AU2002316230A1 - Methods of culturing animal cells and polypeptide production in animal cells - Google Patents
Methods of culturing animal cells and polypeptide production in animal cellsInfo
- Publication number
- AU2002316230A1 AU2002316230A1 AU2002316230A AU2002316230A AU2002316230A1 AU 2002316230 A1 AU2002316230 A1 AU 2002316230A1 AU 2002316230 A AU2002316230 A AU 2002316230A AU 2002316230 A AU2002316230 A AU 2002316230A AU 2002316230 A1 AU2002316230 A1 AU 2002316230A1
- Authority
- AU
- Australia
- Prior art keywords
- animal cells
- methods
- polypeptide production
- culturing
- culturing animal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/34—Sugars
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29801301P | 2001-06-13 | 2001-06-13 | |
| US60/298,013 | 2001-06-13 | ||
| PCT/US2002/018687 WO2002101019A2 (en) | 2001-06-13 | 2002-06-11 | Methods of culturing animal cells and polypeptide production in animal cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2002316230A1 true AU2002316230A1 (en) | 2002-12-23 |
Family
ID=23148629
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2002316230A Abandoned AU2002316230A1 (en) | 2001-06-13 | 2002-06-11 | Methods of culturing animal cells and polypeptide production in animal cells |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20030087372A1 (enExample) |
| EP (1) | EP1404813A4 (enExample) |
| JP (1) | JP2004532642A (enExample) |
| AU (1) | AU2002316230A1 (enExample) |
| CA (1) | CA2447791A1 (enExample) |
| WO (1) | WO2002101019A2 (enExample) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030109680A1 (en) * | 2001-11-21 | 2003-06-12 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
| US7749498B2 (en) * | 1997-03-10 | 2010-07-06 | Genentech, Inc. | Antibodies for inhibiting blood coagulation and methods of use thereof |
| US5986065A (en) * | 1997-03-10 | 1999-11-16 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
| US20060235209A9 (en) * | 1997-03-10 | 2006-10-19 | Jin-An Jiao | Use of anti-tissue factor antibodies for treating thromboses |
| EP1360314B1 (en) | 2001-02-15 | 2009-01-14 | Centocor, Inc. | Chemically defined medium for cultured mammalian cells |
| EP1623023B1 (en) * | 2003-05-09 | 2008-11-12 | Crucell Holland B.V. | Cultures of e1-immortalized cells and processes for culturing the same to increase product yields therefrom |
| DK1623019T4 (en) * | 2003-05-15 | 2017-03-27 | Wyeth Llc | LIMITED GLUCOSE SUPPLY TO ANIMAL CELL CULTURE |
| EP1644039B1 (en) * | 2003-06-19 | 2014-10-01 | Genentech, Inc. | Compositions and methods for treating coagulation related disorders |
| WO2005035748A1 (en) * | 2003-10-10 | 2005-04-21 | Novo Nordisk Health Care Ag | Method for large-scale production of a polypeptide in eukaryote cells and a culture vessel suitable therefor |
| US7335491B2 (en) * | 2004-08-27 | 2008-02-26 | Wyeth Research Ireland Limited | Production of anti-abeta |
| RU2451082C2 (ru) * | 2004-08-27 | 2012-05-20 | Вайет Рисёрч Айрлэнд Лимитед | Производство полипептидов |
| TWI364458B (en) * | 2004-08-27 | 2012-05-21 | Wyeth Res Ireland Ltd | Production of tnfr-lg |
| AU2012200353B2 (en) * | 2004-08-27 | 2014-06-19 | Pfizer Ireland Pharmaceuticals | PRODUCTION OF a-ABeta |
| TWI384069B (zh) * | 2004-08-27 | 2013-02-01 | Pfizer Ireland Pharmaceuticals | 多胜肽之製法 |
| KR101423344B1 (ko) | 2006-01-04 | 2014-07-30 | 백스터 인터내셔널 인코포레이티드 | 올리고펩티드-무함유 세포 배양 배지를 이용하여 단백질을 발현시키는 방법 |
| AR059065A1 (es) * | 2006-01-23 | 2008-03-12 | Amgen Inc | Metodos para modular el contenido de manosa de las proteinas recombinantes |
| US20070190057A1 (en) | 2006-01-23 | 2007-08-16 | Jian Wu | Methods for modulating mannose content of recombinant proteins |
| CA2842964A1 (en) | 2006-09-13 | 2008-03-20 | Abbvie Inc. | Cell culture improvements |
| US9012180B2 (en) | 2007-03-02 | 2015-04-21 | Wyeth Llc | Use of copper and glutamate in cell culture for production of polypeptides |
| WO2008121615A2 (en) * | 2007-03-30 | 2008-10-09 | Medimmune, Inc. | Antibody formulation |
| CN105567627B (zh) | 2007-04-26 | 2020-09-29 | 中外制药株式会社 | 使用含高浓度氨基酸的培养基的细胞培养方法 |
| PL4365189T3 (pl) | 2007-07-09 | 2025-05-26 | F. Hoffmann-La Roche Ag | Zapobieganie redukcji wiązania disiarczkowego podczas rekombinacyjnego wytwarzania polipeptydów |
| EP2188371B1 (en) | 2007-08-09 | 2017-12-20 | Wyeth LLC | Use of perfusion to enhance production of fed-batch cell culture in bioreactors |
| MX2010011356A (es) * | 2008-04-17 | 2010-11-09 | Wyeth Llc | Metodos para la produccion mejorada de proteinas morfogeneticas de hueso. |
| EP2331700A2 (en) | 2008-08-08 | 2011-06-15 | Biogen Idec MA Inc. | Nutrient monitoring and feedback control for increased bioproduct production |
| HRP20200768T4 (hr) | 2009-08-11 | 2025-03-28 | F. Hoffmann - La Roche Ag | Proizvodnja proteina u mediju za uzgoj stanica bez glutamina |
| DK2493922T3 (en) | 2009-10-26 | 2017-04-24 | Hoffmann La Roche | Process for preparing a glycosylated immunoglobulin |
| HUE035508T2 (en) | 2009-11-17 | 2018-05-02 | Squibb & Sons Llc | Methods for enhanced protein production |
| US20130210075A1 (en) * | 2010-01-07 | 2013-08-15 | Dr. Reddy's Laboratories, Inc. | Enhanced protein expression |
| LT3330370T (lt) | 2010-04-26 | 2021-06-10 | Novartis Ag | Cho ląstelių auginimo būdas |
| US8986957B2 (en) * | 2010-04-26 | 2015-03-24 | Novartis Ag | Cell culture medium |
| CN102858952B (zh) | 2010-04-26 | 2015-10-14 | 诺瓦提斯公司 | 改进的细胞培养基 |
| TWI621625B (zh) | 2010-09-17 | 2018-04-21 | 巴克斯歐塔公司 | 在弱酸性至中性ph中經由具有組胺酸的水性調配物穩定免疫球蛋白 |
| US9062106B2 (en) | 2011-04-27 | 2015-06-23 | Abbvie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| WO2012147048A2 (en) * | 2011-04-29 | 2012-11-01 | Biocon Research Limited | Methods for reducing accumulation of lactate during culturing and method for producing polypeptide |
| RU2580020C2 (ru) | 2011-04-29 | 2016-04-10 | Биокон Рисерч Лимитед | Способ снижения гетерогенности антител и способ получения соответствующих антител |
| JP5897708B2 (ja) | 2011-07-01 | 2016-03-30 | アムジエン・インコーポレーテツド | 哺乳類細胞培養物 |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
| US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
| RU2496869C1 (ru) * | 2012-04-23 | 2013-10-27 | Государственное научное учреждение Прикаспийский зональный научно-исследовательский ветеринарный институт Российской академии сельскохозяйственных наук | Способ культивирования клеток человека и животных |
| US20130281355A1 (en) | 2012-04-24 | 2013-10-24 | Genentech, Inc. | Cell culture compositions and methods for polypeptide production |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| HK1207960A1 (en) | 2013-03-12 | 2016-02-19 | Abbvie Inc. | Human antibodies that bind human tnf-alpha and methods of preparing the same |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
| US9217168B2 (en) | 2013-03-14 | 2015-12-22 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
| BR112015021993A8 (pt) | 2013-03-15 | 2019-12-03 | Genentech Inc | polipeptídeo, métodos para sua produção, métodos para cultivo de uma célula, composição farmacêutica, kit, e meio de cultura celular |
| WO2015000865A1 (en) | 2013-07-04 | 2015-01-08 | F. Hoffmann-La Roche Ag | Interference-suppressed immunoassay to detect anti-drug antibodies in serum samples |
| US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US11390663B2 (en) | 2013-10-11 | 2022-07-19 | Regeneron Pharmaceuticals, Inc. | Metabolically optimized cell culture |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| CN106029871A (zh) * | 2014-01-29 | 2016-10-12 | 株式会社Lg生命科学 | 通过优化培养基调节重组蛋白的半乳糖基化的方法 |
| WO2015128795A1 (en) | 2014-02-25 | 2015-09-03 | Dr. Reddy's Laboratories Limited | Process for modifying galactosylation and g0f content of a glycoprotein composition by glutamine supplementation |
| MA40864A (fr) | 2014-10-31 | 2017-09-05 | Biogen Ma Inc | Hypotaurine, gaba, bêta-alanine et choline pour la régulation de l'accumulation de sous-produits résiduaires dans des procédés de culture de cellules mammifères |
| IL253071B2 (en) | 2014-12-22 | 2024-04-01 | Genzyme Corp | Methods for growing mammalian cells |
| TW202440903A (zh) | 2015-08-04 | 2024-10-16 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法(一) |
| EP3775251A1 (en) | 2018-03-26 | 2021-02-17 | Amgen Inc. | Total afucosylated glycoforms of antibodies produced in cell culture |
| JP2020005511A (ja) * | 2018-07-03 | 2020-01-16 | 株式会社日立製作所 | 培養方法及び培養装置 |
| WO2020229584A1 (en) * | 2019-05-16 | 2020-11-19 | Formycon Ag | Method for reducing methionine oxidation in recombinant proteins |
| CN110257319A (zh) * | 2019-07-26 | 2019-09-20 | 苏州瑞徕生物科技有限公司 | 一种微载体上细胞维持培养的培养液及方法 |
| US12297451B1 (en) | 2019-10-25 | 2025-05-13 | Regeneron Pharmaceuticals, Inc. | Cell culture medium |
| KR20230152810A (ko) | 2019-12-06 | 2023-11-03 | 리제너론 파아마슈티컬스, 인크. | 항-vegf 단백질 조성물 및 이를 생산하는 방법 |
| JP2023525034A (ja) | 2020-05-08 | 2023-06-14 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Vegfトラップおよびミニトラップならびに眼障害およびがんの治療方法 |
| US20230323422A1 (en) * | 2020-08-14 | 2023-10-12 | Bristol-Myers Squibb Company | Method of making protein |
| AU2022258569A1 (en) * | 2021-04-14 | 2023-11-30 | Genzyme Corporation | Methods of perfusion culturing a mammalian cell |
| US20240174752A1 (en) * | 2021-04-27 | 2024-05-30 | Amgen Inc. | Modulating product quality of asymmetric multispecific antibodies through the use of temperature |
| CN115927160B (zh) * | 2022-12-28 | 2025-05-30 | 无锡药明生物技术股份有限公司 | 细胞培养基测试方法及其在生物制药中的应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US30985A (en) * | 1860-12-18 | Thomas l | ||
| US3926723A (en) * | 1974-08-08 | 1975-12-16 | Massachusetts Inst Technology | Method of controllably releasing glucose to a cell culture medium |
| US4560655A (en) * | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
| US4657866A (en) * | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
| US4767704A (en) * | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
| US4724206A (en) * | 1984-02-13 | 1988-02-09 | Damon Biotech, Inc. | Protein production using hypertonic media |
| US5672502A (en) * | 1985-06-28 | 1997-09-30 | Celltech Therapeutics Limited | Animal cell culture |
| US4927762A (en) * | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
| US6238891B1 (en) * | 1987-11-18 | 2001-05-29 | Cetus Oncology Corporation | Method of increasing product expression through solute stress |
| US5151359A (en) * | 1988-05-19 | 1992-09-29 | Mitsui Toatsu Chemicals Incorporated | Method for producing of human tissue type plasminogen activator |
| US5122469A (en) * | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
| US6180403B1 (en) * | 1999-10-28 | 2001-01-30 | Isis Pharmaceuticals Inc. | Antisense inhibition of tumor necrosis factor alpha converting enzyme (TACE) expression |
| US5736137A (en) * | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| US5856179A (en) * | 1994-03-10 | 1999-01-05 | Genentech, Inc. | Polypeptide production in animal cell culture |
| US5705364A (en) * | 1995-06-06 | 1998-01-06 | Genentech, Inc. | Mammalian cell culture process |
| US5721121A (en) * | 1995-06-06 | 1998-02-24 | Genentech, Inc. | Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein |
| JP4306813B2 (ja) * | 1995-09-19 | 2009-08-05 | アスビオファーマ株式会社 | 動物細胞の新規培養方法 |
| US6087129A (en) * | 1996-01-19 | 2000-07-11 | Betagene, Inc. | Recombinant expression of proteins from secretory cell lines |
| WO1998041611A1 (en) * | 1997-03-20 | 1998-09-24 | Regents Of The University Of Minnesota | Process for the continuous culture of cells |
| US6237791B1 (en) * | 1997-04-09 | 2001-05-29 | Dtl Technology Limited Partnership | Wide mouth hot fill container |
| US6171586B1 (en) * | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| US6172213B1 (en) * | 1997-07-02 | 2001-01-09 | Genentech, Inc. | Anti-IgE antibodies and method of improving polypeptides |
| US5994511A (en) * | 1997-07-02 | 1999-11-30 | Genentech, Inc. | Anti-IgE antibodies and methods of improving polypeptides |
-
2002
- 2002-06-11 AU AU2002316230A patent/AU2002316230A1/en not_active Abandoned
- 2002-06-11 EP EP02746513A patent/EP1404813A4/en not_active Withdrawn
- 2002-06-11 US US10/167,517 patent/US20030087372A1/en not_active Abandoned
- 2002-06-11 JP JP2003503770A patent/JP2004532642A/ja active Pending
- 2002-06-11 CA CA002447791A patent/CA2447791A1/en not_active Abandoned
- 2002-06-11 WO PCT/US2002/018687 patent/WO2002101019A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CA2447791A1 (en) | 2002-12-19 |
| WO2002101019A3 (en) | 2003-04-10 |
| WO2002101019A2 (en) | 2002-12-19 |
| EP1404813A2 (en) | 2004-04-07 |
| US20030087372A1 (en) | 2003-05-08 |
| JP2004532642A (ja) | 2004-10-28 |
| EP1404813A4 (en) | 2004-11-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |