AU2002302248B2 - Dihydropyrrolo[1,2-A]indole and tetrahydropyrido[1,2-A]-indole derivatives as prostaglandin D2 receptor antagonists - Google Patents

Dihydropyrrolo[1,2-A]indole and tetrahydropyrido[1,2-A]-indole derivatives as prostaglandin D2 receptor antagonists Download PDF

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Publication number
AU2002302248B2
AU2002302248B2 AU2002302248A AU2002302248A AU2002302248B2 AU 2002302248 B2 AU2002302248 B2 AU 2002302248B2 AU 2002302248 A AU2002302248 A AU 2002302248A AU 2002302248 A AU2002302248 A AU 2002302248A AU 2002302248 B2 AU2002302248 B2 AU 2002302248B2
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AU
Australia
Prior art keywords
halogen
phe
optionally substituted
compound
ch2co2h
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Ceased
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AU2002302248A
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AU2002302248A1 (en
Inventor
Claude Dufresne
Daniel Guay
Yves Leblanc
Zhaoyin Wang
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Merck Canada Inc
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Merck Frosst Canada Ltd
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Publication of AU2002302248A1 publication Critical patent/AU2002302248A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
AU2002302248A 2001-05-23 2002-05-22 Dihydropyrrolo[1,2-A]indole and tetrahydropyrido[1,2-A]-indole derivatives as prostaglandin D2 receptor antagonists Ceased AU2002302248B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29307701P 2001-05-23 2001-05-23
US60/293,077 2001-05-23
PCT/CA2002/000745 WO2002094830A2 (en) 2001-05-23 2002-05-22 DIHYDROPYRROLO[1,2-A]INDOLE AND TETRAHYDROPYRIDO[1,2-a]-INDOLE DERIVATIVES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS

Publications (2)

Publication Number Publication Date
AU2002302248A1 AU2002302248A1 (en) 2003-05-08
AU2002302248B2 true AU2002302248B2 (en) 2008-03-06

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ID=23127559

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AU2002302248A Ceased AU2002302248B2 (en) 2001-05-23 2002-05-22 Dihydropyrrolo[1,2-A]indole and tetrahydropyrido[1,2-A]-indole derivatives as prostaglandin D2 receptor antagonists

Country Status (9)

Country Link
US (1) US7144913B2 (enExample)
EP (1) EP1395590B1 (enExample)
JP (1) JP4279561B2 (enExample)
AT (1) ATE340796T1 (enExample)
AU (1) AU2002302248B2 (enExample)
CA (1) CA2447779C (enExample)
DE (1) DE60215000T2 (enExample)
ES (1) ES2272712T3 (enExample)
WO (1) WO2002094830A2 (enExample)

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JP6770522B2 (ja) 2015-02-13 2020-10-14 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 全身性エリテマトーデスを予防し、及び／又は、治療するためのｐｔｇｄｒ−１及び／又はｐｔｇｄｒ−２アンタゴニスト
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Also Published As

Publication number Publication date
WO2002094830A2 (en) 2002-11-28
JP2004534774A (ja) 2004-11-18
ES2272712T3 (es) 2007-05-01
JP4279561B2 (ja) 2009-06-17
CA2447779A1 (en) 2002-11-28
US7144913B2 (en) 2006-12-05
EP1395590A2 (en) 2004-03-10
US20040180934A1 (en) 2004-09-16
WO2002094830A8 (en) 2003-04-10
WO2002094830A3 (en) 2003-03-06
EP1395590B1 (en) 2006-09-27
CA2447779C (en) 2010-08-31
DE60215000D1 (de) 2006-11-09
DE60215000T2 (de) 2007-08-09
ATE340796T1 (de) 2006-10-15

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Owner name: MERCK FROSST CANADA LTD.

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired