AU2003229043B2 - Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof - Google Patents
Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof Download PDFInfo
- Publication number
- AU2003229043B2 AU2003229043B2 AU2003229043A AU2003229043A AU2003229043B2 AU 2003229043 B2 AU2003229043 B2 AU 2003229043B2 AU 2003229043 A AU2003229043 A AU 2003229043A AU 2003229043 A AU2003229043 A AU 2003229043A AU 2003229043 B2 AU2003229043 B2 AU 2003229043B2
- Authority
- AU
- Australia
- Prior art keywords
- ethyl
- oxo
- carboxylic acid
- dihydroquinoline
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 78
- 239000001257 hydrogen Substances 0.000 claims description 78
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 64
- 150000002431 hydrogen Chemical class 0.000 claims description 41
- 150000003839 salts Chemical class 0.000 claims description 38
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 35
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 33
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 33
- 208000035475 disorder Diseases 0.000 claims description 32
- DTYLXDLAOLOTKT-UHFFFAOYSA-N 1,4-dihydroquinoline-3-carboxylic acid Chemical compound C1=CC=C2CC(C(=O)O)=CNC2=C1 DTYLXDLAOLOTKT-UHFFFAOYSA-N 0.000 claims description 30
- 229910052757 nitrogen Inorganic materials 0.000 claims description 23
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Classifications
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- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38064102P | 2002-05-14 | 2002-05-14 | |
| US60/380,641 | 2002-05-14 | ||
| PCT/US2003/014948 WO2003097564A2 (en) | 2002-05-14 | 2003-05-12 | Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2003229043A1 AU2003229043A1 (en) | 2003-12-02 |
| AU2003229043B2 true AU2003229043B2 (en) | 2008-12-04 |
Family
ID=29549994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003229043A Ceased AU2003229043B2 (en) | 2002-05-14 | 2003-05-12 | Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US7355047B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1503759B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4532263B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20040107525A (cg-RX-API-DMAC7.html) |
| CN (1) | CN1652784A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE417613T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2003229043B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR0309965A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2484308A1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE60325347D1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK1503759T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2319176T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL164734A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MXPA04011156A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ536061A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2003097564A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20040107525A (ko) * | 2002-05-14 | 2004-12-20 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 치환된 퀴놀론 카르복실산, 이들의 유도체, 그의 작용부위 및 용도 |
| US7470706B2 (en) | 2004-01-31 | 2008-12-30 | Sanofi-Aventis Deutschland Gmbh | Cycloalkyl-substituted 7-amino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments |
| DE102004004971B3 (de) * | 2004-01-31 | 2005-09-15 | Aventis Pharma Deutschland Gmbh | Cycloalkyl substituierte 7-Amino-4-chinolon-3-carbonsäure-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arnzeimittel |
| AU2005240657A1 (en) * | 2004-05-06 | 2005-11-17 | The Regents Of The University Of California | Substituted enaminones, their derivatives and uses thereof |
| US8354427B2 (en) * | 2004-06-24 | 2013-01-15 | Vertex Pharmaceutical Incorporated | Modulators of ATP-binding cassette transporters |
| BR122018075478B8 (pt) | 2004-06-24 | 2023-10-31 | Vertex Pharma | moduladores de transportadores de cassete de ligação de atp |
| JP4796622B2 (ja) * | 2005-04-11 | 2011-10-19 | エフ．ホフマン−ラ ロシュ アーゲー | （３，４−ジヒドロ−キナゾリン−２−イル）−インダン−１−イル−アミン |
| AU2006243244A1 (en) * | 2005-05-04 | 2006-11-09 | F. Hoffmann-La Roche Ag | (3,4-dihydro-quinazolin-2-yl)-(2-aryloxy-ethyl)-amines having an activity on the 5-HT receptor |
| AU2006322045A1 (en) * | 2005-12-05 | 2007-06-14 | Merck & Co., Inc. | Quinolone M1 receptor positive allosteric modulators |
| EP1979367A2 (en) * | 2005-12-24 | 2008-10-15 | Vertex Pharmaceuticals Incorporated | Quinolin-4-one derivatives as modulators of abc transporters |
| HUE032813T2 (en) | 2005-12-28 | 2017-11-28 | Vertex Pharma | Solid forms of N- [2,4-bis (1,1-dimethyl ethyl) -5-hydroxyphenyl] -1,4-dihydro-4-oxoquinoline-3-carboxamide |
| EP2013182B1 (en) * | 2006-03-13 | 2013-09-04 | Kyorin Pharmaceutical Co., Ltd. | Aminoquinolones as gsk-3 inhibitors |
| CA2660421A1 (en) * | 2006-08-10 | 2008-02-14 | Ferrer Internacional S.A. | 1h-quinolin-4-one compounds, with affinity for the gaba receptor, processes, uses and compositions |
| EP1886996A1 (en) * | 2006-08-10 | 2008-02-13 | Ferrer Internacional, S.A. | 1H-Quinolin-4-one compounds, with affinity for the GABA receptor, processes, uses and compositions |
| NZ576036A (en) | 2006-10-16 | 2010-10-29 | Bionomics Ltd | Naphthyridine containing compounds for treating anxiety disorders |
| US10954231B2 (en) | 2006-10-16 | 2021-03-23 | Bionomics Limited | Anxiolytic compounds |
| WO2009040377A2 (en) * | 2007-09-27 | 2009-04-02 | Ge Healthcare Limited | Imaging agents |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| US12458635B2 (en) | 2008-08-13 | 2025-11-04 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| JP2012506857A (ja) * | 2008-10-23 | 2012-03-22 | メルク・シャープ・エンド・ドーム・コーポレイション | 縮合複素環式ｍ１受容体ポジティブアロステリック調節因子 |
| HUE035160T2 (en) | 2009-03-20 | 2018-05-02 | Vertex Pharma | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
| US20120093917A1 (en) * | 2009-04-02 | 2012-04-19 | Robert Hromas | Metnase and intnase inhibitors and their use in treating cancer |
| US8802700B2 (en) | 2010-12-10 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| CA2828780A1 (en) | 2011-03-02 | 2012-09-07 | Bionomics Limited | Novel small-molecules as therapeutics |
| AU2012222869B2 (en) * | 2011-03-02 | 2015-08-13 | Bionomics Limited | Methods of treating a disease or condition of the central nervous system |
| US9133188B2 (en) | 2011-05-12 | 2015-09-15 | Bionomics Limited | Methods for preparing naphthyridines |
| CA2865519C (en) | 2012-02-27 | 2018-01-02 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions comprising a solid dispersion of n-[2,4-bis(1,1-dimethylethyl0-5-hydroxyphenyl-1]-1,4-dihydro-4-oxoquinolone-3-carboxamide for treating cystic fibrosis |
| EP3204358B1 (en) | 2014-10-07 | 2018-09-19 | Vertex Pharmaceuticals Incorporated | Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator |
| CN107501107A (zh) * | 2017-09-26 | 2017-12-22 | 兰亚朝 | 喹诺酮药物的中间体合成方法 |
| CN111269131B (zh) * | 2020-03-12 | 2021-12-28 | 江苏飞宇医药科技股份有限公司 | 以三正丙胺为吸酸剂制备环丙乙酯胺化物的工艺 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000068202A1 (en) * | 1999-05-06 | 2000-11-16 | Neurogen Corporation | Substituted 4-oxo-quinoline-3-carboxamides: gaba brain receptor ligands |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1433774A (en) * | 1973-02-26 | 1976-04-28 | Allen & Hanburys Ltd | Heterocyclic compounds apparatus for conveying articles |
| JPS5715760B2 (cg-RX-API-DMAC7.html) * | 1974-06-11 | 1982-04-01 | ||
| US4390541A (en) | 1980-12-19 | 1983-06-28 | Lilly Industries Limited | Quinolone derivatives and their use in a method of controlling an immediate hypersensitivity disease |
| US6248739B1 (en) * | 1999-01-08 | 2001-06-19 | Pharmacia & Upjohn Company | Quinolinecarboxamides as antiviral agents |
| GB0127349D0 (en) * | 2001-11-14 | 2002-01-02 | Glaxo Group Ltd | Macrolides |
| KR20040107525A (ko) * | 2002-05-14 | 2004-12-20 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 치환된 퀴놀론 카르복실산, 이들의 유도체, 그의 작용부위 및 용도 |
-
2003
- 2003-05-12 KR KR10-2004-7018340A patent/KR20040107525A/ko not_active Ceased
- 2003-05-12 CA CA002484308A patent/CA2484308A1/en not_active Abandoned
- 2003-05-12 ES ES03726824T patent/ES2319176T3/es not_active Expired - Lifetime
- 2003-05-12 MX MXPA04011156A patent/MXPA04011156A/es active IP Right Grant
- 2003-05-12 BR BR0309965-2A patent/BR0309965A/pt not_active IP Right Cessation
- 2003-05-12 DK DK03726824T patent/DK1503759T3/da active
- 2003-05-12 JP JP2004505299A patent/JP4532263B2/ja not_active Expired - Fee Related
- 2003-05-12 AT AT03726824T patent/ATE417613T1/de not_active IP Right Cessation
- 2003-05-12 CN CNA03810816XA patent/CN1652784A/zh active Pending
- 2003-05-12 EP EP03726824A patent/EP1503759B1/en not_active Expired - Lifetime
- 2003-05-12 WO PCT/US2003/014948 patent/WO2003097564A2/en not_active Ceased
- 2003-05-12 US US10/514,808 patent/US7355047B2/en not_active Expired - Fee Related
- 2003-05-12 DE DE60325347T patent/DE60325347D1/de not_active Expired - Lifetime
- 2003-05-12 AU AU2003229043A patent/AU2003229043B2/en not_active Ceased
- 2003-05-12 NZ NZ536061A patent/NZ536061A/en unknown
-
2004
- 2004-10-20 IL IL16473404A patent/IL164734A0/xx unknown
-
2008
- 2008-02-15 US US12/032,403 patent/US20080176897A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000068202A1 (en) * | 1999-05-06 | 2000-11-16 | Neurogen Corporation | Substituted 4-oxo-quinoline-3-carboxamides: gaba brain receptor ligands |
Non-Patent Citations (1)
| Title |
|---|
| Uno, T. et al 1987 Journal of Medicinal Chemistry 30(12):2163-2169 * |
Also Published As
| Publication number | Publication date |
|---|---|
| BR0309965A (pt) | 2005-03-01 |
| US7355047B2 (en) | 2008-04-08 |
| EP1503759A2 (en) | 2005-02-09 |
| CA2484308A1 (en) | 2003-11-27 |
| US20080176897A1 (en) | 2008-07-24 |
| HK1072905A1 (en) | 2005-09-16 |
| IL164734A0 (en) | 2005-12-18 |
| ATE417613T1 (de) | 2009-01-15 |
| CN1652784A (zh) | 2005-08-10 |
| AU2003229043A1 (en) | 2003-12-02 |
| EP1503759B1 (en) | 2008-12-17 |
| JP2005535592A (ja) | 2005-11-24 |
| KR20040107525A (ko) | 2004-12-20 |
| MXPA04011156A (es) | 2005-02-17 |
| DE60325347D1 (de) | 2009-01-29 |
| NZ536061A (en) | 2008-09-26 |
| DK1503759T3 (da) | 2009-04-14 |
| JP4532263B2 (ja) | 2010-08-25 |
| WO2003097564A3 (en) | 2004-02-26 |
| EP1503759A4 (en) | 2006-02-15 |
| ES2319176T3 (es) | 2009-05-05 |
| WO2003097564A2 (en) | 2003-11-27 |
| US20060178516A1 (en) | 2006-08-10 |
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Legal Events
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| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |