AU2002317409B2 - Aqueous dispersion comprising stable nanoparticles of a water-insoluble active and an excipient like middle chain triglycerides (MCT) - Google Patents

Aqueous dispersion comprising stable nanoparticles of a water-insoluble active and an excipient like middle chain triglycerides (MCT) Download PDF

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Publication number
AU2002317409B2
AU2002317409B2 AU2002317409A AU2002317409A AU2002317409B2 AU 2002317409 B2 AU2002317409 B2 AU 2002317409B2 AU 2002317409 A AU2002317409 A AU 2002317409A AU 2002317409 A AU2002317409 A AU 2002317409A AU 2002317409 B2 AU2002317409 B2 AU 2002317409B2
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AU
Australia
Prior art keywords
inhibitor
water
insoluble
substance
particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2002317409A
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English (en)
Other versions
AU2002317409A1 (en
Inventor
Pia Margaretha Cecilia Hedberg
Per Lennart Lindfors
Ulf Olsson
Tommy Urban Skantze
Lars Christian Von Corswant
Anna Elisabeth Zackrisson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0119081A external-priority patent/GB0119081D0/en
Priority claimed from GB0212463A external-priority patent/GB0212463D0/en
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of AU2002317409A1 publication Critical patent/AU2002317409A1/en
Application granted granted Critical
Publication of AU2002317409B2 publication Critical patent/AU2002317409B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Dental Preparations (AREA)
AU2002317409A 2001-08-06 2002-08-01 Aqueous dispersion comprising stable nanoparticles of a water-insoluble active and an excipient like middle chain triglycerides (MCT) Ceased AU2002317409B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0119081.8 2001-08-06
GB0119081A GB0119081D0 (en) 2001-08-06 2001-08-06 Process
GB0212463A GB0212463D0 (en) 2002-05-30 2002-05-30 Process
GB0212463.4 2002-05-30
PCT/GB2002/003583 WO2003013472A1 (en) 2001-08-06 2002-08-01 Aqueous dispersion comprising stable nanoparticles of a water-insoluble active and an excipient like middle chain triglycerides (mct)

Publications (2)

Publication Number Publication Date
AU2002317409A1 AU2002317409A1 (en) 2003-06-19
AU2002317409B2 true AU2002317409B2 (en) 2007-06-21

Family

ID=26246405

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002317409A Ceased AU2002317409B2 (en) 2001-08-06 2002-08-01 Aqueous dispersion comprising stable nanoparticles of a water-insoluble active and an excipient like middle chain triglycerides (MCT)

Country Status (19)

Country Link
US (1) US20050009908A1 (https=)
EP (1) EP1416917B1 (https=)
JP (1) JP4714412B2 (https=)
KR (1) KR100914113B1 (https=)
CN (1) CN1254233C (https=)
AT (1) ATE365537T1 (https=)
AU (1) AU2002317409B2 (https=)
BR (1) BR0211705A (https=)
CA (1) CA2456180C (https=)
CY (1) CY1107059T1 (https=)
DE (1) DE60220923T2 (https=)
DK (1) DK1416917T3 (https=)
ES (1) ES2287293T3 (https=)
IL (2) IL160103A0 (https=)
MX (1) MXPA04001071A (https=)
NO (1) NO20040484L (https=)
NZ (1) NZ530916A (https=)
PT (1) PT1416917E (https=)
WO (1) WO2003013472A1 (https=)

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GB0302672D0 (en) * 2003-02-06 2003-03-12 Astrazeneca Ab Pharmaceutical formulations
GB0302673D0 (en) * 2003-02-06 2003-03-12 Astrazeneca Ab Pharmaceutical formulations
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GB0314057D0 (en) * 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
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WO2006069098A1 (en) * 2004-12-22 2006-06-29 Elan Pharma International Ltd. Nanoparticulate bicalutamide formulations
US20080193534A1 (en) * 2005-08-12 2008-08-14 Astrazeneca Ab Process
EP2054036B1 (en) 2006-07-24 2019-12-18 Singh-Broemer and Company, Inc. Solid nanoparticle formulation of water insoluble pharmaceutical substances with reduced ostwald ripening
US20100260691A1 (en) * 2006-07-31 2010-10-14 Narayanan Kolazi S Aqueous compositions containing a hydrophobic material
US8168662B1 (en) 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8178564B2 (en) * 2006-11-06 2012-05-15 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8173686B2 (en) 2006-11-06 2012-05-08 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8168661B2 (en) * 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US20110033528A1 (en) * 2009-08-05 2011-02-10 Poniard Pharmaceuticals, Inc. Stabilized picoplatin oral dosage form
WO2008097165A1 (en) * 2007-02-09 2008-08-14 Astrazeneca Ab Process for preparation of a stable dispersion of solid amorphous submicron particles in an aqueous medium
TW200916094A (en) * 2007-06-27 2009-04-16 Poniard Pharmaceuticals Inc Stabilized picoplatin dosage form
US20100260832A1 (en) * 2007-06-27 2010-10-14 Poniard Pharmaceuticals, Inc. Combination therapy for ovarian cancer
EP2178893A4 (en) * 2007-07-16 2012-09-19 Poniard Pharmaceuticals Inc ORAL FORMULATIONS FOR PICOPLATIN
WO2009099649A1 (en) * 2008-02-08 2009-08-13 Poniard Pharmaceuticals, Inc. Use of picoplatin and bevacizumab to treat colorectal cancer
BRPI1004808B1 (pt) * 2010-10-27 2020-09-29 Embrapa - Empresa Brasileira De Pesquisa Agropecuária Composições baseadas em nanopartículas de própolis, processos de obtenção e uso
CN107596518B (zh) 2012-02-29 2021-04-23 普马特里克斯营业公司 可吸入干粉剂
KR102045732B1 (ko) * 2012-12-28 2019-11-18 엘지디스플레이 주식회사 온도감응형 계면활성제를 이용한 수용성 나노입자의 제조방법
PT106738B (pt) * 2013-01-09 2015-06-08 Hovione Farmaciencia Sa Método para o controlo do fenómeno de degradação difusional de ostwald (ostwald ripening) no processamento de partículas de um ingrediente farmacêutico
EP2954009A1 (de) * 2013-02-08 2015-12-16 Basf Se Herstellung von anorganisch-organischen kompositmaterialien durch reaktive sprühtrocknung
WO2019055525A1 (en) * 2017-09-12 2019-03-21 Raj Selvaraj FORMULATION OF SOLID NANOPARTICLES OF WATER-INSOLUBLE PHARMACEUTICAL SUBSTANCES WITH REDUCED OSTWALD CURING
IL312564A (en) 2021-11-05 2024-07-01 Cinclus Pharma Holding Ab Publ Polymorphs of the hydrochloride salt of linfarezan glurate

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Also Published As

Publication number Publication date
JP4714412B2 (ja) 2011-06-29
MXPA04001071A (es) 2004-05-20
ATE365537T1 (de) 2007-07-15
CN1254233C (zh) 2006-05-03
DE60220923D1 (de) 2007-08-09
DE60220923T2 (de) 2008-03-06
EP1416917A1 (en) 2004-05-12
KR20040025739A (ko) 2004-03-25
NZ530916A (en) 2005-07-29
KR100914113B1 (ko) 2009-08-27
IL160103A0 (en) 2004-06-20
DK1416917T3 (da) 2007-09-17
ES2287293T3 (es) 2007-12-16
IL160103A (en) 2008-11-26
EP1416917B1 (en) 2007-06-27
US20050009908A1 (en) 2005-01-13
BR0211705A (pt) 2004-09-28
CY1107059T1 (el) 2012-10-24
CN1564677A (zh) 2005-01-12
CA2456180C (en) 2011-10-11
WO2003013472A1 (en) 2003-02-20
HK1064048A1 (en) 2005-01-21
CA2456180A1 (en) 2003-02-20
NO20040484L (no) 2004-03-31
PT1416917E (pt) 2007-08-16
JP2005500362A (ja) 2005-01-06

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Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired