AU2003263411B8 - Mucin-Immunoglobulin fusion proteins - Google Patents
Mucin-Immunoglobulin fusion proteins Download PDFInfo
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- AU2003263411B8 AU2003263411B8 AU2003263411A AU2003263411A AU2003263411B8 AU 2003263411 B8 AU2003263411 B8 AU 2003263411B8 AU 2003263411 A AU2003263411 A AU 2003263411A AU 2003263411 A AU2003263411 A AU 2003263411A AU 2003263411 B8 AU2003263411 B8 AU 2003263411B8
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- Prior art keywords
- polypeptide
- mucin
- cell
- fusion
- hex
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- 108091008146 restriction endonucleases Proteins 0.000 description 1
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- 238000005096 rolling process Methods 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
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- 238000009738 saturating Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
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- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 1
- 125000005629 sialic acid group Chemical group 0.000 description 1
- 125000005630 sialyl group Chemical group 0.000 description 1
- 230000009450 sialylation Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- VGTPCRGMBIAPIM-UHFFFAOYSA-M sodium thiocyanate Chemical compound [Na+].[S-]C#N VGTPCRGMBIAPIM-UHFFFAOYSA-M 0.000 description 1
- YEENEYXBHNNNGV-XEHWZWQGSA-M sodium;3-acetamido-5-[acetyl(methyl)amino]-2,4,6-triiodobenzoate;(2r,3r,4s,5s,6r)-2-[(2r,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound [Na+].CC(=O)N(C)C1=C(I)C(NC(C)=O)=C(I)C(C([O-])=O)=C1I.O[C@H]1[C@H](O)[C@@H](CO)O[C@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 YEENEYXBHNNNGV-XEHWZWQGSA-M 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 210000003594 spinal ganglia Anatomy 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
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- 238000003153 stable transfection Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000002511 suppository base Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 150000004044 tetrasaccharides Chemical group 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000003151 transfection method Methods 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
- 230000010474 transient expression Effects 0.000 description 1
- 238000003146 transient transfection Methods 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 230000014621 translational initiation Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000013638 trimer Substances 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 150000004043 trisaccharides Chemical class 0.000 description 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
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- 230000003245 working effect Effects 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4727—Mucins, e.g. human intestinal mucin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Transplantation (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40221102P | 2002-08-09 | 2002-08-09 | |
| US60/402,211 | 2002-08-09 | ||
| PCT/IB2003/003881 WO2004015057A2 (en) | 2002-08-09 | 2003-08-11 | Mucin-immunoglobulin fusion proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| AU2003263411A1 AU2003263411A1 (en) | 2004-02-25 |
| AU2003263411B2 AU2003263411B2 (en) | 2010-12-16 |
| AU2003263411B8 true AU2003263411B8 (en) | 2011-04-14 |
Family
ID=31715806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003263411A Ceased AU2003263411B8 (en) | 2002-08-09 | 2003-08-11 | Mucin-Immunoglobulin fusion proteins |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7638323B2 (enExample) |
| EP (1) | EP1534748A2 (enExample) |
| JP (2) | JP4648001B2 (enExample) |
| AU (1) | AU2003263411B8 (enExample) |
| CA (1) | CA2495743C (enExample) |
| NZ (1) | NZ538629A (enExample) |
| WO (1) | WO2004015057A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003233008B2 (en) * | 2002-04-22 | 2008-04-24 | Recopharma Ab | Fusion polypeptides and methods for inhibiting microbial adhesion |
| US8129506B2 (en) * | 2003-10-24 | 2012-03-06 | Genzyme Corporation | Modulation of the interaction of MUC1 with MUC1 ligands |
| AU2007251256B2 (en) * | 2006-01-26 | 2013-03-07 | Recopharma Ab | Compositions and methods for inhibiting viral adhesion |
| WO2009003621A1 (en) * | 2007-06-29 | 2009-01-08 | F. Hoffmann-La Roche Ag | Cho cell |
| US20090280134A1 (en) * | 2008-05-09 | 2009-11-12 | Recopharma Ab | Compositions and methods for inhibiting toxin a from clostridium difficile |
| CA2722127A1 (en) * | 2008-05-09 | 2009-11-12 | Recopharma Ab | Compositions and methods for inhibiting shiga toxin and shiga-like toxin |
| JP2012503471A (ja) | 2008-05-30 | 2012-02-09 | グライコフィ， インコーポレイテッド | 末端アルファ−１，３−結合ガラクトースを有するタンパク質の製造のための酵母株 |
| EP2593467A4 (en) * | 2010-07-14 | 2014-03-12 | Vancouver Biotech Ltd | ANTICANCER VACCINES AND ANTIBODY-BASED MEDICINES BASED ON GLUCIDIC HAPTENES |
| WO2012085165A1 (en) * | 2010-12-21 | 2012-06-28 | Recopharma Ab | Tear substitutes |
| WO2013184938A2 (en) | 2012-06-08 | 2013-12-12 | Alkermes. Inc. | Fusion polypeptides comprising mucin-domain polypeptide linkers |
| RU2528251C2 (ru) * | 2012-12-07 | 2014-09-10 | Общество с ограниченной ответственностью "Гематологическая Корпорация" (ООО "ГемаКор") | СЛИТЫЙ БЕЛОК ТИОРЕДОКСИНА И ДОМЕНА 4 ИНФЕСТИНА, СПОСОБ ЕГО ПОЛУЧЕНИЯ, ЭКСПРЕССИОННАЯ ПЛАЗМИДНАЯ ДНК, КОДИРУЮЩАЯ СЛИТЫЙ БЕЛОК, И БАКТЕРИЯ РОДА Escherichia coli, ТРАНСФОРМИРОВАННАЯ ТАКОЙ ПЛАЗМИДНОЙ ДНК |
| SI4065585T1 (sl) | 2019-11-25 | 2025-11-28 | Alkermes, Inc. | Substituirane makrociklične spojine ter z njimi povezani postopki zdravljenja |
| US11760747B2 (en) | 2020-12-21 | 2023-09-19 | Alkermes, Inc. | Substituted piperidino compounds and related methods of treatment |
| WO2024158939A1 (en) * | 2023-01-25 | 2024-08-02 | Sanford Burnham Prebys Medical Discovery Institute | Psgl1 antagonists and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5225538A (en) * | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
| US6136310A (en) * | 1991-07-25 | 2000-10-24 | Idec Pharmaceuticals Corporation | Recombinant anti-CD4 antibodies for human therapy |
| US5516964A (en) * | 1994-01-21 | 1996-05-14 | Sun Company, Inc. (R&M) | Hydrocarbon isomerization using solid superacid catalysts comprising platinum metal |
| SE9701127D0 (sv) * | 1997-03-26 | 1997-03-26 | Karolinska Innovations Ab | Antigenic fusionprotein carrying GALal, 3GAL epitopes |
-
2003
- 2003-08-11 US US10/638,820 patent/US7638323B2/en not_active Expired - Fee Related
- 2003-08-11 CA CA2495743A patent/CA2495743C/en not_active Expired - Fee Related
- 2003-08-11 AU AU2003263411A patent/AU2003263411B8/en not_active Ceased
- 2003-08-11 EP EP03784433A patent/EP1534748A2/en not_active Withdrawn
- 2003-08-11 NZ NZ538629A patent/NZ538629A/en not_active IP Right Cessation
- 2003-08-11 JP JP2004527246A patent/JP4648001B2/ja not_active Expired - Fee Related
- 2003-08-11 WO PCT/IB2003/003881 patent/WO2004015057A2/en not_active Ceased
-
2010
- 2010-05-17 JP JP2010113707A patent/JP2010235614A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA2495743A1 (en) | 2004-02-19 |
| WO2004015057A9 (en) | 2004-07-29 |
| US20040137580A1 (en) | 2004-07-15 |
| US7638323B2 (en) | 2009-12-29 |
| JP2010235614A (ja) | 2010-10-21 |
| JP2005535699A (ja) | 2005-11-24 |
| AU2003263411B2 (en) | 2010-12-16 |
| NZ538629A (en) | 2008-05-30 |
| JP4648001B2 (ja) | 2011-03-09 |
| WO2004015057A3 (en) | 2005-01-20 |
| CA2495743C (en) | 2011-01-25 |
| WO2004015057A2 (en) | 2004-02-19 |
| EP1534748A2 (en) | 2005-06-01 |
| AU2003263411A1 (en) | 2004-02-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| TH | Corrigenda |
Free format text: IN VOL 24, NO 50, PAGE(S) 5871 UNDER THE HEADING APPLICATIONS ACCEPTED - NAME INDEX UNDER THE NAME RECOPHARMA AB, APPLICATION NO. 2003263411, UNDER INID (54) CORRECT TITLE TO READ MUCIN- IMMUNOGLOBULIN FUSION PROTEINS |
|
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |