AU2002308533B2 - Modified organs and cells for xenotransplantation - Google Patents
Modified organs and cells for xenotransplantation Download PDFInfo
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- AU2002308533B2 AU2002308533B2 AU2002308533A AU2002308533A AU2002308533B2 AU 2002308533 B2 AU2002308533 B2 AU 2002308533B2 AU 2002308533 A AU2002308533 A AU 2002308533A AU 2002308533 A AU2002308533 A AU 2002308533A AU 2002308533 B2 AU2002308533 B2 AU 2002308533B2
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/18—Erythrocytes
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
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- Environmental Sciences (AREA)
- Biotechnology (AREA)
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- Veterinary Medicine (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Hematology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28768401P | 2001-04-30 | 2001-04-30 | |
| US60/287,684 | 2001-04-30 | ||
| US30060401P | 2001-06-22 | 2001-06-22 | |
| US60/300,604 | 2001-06-22 | ||
| US33387601P | 2001-11-28 | 2001-11-28 | |
| US60/333,876 | 2001-11-28 | ||
| PCT/US2002/013564 WO2002088351A1 (en) | 2001-04-30 | 2002-04-29 | Modified organs and cells for xenotransplantation |
Publications (2)
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| AU2002308533A1 AU2002308533A1 (en) | 2003-04-17 |
| AU2002308533B2 true AU2002308533B2 (en) | 2007-07-19 |
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| US (3) | US7166278B2 (https=) |
| EP (1) | EP1383889B1 (https=) |
| JP (1) | JP2004533242A (https=) |
| AU (1) | AU2002308533B2 (https=) |
| CA (1) | CA2445945A1 (https=) |
| ES (1) | ES2530872T3 (https=) |
| WO (1) | WO2002088351A1 (https=) |
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| EP1639083A4 (en) * | 2003-06-06 | 2008-05-28 | Univ Pittsburgh | GENE OF CMP-N-ACETYLNEURAMIC ACID HYDROXYLASE FROM PIG |
| CA2533259C (en) * | 2003-07-21 | 2014-01-28 | Lifecell Corporation | Acellular tissue matrices made from galactose .alpha.-1,3-galactose-deficient tissue |
| AU2005223617A1 (en) | 2004-03-17 | 2005-09-29 | Revivicor, Inc. | Tissue products from animals lacking functional alpha 1,3 galactosyl transferase |
| JP2006129736A (ja) * | 2004-11-02 | 2006-05-25 | Nippon Dobutsu Kogaku Kenkyusho:Kk | 異種移植用豚細胞、その選抜方法及び異種移植用豚 |
| US20060147429A1 (en) * | 2004-12-30 | 2006-07-06 | Paul Diamond | Facilitated cellular reconstitution of organs and tissues |
| WO2006074373A2 (en) * | 2005-01-06 | 2006-07-13 | Crosscart, Inc. | Immunochemically modified and sterilized xenografts and allografts |
| EP1893756B1 (en) * | 2005-06-08 | 2015-08-12 | The Regents of The University of California | Elimination of n-glycolylneuraminic acid from mammalian products for human use |
| FI20055398A0 (fi) | 2005-07-08 | 2005-07-08 | Suomen Punainen Risti Veripalv | Menetelmä solupopulaatioiden evaluoimiseksi |
| FI20075030A0 (fi) | 2007-01-18 | 2007-01-18 | Suomen Punainen Risti Veripalv | Menetelmä solujen modifioimiseksi |
| KR101149475B1 (ko) | 2007-11-30 | 2012-05-25 | 한국생명공학연구원 | 이종 장기 이식용 미니 복제돼지 생산을 위한 유전자 조작된 세포주 및 그의 생산방법 |
| EP2166085A1 (en) | 2008-07-16 | 2010-03-24 | Suomen Punainen Risti Veripalvelu | Divalent modified cells |
| EP2324110A4 (en) * | 2008-09-09 | 2013-01-09 | Univ California | ELIMINATION OF A CONTAMINATING NON-HUMAN SIALIC ACID BY METABOLISM COMPETITION |
| US9420770B2 (en) | 2009-12-01 | 2016-08-23 | Indiana University Research & Technology Corporation | Methods of modulating thrombocytopenia and modified transgenic pigs |
| KR101276801B1 (ko) * | 2011-01-21 | 2013-06-19 | 한화엘앤씨 주식회사 | ｓＴＮＦＲ1-Ｆｃ 유전자를 발현하는 형질전환 돼지 및 이의 용도 |
| WO2013151649A1 (en) | 2012-04-04 | 2013-10-10 | Sialix Inc | Glycan-interacting compounds |
| US20140115728A1 (en) | 2012-10-24 | 2014-04-24 | A. Joseph Tector | Double knockout (gt/cmah-ko) pigs, organs and tissues |
| WO2015066668A1 (en) | 2013-11-04 | 2015-05-07 | Lifecell Corporation | Methods of removing alpha-galactose |
| CA2965550A1 (en) | 2014-10-22 | 2016-04-28 | Indiana University Research & Technology Corporation | Triple transgenic pigs suitable for xenograft |
| FI3218005T3 (fi) | 2014-11-12 | 2023-03-31 | Seagen Inc | Glykaanin kanssa vuorovaikutteisia yhdisteitä ja käyttömenetelmiä |
| US9879087B2 (en) | 2014-11-12 | 2018-01-30 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
| CN116059378A (zh) | 2014-12-10 | 2023-05-05 | 明尼苏达大学董事会 | 用于治疗疾病的遗传修饰的细胞、组织和器官 |
| CA3002097A1 (en) | 2015-11-12 | 2017-05-18 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
| WO2018094143A1 (en) | 2016-11-17 | 2018-05-24 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
| WO2018160909A1 (en) | 2017-03-03 | 2018-09-07 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
| KR102746223B1 (ko) | 2017-04-20 | 2024-12-27 | 이제네시스, 인크. | 유전자 변형 동물의 생성 방법 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03255028A (ja) | 1990-03-01 | 1991-11-13 | Imeeji Meekaa:Kk | 免疫抑制剤 |
| WO1992017189A1 (en) | 1991-03-29 | 1992-10-15 | The Regents Of The University Of California | Gangliosides with immunosuppressive activity |
| US6228631B1 (en) * | 1992-10-22 | 2001-05-08 | New York Blood Center, Inc. | Recombinant α-N-acetylgalactosaminidase enzyme and cDNA encoding said enzyme |
| US5330974A (en) * | 1993-03-01 | 1994-07-19 | Fibratek, Inc. | Therapeutic fibrinogen compositions |
| US6331658B1 (en) * | 1993-04-20 | 2001-12-18 | Integris Baptist Medical Center, Inc. | Genetically engineered mammals for use as organ donors |
| JPH09508277A (ja) | 1994-01-27 | 1997-08-26 | ブレサゲン リミテッド | ヒト異種移植における超急性拒絶の管理のための物質及び方法 |
| US6166288A (en) * | 1995-09-27 | 2000-12-26 | Nextran Inc. | Method of producing transgenic animals for xenotransplantation expressing both an enzyme masking or reducing the level of the gal epitope and a complement inhibitor |
| US6245890B1 (en) * | 1999-03-26 | 2001-06-12 | New York Blood Center, Inc. | Porcine protein and uses thereof |
-
2002
- 2002-04-29 US US10/135,919 patent/US7166278B2/en not_active Expired - Lifetime
- 2002-04-29 ES ES02766869T patent/ES2530872T3/es not_active Expired - Lifetime
- 2002-04-29 WO PCT/US2002/013564 patent/WO2002088351A1/en not_active Ceased
- 2002-04-29 EP EP02766869.8A patent/EP1383889B1/en not_active Expired - Lifetime
- 2002-04-29 CA CA002445945A patent/CA2445945A1/en not_active Abandoned
- 2002-04-29 JP JP2002585632A patent/JP2004533242A/ja active Pending
- 2002-04-29 AU AU2002308533A patent/AU2002308533B2/en not_active Ceased
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2006
- 2006-11-20 US US11/561,470 patent/US8034330B2/en not_active Expired - Fee Related
-
2011
- 2011-08-16 US US13/211,040 patent/US20110301341A1/en not_active Abandoned
Non-Patent Citations (1)
| Title |
|---|
| Bouhours et al. Glycoconjugate J (1996) 13: 947-953 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1383889A1 (en) | 2004-01-28 |
| EP1383889A4 (en) | 2005-01-26 |
| US20070089178A1 (en) | 2007-04-19 |
| US20110301341A1 (en) | 2011-12-08 |
| CA2445945A1 (en) | 2002-11-07 |
| ES2530872T3 (es) | 2015-03-06 |
| US8034330B2 (en) | 2011-10-11 |
| JP2004533242A (ja) | 2004-11-04 |
| WO2002088351A1 (en) | 2002-11-07 |
| US7166278B2 (en) | 2007-01-23 |
| EP1383889B1 (en) | 2014-11-19 |
| US20030165480A1 (en) | 2003-09-04 |
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| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |