectin Proteins 0.000 description 1
• 102100035140 Vitronectin Human genes 0.000 description 1
• 241000269370 Xenopus <genus> Species 0.000 description 1
• 101000756604 Xenopus laevis Actin, cytoplasmic 1 Proteins 0.000 description 1
• 101710187480 Zinc finger protein 354B Proteins 0.000 description 1
• 102100021144 Zinc-alpha-2-glycoprotein Human genes 0.000 description 1
• 231100000071 abnormal chromosome number Toxicity 0.000 description 1
• 238000002835 absorbance Methods 0.000 description 1
• 238000011256 aggressive treatment Methods 0.000 description 1
• 238000013019 agitation Methods 0.000 description 1
• 238000007605 air drying Methods 0.000 description 1
• 150000001299 aldehydes Chemical class 0.000 description 1
• 125000001931 aliphatic group Chemical group 0.000 description 1
• 108090000183 alpha-2-Antiplasmin Proteins 0.000 description 1
• 108010075843 alpha-2-HS-Glycoprotein Proteins 0.000 description 1
• 102000012005 alpha-2-HS-Glycoprotein Human genes 0.000 description 1
• 235000012538 ammonium bicarbonate Nutrition 0.000 description 1
• 239000001099 ammonium carbonate Substances 0.000 description 1
• 206010002022 amyloidosis Diseases 0.000 description 1
• 239000012491 analyte Substances 0.000 description 1
• 230000003322 aneuploid effect Effects 0.000 description 1
• ORWYRWWVDCYOMK-HBZPZAIKSA-N angiotensin I Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C1=CC=C(O)C=C1 ORWYRWWVDCYOMK-HBZPZAIKSA-N 0.000 description 1
• 238000010171 animal model Methods 0.000 description 1
• 238000005571 anion exchange chromatography Methods 0.000 description 1
• 230000003276 anti-hypertensive effect Effects 0.000 description 1
• 230000000692 anti-sense effect Effects 0.000 description 1
• 230000009830 antibody antigen interaction Effects 0.000 description 1
• 239000002220 antihypertensive agent Substances 0.000 description 1
• 229940030600 antihypertensive agent Drugs 0.000 description 1
• 108010073614 apolipoprotein A-IV Proteins 0.000 description 1
• 230000001174 ascending effect Effects 0.000 description 1
• FZCSTZYAHCUGEM-UHFFFAOYSA-N aspergillomarasmine B Natural products OC(=O)CNC(C(O)=O)CNC(C(O)=O)CC(O)=O FZCSTZYAHCUGEM-UHFFFAOYSA-N 0.000 description 1
• 238000004630 atomic force microscopy Methods 0.000 description 1
• 101150033568 ats1 gene Proteins 0.000 description 1
• 230000003305 autocrine Effects 0.000 description 1
• 208000022362 bacterial infectious disease Diseases 0.000 description 1
• 239000000022 bacteriostatic agent Substances 0.000 description 1
• 239000007640 basal medium Substances 0.000 description 1
• 210000002469 basement membrane Anatomy 0.000 description 1
• 108010023562 beta 2-Glycoprotein I Proteins 0.000 description 1
• 108010005774 beta-Galactosidase Proteins 0.000 description 1
• 108091008324 binding proteins Proteins 0.000 description 1
• 230000008236 biological pathway Effects 0.000 description 1
• 108091006004 biotinylated proteins Proteins 0.000 description 1
• 230000006287 biotinylation Effects 0.000 description 1
• 238000007413 biotinylation Methods 0.000 description 1
• 208000034158 bleeding Diseases 0.000 description 1
• 230000000740 bleeding effect Effects 0.000 description 1
• 210000004556 brain Anatomy 0.000 description 1
• 239000011575 calcium Substances 0.000 description 1
• 238000004850 capillary HPLC Methods 0.000 description 1
• 238000007623 carbamidomethylation reaction Methods 0.000 description 1
• 210000000748 cardiovascular system Anatomy 0.000 description 1
• 230000015556 catabolic process Effects 0.000 description 1
• MLYYVTUWGNIJIB-BXKDBHETSA-N cefazolin Chemical compound S1C(C)=NN=C1SCC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CN3N=NN=C3)[C@H]2SC1 MLYYVTUWGNIJIB-BXKDBHETSA-N 0.000 description 1
• 229960001139 cefazolin Drugs 0.000 description 1
• 230000003915 cell function Effects 0.000 description 1
• 230000005754 cellular signaling Effects 0.000 description 1
• 210000003169 central nervous system Anatomy 0.000 description 1
• 230000002490 cerebral effect Effects 0.000 description 1
• 210000003679 cervix uteri Anatomy 0.000 description 1
• 239000003795 chemical substances by application Substances 0.000 description 1
• 230000035605 chemotaxis Effects 0.000 description 1
• 238000004587 chromatography analysis Methods 0.000 description 1
• 238000010367 cloning Methods 0.000 description 1
• 229960002424 collagenase Drugs 0.000 description 1
• 238000010835 comparative analysis Methods 0.000 description 1
• 230000000295 complement effect Effects 0.000 description 1
• 239000002299 complementary DNA Substances 0.000 description 1
• 238000004590 computer program Methods 0.000 description 1
• 230000001143 conditioned effect Effects 0.000 description 1
• 230000003750 conditioning effect Effects 0.000 description 1
• 230000001276 controlling effect Effects 0.000 description 1
• 229940109239 creatinine Drugs 0.000 description 1
• 238000004132 cross linking Methods 0.000 description 1
• 235000018417 cysteine Nutrition 0.000 description 1
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
• 230000002559 cytogenic effect Effects 0.000 description 1
• 230000003436 cytoskeletal effect Effects 0.000 description 1
• 210000004292 cytoskeleton Anatomy 0.000 description 1
• 210000003785 decidua Anatomy 0.000 description 1
• 230000003247 decreasing effect Effects 0.000 description 1
• 238000006731 degradation reaction Methods 0.000 description 1
• 230000003111 delayed effect Effects 0.000 description 1
• 108700041286 delta Proteins 0.000 description 1
• 210000005045 desmin Anatomy 0.000 description 1
• 230000014670 detection of bacterium Effects 0.000 description 1
• 239000003599 detergent Substances 0.000 description 1
• 230000010339 dilation Effects 0.000 description 1
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
• 238000007877 drug screening Methods 0.000 description 1
• 239000000975 dye Substances 0.000 description 1
• 208000002296 eclampsia Diseases 0.000 description 1
• 239000012636 effector Substances 0.000 description 1
• 238000001781 electrospray-ionisation quadrupole time-of-flight tandem mass spectrometry Methods 0.000 description 1
• 230000008030 elimination Effects 0.000 description 1
• 238000003379 elimination reaction Methods 0.000 description 1
• 238000010828 elution Methods 0.000 description 1
• 208000023042 endomyometritis Diseases 0.000 description 1
• 239000003623 enhancer Substances 0.000 description 1
• 229940088598 enzyme Drugs 0.000 description 1
• 210000002919 epithelial cell Anatomy 0.000 description 1
• PROQIPRRNZUXQM-ZXXIGWHRSA-N estriol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)C4)O)[C@@H]4[C@@H]3CCC2=C1 PROQIPRRNZUXQM-ZXXIGWHRSA-N 0.000 description 1
• 229960001348 estriol Drugs 0.000 description 1
• 230000001747 exhibiting effect Effects 0.000 description 1
• 238000002474 experimental method Methods 0.000 description 1
• 238000010195 expression analysis Methods 0.000 description 1
• 238000000605 extraction Methods 0.000 description 1
• 229940012413 factor vii Drugs 0.000 description 1
• 239000012894 fetal calf serum Substances 0.000 description 1
• 208000030941 fetal growth restriction Diseases 0.000 description 1
• 229940012952 fibrinogen Drugs 0.000 description 1
• MYRIFIVQGRMHRF-OECXYHNASA-N fibrinopeptide b Chemical compound N([C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(=O)CNC(=O)[C@@H]1CCC(=O)N1 MYRIFIVQGRMHRF-OECXYHNASA-N 0.000 description 1
• 238000002866 fluorescence resonance energy transfer Methods 0.000 description 1
• 238000009472 formulation Methods 0.000 description 1
• 239000005350 fused silica glass Substances 0.000 description 1
• 238000001030 gas--liquid chromatography Methods 0.000 description 1
• 238000002695 general anesthesia Methods 0.000 description 1
• 210000004392 genitalia Anatomy 0.000 description 1
• 210000004907 gland Anatomy 0.000 description 1
• 239000011521 glass Substances 0.000 description 1
• 210000000224 granular leucocyte Anatomy 0.000 description 1
• 230000036541 health Effects 0.000 description 1
• 229960002897 heparin Drugs 0.000 description 1
• 229920000669 heparin Polymers 0.000 description 1
• 108010044853 histidine-rich proteins Proteins 0.000 description 1
• 230000003118 histopathologic effect Effects 0.000 description 1
• 229940088597 hormone Drugs 0.000 description 1
• 239000005556 hormone Substances 0.000 description 1
• 102000044460 human ADAMTS1 Human genes 0.000 description 1
• 102000047279 human B2M Human genes 0.000 description 1
• 102000057327 human CA2 Human genes 0.000 description 1
• 102000052128 human CAPG Human genes 0.000 description 1
• 102000056179 human CLU Human genes 0.000 description 1
• 102000048799 human SERPINA7 Human genes 0.000 description 1
• 102000044507 human SERPING1 Human genes 0.000 description 1
• 229940039715 human prothrombin Drugs 0.000 description 1
• 230000005661 hydrophobic surface Effects 0.000 description 1
• 230000003100 immobilizing effect Effects 0.000 description 1
• 210000002865 immune cell Anatomy 0.000 description 1
• 238000003119 immunoblot Methods 0.000 description 1
• 229940127121 immunoconjugate Drugs 0.000 description 1
• 230000002163 immunogen Effects 0.000 description 1
• 239000012742 immunoprecipitation (IP) buffer Substances 0.000 description 1
• 230000002757 inflammatory effect Effects 0.000 description 1
• 238000001802 infusion Methods 0.000 description 1
• 108010067471 inhibin A Proteins 0.000 description 1
• 239000003112 inhibitor Substances 0.000 description 1
• 230000005764 inhibitory process Effects 0.000 description 1
• 238000002347 injection Methods 0.000 description 1
• 239000007924 injection Substances 0.000 description 1
• 208000014674 injury Diseases 0.000 description 1
• 108010008598 insulin-like growth factor binding protein-related protein 1 Proteins 0.000 description 1
• 230000002452 interceptive effect Effects 0.000 description 1
• 229940047122 interleukins Drugs 0.000 description 1
• PGLTVOMIXTUURA-UHFFFAOYSA-N iodoacetamide Chemical compound NC(=O)CI PGLTVOMIXTUURA-UHFFFAOYSA-N 0.000 description 1
• 229910052742 iron Inorganic materials 0.000 description 1
• 238000001155 isoelectric focusing Methods 0.000 description 1
• 238000002955 isolation Methods 0.000 description 1
• 208000017169 kidney disease Diseases 0.000 description 1
• 239000002523 lectin Substances 0.000 description 1
• 230000000670 limiting effect Effects 0.000 description 1
• 210000004185 liver Anatomy 0.000 description 1
• 238000007477 logistic regression Methods 0.000 description 1
• 210000004698 lymphocyte Anatomy 0.000 description 1
• 238000012423 maintenance Methods 0.000 description 1
• 238000013507 mapping Methods 0.000 description 1
• 239000003550 marker Substances 0.000 description 1
• 230000001404 mediated effect Effects 0.000 description 1
• 108091007169 meprins Proteins 0.000 description 1
• QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
• 229910052753 mercury Inorganic materials 0.000 description 1
• 108020004999 messenger RNA Proteins 0.000 description 1
• 239000003475 metalloproteinase inhibitor Substances 0.000 description 1
• 229940126170 metalloproteinase inhibitor Drugs 0.000 description 1
• -1 micro-wells Substances 0.000 description 1
• 239000011325 microbead Substances 0.000 description 1
• 235000013336 milk Nutrition 0.000 description 1
• 239000008267 milk Substances 0.000 description 1
• 210000004080 milk Anatomy 0.000 description 1
• 238000010369 molecular cloning Methods 0.000 description 1
• 210000001616 monocyte Anatomy 0.000 description 1
• 210000003205 muscle Anatomy 0.000 description 1
• 230000002632 myometrial effect Effects 0.000 description 1
• 201000010193 neural tube defect Diseases 0.000 description 1
• 230000009689 neuronal regeneration Effects 0.000 description 1
• 229910052759 nickel Inorganic materials 0.000 description 1
• 229920001220 nitrocellulos Polymers 0.000 description 1
• 230000009871 nonspecific binding Effects 0.000 description 1
• 210000000056 organ Anatomy 0.000 description 1
• 150000007524 organic acids Chemical class 0.000 description 1
• 235000005985 organic acids Nutrition 0.000 description 1
• 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
• 230000003076 paracrine Effects 0.000 description 1
• 230000036961 partial effect Effects 0.000 description 1
• 230000032696 parturition Effects 0.000 description 1
• 244000052769 pathogen Species 0.000 description 1
• 238000012510 peptide mapping method Methods 0.000 description 1
• 238000000955 peptide mass fingerprinting Methods 0.000 description 1
• 201000005936 periventricular leukomalacia Diseases 0.000 description 1
• 239000008194 pharmaceutical composition Substances 0.000 description 1
• 230000000144 pharmacologic effect Effects 0.000 description 1
• 230000026731 phosphorylation Effects 0.000 description 1
• 238000006366 phosphorylation reaction Methods 0.000 description 1
• 230000035479 physiological effects, processes and functions Effects 0.000 description 1
• 230000008288 physiological mechanism Effects 0.000 description 1
• 108090000102 pigment epithelium-derived factor Proteins 0.000 description 1
• 201000008532 placental abruption Diseases 0.000 description 1
• 229930192033 plastin Natural products 0.000 description 1
• 201000010065 polycystic ovary syndrome Diseases 0.000 description 1
• 238000003752 polymerase chain reaction Methods 0.000 description 1
• 239000003910 polypeptide antibiotic agent Substances 0.000 description 1
• 230000004481 post-translational protein modification Effects 0.000 description 1
• 230000002980 postoperative effect Effects 0.000 description 1
• 238000009609 prenatal screening Methods 0.000 description 1
• 238000002360 preparation method Methods 0.000 description 1
• 230000002265 prevention Effects 0.000 description 1
• 230000000750 progressive effect Effects 0.000 description 1
• 230000000770 proinflammatory effect Effects 0.000 description 1
• 229940097325 prolactin Drugs 0.000 description 1
• 230000035755 proliferation Effects 0.000 description 1
• 230000000069 prophylactic effect Effects 0.000 description 1
• 235000019833 protease Nutrition 0.000 description 1
• 235000019419 proteases Nutrition 0.000 description 1
• 230000001681 protective effect Effects 0.000 description 1
• 238000002331 protein detection Methods 0.000 description 1
• 230000004853 protein function Effects 0.000 description 1
• 230000007065 protein hydrolysis Effects 0.000 description 1
• 230000006916 protein interaction Effects 0.000 description 1
• 230000009145 protein modification Effects 0.000 description 1
• 239000012460 protein solution Substances 0.000 description 1
• 230000017854 proteolysis Effects 0.000 description 1
• 230000006337 proteolytic cleavage Effects 0.000 description 1
• HUDHMIUZDXZZRC-UHFFFAOYSA-N protogonyautoxin 3 Chemical compound N=C1N(O)C(COC(=O)NS(O)(=O)=O)C2NC(=N)NC22C(O)(O)C(OS(O)(=O)=O)CN21 HUDHMIUZDXZZRC-UHFFFAOYSA-N 0.000 description 1
• 102000005962 receptors Human genes 0.000 description 1
• 108020003175 receptors Proteins 0.000 description 1
• 230000009467 reduction Effects 0.000 description 1
• 210000005000 reproductive tract Anatomy 0.000 description 1
• 238000001209 resonance light scattering Methods 0.000 description 1
• 238000005096 rolling process Methods 0.000 description 1
• 239000012488 sample solution Substances 0.000 description 1
• 239000012047 saturated solution Substances 0.000 description 1
• 230000003248 secreting effect Effects 0.000 description 1
• 230000007727 signaling mechanism Effects 0.000 description 1
• 239000010703 silicon Substances 0.000 description 1
• 229910052710 silicon Inorganic materials 0.000 description 1
• 235000020183 skimmed milk Nutrition 0.000 description 1
• 230000008591 skin barrier function Effects 0.000 description 1
• 239000011780 sodium chloride Substances 0.000 description 1
• 239000007921 spray Substances 0.000 description 1
• 230000006641 stabilisation Effects 0.000 description 1
• 238000011105 stabilization Methods 0.000 description 1
• 230000003068 static effect Effects 0.000 description 1
• 239000003270 steroid hormone Substances 0.000 description 1
• 230000035882 stress Effects 0.000 description 1
• 239000000126 substance Substances 0.000 description 1
• 239000005720 sucrose Substances 0.000 description 1
• 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 1
• 208000035581 susceptibility to neural tube defects Diseases 0.000 description 1
• 230000002123 temporal effect Effects 0.000 description 1
• 229960005105 terbutaline sulfate Drugs 0.000 description 1
• KFVSLSTULZVNPG-UHFFFAOYSA-N terbutaline sulfate Chemical compound [O-]S([O-])(=O)=O.CC(C)(C)[NH2+]CC(O)C1=CC(O)=CC(O)=C1.CC(C)(C)[NH2+]CC(O)C1=CC(O)=CC(O)=C1 KFVSLSTULZVNPG-UHFFFAOYSA-N 0.000 description 1
• IDTQQOOKLSBNKR-VIFPVBQESA-N tert-butyl (2s)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-4-oxobutanoate Chemical compound CC(C)(C)OC(=O)N[C@@H](CC=O)C(=O)OC(C)(C)C IDTQQOOKLSBNKR-VIFPVBQESA-N 0.000 description 1
• 108010013645 tetranectin Proteins 0.000 description 1
• ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 1
• 238000001269 time-of-flight mass spectrometry Methods 0.000 description 1
• 210000001519 tissue Anatomy 0.000 description 1
• 231100000027 toxicology Toxicity 0.000 description 1
• 230000026683 transduction Effects 0.000 description 1
• 238000010361 transduction Methods 0.000 description 1
• 102000035160 transmembrane proteins Human genes 0.000 description 1
• 108091005703 transmembrane proteins Proteins 0.000 description 1
• 210000002993 trophoblast Anatomy 0.000 description 1
• 208000029387 trophoblastic neoplasm Diseases 0.000 description 1
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
• 108090000195 villin Proteins 0.000 description 1
• 210000004885 white matter Anatomy 0.000 description 1
• 230000029663 wound healing Effects 0.000 description 1