AU2004204362A1 - Multi-layered electrochemical microfluidic sensor comprising reagent on porous layer - Google Patents
Multi-layered electrochemical microfluidic sensor comprising reagent on porous layer Download PDFInfo
- Publication number
- AU2004204362A1 AU2004204362A1 AU2004204362A AU2004204362A AU2004204362A1 AU 2004204362 A1 AU2004204362 A1 AU 2004204362A1 AU 2004204362 A AU2004204362 A AU 2004204362A AU 2004204362 A AU2004204362 A AU 2004204362A AU 2004204362 A1 AU2004204362 A1 AU 2004204362A1
- Authority
- AU
- Australia
- Prior art keywords
- microstructure
- analyte
- reagent
- porous layer
- detection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000003153 chemical reaction reagent Substances 0.000 title claims description 87
- 238000001514 detection method Methods 0.000 claims description 86
- 239000012491 analyte Substances 0.000 claims description 63
- 239000012085 test solution Substances 0.000 claims description 51
- 239000012528 membrane Substances 0.000 claims description 43
- 239000000243 solution Substances 0.000 claims description 39
- 229920000642 polymer Polymers 0.000 claims description 30
- 238000003556 assay Methods 0.000 claims description 19
- 239000000047 product Substances 0.000 claims description 16
- 108090000790 Enzymes Proteins 0.000 claims description 14
- 102000004190 Enzymes Human genes 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 14
- 239000000427 antigen Substances 0.000 claims description 11
- 102000036639 antigens Human genes 0.000 claims description 11
- 108091007433 antigens Proteins 0.000 claims description 11
- 239000011324 bead Substances 0.000 claims description 9
- 150000001875 compounds Chemical class 0.000 claims description 9
- 239000007787 solid Substances 0.000 claims description 8
- 238000005259 measurement Methods 0.000 claims description 7
- 230000003287 optical effect Effects 0.000 claims description 7
- 102000004169 proteins and genes Human genes 0.000 claims description 7
- 108090000623 proteins and genes Proteins 0.000 claims description 7
- 238000005086 pumping Methods 0.000 claims description 7
- 210000004027 cell Anatomy 0.000 claims description 5
- 239000011148 porous material Substances 0.000 claims description 5
- 108091034117 Oligonucleotide Proteins 0.000 claims description 4
- 239000011521 glass Substances 0.000 claims description 4
- 230000001900 immune effect Effects 0.000 claims description 4
- 239000003446 ligand Substances 0.000 claims description 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 4
- 238000004458 analytical method Methods 0.000 claims description 3
- 229910052751 metal Inorganic materials 0.000 claims description 3
- 239000002184 metal Substances 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 238000001020 plasma etching Methods 0.000 claims description 3
- 210000000601 blood cell Anatomy 0.000 claims description 2
- 238000005266 casting Methods 0.000 claims description 2
- 238000006073 displacement reaction Methods 0.000 claims description 2
- 238000005370 electroosmosis Methods 0.000 claims description 2
- 238000004049 embossing Methods 0.000 claims description 2
- 238000005516 engineering process Methods 0.000 claims description 2
- 238000001746 injection moulding Methods 0.000 claims description 2
- 238000001139 pH measurement Methods 0.000 claims description 2
- 238000004375 physisorption Methods 0.000 claims description 2
- 229920001296 polysiloxane Polymers 0.000 claims description 2
- 238000006276 transfer reaction Methods 0.000 claims description 2
- 238000004949 mass spectrometry Methods 0.000 claims 3
- 230000005518 electrochemistry Effects 0.000 claims 2
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- 238000004166 bioassay Methods 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 238000007705 chemical test Methods 0.000 claims 1
- 230000002452 interceptive effect Effects 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- 239000002244 precipitate Substances 0.000 claims 1
- 230000027756 respiratory electron transport chain Effects 0.000 claims 1
- 238000012360 testing method Methods 0.000 description 45
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N 1,4-Benzenediol Natural products OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 25
- 238000006243 chemical reaction Methods 0.000 description 24
- 239000000523 sample Substances 0.000 description 17
- 239000000758 substrate Substances 0.000 description 16
- 238000005406 washing Methods 0.000 description 12
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 11
- 239000000463 material Substances 0.000 description 7
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 6
- 229940098773 bovine serum albumin Drugs 0.000 description 6
- 238000002484 cyclic voltammetry Methods 0.000 description 6
- 238000006911 enzymatic reaction Methods 0.000 description 6
- 238000012546 transfer Methods 0.000 description 6
- CDAWCLOXVUBKRW-UHFFFAOYSA-N 2-aminophenol Chemical compound NC1=CC=CC=C1O CDAWCLOXVUBKRW-UHFFFAOYSA-N 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 230000003647 oxidation Effects 0.000 description 5
- 238000007254 oxidation reaction Methods 0.000 description 5
- 239000008363 phosphate buffer Substances 0.000 description 5
- 238000000926 separation method Methods 0.000 description 5
- 241000894007 species Species 0.000 description 5
- 229910021607 Silver chloride Inorganic materials 0.000 description 4
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 4
- 229910052737 gold Inorganic materials 0.000 description 4
- 239000010931 gold Substances 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 4
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 3
- 239000002033 PVDF binder Substances 0.000 description 3
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 3
- 239000002250 absorbent Substances 0.000 description 3
- 230000002745 absorbent Effects 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 229920002678 cellulose Polymers 0.000 description 3
- 229910052802 copper Inorganic materials 0.000 description 3
- 239000010949 copper Substances 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 238000007824 enzymatic assay Methods 0.000 description 3
- 230000002255 enzymatic effect Effects 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000002861 polymer material Substances 0.000 description 3
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 3
- 239000012488 sample solution Substances 0.000 description 3
- 229910052709 silver Inorganic materials 0.000 description 3
- 239000004332 silver Substances 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 239000004642 Polyimide Substances 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000004020 conductor Substances 0.000 description 2
- 238000000840 electrochemical analysis Methods 0.000 description 2
- 238000000835 electrochemical detection Methods 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 238000010324 immunological assay Methods 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 238000004020 luminiscence type Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 description 2
- 239000005020 polyethylene terephthalate Substances 0.000 description 2
- 229920001721 polyimide Polymers 0.000 description 2
- 230000035935 pregnancy Effects 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 108020003215 DNA Probes Proteins 0.000 description 1
- 239000003298 DNA probe Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 102000001253 Protein Kinase Human genes 0.000 description 1
- 101710123661 Venom allergen 5 Proteins 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 238000010256 biochemical assay Methods 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000002848 electrochemical method Methods 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000002330 electrospray ionisation mass spectrometry Methods 0.000 description 1
- 238000001952 enzyme assay Methods 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000001917 fluorescence detection Methods 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000005534 hematocrit Methods 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 125000000687 hydroquinonyl group Chemical group C1(O)=C(C=C(O)C=C1)* 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 238000003317 immunochromatography Methods 0.000 description 1
- 238000002847 impedance measurement Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000002032 lab-on-a-chip Methods 0.000 description 1
- 238000003475 lamination Methods 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 238000003541 multi-stage reaction Methods 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 230000016087 ovulation Effects 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 102000013415 peroxidase activity proteins Human genes 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 239000007793 ph indicator Substances 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000004094 preconcentration Methods 0.000 description 1
- 238000009597 pregnancy test Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108060006633 protein kinase Proteins 0.000 description 1
- 238000012205 qualitative assay Methods 0.000 description 1
- 238000012207 quantitative assay Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 230000002463 transducing effect Effects 0.000 description 1
- 238000013022 venting Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0645—Electrodes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0825—Test strips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/333—Ion-selective electrodes or membranes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0300820.8 | 2003-01-14 | ||
| GBGB0300820.8A GB0300820D0 (en) | 2003-01-14 | 2003-01-14 | Membrane-microchannel strip |
| PCT/EP2004/001013 WO2004062801A1 (en) | 2003-01-14 | 2004-01-14 | Multi-layered electrochemical microfluidic sensor comprising reagent on porous layer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2004204362A8 AU2004204362A8 (en) | 2004-07-29 |
| AU2004204362A1 true AU2004204362A1 (en) | 2004-07-29 |
Family
ID=9951133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2004204362A Abandoned AU2004204362A1 (en) | 2003-01-14 | 2004-01-14 | Multi-layered electrochemical microfluidic sensor comprising reagent on porous layer |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20060141469A1 (enExample) |
| EP (1) | EP1585596A1 (enExample) |
| JP (1) | JP2006516721A (enExample) |
| AU (1) | AU2004204362A1 (enExample) |
| GB (1) | GB0300820D0 (enExample) |
| WO (1) | WO2004062801A1 (enExample) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6803568B2 (en) | 2001-09-19 | 2004-10-12 | Predicant Biosciences, Inc. | Multi-channel microfluidic chip for electrospray ionization |
| US7105810B2 (en) | 2001-12-21 | 2006-09-12 | Cornell Research Foundation, Inc. | Electrospray emitter for microfluidic channel |
| US7955559B2 (en) * | 2005-11-15 | 2011-06-07 | Nanomix, Inc. | Nanoelectronic electrochemical test device |
| US7312095B1 (en) * | 2002-03-15 | 2007-12-25 | Nanomix, Inc. | Modification of selectivity for sensing for nanostructure sensing device arrays |
| US7810380B2 (en) | 2003-03-25 | 2010-10-12 | Tearlab Research, Inc. | Systems and methods for collecting tear film and measuring tear film osmolarity |
| US8020433B2 (en) * | 2003-03-25 | 2011-09-20 | Tearlab Research, Inc. | Systems and methods for a sample fluid collection device |
| US7905134B2 (en) * | 2002-08-06 | 2011-03-15 | The Regents Of The University Of California | Biomarker normalization |
| US7007710B2 (en) | 2003-04-21 | 2006-03-07 | Predicant Biosciences, Inc. | Microfluidic devices and methods |
| US9234867B2 (en) | 2003-05-16 | 2016-01-12 | Nanomix, Inc. | Electrochemical nanosensors for biomolecule detection |
| US8425745B2 (en) * | 2006-10-06 | 2013-04-23 | Nanomix, Inc. | Electrochemical nanosensors for biomolecule detection |
| US20070039835A1 (en) * | 2003-09-15 | 2007-02-22 | Diagno Swiss S.A. | Microfluidic flow monitoring device |
| US7537807B2 (en) | 2003-09-26 | 2009-05-26 | Cornell University | Scanned source oriented nanofiber formation |
| CA2553632A1 (en) | 2004-02-06 | 2005-08-25 | Bayer Healthcare Llc | Oxidizable species as an internal reference for biosensors and method of use |
| US20060060769A1 (en) | 2004-09-21 | 2006-03-23 | Predicant Biosciences, Inc. | Electrospray apparatus with an integrated electrode |
| US7591883B2 (en) | 2004-09-27 | 2009-09-22 | Cornell Research Foundation, Inc. | Microfiber supported nanofiber membrane |
| EP1817576A1 (en) * | 2004-11-12 | 2007-08-15 | DiagnoSwiss S.A. | Microfluidic device with minimised ohmic resistance |
| FR2881363B1 (fr) * | 2005-02-02 | 2008-03-14 | Commissariat Energie Atomique | Dispositif d'analyses biologiques avec detecteur integre |
| JP4693657B2 (ja) * | 2005-03-29 | 2011-06-01 | シチズンホールディングス株式会社 | バイオセンサ |
| WO2006104460A1 (en) * | 2005-03-30 | 2006-10-05 | Agency For Science, Technology And Research | A method and apparatus for continuous formation of microfluidic devices |
| EP1717585B1 (en) | 2005-04-28 | 2013-01-16 | FUJIFILM Corporation | Microchip and analysis method using the same |
| JP2006308419A (ja) * | 2005-04-28 | 2006-11-09 | Fuji Photo Film Co Ltd | マイクロチップ及びそれを用いた分析方法 |
| US20090294298A1 (en) | 2005-06-16 | 2009-12-03 | Isis Innovation Limited | Detection of Phenols |
| EP1913374B1 (en) | 2005-07-20 | 2019-01-09 | Ascensia Diabetes Care Holdings AG | Method for signalling the user to add additional sample to a test strip, method for measuring the temperature of a sample and methods for determining the concentration of an analyte based on gated amperometry |
| EP1919619A2 (en) | 2005-07-21 | 2008-05-14 | Koninklijke Philips Electronics N.V. | Sensor chip for a biosensor |
| ATE499607T1 (de) * | 2005-08-31 | 2011-03-15 | Egomedical Technologies Ag | Analytentestsystem unter verwendung nichtenzymatischer analytenerkennungselemente |
| EP3483598B1 (en) | 2005-09-30 | 2024-11-06 | Ascensia Diabetes Care Holdings AG | Gated voltammetry |
| US7910381B2 (en) * | 2005-10-13 | 2011-03-22 | BioAssay Works | Immuno gold lateral flow assay |
| US7344679B2 (en) * | 2005-10-14 | 2008-03-18 | International Business Machines Corporation | Method and apparatus for point of care osmolarity testing |
| US20090064790A1 (en) * | 2005-12-31 | 2009-03-12 | Corning Incorporated | Microreactor Glass Diaphragm Sensors |
| JP4660768B2 (ja) * | 2006-03-28 | 2011-03-30 | 国立大学法人 筑波大学 | 微小分析装置及び微少試料の分析方法 |
| JP5187759B2 (ja) * | 2006-04-07 | 2013-04-24 | 国立大学法人北陸先端科学技術大学院大学 | 被検物質の測定方法 |
| GB0607205D0 (en) * | 2006-04-10 | 2006-05-17 | Diagnoswiss Sa | Miniaturised biosensor with optimized anperimetric detection |
| MX347099B (es) | 2006-10-24 | 2017-04-12 | Ascensia Diabetes Care Holdings Ag | Amperimetria de decadencia transitoria. |
| US9658178B2 (en) | 2012-09-28 | 2017-05-23 | General Electric Company | Sensor systems for measuring an interface level in a multi-phase fluid composition |
| US9538657B2 (en) | 2012-06-29 | 2017-01-03 | General Electric Company | Resonant sensor and an associated sensing method |
| US9536122B2 (en) | 2014-11-04 | 2017-01-03 | General Electric Company | Disposable multivariable sensing devices having radio frequency based sensors |
| US9589686B2 (en) * | 2006-11-16 | 2017-03-07 | General Electric Company | Apparatus for detecting contaminants in a liquid and a system for use thereof |
| US10914698B2 (en) | 2006-11-16 | 2021-02-09 | General Electric Company | Sensing method and system |
| WO2008072153A1 (en) * | 2006-12-12 | 2008-06-19 | Koninklijke Philips Electronics N. V. | Electrochemical sensor device, method of manufacturing the same |
| WO2008128248A1 (en) * | 2007-04-16 | 2008-10-23 | The Regents Of The University Of California | Biomarker normalization |
| JP2008286714A (ja) * | 2007-05-18 | 2008-11-27 | Mitsubishi Kagaku Iatron Inc | ボルタノメトリック型バイオセンサ |
| WO2009076302A1 (en) | 2007-12-10 | 2009-06-18 | Bayer Healthcare Llc | Control markers for auto-detection of control solution and methods of use |
| JP5207295B2 (ja) * | 2008-07-01 | 2013-06-12 | 国立大学法人北陸先端科学技術大学院大学 | プレーナー型電極 |
| KR101178014B1 (ko) * | 2008-10-09 | 2012-08-29 | 액텀 아이엔씨. | 액체를 시험하는 방법 |
| TWI398636B (zh) * | 2008-10-14 | 2013-06-11 | Actherm Inc | 流體檢測方法 |
| DE102009015114B4 (de) * | 2009-03-31 | 2014-05-22 | Siemens Aktiengesellschaft | Vorrichtung nach Art einer elektrochemischen Kamera sowie Verfahren zur Herstellung und Verwendung der Vorrichtung |
| GB2469071A (en) * | 2009-03-31 | 2010-10-06 | Diamatrix Ltd | Electrochemical test device |
| US8758704B2 (en) * | 2009-08-11 | 2014-06-24 | Baril Corporation | Microfluidic diagnostic device |
| JP5806892B2 (ja) | 2010-09-30 | 2015-11-10 | シスメックス株式会社 | 検出物質の電気化学的検出方法および被検物質の電気化学的検出方法 |
| US8542023B2 (en) | 2010-11-09 | 2013-09-24 | General Electric Company | Highly selective chemical and biological sensors |
| JP5796344B2 (ja) * | 2011-05-13 | 2015-10-21 | セイコーエプソン株式会社 | センサー装置 |
| US10598650B2 (en) | 2012-08-22 | 2020-03-24 | General Electric Company | System and method for measuring an operative condition of a machine |
| CN104583664B (zh) | 2012-08-22 | 2018-06-08 | 通用电气公司 | 用于测量机器运转状况的无线系统和方法 |
| US10684268B2 (en) | 2012-09-28 | 2020-06-16 | Bl Technologies, Inc. | Sensor systems for measuring an interface level in a multi-phase fluid composition |
| CN106029863A (zh) * | 2013-11-06 | 2016-10-12 | 贝克顿·迪金森公司 | 微流体性装置和制造和使用其的方法 |
| US9921181B2 (en) | 2014-06-26 | 2018-03-20 | International Business Machines Corporation | Detection of translocation events using graphene-based nanopore assemblies |
| BR112017005121A2 (pt) | 2014-09-23 | 2018-07-31 | Tearlab Res Inc | sistemas e métodos para integração de coleta de lágrima microfluídica e análise de fluxo lateral de analitos de interesse. |
| JP6486065B2 (ja) * | 2014-10-28 | 2019-03-20 | シスメックス株式会社 | 被検物質の検出方法 |
| CN105483002B (zh) * | 2016-01-27 | 2018-06-29 | 河海大学常州校区 | 可控剂量显微注射装置及其操作方法 |
| CN105647789B (zh) * | 2016-01-29 | 2019-01-04 | 清华大学 | 一种基于微流控芯片的细胞代谢产物实时检测装置 |
| US10359391B2 (en) | 2016-07-07 | 2019-07-23 | e-SENS, Inc. | Sensor with a membrane having full circumferential adhesion |
| WO2018022458A1 (en) * | 2016-07-25 | 2018-02-01 | Bio-Rad Laboratories, Inc. | Lateral flow device and method of use |
| WO2018049101A1 (en) * | 2016-09-12 | 2018-03-15 | Schlereth Fritz H | Improved piezoelectric sensors and quartz crystal monitors |
| US11630076B2 (en) | 2017-04-28 | 2023-04-18 | Corning Incorporated | Glass electrochemical sensor with wafer level stacking and through glass via (TGV) interconnects |
| US10710068B2 (en) * | 2017-09-20 | 2020-07-14 | e-SENSE, Inc. | Microfluidic chip with chemical sensor having back-side contacts |
| JP7022844B2 (ja) * | 2018-10-17 | 2022-02-18 | 株式会社日立ハイテク | 生化学用カートリッジ及び生化学分析装置 |
| CN110146567A (zh) * | 2018-11-05 | 2019-08-20 | 浙江大学山东工业技术研究院 | 一种基于微球的抗干扰丝网印刷电极 |
| CN109701674A (zh) * | 2019-01-28 | 2019-05-03 | 广东工业大学 | 微流控芯片微电极工艺 |
| CN111686826B (zh) * | 2019-03-15 | 2023-05-23 | 国家纳米科学中心 | 分层结构的微流控芯片及其应用 |
| WO2020232405A1 (en) * | 2019-05-16 | 2020-11-19 | California Institute Of Technology | Laser-enabled lab on skin |
| US20230294091A1 (en) * | 2020-08-11 | 2023-09-21 | Colorado State University Research Foundation | Electrochemical microfluidic assay devices |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4906439A (en) * | 1986-03-25 | 1990-03-06 | Pb Diagnostic Systems, Inc. | Biological diagnostic device and method of use |
| US4774192A (en) * | 1987-01-28 | 1988-09-27 | Technimed Corporation | A dry reagent delivery system with membrane having porosity gradient |
| US5338513A (en) * | 1988-07-30 | 1994-08-16 | Boehringer Mannheim Gmbh | Test carrier for the analytical determination of a component of a liquid sample |
| US5030352A (en) * | 1990-01-25 | 1991-07-09 | Purdue Research Foundation | Coated media for chromatography |
| US5167824A (en) * | 1990-02-14 | 1992-12-01 | Creative Biomolecules, Inc. | Separation by carrier mediated transport |
| US5231004A (en) * | 1990-05-11 | 1993-07-27 | Eastman Kodak Company | Use of heme-containing proteins as stabilizers for enzyme-labeled immunoreactants |
| DE4217733A1 (de) * | 1992-05-29 | 1993-12-02 | Boehringer Mannheim Gmbh | Testträger zur Analytbestimmung sowie Verfahren zu dessen Herstellung |
| WO1995022051A1 (en) * | 1994-02-09 | 1995-08-17 | Abbott Laboratories | Diagnostic flow cell device |
| GB9419267D0 (en) * | 1994-09-23 | 1994-11-09 | Unilever Plc | Assay devices |
| US5786220A (en) * | 1995-04-28 | 1998-07-28 | Quidel Corporation | Assays and devices for distinguishing between normal and abnormal pregnancy |
| AU704863B2 (en) * | 1995-11-15 | 1999-05-06 | Arkray, Inc. | Device and method for assaying biological components in sample |
| JPH09196920A (ja) * | 1995-11-15 | 1997-07-31 | Nihon Medi Physics Co Ltd | 体液成分分析器具および分析方法 |
| US6241862B1 (en) * | 1996-02-14 | 2001-06-05 | Inverness Medical Technology, Inc. | Disposable test strips with integrated reagent/blood separation layer |
| JP3480884B2 (ja) * | 1996-09-12 | 2003-12-22 | 日本電信電話株式会社 | オンラインバイオセンサー |
| GB2322192B (en) * | 1997-02-14 | 2001-01-31 | Unilever Plc | Assay devices |
| US6156273A (en) * | 1997-05-27 | 2000-12-05 | Purdue Research Corporation | Separation columns and methods for manufacturing the improved separation columns |
| US6521182B1 (en) * | 1998-07-20 | 2003-02-18 | Lifescan, Inc. | Fluidic device for medical diagnostics |
| US6140136A (en) * | 1998-09-18 | 2000-10-31 | Syntron Bioresearch, Inc. | Analytical test device and method of use |
| WO2000042430A1 (en) * | 1999-01-15 | 2000-07-20 | Medtox Scientific, Inc. | Lateral flow test strip |
| JP3462418B2 (ja) * | 1999-02-12 | 2003-11-05 | 日本電信電話株式会社 | 集積型バイオセンサおよびその製造方法 |
| JP3751480B2 (ja) * | 1999-08-27 | 2006-03-01 | 日本電信電話株式会社 | ヒスタミンセンサ |
| AU2765201A (en) * | 2000-01-07 | 2001-07-24 | President And Fellows Of Harvard College | Fabrication of metallic microstructures via exposure of photosensitive composition |
| AU2001229633A1 (en) * | 2000-01-18 | 2001-07-31 | Advion Biosciences, Inc. | Separation media, multiple electrospray nozzle system and method |
| JP2001201479A (ja) * | 2000-01-21 | 2001-07-27 | Matsushita Electric Ind Co Ltd | バイオセンサ |
| JP2001201480A (ja) * | 2000-01-21 | 2001-07-27 | Matsushita Electric Ind Co Ltd | バイオセンサ |
| US20020092612A1 (en) * | 2000-03-28 | 2002-07-18 | Davies Oliver William Hardwicke | Rapid response glucose sensor |
| GB0010957D0 (en) * | 2000-05-05 | 2000-06-28 | Novartis Ag | Compound & method |
| US6540890B1 (en) * | 2000-11-01 | 2003-04-01 | Roche Diagnostics Corporation | Biosensor |
| GB0103516D0 (en) * | 2001-02-13 | 2001-03-28 | Cole Polytechnique Federale De | Apparatus for dispensing a sample |
| US7037417B2 (en) * | 2001-03-19 | 2006-05-02 | Ecole Polytechnique Federale De Lausanne | Mechanical control of fluids in micro-analytical devices |
| GB0111438D0 (en) * | 2001-05-10 | 2001-07-04 | Cole Polytechnique Federale De | Polymer bonding by means of plasma activation |
| DE10122659A1 (de) * | 2001-05-10 | 2002-12-05 | Infineon Technologies Ag | Biochip-Anordnung |
| GB0116384D0 (en) * | 2001-07-04 | 2001-08-29 | Diagnoswiss Sa | Microfluidic chemical assay apparatus and method |
| US6818456B2 (en) * | 2001-07-20 | 2004-11-16 | Varian, Inc. | Color contrast system for lateral flow immunoassay tests |
| GB0121189D0 (en) * | 2001-08-31 | 2001-10-24 | Diagnoswiss Sa | Apparatus and method for separating an analyte |
-
2003
- 2003-01-14 GB GBGB0300820.8A patent/GB0300820D0/en not_active Ceased
-
2004
- 2004-01-14 US US10/543,762 patent/US20060141469A1/en not_active Abandoned
- 2004-01-14 JP JP2006500022A patent/JP2006516721A/ja active Pending
- 2004-01-14 AU AU2004204362A patent/AU2004204362A1/en not_active Abandoned
- 2004-01-14 EP EP04701957A patent/EP1585596A1/en not_active Withdrawn
- 2004-01-14 WO PCT/EP2004/001013 patent/WO2004062801A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004062801A1 (en) | 2004-07-29 |
| GB0300820D0 (en) | 2003-02-12 |
| AU2004204362A8 (en) | 2004-07-29 |
| JP2006516721A (ja) | 2006-07-06 |
| US20060141469A1 (en) | 2006-06-29 |
| EP1585596A1 (en) | 2005-10-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20060141469A1 (en) | Multi-layered electrochemical microfluidic sensor comprising reagent on porous layer | |
| JP4216712B2 (ja) | マイクロ流体式化学検定装置および方法 | |
| US6548311B1 (en) | Device and method for detecting analytes | |
| KR100635110B1 (ko) | 현장분석용 랩온어칩 및 랩온어칩용 신호탐지기 | |
| RU2423073C2 (ru) | Микрофлюидные устройства и способы их подготовки и применения | |
| EP1481246B1 (en) | Apparatus and methods for analyte measurement and immunoassay | |
| CN101421616A (zh) | 安培计检测优化的小型化生物传感器 | |
| US20070240986A1 (en) | Microfluidic Device with Minimized Ohmic Resistance | |
| AU2002329526A1 (en) | Microfluidic chemical assay apparatus and method | |
| EP3059588B1 (en) | Method and device for detection and quantification of analytes | |
| US20150047978A1 (en) | Biosensor having nanostructured electrodes | |
| WO2006080186A1 (ja) | カートリッジを使用する検出装置 | |
| CN111051885A (zh) | 检测系统及生产方法 | |
| US12072311B2 (en) | Sensor assembly and method of using same | |
| US20230271185A1 (en) | Biosensor system for multiplexed detection of biomarkers | |
| Sabbagh et al. | Enhancing commercially available immunoassays through a customized electrokinetic biomolecular preconcentration device | |
| JP2009092514A (ja) | 試料液分析チップ、および試料液の移送制御方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TH | Corrigenda |
Free format text: IN VOL 19, NO 30, PAGE(S) 2019 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE - NAME INDEX UNDER THE NAME DIAGNOSWISS S.A., APPLICATION NO 2004204362, UNDER INID (72), CORRECT THE INVENTOR NAMES TO READ ROSSIER,JOEL STEPHANE; MORIER, PATRICK |
|
| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |