AU2002334358B2 - A method for preparing liposome formulations with a predefined release profile - Google Patents

A method for preparing liposome formulations with a predefined release profile Download PDF

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Publication number
AU2002334358B2
AU2002334358B2 AU2002334358A AU2002334358A AU2002334358B2 AU 2002334358 B2 AU2002334358 B2 AU 2002334358B2 AU 2002334358 A AU2002334358 A AU 2002334358A AU 2002334358 A AU2002334358 A AU 2002334358A AU 2002334358 B2 AU2002334358 B2 AU 2002334358B2
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AU
Australia
Prior art keywords
ammonium
liposome
counter ion
active agent
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2002334358A
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English (en)
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AU2002334358A1 (en
Inventor
Yechezkel Barenholz
Veronica Wasserman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yissum Research Development Co of Hebrew University of Jerusalem
Original Assignee
Yissum Research Development Co of Hebrew University of Jerusalem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by Yissum Research Development Co of Hebrew University of Jerusalem filed Critical Yissum Research Development Co of Hebrew University of Jerusalem
Publication of AU2002334358A1 publication Critical patent/AU2002334358A1/en
Application granted granted Critical
Publication of AU2002334358B2 publication Critical patent/AU2002334358B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2002334358A 2001-09-06 2002-09-09 A method for preparing liposome formulations with a predefined release profile Ceased AU2002334358B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31718701P 2001-09-06 2001-09-06
US60/317,187 2001-09-06
PCT/IL2002/000745 WO2003032947A2 (en) 2001-09-06 2002-09-09 A method for preparing liposome formulations with a predefined release profile

Publications (2)

Publication Number Publication Date
AU2002334358A1 AU2002334358A1 (en) 2003-07-03
AU2002334358B2 true AU2002334358B2 (en) 2008-02-07

Family

ID=23232510

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002334358A Ceased AU2002334358B2 (en) 2001-09-06 2002-09-09 A method for preparing liposome formulations with a predefined release profile

Country Status (7)

Country Link
US (2) US20060165766A1 (enExample)
EP (1) EP1429726A2 (enExample)
JP (1) JP2005505602A (enExample)
AU (1) AU2002334358B2 (enExample)
CA (1) CA2460209A1 (enExample)
IL (1) IL160350A0 (enExample)
WO (1) WO2003032947A2 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5107573B2 (ja) 2003-04-25 2012-12-26 ザ ペン ステイト リサーチ ファウンデーション 増殖抑制性脂質由来生物活性化合物の全身送達方法およびシステム
US20050129753A1 (en) * 2003-11-14 2005-06-16 Gabizon Alberto A. Method for drug loading in liposomes
EP1793805A1 (en) * 2004-09-09 2007-06-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposomal formulations comprising an amphipathic weak base like tempamine for treatment of neurodegenerative conditions
US7744920B2 (en) * 2004-09-09 2010-06-29 Hadasit Medical Research Services & Development Limited Use of liposomal glucocorticoids for treating inflammatory states
DK1802277T3 (da) 2004-10-18 2010-05-17 Polymun Scient Immunbio Forsch Liposomal sammensætning indeholdende en aktiv bestanddel til relaksation af glat muskulatur og terapeutisk anvendelse af sammensætningen
WO2008109032A2 (en) * 2007-03-02 2008-09-12 Luna Innovations Incorporated Amphiphilic or lipophilic polar functionalized fullerenes and their uses
DE102007036294A1 (de) 2007-07-31 2009-02-05 Gea Westfaliasurge Gmbh Vorrichtung und ein Verfahren zum Bereitstellen von Informationen über Tiere beim Durchlaufen eines Tierdurchganges
AU2009302042A1 (en) 2008-10-07 2010-04-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Liposomal systems comprising sphingomyelin
JPWO2010058840A1 (ja) * 2008-11-20 2012-04-19 テルモ株式会社 リポソームからの薬物放出手段および放出性評価法
US20100129430A1 (en) * 2008-11-24 2010-05-27 Stavroula Sofou Liposome drug carriers with ph-sensitivity
EP2630953B1 (en) * 2010-12-27 2017-08-09 Terumo Kabushiki Kaisha Liposome composition and process for production thereof
KR101494594B1 (ko) 2011-08-30 2015-02-23 주식회사 종근당 약리학적 활성물질의 서방성 지질 초기제제 및 이를 포함하는 약제학적 조성물
KR101586791B1 (ko) 2012-12-28 2016-01-19 주식회사 종근당 ＧｎＲＨ 유도체의 서방성 지질 초기제제 및 이를 포함하는 약제학적 조성물
KR101586790B1 (ko) * 2012-12-28 2016-01-19 주식회사 종근당 음이온성 약리학적 활성물질의 서방성 지질 초기제제 및 이를 포함하는 약제학적 조성물
KR102554628B1 (ko) * 2013-02-01 2023-07-12 존원 파마, 인코포레이티드 리포좀 내로 난수용성 약물의 원격 부하
WO2014121235A2 (en) * 2013-02-01 2014-08-07 Zoneone Pharma, Inc. Transformation of drug cyclodextrin complex compositions into compositions of mixtures of lipid vesicle encapsulated drug and cyclodextrin drug complexes
CA2906794A1 (en) * 2013-03-14 2014-09-25 Zoneone Pharma, Inc. Pharmaceutical formulations of chelating agents as a metal removal treatment system
WO2016022549A1 (en) 2014-08-04 2016-02-11 Zoneone Pharma, Inc. Remote loading of sparingly water-soluble drugs into lipid vesicles
RU2765736C2 (ru) * 2017-01-18 2022-02-02 Темасек Лайф Сайенсиз Лаборатори Лимитед Гиперстабилизированные липосомы, повышающие направленное таргетирование митотических клеток
JP2020111523A (ja) * 2019-01-09 2020-07-27 国立研究開発法人理化学研究所 機能性ナノ構造体
GB202200962D0 (en) * 2022-01-25 2022-03-09 Cytoseek Ltd Polymer additives

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988006442A1 (en) * 1987-03-05 1988-09-07 The Liposome Company, Inc. High drug:lipid formulations of liposomal-antineoplastic agents
US5192549A (en) * 1988-09-28 1993-03-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of amphiphatic drug loading in liposomes by pH gradient
US5939096A (en) * 1995-04-18 1999-08-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposome drug-loading method and composition
WO2000066126A2 (en) * 1999-04-29 2000-11-09 Alza Corporation Liposome compositions for improved drug retention

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5972379A (en) * 1995-02-14 1999-10-26 Sequus Pharmaceuticals, Inc. Liposome composition and method for administering a quinolone
IL140892A0 (en) * 1998-08-12 2002-02-10 Yissum Res Dev Co Liposomal bupivacaine compositions prepared using an ammonium sulfate gradient

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988006442A1 (en) * 1987-03-05 1988-09-07 The Liposome Company, Inc. High drug:lipid formulations of liposomal-antineoplastic agents
US5192549A (en) * 1988-09-28 1993-03-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of amphiphatic drug loading in liposomes by pH gradient
US5939096A (en) * 1995-04-18 1999-08-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposome drug-loading method and composition
WO2000066126A2 (en) * 1999-04-29 2000-11-09 Alza Corporation Liposome compositions for improved drug retention

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CLERC, S ET AL. ANALYTICAL BIOCHEMISTRY 1998 Vol. 259 pages 104-111 *
CLERC, S ET AL. BIOCHIMICA ET BIOPHYSICA ACTA, BIOMEMBRANES 1995 Vol. 1240 pages 257-265 *
HARAN, G. BIOCHIMICA ET BIOPHYSICA ACTA, BIOMEMBRANES 1993 Vol. 1151 pages 201-215 *
JOHNSSON, M ET AL. JOURNAL OF LIPOSOME RESEARCH 1999 Vol. 9(1) pages 71-72 *
LASIC, DD ET AL. BIOCHIMICA ET BIOPHYSICA ACTA, BIOMEMBRANES 1995 Vol. 1239 pages 145-156 *
LI, X ET AL. BIOCHIMICA ET BIOPHYSICA ACTA, BIOMEMBRANES 1998 Vol. 1415 pages 23-40 *

Also Published As

Publication number Publication date
CA2460209A1 (en) 2003-04-24
US20060165766A1 (en) 2006-07-27
WO2003032947A3 (en) 2003-09-25
WO2003032947A2 (en) 2003-04-24
US20080213353A1 (en) 2008-09-04
EP1429726A2 (en) 2004-06-23
IL160350A0 (en) 2004-07-25
JP2005505602A (ja) 2005-02-24

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired