AU2002339977B2 - Cell populations which co-express CD49C and CD90 - Google Patents
Cell populations which co-express CD49C and CD90 Download PDFInfo
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- AU2002339977B2 AU2002339977B2 AU2002339977A AU2002339977A AU2002339977B2 AU 2002339977 B2 AU2002339977 B2 AU 2002339977B2 AU 2002339977 A AU2002339977 A AU 2002339977A AU 2002339977 A AU2002339977 A AU 2002339977A AU 2002339977 B2 AU2002339977 B2 AU 2002339977B2
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- cell population
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| PCT/US2002/029971 WO2003025149A2 (en) | 2001-09-21 | 2002-09-20 | Cell populations which co-express cd49c and cd90 |
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Families Citing this family (114)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7514074B2 (en) | 1997-07-14 | 2009-04-07 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
| WO2002064748A2 (en) * | 2001-02-14 | 2002-08-22 | Furcht Leo T | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
| US8609412B2 (en) * | 1999-08-05 | 2013-12-17 | Regents Of The University Of Minnesota | Mapc generation of lung tissue |
| US7015037B1 (en) * | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
| WO2001011011A2 (en) * | 1999-08-05 | 2001-02-15 | Mcl Llc | Multipotent adult stem cells and methods for isolation |
| US8147824B2 (en) | 1999-08-05 | 2012-04-03 | Athersys, Inc. | Immunomodulatory properties of multipotent adult progenitor cells and uses thereof |
| US10638734B2 (en) | 2004-01-05 | 2020-05-05 | Abt Holding Company | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
| US8252280B1 (en) | 1999-08-05 | 2012-08-28 | Regents Of The University Of Minnesota | MAPC generation of muscle |
| US8075881B2 (en) | 1999-08-05 | 2011-12-13 | Regents Of The University Of Minnesota | Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure |
| US7927587B2 (en) * | 1999-08-05 | 2011-04-19 | Regents Of The University Of Minnesota | MAPC administration for the treatment of lysosomal storage disorders |
| US7311905B2 (en) | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
| DK1349918T3 (da) | 2000-12-06 | 2014-11-10 | Anthrogenesis Corp | Fremgangsmåde til indsamling af stamceller fra moderkagen |
| EP3246396B1 (en) * | 2001-02-14 | 2020-01-29 | Celularity, Inc. | Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells |
| EP2316919B1 (en) * | 2001-02-14 | 2015-10-07 | Anthrogenesis Corporation | Post-partum mammalian placenta, its use and placental stem cells therefrom |
| DE10144326B4 (de) * | 2001-09-10 | 2005-09-22 | Siemens Ag | Verfahren und System zur Überwachung eines Reifenluftdrucks |
| US9969980B2 (en) * | 2001-09-21 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
| US7129034B2 (en) * | 2001-10-25 | 2006-10-31 | Cedars-Sinai Medical Center | Differentiation of whole bone marrow |
| US9969977B2 (en) * | 2002-09-20 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
| AU2003298775B2 (en) | 2002-11-26 | 2008-07-17 | Anthrogenesis Corporation | Cytotherapeutics, cytotherapeutic units and methods for treatments using them |
| US20060228798A1 (en) * | 2002-11-27 | 2006-10-12 | Catherine Verfaillie | Homologous recombination in multipotent adult progenitor cells |
| WO2004071283A2 (en) * | 2003-02-13 | 2004-08-26 | Anthrogenesis Corporation | Use of umbilical cord blood to treat individuals having a disease, disorder or condition |
| WO2005001080A2 (en) | 2003-06-27 | 2005-01-06 | Ethicon, Incorporated | Postpartum-derived cells for use in treatment of disease of the heart and circulatory system |
| US8790637B2 (en) | 2003-06-27 | 2014-07-29 | DePuy Synthes Products, LLC | Repair and regeneration of ocular tissue using postpartum-derived cells |
| US8491883B2 (en) | 2003-06-27 | 2013-07-23 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of amyotrophic lateral sclerosis using umbilical derived cells |
| US7875272B2 (en) | 2003-06-27 | 2011-01-25 | Ethicon, Incorporated | Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells |
| US9592258B2 (en) | 2003-06-27 | 2017-03-14 | DePuy Synthes Products, Inc. | Treatment of neurological injury by administration of human umbilical cord tissue-derived cells |
| US9572840B2 (en) | 2003-06-27 | 2017-02-21 | DePuy Synthes Products, Inc. | Regeneration and repair of neural tissue using postpartum-derived cells |
| WO2005003320A2 (en) * | 2003-07-02 | 2005-01-13 | Regents Of The University Of Minnesota | Neuronal differentiation of stem cells |
| EP1694345A1 (en) | 2003-12-04 | 2006-08-30 | Regents Of The University Of Minnesota | Compositions and methods for the treatment of lysosomal storage disorders |
| JP2007536936A (ja) | 2004-05-14 | 2007-12-20 | ベクトン・ディキンソン・アンド・カンパニー | 幹細胞集団および使用方法 |
| NZ551832A (en) * | 2004-06-09 | 2010-01-29 | Univ Edinburgh | Neural stem cells |
| WO2006071778A2 (en) | 2004-12-23 | 2006-07-06 | Ethicon Incorporated | Treatment of parkinson's disease and related disorders using postpartum derived cells |
| EP1859028B1 (en) * | 2005-02-10 | 2015-12-02 | Regents Of The University Of Minnesota | Vascular endothelial cells |
| WO2006121428A1 (en) * | 2005-05-05 | 2006-11-16 | Regents Of The University Of Minnesota | Use of nk cell inhibition to facilitate persistence of engrafted mhc- i negative cells |
| CA2607218C (en) * | 2005-05-05 | 2016-08-23 | Regents Of The University Of Minnesota | Use of mapc or progeny therefrom to populate lymphohematopoietic tissues |
| EP2465924A3 (en) * | 2005-06-16 | 2013-01-02 | Ramot at Tel-Aviv University Ltd. | Isolated cells and populations comprising same for the treament of cns diseases |
| WO2007117262A2 (en) * | 2005-07-29 | 2007-10-18 | Athersys, Inc. | Culture of non-embryonic cells at high cell density |
| DK1957633T3 (en) * | 2005-10-13 | 2014-03-17 | Anthrogenesis Corp | Immunomodulation USING PLACE SPEECH STEM CELLS |
| CN101310012B (zh) * | 2005-10-14 | 2012-05-09 | 明尼苏达大学董事会 | 非胚胎干细胞分化成具有胰腺表型的细胞 |
| US20110076255A1 (en) | 2005-11-07 | 2011-03-31 | Pecora Andrew L | Compositions and methods for treating progressive myocardial injury due to a vascular insufficiency |
| EP1951864B1 (en) * | 2005-11-07 | 2014-05-07 | Amorcyte, Inc. | Compositions and methods of vascular injury repair |
| US8637005B2 (en) | 2005-11-07 | 2014-01-28 | Amorcyte, Inc. | Compositions and methods of vascular injury repair |
| US11000546B2 (en) | 2005-11-09 | 2021-05-11 | Athersys, Inc. | Immunomodulatory properties of MAPCs and uses thereof |
| US10117900B2 (en) * | 2005-11-09 | 2018-11-06 | Athersys, Inc. | MAPC treatment of brain injuries and diseases |
| WO2007070870A1 (en) | 2005-12-16 | 2007-06-21 | Ethicon, Inc. | Compositions and methods for inhibiting adverse immune response in histocompatibility-mismatched transplantation |
| US9125906B2 (en) | 2005-12-28 | 2015-09-08 | DePuy Synthes Products, Inc. | Treatment of peripheral vascular disease using umbilical cord tissue-derived cells |
| CN101389754A (zh) | 2005-12-29 | 2009-03-18 | 人类起源公司 | 胎盘干细胞和第二来源干细胞的联合培养 |
| PT2471904T (pt) | 2005-12-29 | 2019-02-25 | Celularity Inc | População de células estaminais placentárias |
| CN104027359A (zh) * | 2006-01-23 | 2014-09-10 | 阿特西斯公司 | 无附加的免疫抑制治疗的mapc治疗法 |
| NZ570614A (en) * | 2006-01-23 | 2012-07-27 | Athersys Inc | Multipotent adult progenitor cell treatment of brain injuries and diseases |
| EP2013333A2 (en) * | 2006-05-04 | 2009-01-14 | GE Healthcare Bio-Sciences AB | Separation of cells |
| US7993918B2 (en) | 2006-08-04 | 2011-08-09 | Anthrogenesis Corporation | Tumor suppression using placental stem cells |
| ZA200902233B (en) | 2006-10-23 | 2010-07-28 | Anthrogenesis Corp | Methods and compositions for treatment of bone defects with placental cell populations |
| CA2913024A1 (en) * | 2006-11-03 | 2008-05-08 | Aastrom Biosciences, Inc. | Mixed cell populations for tissue repair and separation technique for cell processing |
| EP3763376A1 (en) | 2007-02-12 | 2021-01-13 | Celularity, Inc. | Treatment of inflammatory diseases using placental stem cells |
| US20100172830A1 (en) * | 2007-03-29 | 2010-07-08 | Cellx Inc. | Extraembryonic Tissue cells and method of use thereof |
| EP2171043B1 (en) * | 2007-06-15 | 2015-03-18 | Garnet BioTherapeutics, Inc | Treatment of diseases and disorders using self-renewing colony forming cells cultured and expanded in vitro |
| NZ599825A (en) | 2007-09-28 | 2014-10-31 | Anthrogenesis Corp | Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells |
| AU2009205886B2 (en) * | 2008-01-18 | 2015-08-27 | Katholieke Universiteit Leuven | Stem cell aggregates and methods for making and using |
| EP2128245A1 (en) * | 2008-05-27 | 2009-12-02 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Generation of induced pluripotent stem (iPS) cells |
| EP2620493B1 (en) | 2008-05-28 | 2019-03-27 | Ramot at Tel Aviv University Ltd. | Mesenchymal stem cells for the treatment of CNS diseases |
| WO2010021715A1 (en) | 2008-08-20 | 2010-02-25 | Anthrogenesis Corporation | Treatment of stroke using isolated placental cells |
| KR20240052847A (ko) * | 2008-08-20 | 2024-04-23 | 셀룰래리티 인코포레이티드 | 개선된 세포 조성물 및 그의 제조 방법 |
| CA2734446C (en) * | 2008-08-22 | 2017-06-20 | Anthrogenesis Corporation | Methods and compositions for treatment of bone defects with placental cell populations |
| WO2010049752A1 (en) | 2008-10-31 | 2010-05-06 | Katholieke Universiteit Leuven | Optimized methods for differentiation of cells into cells with hepatocyte and hepatocyte progenitor phenotypes, cells produced by the methods, and methods for using the cells |
| AU2009316541B2 (en) | 2008-11-19 | 2015-08-06 | Celularity Inc. | Amnion derived adherent cells |
| RU2497532C2 (ru) * | 2008-12-03 | 2013-11-10 | Эморсайт, Инк. | Композиции, улучшающие перфузию в области инфаркта и способы восстановления сосудистого повреждения |
| CN102387807A (zh) | 2008-12-19 | 2012-03-21 | 先进科技及再生医学有限责任公司 | 肺部疾病和病症的治疗 |
| BRPI0923177A2 (pt) | 2008-12-19 | 2020-08-25 | Advanced Technologies And Regenerative Medicine, Llc | usos de composições para tratar dor neuropática e espacidade, as referidas composições, e kit |
| US10179900B2 (en) | 2008-12-19 | 2019-01-15 | DePuy Synthes Products, Inc. | Conditioned media and methods of making a conditioned media |
| US20130302283A1 (en) | 2012-05-14 | 2013-11-14 | Advanced Technologies And Regenerative Medicine, Llc | hUTC MODULATION OF PRO-INFLAMMATORY MEDIATORS OF LUNG AND PULMONARY DISEASES AND DISORDERS |
| EP3187581A1 (en) | 2008-12-23 | 2017-07-05 | BOCO Silicon Valley, Inc. | Target populations of oligodendrocyte precursor cells and methods of making and using same |
| US8790638B2 (en) * | 2009-02-04 | 2014-07-29 | Stemedica Cell Technologies, Inc. | Compositions of stem cells and stem cell factors and methods for their use and manufacture |
| SG174551A1 (en) | 2009-03-26 | 2011-10-28 | Ethicon Inc | Human umbilical cord tissue cells as therapy for alzheimer' s disease |
| WO2011011500A1 (en) | 2009-07-21 | 2011-01-27 | Abt Holding Company | Use of stem cells to reduce leukocyte extravasation |
| WO2011011477A1 (en) | 2009-07-21 | 2011-01-27 | Abt Holding Company | Use of stem cells to reduce leukocyte extravasation |
| DK3284818T3 (da) | 2010-01-26 | 2022-06-20 | Celularity Inc | Behandling af knoglerelateret kræft ved hjælp af placenta stamceller |
| DK2539436T3 (da) | 2010-02-25 | 2021-10-18 | Abt Holding Co | Modulering af makrofagaktivering |
| SG183498A1 (en) | 2010-02-25 | 2012-09-27 | Abt Holding Co | Modulation of angiogenesis |
| WO2011106476A1 (en) * | 2010-02-25 | 2011-09-01 | Abt Holding Company | Modulation of microglia activation |
| US20110206647A1 (en) * | 2010-02-25 | 2011-08-25 | Abt Holding Company | Modulation of Angiogenesis |
| LT2556145T (lt) | 2010-04-07 | 2016-11-10 | Anthrogenesis Corporation | Angiogenezė naudojant placentos kamienines ląsteles |
| MX2012011543A (es) | 2010-04-08 | 2013-05-06 | Anthrogenesis Corp | Tratamiento de sarcoidosis empleando celulas madre placentarias. |
| SG185526A1 (en) | 2010-05-12 | 2012-12-28 | Abt Holding Co | Modulation of splenocytes in cell therapy |
| WO2011158125A2 (en) | 2010-06-17 | 2011-12-22 | Katholieke Universiteit Leuven | Methods for differentiating cells into hepatic stellate cells and hepatic sinusoidal endothelial cells, cells produced by the methods, and methods for using the cells |
| ES2666746T3 (es) | 2010-07-13 | 2018-05-07 | Anthrogenesis Corporation | Métodos para generar linfocitos citolíticos naturales |
| EP2609191B1 (en) | 2010-08-24 | 2017-11-22 | Regents Of The University Of Minnesota | Non-static suspension culture of cell aggregates |
| WO2012048276A2 (en) | 2010-10-08 | 2012-04-12 | Caridianbct, Inc. | Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system |
| US8969315B2 (en) | 2010-12-31 | 2015-03-03 | Anthrogenesis Corporation | Enhancement of placental stem cell potency using modulatory RNA molecules |
| JP6104896B2 (ja) | 2011-06-01 | 2017-03-29 | アントフロゲネシス コーポレーション | 胎盤幹細胞を使用する疼痛の治療 |
| PL2718416T3 (pl) | 2011-06-06 | 2020-05-18 | ReGenesys BVBA | Namnażanie komórek macierzystych w bioreaktorach włóknisto-kapilarnych |
| WO2013055476A1 (en) | 2011-09-09 | 2013-04-18 | Anthrogenesis Corporation | Treatment of amyotrophic lateral sclerosis using placental stem cells |
| GB201119335D0 (en) | 2011-11-09 | 2011-12-21 | Univ Leuven Kath | Hepatitis virus infectable stem cells |
| AU2012358810B2 (en) | 2011-12-23 | 2018-03-15 | DePuy Synthes Products, Inc. | Detection of human umbilical cord tissue-derived cells |
| US20140170748A1 (en) | 2012-12-14 | 2014-06-19 | DePuy Synthes Products, LLC | Nutrient Enriched Media for hUTC Growth |
| CN115137753A (zh) | 2013-02-05 | 2022-10-04 | 细胞结构公司 | 来自胎盘的自然杀伤细胞 |
| EP2953473B1 (en) | 2013-02-06 | 2018-11-28 | Nc Medical Research Inc. | Method of producing a heterogeneous subpopulation of bone marrow cells suitable for the treatement of neurodegeneration cased by ischemic stroke |
| US20140274649A1 (en) * | 2013-03-14 | 2014-09-18 | Sean Kerr | Bone Marrow Concentrator |
| IL289870B2 (en) | 2013-04-12 | 2023-03-01 | Lafrancesca Saverio | Improving organs for transplantation |
| AU2014266935B2 (en) | 2013-04-30 | 2020-06-11 | Katholieke Universiteit Leuven | Cell therapy for myelodysplastic syndromes |
| WO2015073913A1 (en) | 2013-11-16 | 2015-05-21 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
| KR101949630B1 (ko) | 2015-04-20 | 2019-02-18 | 히타치 오므론 터미널 솔루션즈 가부시키가이샤 | 카드 처리 장치 |
| KR102211270B1 (ko) | 2016-01-14 | 2021-02-04 | 디퍼이 신테스 프로덕츠, 인코포레이티드 | Hutc의 동결보존을 위한 조성물 및 방법 |
| NZ745530A (en) | 2016-01-21 | 2023-03-31 | Abt Holding Co | Stem cells for wound healing |
| US9788950B1 (en) | 2016-04-22 | 2017-10-17 | Vivex Biomedical, Inc. | Cohesive bone composition |
| US11253630B2 (en) | 2016-04-22 | 2022-02-22 | Vivex Biologics Group, Inc. | Malleable demineralized bone composition and method of manufacture |
| US11253629B2 (en) | 2016-04-22 | 2022-02-22 | Vivex Biologics Group, Inc. | Bone gel sheet composition and method of manufacture |
| US10596298B2 (en) | 2016-04-22 | 2020-03-24 | Vivex Biologics Group, Inc. | Malleable demineralized bone composition and method of manufacture |
| US10463767B2 (en) | 2016-04-22 | 2019-11-05 | Vivex Biologics Group, Inc. | Moldable bone composition |
| CA3029997A1 (en) | 2016-07-05 | 2018-01-11 | Janssen Biotech, Inc. | Treatment of retinal vascular disease using progenitor cells |
| JP6438527B2 (ja) * | 2017-06-01 | 2018-12-12 | Ｎｃメディカルリサーチ株式会社 | 神経変性の治療のための細胞療法 |
| EP3909591B1 (en) * | 2018-12-13 | 2024-07-24 | SCM Lifescience Co., Ltd. | Pharmaceutical composition for treating pancreatitis, comprising clonal stem cells |
| EP3903794B1 (en) * | 2018-12-17 | 2024-07-24 | SCM Lifescience Co., Ltd. | Pharmaceutical composition comprising clonal stem cells for treating graft-versus-host disease |
| EP3976069A4 (en) * | 2019-05-31 | 2023-07-19 | Figene, LLC | FIBROBLAST THERAPY FOR THE TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001011011A2 (en) * | 1999-08-05 | 2001-02-15 | Mcl Llc | Multipotent adult stem cells and methods for isolation |
Family Cites Families (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1168205B (it) * | 1983-07-21 | 1987-05-20 | Wellcome Italia | Derivato di monsialo ganglioside dotato di attivita' antibatterica, antifungina ed antitumorale, composizioni che lo contengono e procedimento per la loro preparazione |
| US4608199A (en) * | 1984-03-20 | 1986-08-26 | Arnold Caplan | Bone protein purification process |
| US4609551A (en) * | 1984-03-20 | 1986-09-02 | Arnold Caplan | Process of and material for stimulating growth of cartilage and bony tissue at anatomical sites |
| US4620327A (en) * | 1984-07-05 | 1986-11-04 | Caplan Arnold I | Process of adapting soluble bone protein for use in stimulating osteoinduction |
| US5061620A (en) * | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
| US5733542A (en) * | 1990-11-16 | 1998-03-31 | Haynesworth; Stephen E. | Enhancing bone marrow engraftment using MSCS |
| US6010696A (en) * | 1990-11-16 | 2000-01-04 | Osiris Therapeutics, Inc. | Enhancing hematopoietic progenitor cell engraftment using mesenchymal stem cells |
| US5811094A (en) * | 1990-11-16 | 1998-09-22 | Osiris Therapeutics, Inc. | Connective tissue regeneration using human mesenchymal stem cell preparations |
| US5226914A (en) * | 1990-11-16 | 1993-07-13 | Caplan Arnold I | Method for treating connective tissue disorders |
| US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5837539A (en) * | 1990-11-16 | 1998-11-17 | Osiris Therapeutics, Inc. | Monoclonal antibodies for human mesenchymal stem cells |
| US5197985A (en) * | 1990-11-16 | 1993-03-30 | Caplan Arnold I | Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells |
| US5591625A (en) * | 1993-11-24 | 1997-01-07 | Case Western Reserve University | Transduced mesenchymal stem cells |
| US6719972B1 (en) * | 1994-06-03 | 2004-04-13 | Repligen Corporation | Methods of inhibiting T cell proliferation or IL-2 accumulation with CTLA4- specific antibodies |
| US6174333B1 (en) * | 1994-06-06 | 2001-01-16 | Osiris Therapeutics, Inc. | Biomatrix for soft tissue regeneration using mesenchymal stem cells |
| CA2192103C (en) * | 1994-06-06 | 2002-02-05 | Arnold I. Caplan | Biomatrix for tissue regeneration |
| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| US5736396A (en) * | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
| US5643736A (en) * | 1995-02-06 | 1997-07-01 | Osiris Therapeutics, Inc. | Monoclonal antibodies for human osteogenic cell surface antigens |
| US6653134B2 (en) * | 1995-03-28 | 2003-11-25 | Cp Hahnemann University | Isolated stromal cells for use in the treatment of diseases of the central nervous system |
| US6974571B2 (en) * | 1995-03-28 | 2005-12-13 | Thomas Jefferson University | Isolated stromal cells and methods of using the same |
| US5716616A (en) * | 1995-03-28 | 1998-02-10 | Thomas Jefferson University | Isolated stromal cells for treating diseases, disorders or conditions characterized by bone defects |
| US5728581A (en) * | 1995-06-07 | 1998-03-17 | Systemix, Inc. | Method of expanding hematopoietic stem cells, reagents and bioreactors for use therein |
| CN1209836A (zh) * | 1995-12-29 | 1999-03-03 | 阿尔格公司 | 骨髓基质细胞的扩展 |
| CA2221195A1 (en) | 1997-11-14 | 1999-05-14 | Chantal E. Holy | Biodegradable polymer matrix |
| AU3888699A (en) * | 1998-05-07 | 1999-11-23 | University Of South Florida | Bone marrow cells as a source of neurons for brain and spinal cord repair |
| AU766064B2 (en) * | 1998-10-26 | 2003-10-09 | Philadelphia Health & Education Corporation | Stromal cell use |
| US6610540B1 (en) | 1998-11-18 | 2003-08-26 | California Institute Of Technology | Low oxygen culturing of central nervous system progenitor cells |
| US6184035B1 (en) * | 1998-11-18 | 2001-02-06 | California Institute Of Technology | Methods for isolation and activation of, and control of differentiation from, skeletal muscle stem or progenitor cells |
| US20030003572A1 (en) * | 1999-03-05 | 2003-01-02 | David J. Anderson | Isolation and enrichment of neural stem cells from uncultured tissue based on cell-surface marker expression |
| ES2531592T3 (es) | 1999-05-14 | 2015-03-17 | Henry Ford Health System | Trasplante de médula ósea para el tratamiento de la apoplejía |
| AUPQ147799A0 (en) | 1999-07-07 | 1999-07-29 | Medvet Science Pty. Ltd. | Mesenchymal precursor cell |
| WO2001004266A1 (en) * | 1999-07-08 | 2001-01-18 | The Regents Of The Universty Of California | A lung cancer associated retrovirus, gene delivery vector and methods of use thereof |
| US7015037B1 (en) * | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
| WO2002064748A2 (en) * | 2001-02-14 | 2002-08-22 | Furcht Leo T | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
| US8075881B2 (en) * | 1999-08-05 | 2011-12-13 | Regents Of The University Of Minnesota | Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure |
| WO2001021767A2 (en) * | 1999-09-24 | 2001-03-29 | Morphogen Pharmaceuticals, Inc. | Pluripotent embryonic-like stem cells, compositions, methods and uses thereof |
| AU781449B2 (en) | 1999-10-29 | 2005-05-26 | Philadelphia Health & Education Corporation | Isolation and expansion of human marrow stromal cells |
| FR2801979B1 (fr) * | 1999-12-03 | 2002-02-08 | Oreal | Utilisation d'un anticorps specifique des fibroblastes papillaires comme marqueur de qualite d'une peau |
| US7544509B2 (en) * | 2000-01-24 | 2009-06-09 | Mcgill University | Method for preparing stem cell preparations |
| JP2003521935A (ja) * | 2000-02-11 | 2003-07-22 | フイラデルフイア・ヘルス・アンド・エデユケーシヨン・コーポレーシヨン | 骨髄細胞のニューロン細胞への分化およびそのための使用 |
| AU2001246894A1 (en) | 2000-04-11 | 2001-10-23 | Kyowa Hakko Kogyo Co. Ltd. | Alpha1,2-fucosyltransferase and process for producing fucose-containing complex carbohydrate |
| JP2004511266A (ja) | 2000-04-12 | 2004-04-15 | チルドレンズ ホスピタル オブ フィラデルフィア | 間葉間質細胞に対する治療的利用法 |
| AU2001285359A1 (en) | 2000-09-01 | 2002-03-13 | Neuronyx, Inc. | Novel synthetic gangliosides |
| WO2002034889A2 (en) | 2000-10-24 | 2002-05-02 | Children's Hospital Of Philadelphia | Therapeutic uses for mesenchymal stromal cells |
| US7056738B2 (en) * | 2001-03-23 | 2006-06-06 | Tulane University | Early stage multipotential stem cells in colonies of bone marrow stromal cells |
| US20030003090A1 (en) * | 2001-05-31 | 2003-01-02 | Prockop Darwin J. | Directed in vitro differentiation of marrow stromal cells into neural cell progenitors |
| US20030059941A1 (en) * | 2001-06-14 | 2003-03-27 | Prockop Darwin J. | Transduced marrow stromal cells |
| US20030017587A1 (en) * | 2001-07-18 | 2003-01-23 | Rader William C. | Embryonic stem cells, clinical applications and methods for expanding in vitro |
| US9969980B2 (en) | 2001-09-21 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
| US9969977B2 (en) * | 2002-09-20 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
| US7521465B2 (en) * | 2003-01-17 | 2009-04-21 | Bexel Pharmaceuticals, Inc. | Diphenyl ether derivatives |
| US20060288431A1 (en) * | 2003-02-13 | 2006-12-21 | Norio Nakatsuji | Marker for undifferentiated state of cell and composition and method for separation and preparation of stem cells |
| EP3461884B1 (en) | 2004-03-22 | 2025-05-28 | Mesoblast International Sàrl | Mesenchymal stem cells and uses therefor |
| EP1753859B1 (en) | 2004-06-04 | 2014-07-30 | Université Pierre et Marie Curie (Paris 6) | A method for producing red blood cells |
| ATE450276T1 (de) * | 2004-12-08 | 2009-12-15 | Pervasis Therapeutics Inc | Materialien und verfahren zur minimal invasiven abgabe einer zellhaltigen fliessfähigen zusammensetzung |
| EP2171043B1 (en) | 2007-06-15 | 2015-03-18 | Garnet BioTherapeutics, Inc | Treatment of diseases and disorders using self-renewing colony forming cells cultured and expanded in vitro |
| BRPI0816157A2 (pt) | 2007-08-15 | 2017-06-13 | Allergan Inc | compostos adrenérgicos |
| WO2011150398A1 (en) | 2010-05-28 | 2011-12-01 | Garnet Biotherapeutics, Inc | Compositions and methods of using living and non-living bioactive devices with components derived from self- renewing colony forming cells cultured and expanded in vitro |
-
2001
- 2001-09-21 US US09/960,244 patent/US9969980B2/en active Active
-
2002
- 2002-09-20 EP EP02778303.4A patent/EP1438392B1/en not_active Revoked
- 2002-09-20 CA CA2461068A patent/CA2461068C/en not_active Expired - Fee Related
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- 2002-09-20 CA CA2709442A patent/CA2709442A1/en not_active Abandoned
- 2002-09-20 AU AU2002339977A patent/AU2002339977B2/en not_active Ceased
- 2002-09-20 JP JP2003529923A patent/JP5273329B2/ja not_active Expired - Lifetime
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- 2005-02-10 US US11/054,824 patent/US8486696B2/en not_active Expired - Fee Related
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- 2007-03-19 US US11/723,348 patent/US20070231309A1/en not_active Abandoned
- 2007-03-20 AU AU2007201194A patent/AU2007201194A1/en not_active Abandoned
- 2007-05-02 US US11/797,322 patent/US10351826B2/en not_active Expired - Fee Related
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2010
- 2010-02-25 JP JP2010040861A patent/JP2010172334A/ja not_active Withdrawn
-
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- 2013-03-11 US US13/792,734 patent/US20140073046A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001011011A2 (en) * | 1999-08-05 | 2001-02-15 | Mcl Llc | Multipotent adult stem cells and methods for isolation |
Non-Patent Citations (1)
| Title |
|---|
| Advances in Peritoneal Dialysis, Vol 14, 1998, Ross J. A. et. al., pages 25-30 * |
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