CA2495743C - Fusion proteins and methods of producing same - Google Patents
Fusion proteins and methods of producing same Download PDFInfo
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- CA2495743C CA2495743C CA2495743A CA2495743A CA2495743C CA 2495743 C CA2495743 C CA 2495743C CA 2495743 A CA2495743 A CA 2495743A CA 2495743 A CA2495743 A CA 2495743A CA 2495743 C CA2495743 C CA 2495743C
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- polypeptide
- cell
- fusion
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- 238000012360 testing method Methods 0.000 description 1
- 150000004044 tetrasaccharides Chemical group 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000003151 transfection method Methods 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
- 230000010474 transient expression Effects 0.000 description 1
- 238000003146 transient transfection Methods 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 230000014621 translational initiation Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000013638 trimer Substances 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 150000004043 trisaccharides Chemical class 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 238000009777 vacuum freeze-drying Methods 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 230000003245 working effect Effects 0.000 description 1
- 206010048282 zoonosis Diseases 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4727—Mucins, e.g. human intestinal mucin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Transplantation (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40221102P | 2002-08-09 | 2002-08-09 | |
| US60/402,211 | 2002-08-09 | ||
| PCT/IB2003/003881 WO2004015057A2 (en) | 2002-08-09 | 2003-08-11 | Mucin-immunoglobulin fusion proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2495743A1 CA2495743A1 (en) | 2004-02-19 |
| CA2495743C true CA2495743C (en) | 2011-01-25 |
Family
ID=31715806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2495743A Expired - Fee Related CA2495743C (en) | 2002-08-09 | 2003-08-11 | Fusion proteins and methods of producing same |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7638323B2 (enExample) |
| EP (1) | EP1534748A2 (enExample) |
| JP (2) | JP4648001B2 (enExample) |
| AU (1) | AU2003263411B8 (enExample) |
| CA (1) | CA2495743C (enExample) |
| NZ (1) | NZ538629A (enExample) |
| WO (1) | WO2004015057A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003089450A2 (en) * | 2002-04-22 | 2003-10-30 | Recopharma Ab | Fusion polypeptides and methods for inhibiting microbial adhesion |
| WO2005042573A1 (en) * | 2003-10-24 | 2005-05-12 | Dana-Farber Cancer Institute, Inc. | Modulation of the interaction of muc1 with muc1 ligands |
| WO2007132355A2 (en) * | 2006-01-26 | 2007-11-22 | Recopharma Ab | Compositions and methods for inhibiting viral adhesion |
| CN101688181A (zh) * | 2007-06-29 | 2010-03-31 | 弗·哈夫曼-拉罗切有限公司 | Cho细胞 |
| WO2009136297A2 (en) * | 2008-05-09 | 2009-11-12 | Recopharma Ab | Compositions and methods for inhibiting toxin a from clostridium difficile |
| WO2009136298A2 (en) * | 2008-05-09 | 2009-11-12 | Recopharma Ab | Compositions and methods for inhibiting shiga toxin and shiga-like toxin |
| MX2010013059A (es) | 2008-05-30 | 2010-12-20 | Glycofi Inc | Cepa de levadura para la produccion de proteinas con galactosa alfa-1,3-enlazada terminal. |
| WO2012006718A1 (en) * | 2010-07-14 | 2012-01-19 | Vancouver Biotech Ltd. | Carbohydrate hapten-based anti-cancer vaccines and antibody drugs |
| CN103501804A (zh) * | 2010-12-21 | 2014-01-08 | 雷科制药公司 | 眼泪替代物 |
| US9156897B2 (en) | 2012-06-08 | 2015-10-13 | Alkermes, Inc. | Fusion polypeptides comprising an active protein linked to a mucin-domain polypeptide |
| RU2528251C2 (ru) * | 2012-12-07 | 2014-09-10 | Общество с ограниченной ответственностью "Гематологическая Корпорация" (ООО "ГемаКор") | СЛИТЫЙ БЕЛОК ТИОРЕДОКСИНА И ДОМЕНА 4 ИНФЕСТИНА, СПОСОБ ЕГО ПОЛУЧЕНИЯ, ЭКСПРЕССИОННАЯ ПЛАЗМИДНАЯ ДНК, КОДИРУЮЩАЯ СЛИТЫЙ БЕЛОК, И БАКТЕРИЯ РОДА Escherichia coli, ТРАНСФОРМИРОВАННАЯ ТАКОЙ ПЛАЗМИДНОЙ ДНК |
| KR20260083444A (ko) | 2019-11-25 | 2026-06-05 | 알케르메스,인코포레이티드 | 치환된 마크로사이클릭 화합물 및 관련 치료 방법 |
| US11760747B2 (en) | 2020-12-21 | 2023-09-19 | Alkermes, Inc. | Substituted piperidino compounds and related methods of treatment |
| AU2023280994A1 (en) * | 2022-06-01 | 2024-12-12 | Cornell University | Cancer immunotherapies to promote hyperacute rejection |
| WO2024158939A1 (en) * | 2023-01-25 | 2024-08-02 | Sanford Burnham Prebys Medical Discovery Institute | Psgl1 antagonists and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5225538A (en) * | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
| US6136310A (en) * | 1991-07-25 | 2000-10-24 | Idec Pharmaceuticals Corporation | Recombinant anti-CD4 antibodies for human therapy |
| US5516964A (en) * | 1994-01-21 | 1996-05-14 | Sun Company, Inc. (R&M) | Hydrocarbon isomerization using solid superacid catalysts comprising platinum metal |
| SE9701127D0 (sv) * | 1997-03-26 | 1997-03-26 | Karolinska Innovations Ab | Antigenic fusionprotein carrying GALal, 3GAL epitopes |
-
2003
- 2003-08-11 US US10/638,820 patent/US7638323B2/en not_active Expired - Fee Related
- 2003-08-11 JP JP2004527246A patent/JP4648001B2/ja not_active Expired - Fee Related
- 2003-08-11 WO PCT/IB2003/003881 patent/WO2004015057A2/en not_active Ceased
- 2003-08-11 AU AU2003263411A patent/AU2003263411B8/en not_active Ceased
- 2003-08-11 NZ NZ538629A patent/NZ538629A/en not_active IP Right Cessation
- 2003-08-11 CA CA2495743A patent/CA2495743C/en not_active Expired - Fee Related
- 2003-08-11 EP EP03784433A patent/EP1534748A2/en not_active Withdrawn
-
2010
- 2010-05-17 JP JP2010113707A patent/JP2010235614A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003263411A1 (en) | 2004-02-25 |
| WO2004015057A3 (en) | 2005-01-20 |
| WO2004015057A2 (en) | 2004-02-19 |
| NZ538629A (en) | 2008-05-30 |
| EP1534748A2 (en) | 2005-06-01 |
| WO2004015057A9 (en) | 2004-07-29 |
| AU2003263411B8 (en) | 2011-04-14 |
| CA2495743A1 (en) | 2004-02-19 |
| JP4648001B2 (ja) | 2011-03-09 |
| JP2005535699A (ja) | 2005-11-24 |
| US7638323B2 (en) | 2009-12-29 |
| AU2003263411B2 (en) | 2010-12-16 |
| US20040137580A1 (en) | 2004-07-15 |
| JP2010235614A (ja) | 2010-10-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20140812 |