AU2003250323A1 - A method of preparing enantiomers of indole-2,3-dione-3-oxime derivatives - Google Patents

A method of preparing enantiomers of indole-2,3-dione-3-oxime derivatives Download PDF

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Publication number
AU2003250323A1
AU2003250323A1 AU2003250323A AU2003250323A AU2003250323A1 AU 2003250323 A1 AU2003250323 A1 AU 2003250323A1 AU 2003250323 A AU2003250323 A AU 2003250323A AU 2003250323 A AU2003250323 A AU 2003250323A AU 2003250323 A1 AU2003250323 A1 AU 2003250323A1
Authority
AU
Australia
Prior art keywords
butyrolactone
enantiopure
isoquinolin
iii
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003250323A
Other languages
English (en)
Inventor
William Dalby Brown
Alex Haahr Gouliaev
Frank Watjen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NTG Nordic Transport Group AS
Original Assignee
Neurosearch AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch AS filed Critical Neurosearch AS
Publication of AU2003250323A1 publication Critical patent/AU2003250323A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2003250323A 2002-08-22 2003-08-13 A method of preparing enantiomers of indole-2,3-dione-3-oxime derivatives Abandoned AU2003250323A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200201237 2002-08-22
DKPA200201237 2002-08-22
PCT/DK2003/000539 WO2004018466A2 (en) 2002-08-22 2003-08-13 A method of preparing enantiomers of indole-2,3-dione-3-oxime derivatives

Publications (1)

Publication Number Publication Date
AU2003250323A1 true AU2003250323A1 (en) 2004-03-11

Family

ID=31896777

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003250323A Abandoned AU2003250323A1 (en) 2002-08-22 2003-08-13 A method of preparing enantiomers of indole-2,3-dione-3-oxime derivatives

Country Status (12)

Country Link
US (1) US7632948B2 (https=)
EP (1) EP1532146B1 (https=)
JP (1) JP2006503011A (https=)
CN (1) CN1296372C (https=)
AT (1) ATE318815T1 (https=)
AU (1) AU2003250323A1 (https=)
CA (1) CA2493244A1 (https=)
DE (1) DE60303825T2 (https=)
DK (1) DK1532146T3 (https=)
MX (1) MXPA05002056A (https=)
NZ (1) NZ537810A (https=)
WO (1) WO2004018466A2 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1183025T3 (da) 1999-05-19 2009-05-04 Painceptor Pharma Corp Hæmmere af proton-styrede kationskanaler og deres anvendelse til behandling af iskæmiske lidelser
GT200600180A (es) * 2005-04-29 2006-11-22 Proceso para preparar isatinas con control de formacion de subproductos
WO2007059608A1 (en) 2005-11-23 2007-05-31 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
CA2652307A1 (en) * 2006-04-10 2007-10-18 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
US20090246134A1 (en) * 2007-05-30 2009-10-01 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
AU2016359230B2 (en) 2015-11-25 2020-04-23 Ligachem Biosciences Inc. Conjugates comprising self-immolative groups and methods related thereto

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2542941B2 (ja) * 1990-02-02 1996-10-09 チッソ株式会社 光学活性ヒドロキシラクトン類の製造方法
JP2939646B2 (ja) * 1990-07-17 1999-08-25 チッソ株式会社 ４―置換―２―ヒドロキシブタン酸エステルおよび製造法
JP3789951B2 (ja) * 1993-11-25 2006-06-28 三共アグロ株式会社 Ｏ−ｎ結合を有する糖誘導体及び製造方法
UA54403C2 (uk) * 1996-10-01 2003-03-17 Н'Юросерч А/С Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
EP1066037B1 (en) * 1998-03-31 2004-12-29 Neurosearch A/S Use of indole-2,3-dione-3-oxime derivatives as ampa antagonists
WO2001018231A2 (de) * 1999-09-08 2001-03-15 Lonza Ag VERFAHREN ZUR HERSTELLUNG VON (R)- ODER (S)-HYDROXY-η-BUTYROLACTON

Also Published As

Publication number Publication date
JP2006503011A (ja) 2006-01-26
DK1532146T3 (da) 2006-07-03
US20060178391A1 (en) 2006-08-10
EP1532146A2 (en) 2005-05-25
ATE318815T1 (de) 2006-03-15
US7632948B2 (en) 2009-12-15
CA2493244A1 (en) 2004-03-04
CN1671704A (zh) 2005-09-21
MXPA05002056A (es) 2005-06-08
NZ537810A (en) 2006-10-27
CN1296372C (zh) 2007-01-24
DE60303825D1 (de) 2006-04-27
DE60303825T2 (de) 2006-08-17
WO2004018466A3 (en) 2004-03-25
EP1532146B1 (en) 2006-03-01
WO2004018466A2 (en) 2004-03-04

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Legal Events

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MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application