AU2003246740B2 - Use of new etonogestrel esters - Google Patents
Use of new etonogestrel esters Download PDFInfo
- Publication number
- AU2003246740B2 AU2003246740B2 AU2003246740A AU2003246740A AU2003246740B2 AU 2003246740 B2 AU2003246740 B2 AU 2003246740B2 AU 2003246740 A AU2003246740 A AU 2003246740A AU 2003246740 A AU2003246740 A AU 2003246740A AU 2003246740 B2 AU2003246740 B2 AU 2003246740B2
- Authority
- AU
- Australia
- Prior art keywords
- etonogestrel
- undecanoate
- ment
- testosterone
- esters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- GCKFUYQCUCGESZ-BPIQYHPVSA-N etonogestrel Chemical class O=C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 GCKFUYQCUCGESZ-BPIQYHPVSA-N 0.000 title claims description 91
- 229960002941 etonogestrel Drugs 0.000 claims description 95
- ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 claims description 33
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims description 11
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 claims description 11
- 239000007924 injection Substances 0.000 claims description 11
- 238000002347 injection Methods 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 10
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- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 32
- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 description 30
- 239000000243 solution Substances 0.000 description 28
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- YSGQGNQWBLYHPE-CFUSNLFHSA-N (7r,8r,9s,10r,13s,14s,17s)-17-hydroxy-7,13-dimethyl-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-one Chemical compound C1C[C@]2(C)[C@@H](O)CC[C@H]2[C@@H]2[C@H](C)CC3=CC(=O)CC[C@@H]3[C@H]21 YSGQGNQWBLYHPE-CFUSNLFHSA-N 0.000 description 19
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- 229960002903 benzyl benzoate Drugs 0.000 description 15
- BWEZMBMJQRHPSZ-UHFFFAOYSA-N ethyl undecanoate Chemical compound CCCCCCCCCCC(=O)OCC.CCCCCCCCCCC(=O)OCC BWEZMBMJQRHPSZ-UHFFFAOYSA-N 0.000 description 13
- 150000001875 compounds Chemical class 0.000 description 11
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 9
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- 239000000583 progesterone congener Substances 0.000 description 9
- 239000003098 androgen Substances 0.000 description 8
- FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical compound CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 description 8
- VOCBWIIFXDYGNZ-IXKNJLPQSA-N testosterone enanthate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CCCCCC)[C@@]1(C)CC2 VOCBWIIFXDYGNZ-IXKNJLPQSA-N 0.000 description 8
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- MNWFXJYAOYHMED-UHFFFAOYSA-M heptanoate Chemical compound CCCCCCC([O-])=O MNWFXJYAOYHMED-UHFFFAOYSA-M 0.000 description 4
- WQEPLUUGTLDZJY-UHFFFAOYSA-M pentadecanoate Chemical compound CCCCCCCCCCCCCCC([O-])=O WQEPLUUGTLDZJY-UHFFFAOYSA-M 0.000 description 4
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- WAHQVRCNDCHDIB-QZYSPNBYSA-N [(3s,8r,9s,10r,13s,14s,17r)-17-acetyl-17-acetyloxy-6,10,13-trimethyl-1,2,3,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-yl] 3-cyclopentylpropanoate Chemical compound O([C@@H]1C=C2C(C)=C[C@H]3[C@@H]4CC[C@]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)(OC(=O)C)C(C)=O)C(=O)CCC1CCCC1 WAHQVRCNDCHDIB-QZYSPNBYSA-N 0.000 description 2
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
-
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Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
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- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Physical Education & Sports Medicine (AREA)
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- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02077118 | 2002-05-30 | ||
| EP02077118.4 | 2002-05-30 | ||
| PCT/EP2003/050188 WO2003101374A2 (en) | 2002-05-30 | 2003-05-22 | Use of new etonogestrel esters |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2003246740A1 AU2003246740A1 (en) | 2003-12-19 |
| AU2003246740B2 true AU2003246740B2 (en) | 2009-01-08 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003246740A Ceased AU2003246740B2 (en) | 2002-05-30 | 2003-05-22 | Use of new etonogestrel esters |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US20050222114A1 (enExample) |
| EP (1) | EP1513588B1 (enExample) |
| JP (1) | JP2005532336A (enExample) |
| KR (1) | KR20050005507A (enExample) |
| CN (1) | CN1655848A (enExample) |
| AR (1) | AR040129A1 (enExample) |
| AT (1) | ATE394140T1 (enExample) |
| AU (1) | AU2003246740B2 (enExample) |
| BR (1) | BR0311248A (enExample) |
| CA (1) | CA2487293A1 (enExample) |
| DE (1) | DE60320786D1 (enExample) |
| ES (1) | ES2305498T3 (enExample) |
| HR (1) | HRP20041127A2 (enExample) |
| IL (1) | IL165125A0 (enExample) |
| IS (1) | IS7537A (enExample) |
| MX (1) | MXPA04011798A (enExample) |
| NO (1) | NO20044903L (enExample) |
| NZ (1) | NZ536618A (enExample) |
| PE (1) | PE20040042A1 (enExample) |
| PL (1) | PL373295A1 (enExample) |
| RS (1) | RS101004A (enExample) |
| RU (1) | RU2322986C2 (enExample) |
| TW (1) | TW200400041A (enExample) |
| UA (1) | UA80703C2 (enExample) |
| WO (1) | WO2003101374A2 (enExample) |
| ZA (1) | ZA200409498B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200403065A (en) * | 2002-05-30 | 2004-03-01 | Akzo Nobel Nv | New etonogestrel esters |
| US20130123523A1 (en) * | 2011-11-10 | 2013-05-16 | Klaus Nickisch | Methods for the preparation of etonogestrel and desogestrel |
| DE102012211511A1 (de) * | 2012-07-03 | 2014-01-09 | Siemens Aktiengesellschaft | Bestimmung der Eignung einer Ressource |
| MX2020003470A (es) * | 2017-10-19 | 2020-10-01 | Evestra Inc | Anticonceptivos de profarmacos de progestina de accion mas prolongada. |
| CN111057120B (zh) * | 2019-12-27 | 2021-04-27 | 苏州翔实医药发展有限公司 | 一种依托孕烯衍生物a及其制备方法和用途 |
| WO2021252761A2 (en) * | 2020-06-11 | 2021-12-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Monomeric and oligomeric compound embodiments as contraceptives and therapies and methods of making and using the same |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0737477A1 (en) * | 1993-12-27 | 1996-10-16 | Akzo Nobel N.V. | Percutaneously absorbable preparation |
| WO1997003709A1 (de) * | 1995-07-17 | 1997-02-06 | Schering Aktiengesellschaft | Mittel zur transdermalen applikation enthaltend ester des 3-ketodegestrel |
| WO1999067271A1 (en) * | 1998-06-19 | 1999-12-29 | Akzo Nobel N.V. | Testosterone derivative |
| WO1999067270A1 (en) * | 1998-06-19 | 1999-12-29 | Akzo Nobel N.V. | Cycloalkyl-carboxylic acid esters of 7.alpha.methyl-estr-4-en-3-one 17.beta.-ol (19-nor 7.alpha.-methyltestosterone) |
| WO2000042942A2 (en) * | 1999-01-26 | 2000-07-27 | Place Virgil A | Buccal drug delivery system for use in male contraception |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4227989A1 (de) * | 1992-08-21 | 1994-06-09 | Schering Ag | Mittel zur transdermalen Applikation enthaltend 3-Keto-desogestrel |
| DE4240806A1 (de) * | 1992-12-01 | 1994-06-09 | Schering Ag | Mittel zur transdermalen Applikation enthaltend 14alpha,17alpha-Ethanoestra-1,3,5(10)-trien-3,17beta-diol |
| JPH07101884A (ja) * | 1993-10-01 | 1995-04-18 | Sanei Gen F F I Inc | 水溶性ヘミセルロースを含有する製剤 |
| TW200403065A (en) * | 2002-05-30 | 2004-03-01 | Akzo Nobel Nv | New etonogestrel esters |
-
2003
- 2003-05-19 TW TW092113492A patent/TW200400041A/zh unknown
- 2003-05-22 CN CNA038123657A patent/CN1655848A/zh active Pending
- 2003-05-22 US US10/517,362 patent/US20050222114A1/en not_active Abandoned
- 2003-05-22 KR KR10-2004-7019327A patent/KR20050005507A/ko not_active Withdrawn
- 2003-05-22 HR HR20041127A patent/HRP20041127A2/hr not_active Application Discontinuation
- 2003-05-22 PL PL03373295A patent/PL373295A1/xx not_active Application Discontinuation
- 2003-05-22 AT AT03755980T patent/ATE394140T1/de not_active IP Right Cessation
- 2003-05-22 EP EP03755980A patent/EP1513588B1/en not_active Expired - Lifetime
- 2003-05-22 UA UA20041109285A patent/UA80703C2/uk unknown
- 2003-05-22 BR BR0311248-9A patent/BR0311248A/pt not_active IP Right Cessation
- 2003-05-22 DE DE60320786T patent/DE60320786D1/de not_active Expired - Fee Related
- 2003-05-22 RS YU101004A patent/RS101004A/sr unknown
- 2003-05-22 AU AU2003246740A patent/AU2003246740B2/en not_active Ceased
- 2003-05-22 CA CA002487293A patent/CA2487293A1/en not_active Abandoned
- 2003-05-22 WO PCT/EP2003/050188 patent/WO2003101374A2/en not_active Ceased
- 2003-05-22 RU RU2004138809/15A patent/RU2322986C2/ru active
- 2003-05-22 MX MXPA04011798A patent/MXPA04011798A/es unknown
- 2003-05-22 JP JP2004508732A patent/JP2005532336A/ja not_active Withdrawn
- 2003-05-22 ES ES03755980T patent/ES2305498T3/es not_active Expired - Lifetime
- 2003-05-22 NZ NZ536618A patent/NZ536618A/en unknown
- 2003-05-26 PE PE2003000508A patent/PE20040042A1/es not_active Application Discontinuation
- 2003-05-28 AR ARP030101858A patent/AR040129A1/es unknown
-
2004
- 2004-11-09 IL IL16512504A patent/IL165125A0/xx unknown
- 2004-11-10 NO NO20044903A patent/NO20044903L/no not_active Application Discontinuation
- 2004-11-18 IS IS7537A patent/IS7537A/is unknown
- 2004-11-24 ZA ZA200409498A patent/ZA200409498B/xx unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0737477A1 (en) * | 1993-12-27 | 1996-10-16 | Akzo Nobel N.V. | Percutaneously absorbable preparation |
| WO1997003709A1 (de) * | 1995-07-17 | 1997-02-06 | Schering Aktiengesellschaft | Mittel zur transdermalen applikation enthaltend ester des 3-ketodegestrel |
| WO1999067271A1 (en) * | 1998-06-19 | 1999-12-29 | Akzo Nobel N.V. | Testosterone derivative |
| WO1999067270A1 (en) * | 1998-06-19 | 1999-12-29 | Akzo Nobel N.V. | Cycloalkyl-carboxylic acid esters of 7.alpha.methyl-estr-4-en-3-one 17.beta.-ol (19-nor 7.alpha.-methyltestosterone) |
| WO2000042942A2 (en) * | 1999-01-26 | 2000-07-27 | Place Virgil A | Buccal drug delivery system for use in male contraception |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2487293A1 (en) | 2003-12-11 |
| IL165125A0 (en) | 2005-12-18 |
| ZA200409498B (en) | 2006-05-31 |
| AU2003246740A1 (en) | 2003-12-19 |
| EP1513588A2 (en) | 2005-03-16 |
| ES2305498T3 (es) | 2008-11-01 |
| DE60320786D1 (de) | 2008-06-19 |
| AR040129A1 (es) | 2005-03-16 |
| BR0311248A (pt) | 2005-03-15 |
| RU2322986C2 (ru) | 2008-04-27 |
| IS7537A (is) | 2004-11-18 |
| CN1655848A (zh) | 2005-08-17 |
| PL373295A1 (en) | 2005-08-22 |
| RS101004A (sr) | 2006-10-27 |
| RU2004138809A (ru) | 2005-06-10 |
| WO2003101374A2 (en) | 2003-12-11 |
| US20050222114A1 (en) | 2005-10-06 |
| NO20044903L (no) | 2005-02-25 |
| HK1072568A1 (en) | 2005-09-02 |
| MXPA04011798A (es) | 2005-03-31 |
| HRP20041127A2 (en) | 2005-02-28 |
| JP2005532336A (ja) | 2005-10-27 |
| ATE394140T1 (de) | 2008-05-15 |
| PE20040042A1 (es) | 2004-01-31 |
| TW200400041A (en) | 2004-01-01 |
| EP1513588B1 (en) | 2008-05-07 |
| NZ536618A (en) | 2007-06-29 |
| KR20050005507A (ko) | 2005-01-13 |
| UA80703C2 (en) | 2007-10-25 |
| WO2003101374A3 (en) | 2004-02-26 |
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| Date | Code | Title | Description |
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| PC1 | Assignment before grant (sect. 113) |
Owner name: N.V. ORGANON Free format text: FORMER APPLICANT(S): AKZO NOBEL N.V. |
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| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |