AU2002336390B2 - 2,4-disubstituted pyrimidinyl derivatives for use as anticancer agents - Google Patents

2,4-disubstituted pyrimidinyl derivatives for use as anticancer agents Download PDF

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Publication number
AU2002336390B2
AU2002336390B2 AU2002336390A AU2002336390A AU2002336390B2 AU 2002336390 B2 AU2002336390 B2 AU 2002336390B2 AU 2002336390 A AU2002336390 A AU 2002336390A AU 2002336390 A AU2002336390 A AU 2002336390A AU 2002336390 B2 AU2002336390 B2 AU 2002336390B2
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Australia
Prior art keywords
phenyl
methoxy
quinolin
optionally substituted
methyl
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Ceased
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AU2002336390A
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AU2002336390A1 (en
Inventor
Shon Booker
John L. Buchanan
Stuart Chaffee
Jean-Christophe Harmange
Spencer Charles R. Napier
Perry M. Novak
Simon Van Der Plas
Xiaotian Zhu
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Amgen Inc
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Amgen Inc
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Publication of AU2002336390B2 publication Critical patent/AU2002336390B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2002336390A 2001-08-22 2002-08-22 2,4-disubstituted pyrimidinyl derivatives for use as anticancer agents Ceased AU2002336390B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US31433901P 2001-08-22 2001-08-22
US60/314,339 2001-08-22
US10/225,783 2002-08-21
US10/225,783 US6939874B2 (en) 2001-08-22 2002-08-21 Substituted pyrimidinyl derivatives and methods of use
PCT/US2002/026870 WO2003018021A1 (en) 2001-08-22 2002-08-22 2,4-disubstituted pyrimidinyl derivatives for use as anticancer agents

Publications (2)

Publication Number Publication Date
AU2002336390A1 AU2002336390A1 (en) 2003-06-05
AU2002336390B2 true AU2002336390B2 (en) 2005-10-20

Family

ID=26919901

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002336390A Ceased AU2002336390B2 (en) 2001-08-22 2002-08-22 2,4-disubstituted pyrimidinyl derivatives for use as anticancer agents

Country Status (8)

Country Link
US (1) US6939874B2 (xx)
EP (1) EP1427421A1 (xx)
JP (1) JP2005505535A (xx)
AU (1) AU2002336390B2 (xx)
CA (1) CA2457838A1 (xx)
MX (1) MXPA04001623A (xx)
PL (1) PL370041A1 (xx)
WO (1) WO2003018021A1 (xx)

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